[Hub]/) : Traits : Hypothyroidism/myxoedema (self-reported) : ← →

chr17:44,788,310-46,602,432

Best TWAS P=1.76e-13 · Best GWAS P=5.39e-13 conditioned to 0.00432

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex TBKBP1 0.03 0.00 blup 415 0.01 5.4e-02 -4.4 5.4 6.0e-08 0.70 0.20 0.27 FALSE
2 GTEx Adipose Subcutaneous MRPL10 0.19 0.10 lasso 6 0.13 1.7e-10 3.5 -5.4 7.1e-08 -0.20 0.94 0.05 FALSE
3 GTEx Heart Atrial Appendage TBKBP1 0.09 0.02 lasso 5 0.01 8.8e-02 4.1 5.5 4.5e-08 0.50 0.31 0.07 FALSE
4 GTEx Ovary TBKBP1 0.19 0.08 enet 16 0.10 2.5e-03 4.3 5.1 3.0e-07 0.80 0.31 0.12 FALSE
5 GTEx Uterus EFCAB13 0.41 0.03 lasso 9 0.28 1.7e-06 4.4 -5.7 1.6e-08 -0.23 0.04 0.51 FALSE
6 METSIM Adipose NPEPPS 0.04 0.02 lasso 6 0.03 1.4e-05 6.9 7.4 1.8e-13 0.70 0.02 0.98 TRUE
7 METSIM Adipose TBKBP1 0.08 0.10 lasso 4 0.10 2.1e-14 4.4 5.1 3.1e-07 0.85 0.61 0.39 FALSE
8 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma TBKBP1 0.12 0.09 blup 46 0.08 8.4e-05 4.4 6.1 1.2e-09 0.84 0.11 0.70 FALSE
9 The Cancer Genome Atlas Colon Adenocarcinoma TBKBP1 0.09 0.06 blup 46 0.09 7.8e-06 4.4 5.7 1.1e-08 0.80 0.18 0.76 FALSE
10 The Cancer Genome Atlas Lung Squamous Cell Carcinoma TBKBP1 0.05 0.04 enet 11 0.05 2.9e-06 4.4 5.5 4.9e-08 0.91 0.04 0.96 FALSE
11 The Cancer Genome Atlas Prostate Adenocarcinoma TBKBP1 0.06 0.07 blup 47 0.08 1.3e-08 3.2 5.5 4.4e-08 0.84 0.04 0.96 FALSE
12 The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma TBKBP1 0.11 0.04 blup 45 0.03 5.3e-02 -4.7 5.4 7.5e-08 0.79 0.03 0.60 FALSE