Best TWAS P=1.3e-10 · Best GWAS P=1.74e-10 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | CPT1C | 0.30 | 0.20 | lasso | 4 | 0.22 | 1.1e-25 | -6.4 | 6.4 | 1.3e-10 | -0.96 | 0.00 | 1.00 | TRUE |
| 2 | GTEx | Brain Cerebellar Hemisphere | ALDH16A1 | 0.25 | 0.06 | enet | 15 | 0.15 | 1.4e-04 | 4.9 | 5.2 | 2.3e-07 | -0.26 | 0.09 | 0.49 | FALSE |
| 3 | GTEx | Brain Cerebellum | ALDH16A1 | 0.71 | 0.43 | lasso | 11 | 0.50 | 6.8e-17 | 4.3 | 5.3 | 9.7e-08 | -0.28 | 0.98 | 0.02 | FALSE |
| 4 | GTEx | Cells Transformed fibroblasts | CPT1C | 0.21 | 0.17 | lasso | 2 | 0.16 | 5.4e-12 | -6.4 | 6.2 | 4.4e-10 | -1.00 | 0.00 | 1.00 | FALSE |
| 5 | GTEx | Ovary | ALDH16A1 | 0.33 | 0.21 | lasso | 3 | 0.15 | 1.5e-04 | 4.4 | 6.3 | 2.3e-10 | -0.59 | 0.05 | 0.71 | FALSE |
| 6 | The Cancer Genome Atlas | Brain Lower Grade Glioma | RPS11 | 0.03 | 0.01 | enet | 11 | 0.01 | 1.5e-02 | -2.8 | 5.6 | 2.5e-08 | -0.18 | 0.01 | 0.69 | TRUE |