Hub : Genes

NPEPPS

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Cells Transformed fibroblasts 0.0470 0.0230 0.00570 0.029 NA 0.002 NA 0.009 2.7e-03 NA 0.20000 NA 6.6e-02
2 GTEx Pituitary 0.2040 0.0940 0.00600 0.102 NA 0.046 NA 0.038 1.6e-03 NA 0.02600 NA 4.0e-02
3 METSIM Adipose 0.0354 0.0142 0.00012 0.021 0.024 0.024 0.025 0.031 3.1e-04 0.00014 0.00014 9.9e-05 1.4e-05
4 NTR Blood 0.0212 0.0092 0.00059 0.004 0.010 0.004 0.010 0.004 1.2e-02 0.00027 0.01400 2.7e-04 1.9e-02
5 TCGA Breast Invasive Carcinoma 0.0204 0.0132 0.00035 0.021 0.014 0.017 NA 0.018 2.4e-05 0.00060 0.00015 NA 1.1e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 1.1 1.7 2.8 1.5 1.7 -0.2 -0.9 1.6
Bipolar Disorder or Schizophrenia 1.3 3.2 4.0 1.5 2.0 -1.8 -1.9 1.7
Depressed Affect (Nagel 2018) 1.0 2.1 8.5 -0.7 0.3 2.9 0.6 -1.0
Depression (Nagel 2018) 4.4 6.6 8.9 -2.7 -1.7 3.0 2.6 -2.7
Intelligence (Savage-Jansen 2018) 0.8 2.3 6.5 1.1 1.2 -0.5 -2.5 1.4
Neuroticism (Nagel 2018) 1.2 2.8 11.6 -0.4 0.0 3.4 0.5 -1.3
Schizophrenia (2018) 0.9 2.0 4.2 0.7 1.2 -2.0 -1.7 0.9
Schizophrenia vs Biploar Disorder 0.5 0.6 1.2 -1.1 -1.1 -0.1 -0.2 -0.8
Worry (Nagel 2018) 1.4 3.0 8.3 -0.9 -1.3 2.9 -0.1 -2.1
Alzheimer’s Disease (in mother) 0.9 1.1 2.7 -0.8 -1.3 1.6 0.4 -0.2
Alzheimer’s Disease (in father) 0.5 0.5 1.6 -0.5 -1.3 0.3 0.6 0.6
Alzheimer’s Disease (including proxy) 3.2 4.6 6.7 -2.0 -2.5 2.6 2.2 -1.1
Crohns Disease (2017) 0.5 1.0 2.4 -1.4 0.8 1.6 -0.4 -0.0
Irritable Bowel Disease (IBD) 1.6 3.9 9.2 -2.7 -0.2 3.0 0.3 -1.7
Ulcerative Colitis (UC) 2.2 4.1 9.5 -2.4 -0.8 3.1 0.7 -2.0
Major Depression (MDD) 0.7 0.8 1.1 -0.9 1.1 0.6 1.0 -0.8
Reaction Time 0.6 1.2 3.3 1.8 0.7 -1.4 -0.3 0.6
Verbal and Numeric Reasoning (VNR) 1.1 2.6 5.0 1.7 0.4 -1.3 -1.8 2.2
Breast Cancer 1.3 3.1 5.1 -1.9 -2.2 1.8 0.6 -1.8
Ovarian Cancer 0.7 0.9 2.5 -0.7 -0.9 1.6 0.8 -0.3
Prostate Cancer 0.4 0.6 1.7 -1.3 -0.2 0.2 -0.6 -0.9
Age at First Birth 0.4 0.6 2.1 0.7 1.4 -0.3 -0.7 -0.2
Bipolar Disorder (2011) 2.3 2.2 3.8 1.9 1.4 -1.4 -0.8 1.6
Body Mass Index (BMI) (2010) 2.3 3.1 5.0 -2.2 -2.0 1.9 -0.8 -1.5
Coronary Artery Disease (CAD) 0.4 0.4 1.2 0.7 1.1 -0.0 0.7 0.2
Crohns Disease (2012) 0.5 0.8 1.6 -1.0 -1.0 1.3 -0.7 -0.5
Mean Putamen Volume 0.1 0.2 0.8 0.2 -0.2 -0.0 -0.9 -0.0
Fasting Glucose 0.1 0.1 0.2 0.1 0.5 0.1 -0.4 0.0
HbA1C 0.6 0.7 1.1 1.0 1.0 -0.3 -0.6 1.0
HDL Cholesterol 5.4 9.0 16.5 2.6 4.1 -2.4 -3.4 2.1
LDL Cholesterol 12.7 20.0 24.9 4.8 4.4 -3.3 -5.0 4.8
Lupus 0.5 0.8 2.2 0.6 0.8 -0.8 0.3 1.5
Neuroticism (2016) 0.9 1.2 4.0 -0.0 2.0 1.3 -0.7 0.0
Primary Biliary Cirrhosis 0.4 0.6 1.4 0.2 0.7 0.6 -0.8 1.2
Rheumatoid Arthritis 0.5 0.7 1.5 0.9 -0.3 -1.2 0.4 1.0
Schizophrenia (2014) 0.1 0.3 0.9 0.2 0.2 -0.9 -0.5 0.3
Triglycerides 3.4 5.6 7.5 -2.7 -2.1 2.5 2.7 -1.5
Type 2 Diabetes (T2D) (2012) 0.4 0.4 0.8 -0.8 0.6 0.9 0.5 -0.2
Ulcerative Colitis 3.0 4.3 8.9 -2.2 -1.7 3.0 0.5 -2.2
Blood Eosinophil Count 1.7 12.8 35.3 3.6 0.5 -5.9 -3.6 1.7
Blood Platelet Count 1.1 12.3 30.0 1.7 5.5 -2.8 -4.2 1.8
Blood Red Count 0.7 7.2 20.3 -2.2 2.1 4.5 1.4 -2.0
Blood White Count 0.6 4.5 10.8 -3.3 -1.9 1.2 1.3 -2.2
Heel T-Score 0.3 2.1 3.8 -0.6 -1.8 -1.5 1.9 -1.0
BMI 0.5 3.2 10.5 -2.0 0.3 3.2 0.1 -1.1
Height 3.4 65.2 106.1 -10.3 -7.8 6.1 6.6 -8.9
Waist Hip Ratio (WHR) 1.4 6.4 13.2 2.3 3.6 -2.7 -0.6 2.4
Systolic Blood Pressure 1.8 8.8 36.1 1.6 6.0 -1.7 1.0 1.2
Smoking Status 2.2 5.3 7.2 -2.7 -1.6 2.1 2.4 -2.5
Allergy or Eczema 1.4 3.6 6.2 -1.6 -2.3 0.9 2.5 -1.7
Cardiovascular Disease 5.5 18.3 44.0 3.6 6.6 -2.4 -3.5 4.0
Hypothyroidism (self reported) 11.3 26.1 65.3 -4.9 -3.5 8.1 3.8 -3.8
Respiratory disease 1.1 2.5 11.2 0.4 0.5 -3.3 0.9 0.3
Type 2 Diabetes (T2D) (2018) 0.8 1.5 3.9 1.3 1.3 -0.0 -0.6 2.0
Lung FEV1/FVC ratio 0.4 1.8 5.2 1.0 1.6 0.2 0.3 2.3
Lung FVC 1.5 7.7 15.9 -1.5 -3.9 -0.0 4.0 -2.4
Neuroticism 0.7 1.6 6.9 -0.1 -0.1 2.6 -0.4 -0.9
Chronotype (morning person) 0.1 0.2 0.7 0.3 -0.1 0.4 0.8 -0.2
Hair Pigment 1.0 28.1 112.4 1.4 -4.5 1.6 10.6 1.8
Tanning 0.0 0.3 0.5 -0.3 -0.6 -0.7 -0.4 -0.4
Hand grip strength (left) 0.2 0.6 2.5 -0.1 -1.6 0.4 0.7 -0.1
Number of treatments/medications taken 1.3 2.4 8.1 0.7 2.8 -0.3 -1.3 1.4
Average weekly spirits intake 0.1 0.1 0.3 0.2 0.1 -0.3 0.0 0.5
Sensitivity / hurt feelings 2.1 3.6 6.4 -1.4 -1.2 2.5 2.5 -1.4
Frequency of depressed mood in last 2 weeks 0.7 0.9 2.2 -1.1 0.1 1.5 0.7 -0.9
Hearing difficulty/problems: Yes 3.4 5.2 9.3 3.0 2.1 -1.0 -1.5 3.0
Relative age of first facial hair 0.9 1.9 3.5 1.6 1.0 -0.0 1.9 1.6
Other serious medical condition/disability diagnosed by doctor 1.6 2.1 3.6 -1.9 -1.8 1.2 0.6 -1.3
Ever used hormone-replacement therapy (HRT) 0.8 1.1 1.9 -0.7 -1.1 -0.1 1.4 -1.3
Ever had hysterectomy (womb removed) 1.7 1.9 2.9 1.1 1.7 -1.7 -0.9 1.4
Systolic blood pressure, automated reading 1.2 3.5 11.8 1.5 3.4 -1.6 0.8 0.5
Eye problems/disorders: Diabetes related eye disease 1.9 2.1 5.3 1.0 1.8 -0.2 1.1 2.3
Angina 7.9 10.3 12.5 3.5 3.5 -3.3 -2.2 3.4
Medication for hormone replacement therapy 3.4 3.8 11.1 -1.7 -3.3 0.0 1.0 -2.0
Vitamin and mineral supplements 0.7 1.0 2.6 0.6 0.7 -1.6 -0.2 1.2
Supplements: Zinc 0.1 0.1 0.3 0.5 0.2 0.5 0.4 -0.0
Medication: Co-codamol 0.7 0.8 1.5 1.1 0.2 -0.1 -1.2 1.0
Medication: Metformin 2.8 4.0 6.5 2.4 1.4 -1.6 -1.8 2.5
Diabetes (father) 0.5 0.6 1.3 0.5 1.1 1.0 0.3 0.4
Diabetes (mother) 0.6 0.7 1.5 -1.2 1.1 0.6 0.8 0.2
Severe depression (siblings) 1.2 1.3 3.5 0.7 0.7 -1.5 -1.9 0.1
Pack years adult smoking proportion 0.9 1.4 2.5 0.8 1.6 -0.5 -1.2 1.4
Impedance of leg (right) 0.3 1.3 2.4 -1.3 0.3 -1.3 0.8 -1.6
Leg fat-free mass (left) 0.9 4.9 9.8 -2.8 -1.8 3.1 1.1 -1.5
Trunk fat percentage 1.5 6.1 16.3 -4.0 0.0 1.9 2.1 -2.5
Hand grip strength (right) 0.3 0.7 2.3 0.0 -1.5 0.6 0.7 0.6
Townsend deprivation index at recruitment 0.5 0.7 2.7 0.9 0.3 -0.0 -1.6 -0.0
Current tobacco smoking 0.1 0.2 0.7 -0.1 0.8 -0.0 -0.6 -0.1
Average weekly fortified wine intake 0.2 0.2 0.4 0.4 -0.5 -0.2 0.6 -0.4
Maternal smoking around birth 0.6 0.8 3.6 -0.2 -0.2 -1.9 -0.1 -0.7
Fed-up feelings 0.2 0.3 0.9 0.0 0.9 0.8 -0.1 0.2
Frequency of unenthusiasm / disinterest in last 2 weeks 3.0 4.1 7.3 -2.2 -1.7 2.7 1.5 -1.7
Relative age voice broke 1.3 2.1 3.3 1.5 1.8 -1.7 0.1 1.4
Taking other prescription medications 0.5 0.7 1.6 0.5 1.3 -0.6 -0.9 0.8
Age when periods started (menarche) 2.9 7.1 11.6 -3.3 -2.1 1.5 2.5 -3.4
Bilateral oophorectomy (both ovaries removed) 0.4 0.5 1.3 0.3 0.5 -1.1 -0.8 -0.5
Heel bone mineral density (BMD) T-score, automated (left) 0.9 2.1 6.0 -1.1 -0.6 1.3 2.4 -1.2
Tinnitus: Yes, but not now, but have in the past 0.6 0.7 2.3 -0.7 -0.1 0.0 1.5 -0.7
Qualifications: CSEs or equivalent 0.5 0.7 2.6 -0.1 1.6 -0.1 1.0 0.0
Serious illness, injury or assault to yourself 0.3 0.3 1.6 0.1 1.3 -0.2 -0.1 0.0
High blood pressure 2.7 7.7 14.4 2.4 3.8 -2.3 -2.4 2.6
Hayfever, allergic rhinitis or eczema 0.9 2.0 5.6 -1.4 -0.9 0.5 2.4 -1.3
Multivitamins +/- minerals 0.9 1.1 1.8 -0.8 -1.1 1.4 0.5 -1.2
Stomach or abdominal pain in last month 0.6 0.8 2.1 0.5 1.5 -0.5 -1.0 0.6
Supplements: Glucosamine 0.4 0.5 2.2 -0.5 -1.5 0.5 -0.1 0.1
Diverticular disease/diverticulitis (self-reported) 1.9 2.2 4.7 -2.1 -0.4 0.5 1.3 -2.2
Medication: Atenolol 2.0 2.5 3.0 1.7 1.7 -1.7 -0.9 1.6
Medication: Levothyroxine sodium 12.6 21.3 38.7 -5.0 -3.3 6.2 4.8 -3.0
Sitting height 1.6 11.4 18.1 -4.2 -4.0 2.5 2.2 -3.4
Chronic bronchitis/emphysema (father) 2.3 2.7 4.8 -2.2 -0.9 1.6 1.8 -1.5
High blood pressure (mother) 1.2 1.7 5.3 -1.2 -0.3 2.3 0.3 -1.3
Body mass index (BMI) 0.1 0.5 1.4 -0.6 0.8 1.2 -0.1 0.5
Impedance of leg (left) 0.4 1.9 3.6 -1.7 -0.1 -0.9 1.5 -1.9
Leg predicted mass (left) 0.8 4.4 9.4 -2.7 -1.7 3.1 1.0 -1.3
Trunk fat mass 1.7 7.2 17.7 -4.2 -0.6 2.6 2.0 -2.6
Waist circumference 0.2 0.8 1.9 -1.4 0.8 1.2 0.2 -0.1
Number of incorrect matches in round 4.7 7.7 10.8 -3.0 -3.2 2.1 2.1 -3.3
Past tobacco smoking 1.9 3.4 4.5 2.1 1.6 -1.4 -2.1 1.8
Alcohol usually taken with meals 2.4 3.8 6.1 -2.4 -2.5 1.7 0.9 -1.9
Nervous feelings 0.3 0.6 1.2 -0.0 -0.2 0.9 -0.8 -1.1
Frequency of tenseness / restlessness in last 2 weeks 2.1 3.3 7.7 -1.5 -0.7 2.8 1.8 -1.7
Hearing difficulty/problems with background noise 1.3 2.1 3.3 1.8 1.1 0.1 -1.8 1.6
Hair/balding pattern: Pattern 2 0.5 0.7 1.0 0.7 0.9 -0.8 0.7 1.0
Had menopause 0.8 1.0 4.1 0.0 -2.0 -0.6 0.5 -0.7
Had other major operations 0.4 0.5 1.7 0.2 0.6 -1.3 -0.5 0.3
Forced vital capacity (FVC) 3.6 13.8 19.1 -4.0 -4.1 2.4 4.4 -3.5
Heel bone mineral density (BMD) T-score, automated (right) 1.3 2.9 7.6 -1.6 -1.0 1.3 2.8 -1.3
Ever unenthusiastic/disinterested for a whole week 0.3 0.3 1.3 -0.2 -0.1 1.1 0.3 -0.6
Qualifications: None of the above 0.5 1.1 2.2 -0.1 -0.6 1.5 1.4 -1.1
Financial difficulties in last 2 years 0.6 0.8 1.6 -0.7 -0.1 1.3 -0.7 -1.1
Mouth/teeth dental problems 6.2 9.5 20.0 -3.0 -4.5 2.1 2.0 -3.2
Heart attack 1.4 1.8 3.5 1.8 1.3 -0.3 -0.8 1.9
Allergy 0.7 1.5 6.0 0.5 0.3 1.2 -2.4 0.1
Pain all over the body in last month 0.8 0.8 1.4 0.9 0.8 0.1 -1.1 1.2
Diabetes (self-reported) 3.1 4.8 6.6 2.5 2.2 -2.1 -1.2 2.6
Hayfever/allergic rhinitis (self-reported) 0.7 1.0 4.5 -0.4 -0.2 0.1 2.1 0.1
Medication: Ramipril 2.0 2.5 3.9 1.2 2.0 -1.7 -1.5 1.4
Medication: Simvastatin 10.1 14.9 18.6 4.0 4.1 -3.5 -3.4 4.3
Fluid intelligence score 0.6 1.3 2.9 1.1 0.7 -0.0 -1.3 1.7
Illnesses of siblings 0.3 0.4 0.9 -0.2 -0.6 0.2 -0.9 -0.8
Neuroticism score 0.3 0.5 1.6 0.6 0.2 1.3 -0.8 0.1
Weight 1.3 6.5 13.0 -3.6 -1.6 3.1 1.7 -2.1
Impedance of arm (right) 1.7 7.8 15.7 -4.0 -1.5 0.5 2.7 -3.6
Arm fat percentage (right) 0.5 2.1 5.7 -2.4 0.4 1.4 1.0 -1.3
Trunk fat-free mass 0.8 4.5 7.5 -2.3 -2.5 2.7 0.9 -1.6
Hip circumference 1.8 7.6 15.8 -4.0 -1.8 3.5 1.2 -2.3
Time employed in main current job 0.7 0.9 1.7 -1.0 -1.3 0.6 0.2 -1.1
Alcohol intake versus 10 years previously 0.6 0.9 2.4 -0.6 -0.4 1.2 1.6 -0.4
Father’s age at death 2.9 3.9 7.3 -1.9 -2.5 1.1 1.2 -2.7
Worrier / anxious feelings 0.3 0.6 1.4 0.6 0.5 1.2 -1.1 -0.0
Frequency of tiredness / lethargy in last 2 weeks 2.3 3.8 8.5 -2.6 -0.7 2.9 1.2 -1.3
Falls in the last year 1.4 1.9 3.9 -0.7 -1.4 0.7 1.7 -2.0
Hair/balding pattern: Pattern 3 0.8 1.3 3.4 0.1 -1.3 -1.0 -1.8 -0.4
Number of live births 1.4 2.0 2.4 1.4 1.4 -1.0 -1.6 1.5
Forced expiratory volume in 1-second (FEV1) 2.1 7.1 11.8 -2.7 -3.0 1.8 3.4 -2.0
Pulse rate 0.3 0.5 0.9 -0.2 -0.9 0.9 -0.6 -0.4
Happiness 2.0 2.4 4.1 1.9 2.0 -0.4 -0.7 1.9
Noisy workplace 0.4 0.5 1.2 0.7 1.1 -0.3 -0.2 0.6
Qualifications: A levels/AS levels or equivalent 1.8 3.9 8.0 1.0 0.4 -2.6 -2.8 1.9
Serious illness, injury or assault of a close relative in last 2 years 0.7 0.9 3.6 0.1 0.2 -1.9 -0.7 0.4
Mouth/teeth dental problems: Dentures 5.9 10.0 14.8 3.3 3.5 -1.0 -3.8 3.3
Asthma 1.7 3.3 11.3 0.7 1.6 -3.4 1.4 0.7
Medication: Ibuprofen (e.g. Nurofen) 3.4 4.3 12.7 1.4 2.1 -0.9 -3.6 1.2
Medication: Cholesterol lowering 7.2 11.2 18.4 3.4 4.3 -2.8 -2.9 3.0
Depression (self-reported) 1.0 1.3 3.6 -0.4 -0.5 1.9 0.3 -1.5
Medication: Lansoprazole 0.9 1.0 2.1 1.2 -0.3 -0.5 1.1 1.5
Prospective memory result 2.0 2.4 5.7 -1.5 -2.4 0.4 1.4 -1.4
Lung cancer (father) 0.4 0.5 0.8 0.6 -0.3 -0.9 -0.7 0.9
Illnesses of mother 1.8 2.3 4.6 1.7 0.7 -2.1 -0.6 1.7
Forced expiratory volume in 1-second (FEV1), Best measure 2.1 6.8 9.1 -2.9 -3.0 2.0 2.9 -1.9
Pulse wave Arterial Stiffness index 4.2 5.0 6.4 -2.3 -2.5 1.7 2.2 -2.3
Impedance of arm (left) 1.4 6.4 12.7 -3.6 -0.7 0.3 3.0 -3.1
Arm fat mass (right) 0.6 2.6 6.9 -2.6 -0.2 1.9 1.0 -1.2
Trunk predicted mass 0.9 4.9 7.8 -2.5 -2.6 2.8 0.9 -1.7
Standing height 2.6 25.9 44.9 -6.7 -5.0 4.2 3.7 -5.4
Length of working week for main job 0.5 0.6 1.2 0.8 -0.1 -0.5 -0.9 1.1
Exposure to tobacco smoke at home 0.2 0.3 0.6 -0.4 -0.6 -0.8 -0.4 -0.0
Breastfed as a baby 2.2 2.7 5.1 -2.3 -1.3 0.8 1.4 -2.0
Tense / ‘highly strung’ 1.7 2.8 6.4 -1.4 -1.4 2.5 0.6 -1.8
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.4 1.1 0.6 1.1 -0.6 0.1 -0.1
Hair/balding pattern: Pattern 4 0.5 1.1 2.2 -1.1 -1.1 -1.0 -0.1 -1.5
Birth weight of first child 2.3 4.2 7.9 -2.8 -2.3 1.4 1.0 -2.2
Peak expiratory flow (PEF) 0.9 2.2 2.8 -1.7 -1.6 1.2 1.5 -1.3
Pulse wave reflection index 1.8 2.2 3.7 -1.4 -1.2 1.7 1.9 -1.2
Ever highly irritable/argumentative for 2 days 0.6 0.7 3.0 0.4 0.6 1.7 0.3 0.2
Loud music exposure frequency 1.2 1.3 3.2 -1.5 -1.8 0.0 -0.2 -0.9
Qualifications: O levels/GCSEs or equivalent 1.2 2.0 3.9 0.8 -0.5 -1.7 -2.0 1.5
Mouth/teeth dental problems: Bleeding gums 0.7 0.9 2.2 0.4 1.0 0.9 -0.7 1.5
Blood clot in the leg (DVT) 0.1 0.1 0.3 0.5 -0.0 -0.1 0.2 0.3
Medication: Paracetamol 3.6 6.0 13.5 2.1 3.7 -1.3 -2.5 2.0
Headache pain in last month 1.0 1.7 3.5 1.4 1.9 -0.3 -1.0 1.3
Medication for cholesterol, blood pressure or diabetes 5.6 9.3 16.4 -2.9 -4.1 2.5 2.9 -2.6
Glaucoma (self-reported) 4.5 5.2 8.1 2.4 1.6 -2.8 -1.5 2.8
Gout (self-reported) 2.2 3.0 11.4 1.0 0.8 -0.8 -3.4 1.1
Hypothyroidism/myxoedema (self-reported) 11.6 22.6 54.3 -4.6 -3.4 7.4 3.7 -3.6
Medication: Amlodipine 1.4 1.9 3.8 0.9 2.0 -0.7 -1.9 0.9
Medication: Ventolin 100micrograms inhaler 0.4 0.5 1.2 -1.0 -0.0 -0.4 1.1 -0.2
Birth weight 2.2 4.8 8.0 -2.8 -1.9 2.2 1.7 -2.2
Chronic bronchitis/emphysema (mother) 0.2 0.3 1.1 0.0 1.1 -0.4 0.2 0.0
High blood pressure (siblings) 0.4 0.5 1.5 -0.0 1.2 -0.2 -0.0 1.1
Forced vital capacity (FVC), Best measure 3.5 12.8 16.9 -4.1 -4.0 2.6 3.7 -3.2
Body fat percentage 0.9 3.4 9.3 -3.0 0.5 1.5 1.5 -1.8
Leg fat percentage (right) 0.3 1.0 2.5 -1.6 0.7 1.1 0.1 -0.9
Arm fat-free mass (right) 0.5 2.8 4.8 -2.0 -1.8 2.2 0.8 -1.0
Exposure to tobacco smoke outside home 1.2 1.5 3.2 1.2 1.8 -1.0 0.1 1.4
Comparative body size at age 10 0.3 0.9 2.6 -0.5 0.4 1.1 -1.6 -0.5
Number of full brothers 2.5 3.2 5.5 2.4 1.8 -2.0 -0.7 1.6
Worry too long after embarrassment 2.5 4.1 8.0 2.8 2.0 0.1 -1.7 2.4
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.4 1.0 -0.1 0.4 0.8 0.0 -1.0
Wheeze or whistling in the chest in last year 0.5 0.9 2.4 1.0 1.6 -1.0 0.2 0.2
Number of children fathered 0.6 0.7 2.4 0.0 0.5 0.3 1.5 0.7
Reason for reducing amount of alcohol drunk: Health precaution 0.7 0.8 3.6 0.4 -0.1 -0.3 -1.9 -0.3
Age at first live birth 0.3 0.6 1.4 -1.0 0.3 0.5 0.3 -1.2
Pulse wave peak to peak time 3.2 3.7 5.3 2.0 2.3 -1.4 -2.0 1.9
Health satisfaction 4.0 5.2 8.7 1.7 3.0 -1.4 -2.2 2.8
Shortness of breath walking on level ground 0.2 0.2 0.4 -0.4 0.3 0.6 -0.5 -0.4
Qualifications: College or University degree 0.1 0.4 1.0 -0.6 -1.0 0.6 0.5 -0.3
Eye problems/disorders: None of the above 4.3 5.0 9.4 -2.4 -1.0 2.5 1.6 -3.1
Mouth/teeth dental problems: Loose teeth 0.9 1.1 1.5 0.8 0.6 -1.2 -1.2 1.2
Emphysema/chronic bronchitis 1.0 1.1 1.8 0.4 1.3 -1.3 -1.3 0.4
Medication for pain relief, constipation, heartburn 6.3 10.7 22.2 -2.3 -4.7 1.5 3.6 -3.2
Neck or shoulder pain in last month 0.9 1.3 2.4 1.1 0.9 -1.3 -1.5 0.6
Medication: Blood pressure 2.5 4.4 7.9 1.9 2.8 -1.5 -2.2 1.8
Angina (self-reported) 7.5 9.9 11.2 3.3 3.3 -3.3 -2.3 3.3
Migraine (self-reported) 0.4 0.5 1.9 0.2 -0.7 1.4 0.3 -0.0
Medication: Ibuprofen 4.2 5.0 12.9 1.6 2.4 -1.3 -3.6 1.5
Medication: Allopurinol 0.8 1.0 4.4 0.6 0.1 -0.6 -2.1 0.2
Medication: Omeprazole 0.3 0.3 1.0 -0.6 -0.5 -0.0 1.0 0.3
Medication: Seretide 50 evohaler 2.8 3.2 6.1 1.1 2.0 -1.8 -1.1 2.5
Mean time to correctly identify matches 0.3 0.6 1.3 1.1 -0.4 -1.2 0.2 -0.1
Heart disease (mother) 0.5 0.6 1.3 0.7 0.8 0.7 -1.1 0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.6 0.7 2.1 1.4 0.4 0.0 -0.9 0.6
Whole body fat mass 1.1 4.6 10.9 -3.3 -0.3 2.4 1.6 -1.9
Leg fat mass (right) 0.5 2.0 5.0 -2.2 0.0 1.7 0.7 -1.1
Arm predicted mass (right) 0.4 2.3 4.5 -1.9 -1.5 2.1 0.5 -0.8
Pulse rate, automated reading 0.3 1.0 2.7 1.2 -0.2 0.1 -0.8 1.6
Alcohol intake frequency. 3.9 9.1 16.0 -2.5 -2.2 4.0 3.3 -2.7
Comparative height size at age 10 0.1 0.4 0.8 -0.9 -0.9 0.6 0.0 -0.4
Number of full sisters 0.1 0.1 0.2 -0.4 0.1 -0.4 0.2 0.3
Suffer from ‘nerves’ 0.9 1.5 2.0 -0.6 -1.4 1.4 -1.1 -1.4
Overall health rating 2.4 5.3 10.5 1.6 3.2 -1.0 -2.5 2.4
Chest pain or discomfort 10.6 15.3 18.5 4.1 4.1 -3.5 -3.5 4.3
Had major operations 0.3 0.3 0.8 -0.4 -0.7 0.5 0.9 0.0
Age at last live birth 0.2 0.3 0.8 -0.9 0.1 0.4 -0.2 -0.5
Family relationship satisfaction 0.3 0.4 1.6 0.2 0.4 1.3 0.4 0.1
Leg pain on walking 0.5 0.6 1.5 0.6 1.0 0.1 0.3 1.2
Qualifications: NVQ or HND or HNC or equivalent 3.2 3.9 6.2 2.1 1.7 -2.5 -0.9 2.3
Commuting to job workplace: Car/motor vehicle 0.7 0.8 3.2 0.4 1.8 -0.2 -0.2 0.6
Illness, injury, bereavement, stress in last 2 years 0.2 0.3 0.6 0.8 -0.6 0.0 -0.1 0.5
Medication: Aspirin 2.0 2.7 4.5 1.3 1.9 -1.3 -1.4 2.1
Supplements: Vitamin C 0.2 0.3 1.0 0.2 -0.3 -0.2 -1.0 -0.5
Knee pain experienced in last month 0.0 0.0 0.2 0.4 -0.2 0.1 -0.0 -0.1
Hypertension (Self-reported) 3.0 8.3 14.7 2.6 3.8 -2.5 -2.7 2.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.1 1.3 3.5 1.2 1.1 -1.9 -0.0 0.7
Illnesses of father: Heart disease 2.6 3.7 8.0 1.8 2.8 -1.1 -0.2 2.4
Illnesses of siblings: Diabetes 1.0 1.3 1.6 1.3 1.1 -1.1 -0.9 1.2
Smoking status: Previous 1.9 2.9 4.7 -1.7 -1.9 0.9 2.2 -1.4
Forced expiratory volume in 1-second (FEV1), predicted 1.2 2.4 5.1 -2.2 -1.7 1.6 0.6 -1.1
Whole body fat-free mass 0.9 4.9 9.1 -2.6 -2.3 3.0 1.1 -1.5
Leg fat-free mass (right) 0.9 4.9 10.3 -2.7 -1.8 3.2 1.2 -1.4
Arm fat percentage (left) 0.5 1.9 4.9 -2.2 0.9 1.3 1.2 -1.0
Average weekly red wine intake 0.7 1.0 1.6 -1.3 -1.1 1.1 0.9 -0.5
Handedness (chirality/laterality): Left-handed 2.1 2.5 11.6 0.5 -0.6 -0.5 -3.4 0.2
Mood swings 0.5 1.0 2.9 0.2 1.3 1.7 0.2 -0.5
Loneliness, isolation 0.3 0.3 0.7 0.6 -0.3 0.7 0.4 0.8
Long-standing illness, disability or infirmity 0.4 0.6 1.8 0.1 1.4 -0.0 -0.2 1.0
Ever had bowel cancer screening 1.3 1.5 4.4 -1.6 0.1 0.7 0.3 -2.1
Diabetes diagnosed by doctor 2.0 3.3 5.8 2.2 1.9 -1.1 -0.8 2.4
Ever had stillbirth, spontaneous miscarriage or termination 0.9 1.0 2.1 -0.6 -1.5 1.4 0.3 -0.4
Friendships satisfaction 1.1 1.4 2.7 1.6 0.3 -0.4 -1.3 1.5
Qualifications: nursing, teaching 0.1 0.2 0.5 -0.7 -0.6 0.4 0.2 -0.3
Commuting to job workplace: Walk 0.7 0.7 1.5 0.1 -0.9 -1.2 1.2 0.2
Eye problems/disorders: Cataract 0.3 0.4 1.1 0.7 0.1 -0.6 -0.0 1.0
Mouth/teeth dental problems: Mouth ulcers 1.4 2.3 5.3 0.8 2.3 -1.6 1.7 0.2
Medication for cholesterol 0.1 0.2 0.6 -0.4 0.2 0.7 -0.3 -0.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.1 0.2 0.4 -0.1 -0.6 0.3 -0.6 -0.2
Back pain experienced in last month 1.0 1.5 3.2 -1.2 -0.7 1.8 1.2 -0.9
Mineral and other dietary supplements 0.2 0.3 0.5 -0.7 -0.7 -0.2 0.6 -0.1
Breast cancer (self-reported) 0.9 1.0 1.9 0.7 1.1 -1.4 -0.8 0.9
Asthma (self-reported) 1.4 2.8 9.7 0.6 1.1 -3.1 1.6 0.3
Osteoporosis (self-reported) 0.5 0.7 1.4 0.5 1.0 -0.7 -1.2 0.1
Osteoarthritis (self-reported) 1.4 1.9 3.2 1.3 -0.1 -1.4 -1.8 1.5
Medication: Aspirin 1.5 2.0 3.3 1.3 1.8 -0.9 -1.2 1.7
Medication: Gliclazide 1.6 1.8 3.0 0.9 1.7 0.6 -1.5 1.7
Illnesses of father: None of the above (group 1) 0.3 0.3 1.1 0.3 -0.6 -1.0 0.2 -0.3
Smoking status: Current 0.1 0.2 0.6 -0.4 0.8 -0.0 -0.4 -0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.9 1.9 6.6 -1.4 -1.0 0.1 2.6 -0.3
Whole body water mass 0.8 4.8 8.6 -2.6 -2.3 2.9 1.1 -1.6
Leg predicted mass (right) 0.9 4.7 10.0 -2.7 -1.8 3.2 1.2 -1.4
Arm fat mass (left) 0.7 2.7 6.6 -2.6 0.1 1.9 1.3 -1.2
Number of self-reported non-cancer illnesses 1.6 2.8 6.9 1.1 2.6 -0.7 -1.4 1.8
Average weekly champagne plus white wine intake 0.9 1.3 5.1 0.7 -0.3 -0.7 -2.3 0.3
Miserableness 1.0 1.7 2.7 1.5 1.6 0.3 -1.4 1.3
Guilty feelings 0.9 1.4 2.2 1.4 1.5 0.3 -0.9 1.3
Wears glasses or contact lenses 1.0 1.2 1.6 0.6 -1.2 -1.3 -1.1 1.1
Ever taken oral contraceptive pill 0.8 0.9 2.0 -0.7 -1.4 0.4 -0.3 -1.3
Hearing aid user 0.7 0.8 2.5 -0.1 1.6 0.4 0.5 1.1
Mother’s age at death 2.1 2.6 6.1 -1.6 -2.5 0.4 1.2 -1.8
Financial situation satisfaction 0.3 0.3 1.3 0.0 -0.0 -0.5 1.1 -0.3
Tinnitus: Yes, now most or all of the time 0.4 0.5 2.3 0.1 0.4 1.5 -0.1 0.1
Commuting to job workplace: Public transport 0.4 0.5 1.1 0.7 -0.7 -0.3 -1.1 0.5
Eye problems/disorders: Glaucoma 5.3 6.3 10.6 2.9 1.7 -3.2 -1.3 2.8
Medication: Blood pressure 1.4 2.6 5.0 1.3 1.9 -2.2 -0.8 1.5
Pain type(s) experienced in last month: Hip pain 0.7 0.8 1.4 1.2 1.2 -0.8 -0.6 0.6
Supplements: Fish oil (including cod liver oil) 1.1 1.4 2.1 1.4 1.3 -0.6 -1.4 0.9
High cholesterol (Self-reported) 12.7 22.5 33.4 5.2 5.8 -3.3 -4.4 4.7
Medication: Bendroflumethiazide 0.2 0.4 1.3 -0.3 1.1 0.7 0.3 -0.1
Medication: Paracetamol 2.6 4.0 8.8 2.0 3.0 -0.8 -2.0 1.6
Medication: Lisinopril 0.1 0.2 0.4 0.3 0.4 -0.6 -0.2 0.5
Medication: Atorvastatin 6.7 8.3 20.5 2.6 4.5 -1.1 -2.1 3.0
Illnesses of father: High blood pressure 0.3 0.4 1.2 -0.2 1.1 0.6 -0.5 0.5
Alcohol drinker status: Never 2.3 2.8 5.4 -1.5 -1.0 2.3 1.6 -1.6
Ever smoked 3.0 5.2 6.5 -2.5 -2.1 2.2 2.1 -2.5
Basal metabolic rate 1.0 5.3 9.6 -2.9 -2.1 3.1 1.2 -1.7
Leg fat percentage (left) 0.3 1.1 2.7 -1.6 0.5 1.2 0.3 -0.9
Arm fat-free mass (left) 0.9 4.3 6.4 -2.5 -2.3 2.5 1.0 -1.7
Number of operations (self-reported) 0.2 0.3 0.8 -0.6 -0.1 0.2 -0.6 -0.9
Average weekly beer plus cider intake 0.5 0.7 1.1 -0.5 1.1 0.5 1.0 -1.0
Irritability 2.0 3.5 6.1 2.4 1.4 -0.6 -1.8 2.5
Risk taking 3.1 4.5 7.6 -2.8 -1.5 1.6 1.7 -2.7
Ever had prostate specific antigen (PSA) test 6.3 7.2 10.7 -3.0 -3.3 2.5 0.9 -3.1
Fractured/broken bones in last 5 years 0.4 0.5 0.7 -0.9 -0.7 -0.2 0.7 -0.8
Age started oral contraceptive pill 0.3 0.4 1.2 0.8 0.2 -1.1 -0.2 0.2
Diastolic blood pressure, automated reading 0.3 0.8 1.6 1.2 1.2 0.2 0.1 0.9
Ever depressed for a whole week 2.1 2.5 4.8 1.6 2.2 -0.1 -0.6 2.2
Unable to work because of sickness or disability 0.2 0.3 0.6 -0.0 -0.8 0.1 -0.7 -0.7
Commuting to job workplace: Cycle 0.8 1.0 3.2 -0.2 -0.7 1.0 1.8 -0.3
Myopia 0.3 0.4 2.0 -0.4 0.2 -1.4 -0.1 -0.0
Vascular/heart problems diagnosed by doctor 3.4 9.3 16.3 -2.8 -4.0 2.6 2.5 -3.1
Cholesterol lowering medication 5.8 8.5 11.8 3.4 2.8 -2.3 -2.8 3.2
Medication: Omeprazole (e.g. Zanprol) 0.5 0.6 2.2 -0.5 -0.2 -0.3 1.5 0.7
Pain experienced in last month 0.1 0.2 0.5 -0.6 -0.4 -0.0 0.7 -0.4
Supplements: Calcium 0.2 0.2 0.6 0.0 0.1 0.8 -0.3 -0.5
Basal cell carcinoma (self-reported) 0.3 0.3 0.9 -0.1 0.5 0.7 0.9 -0.2
Heart attack/myocardial infarction (self-reported) 1.4 1.8 3.3 1.7 1.6 -0.1 -0.6 1.8
Deep venous thrombosis (DVT) (self-reported) 0.1 0.1 0.3 0.5 0.1 -0.1 0.1 0.4
Heart disease (siblings) 0.5 0.6 1.2 1.1 0.7 -0.3 0.7 0.9
Alcohol drinker status: Previous 1.2 1.4 4.0 -0.6 -2.0 1.2 0.6 -0.9
Pack years of smoking 0.5 0.7 1.2 0.6 1.1 -0.1 -0.9 1.1
Impedance of whole body 0.8 4.0 7.9 -2.8 -0.3 -0.6 2.3 -2.6
Leg fat mass (left) 0.5 2.1 5.1 -2.3 -0.1 1.9 0.8 -1.2
Arm predicted mass (left) 1.0 4.8 7.5 -2.6 -2.3 2.7 1.0 -1.9