[Hub]/) : Traits : Hypothyroidism/myxoedema (self-reported) :

chr19:49,279,612-50,909,389

Best TWAS P=1.3e-10 · Best GWAS P=1.74e-10 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex CPT1C 0.30 0.20 lasso 4 0.22 1.1e-25 -6.4 6.4 1.3e-10 -0.96 0.00 1.00 TRUE
2 GTEx Brain Cerebellar Hemisphere ALDH16A1 0.25 0.06 enet 15 0.15 1.4e-04 4.9 5.2 2.3e-07 -0.26 0.09 0.49 FALSE
3 GTEx Brain Cerebellum ALDH16A1 0.71 0.43 lasso 11 0.50 6.8e-17 4.3 5.3 9.7e-08 -0.28 0.98 0.02 FALSE
4 GTEx Cells Transformed fibroblasts CPT1C 0.21 0.17 lasso 2 0.16 5.4e-12 -6.4 6.2 4.4e-10 -1.00 0.00 1.00 FALSE
5 GTEx Ovary ALDH16A1 0.33 0.21 lasso 3 0.15 1.5e-04 4.4 6.3 2.3e-10 -0.59 0.05 0.71 FALSE
6 The Cancer Genome Atlas Brain Lower Grade Glioma RPS11 0.03 0.01 enet 11 0.01 1.5e-02 -2.8 5.6 2.5e-08 -0.18 0.01 0.69 TRUE