TWAS hub - CPT1C

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.3040	0.0470	3.8e-14	0.199	0.143	0.206	0.208	0.215	9.2e-24	4.6e-17	1.4e-24	8.5e-25	1.1e-25
2	GTEx	Cells Transformed fibroblasts	0.2130	0.0550	2.7e-05	0.171	NA	0.115	NA	0.159	8.0e-13	NA	6.3e-09	NA	5.4e-12
3	TCGA	Kidney Renal Clear Cell Carcinoma	0.0832	0.0325	2.4e-05	0.002	0.050	0.045	NA	0.022	1.6e-01	2.6e-06	6.9e-06	NA	1.5e-03
4	TCGA	Brain Lower Grade Glioma	0.0572	0.0300	5.5e-03	-0.001	0.004	0.000	NA	0.000	3.9e-01	9.2e-02	2.9e-01	NA	3.2e-01
5	TCGA	Lung Adenocarcinoma	0.0274	0.0152	8.5e-03	0.016	0.008	0.001	NA	0.005	4.9e-03	3.1e-02	2.5e-01	NA	7.3e-02
6	TCGA	Prostate Adenocarcinoma	0.0875	0.0329	4.8e-07	0.076	0.076	0.062	NA	0.074	2.1e-08	2.2e-08	4.5e-07	NA	3.4e-08
7	TCGA	Thyroid Carcinoma	0.0680	0.0270	1.1e-04	0.031	0.038	0.029	NA	0.039	4.5e-04	1.2e-04	7.0e-04	NA	1.1e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Hypothyroidism (self reported)	9.1	21.0	49.3	7.0	6.7	1.2	3.4	3.6	4.3	2.8
Hypothyroidism/myxoedema (self-reported)	8.5	16.6	41.3	6.4	6.2	-0.1	3.3	2.9	3.6	1.9
Medication: Levothyroxine sodium	6.5	11.0	25.7	5.1	4.9	-0.3	3.3	2.4	2.8	1.7
Hayfever, allergic rhinitis or eczema	5.6	12.1	16.0	3.2	3.6	3.9	2.1	4.0	3.5	3.7
Eye problems/disorders: Diabetes related eye disease	5.2	5.7	11.5	2.8	3.1	1.6	0.1	1.9	3.4	2.3
Basal cell carcinoma (self-reported)	4.8	5.7	10.1	-2.7	-2.1	-3.2	-0.5	-2.3	-3.1	-1.6
Allergy	4.3	9.9	12.9	-2.6	-3.3	-3.3	-2.7	-3.6	-2.8	-3.6
Qualifications: CSEs or equivalent	4.2	5.6	8.9	-2.7	-2.8	-1.9	-1.6	-2.6	-3.0	-1.6
Suffer from ‘nerves’	4.1	6.4	8.9	-3.0	-2.8	-2.8	-1.6	-2.5	-3.0	-1.8
Heel bone mineral density (BMD) T-score, automated (right)	4.0	9.1	13.8	-3.5	-3.7	-1.8	-2.5	-2.9	-3.2	-3.1
Crohns Disease (2017)	3.7	8.1	21.5	-4.6	-4.6	-0.3	-0.7	-2.4	-2.6	-1.0
Taking other prescription medications	3.7	5.7	17.7	2.9	2.8	-0.7	4.2	1.8	1.1	0.8
Medication: Ventolin 100micrograms inhaler	3.3	4.2	6.1	2.1	2.2	1.8	2.5	1.8	2.1	1.7
Exposure to tobacco smoke outside home	3.3	4.4	10.3	-3.2	-2.9	0.2	-1.9	-1.7	-2.2	-0.8
Angina (self-reported)	3.2	4.3	6.1	2.3	2.5	0.9	0.8	2.2	2.5	2.5
Irritable Bowel Disease (IBD)	3.1	7.4	21.4	-4.6	-4.2	-0.4	-0.6	-1.8	-2.9	-0.8
Heel bone mineral density (BMD) T-score, automated (left)	3.1	6.9	12.9	-3.6	-3.6	-0.8	-2.4	-2.1	-2.8	-2.1
Angina	3.0	4.0	6.0	2.3	2.5	0.9	0.9	2.1	2.3	2.3
Allergy or Eczema	2.9	7.8	12.1	2.1	2.9	3.0	1.8	3.5	2.5	3.3
Pulse rate	2.8	4.7	7.5	-1.7	-1.8	-2.5	-2.6	-2.7	-1.9	-1.6
Mouth/teeth dental problems: Mouth ulcers	2.7	4.3	10.9	3.3	2.5	0.1	2.1	0.9	2.7	0.5
Forced expiratory volume in 1-second (FEV1), predicted	2.6	5.5	13.4	-3.7	-2.8	-0.6	-1.9	-1.9	-2.8	-1.0
Number of self-reported non-cancer illnesses	2.6	4.5	8.6	2.6	2.9	0.3	2.6	2.4	1.3	1.4
Number of operations (self-reported)	2.6	3.9	8.2	2.4	2.2	1.0	2.9	2.0	1.5	1.0
Serious illness, injury or assault to yourself	2.5	3.0	8.4	0.1	-0.2	-2.9	0.0	-1.7	-2.0	-2.4
Lupus	2.4	3.7	10.5	3.2	2.4	-0.1	2.0	1.3	1.7	-0.8
Rheumatoid Arthritis	2.4	3.3	10.8	3.3	3.1	0.0	0.0	0.0	0.0	1.6
Vitamin and mineral supplements	2.3	3.1	5.6	1.6	2.2	1.6	0.4	1.7	1.7	2.4
Number of full brothers	2.3	2.9	5.6	-2.4	-1.9	-1.4	-0.6	-2.1	-1.8	-1.3
Hayfever/allergic rhinitis (self-reported)	2.2	2.9	5.4	1.7	1.9	1.9	1.0	2.3	1.5	1.3
High blood pressure (siblings)	2.2	3.1	7.6	-1.4	-1.4	-2.8	-0.1	-1.6	-2.3	-1.6
Chronic bronchitis/emphysema (mother)	2.1	2.4	6.5	-1.0	-1.0	-1.6	-2.5	-1.7	-1.1	-1.4
Shortness of breath walking on level ground	2.1	2.5	5.2	1.7	2.0	1.5	-0.3	1.0	2.3	1.5
Mouth/teeth dental problems: Loose teeth	2.1	2.5	3.9	-1.8	-1.4	-1.8	-0.3	-2.0	-1.9	-1.1
Supplements: Vitamin C	2.0	2.3	6.4	-2.0	-2.5	0.3	-1.4	-0.9	-0.9	-1.6
Illnesses of father: High blood pressure	2.0	2.4	5.4	-0.5	-0.7	-2.3	-1.0	-1.3	-2.0	-2.0
Pack years of smoking	2.0	2.9	4.1	1.2	1.8	1.6	1.8	2.0	1.4	2.0
Medication: Atenolol	1.9	2.4	4.9	2.0	2.2	0.2	1.6	1.2	1.2	1.4
Frequency of tiredness / lethargy in last 2 weeks	1.9	3.1	5.7	1.6	2.4	0.8	0.7	1.6	2.1	2.4
Reaction Time	1.8	3.5	4.8	2.1	2.2	0.7	2.1	1.6	2.0	1.9
Pack years adult smoking proportion	1.8	2.7	3.9	1.1	1.7	1.6	1.9	1.9	1.3	2.0
Headache pain in last month	1.8	3.1	5.6	2.3	2.0	1.1	2.4	0.7	1.6	1.4
Mean Putamen Volume	1.7	1.9	4.4	-2.1	-1.5	-0.9	-1.8	-0.7	-1.4	-0.2
Relative age voice broke	1.7	2.7	5.2	-1.1	-1.6	-1.4	-2.1	-1.4	-1.2	-2.3
Illnesses of siblings	1.7	2.4	9.3	-0.2	0.1	3.0	-1.1	0.8	1.8	1.6
Ulcerative Colitis (UC)	1.6	3.0	8.8	-3.0	-2.4	-0.3	-0.4	-0.8	-2.2	-0.3
Heart disease (mother)	1.6	1.9	3.5	1.9	1.9	1.0	-0.2	1.5	1.6	0.8
Chest pain or discomfort	1.6	2.3	4.5	1.5	2.1	0.4	1.5	1.2	1.1	2.1
Diabetes (mother)	1.5	1.9	4.1	-2.0	-1.8	-0.4	-1.7	-1.0	-1.3	-0.8
Number of live births	1.5	2.2	3.9	0.9	0.6	2.0	1.8	1.8	1.3	1.4
Ever taken oral contraceptive pill	1.5	1.6	2.8	0.9	1.3	1.6	0.1	1.5	1.2	1.7
Medication: Paracetamol	1.5	2.4	4.5	2.0	1.9	0.3	1.1	1.4	2.1	1.0
Worry (Nagel 2018)	1.4	2.9	5.9	-2.4	-2.0	-1.2	-1.6	-1.5	-1.7	-1.0
Trunk fat percentage	1.4	5.5	11.5	-2.3	-2.1	-1.7	-3.4	-3.0	-2.2	-0.7
Worrier / anxious feelings	1.4	2.7	6.2	-2.5	-2.2	-0.1	-2.1	-1.1	-1.2	-0.7
Mean time to correctly identify matches	1.4	2.6	5.3	2.2	2.3	-0.4	2.1	1.1	1.1	1.0
Neuroticism (2016)	1.3	1.8	3.0	-1.7	-1.2	-1.4	-1.7	-1.3	-1.1	-0.8
Pain all over the body in last month	1.3	1.4	3.1	1.5	1.8	0.3	0.6	1.7	0.7	0.7
Medication for cholesterol, blood pressure or diabetes	1.3	2.2	4.0	-1.7	-1.4	-0.7	-2.0	-2.0	-1.3	-0.9
Body fat percentage	1.3	4.9	11.4	-1.9	-1.8	-1.8	-3.4	-2.9	-2.0	-0.7
Had major operations	1.3	1.5	2.5	1.6	1.4	0.3	1.6	1.1	1.1	0.8
Illness, injury, bereavement, stress in last 2 years	1.3	1.5	5.0	-0.2	-0.2	2.2	1.4	1.5	1.1	0.7
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	2.1	1.5	1.1	1.2	1.3	1.3	0.6	1.0
Friendships satisfaction	1.3	1.6	3.0	1.3	1.5	0.3	1.6	1.7	1.0	0.8
Medication: Paracetamol	1.2	1.9	4.4	2.1	1.7	0.2	1.0	1.3	1.9	0.5
Average weekly champagne plus white wine intake	1.2	1.6	3.6	-1.9	-1.6	-0.3	-1.2	-0.5	-1.5	-1.1
Guilty feelings	1.2	1.9	4.2	-2.0	-1.8	0.2	-1.8	-1.1	-1.1	-0.3
Fractured/broken bones in last 5 years	1.2	1.5	3.2	1.8	1.2	0.8	1.6	1.2	1.1	0.2
Alcohol drinker status: Previous	1.2	1.4	2.8	1.3	1.7	-0.0	1.7	1.6	0.2	0.1
Verbal and Numeric Reasoning (VNR)	1.1	2.6	4.6	-1.9	-1.3	-1.0	-1.9	-1.9	-2.1	-0.5
Lung FEV1/FVC ratio	1.1	5.6	27.5	-1.3	-1.4	-1.4	-5.2	-1.6	-0.7	-1.7
Trunk fat mass	1.1	4.8	10.5	-2.2	-1.9	-1.5	-3.2	-2.7	-2.1	-0.5
Hair/balding pattern: Pattern 2	1.1	1.3	1.9	-1.1	-1.4	-0.8	-1.0	-1.2	-1.2	-1.4
Qualifications: None of the above	1.1	2.4	4.3	1.9	2.1	0.7	-0.7	1.5	2.0	1.4
Forced expiratory volume in 1-second (FEV1), Best measure	1.1	3.4	7.8	-2.8	-2.3	-0.5	-1.4	-1.3	-2.4	-0.9
Gout (self-reported)	1.1	1.5	3.2	-1.3	-1.8	-0.6	-1.6	-0.8	-0.8	-1.1
Leg fat percentage (right)	1.1	4.0	12.8	-1.4	-1.3	-1.5	-3.6	-2.7	-1.4	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.5	4.0	2.0	1.9	-0.6	1.0	0.8	0.9	-0.0
Whole body fat mass	1.1	4.5	10.3	-1.9	-1.7	-1.6	-3.2	-2.8	-2.0	-0.4
Crohns Disease (2012)	1.0	1.6	5.8	-2.3	-2.4	0.0	0.0	0.0	0.0	0.0
Alcohol intake versus 10 years previously	1.0	1.5	3.2	-0.9	-0.8	-1.7	-0.9	-1.8	-1.1	-0.7
Forced expiratory volume in 1-second (FEV1)	1.0	3.3	7.3	-2.7	-2.2	0.2	-2.4	-1.2	-1.9	-0.6
Peak expiratory flow (PEF)	1.0	2.4	4.5	-2.1	-1.8	0.0	-2.0	-1.0	-1.7	-1.3
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	2.0	-1.2	-1.4	-1.2	-0.6	-0.9	-1.3	-1.2
Leg fat mass (right)	1.0	3.7	10.0	-1.6	-1.5	-1.4	-3.2	-2.6	-1.6	-0.3
Commuting to job workplace: Walk	1.0	1.1	2.4	0.6	0.6	1.4	1.5	1.0	1.0	0.9
Osteoporosis (self-reported)	1.0	1.2	4.4	-0.5	-1.3	-0.8	0.1	-1.0	-0.7	-2.1
Leg fat percentage (left)	1.0	3.7	11.2	-1.2	-1.1	-1.7	-3.4	-2.7	-1.4	-0.1
Risk taking	1.0	1.4	2.8	-0.6	-1.3	-1.1	-0.3	-1.5	-1.2	-1.7
Heart disease (siblings)	1.0	1.2	2.8	1.7	1.2	-1.1	1.3	1.0	0.6	-0.3
Intelligence (Savage-Jansen 2018)	0.9	2.7	7.5	-2.3	-1.4	-0.8	-0.9	-1.6	-2.7	0.2
Neuroticism (Nagel 2018)	0.9	2.0	5.2	-2.3	-1.6	-0.8	-1.1	-1.5	-1.4	-0.5
Alzheimer’s Disease (in mother)	0.9	1.0	2.3	0.5	-0.3	-1.1	0.8	-1.5	-0.6	-1.4
Alzheimer’s Disease (including proxy)	0.9	1.3	3.6	0.3	-0.3	-1.6	0.7	-1.4	-0.7	-1.9
Medication: Co-codamol	0.9	1.1	3.1	1.8	1.7	-0.5	0.2	0.2	0.8	0.6
Past tobacco smoking	0.9	1.6	3.9	1.8	1.0	-0.8	2.0	0.0	0.7	-1.3
Had menopause	0.9	1.1	2.5	-0.8	-1.0	-1.3	0.3	-1.0	-1.0	-1.6
Had other major operations	0.9	1.1	2.4	1.6	1.2	0.5	1.1	1.0	1.1	0.1
Fluid intelligence score	0.9	1.9	5.1	-2.3	-1.6	0.7	-1.8	-0.6	-1.3	0.3
Arm fat percentage (right)	0.9	3.5	9.2	-1.3	-1.2	-1.9	-3.0	-2.4	-1.7	-0.5
Time employed in main current job	0.9	1.0	2.8	0.7	0.7	-1.4	1.7	-0.0	-0.7	-0.8
Eye problems/disorders: None of the above	0.9	1.1	3.5	-0.8	-0.8	-1.1	-0.5	-0.7	-1.9	-0.9
Migraine (self-reported)	0.9	1.2	2.4	1.2	0.8	-1.6	1.2	-1.5	-0.0	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.0	2.6	0.9	0.7	0.8	0.7	0.8	1.6	1.3
Medication: Blood pressure	0.9	1.7	3.6	1.0	1.4	0.7	1.5	1.4	0.9	1.9
Leg fat mass (left)	0.9	3.7	9.4	-1.5	-1.4	-1.6	-3.1	-2.6	-1.7	-0.3
Depression (Nagel 2018)	0.8	1.2	2.0	1.3	1.4	-0.3	1.3	0.8	1.3	0.9
Ovarian Cancer	0.8	1.1	4.8	0.2	0.2	-2.2	-0.1	-0.1	-0.7	-1.5
Ulcerative Colitis	0.8	1.1	4.9	-2.2	-1.7	0.0	0.0	0.0	0.0	0.0
Blood Red Count	0.8	7.9	21.7	-4.7	-3.0	1.3	-0.8	-1.4	-3.7	2.4
Respiratory disease	0.8	1.8	8.4	0.9	1.4	0.4	2.9	0.9	0.1	0.8
Neuroticism	0.8	1.9	4.1	-1.9	-1.5	-0.6	-2.0	-1.6	-0.8	-0.1
Number of treatments/medications taken	0.8	1.5	3.3	1.8	1.8	-0.8	1.6	0.5	0.4	0.7
Bilateral oophorectomy (both ovaries removed)	0.8	1.0	4.3	0.9	1.0	-0.0	2.1	0.3	0.3	0.7
Stomach or abdominal pain in last month	0.8	1.0	2.0	0.8	0.8	1.2	1.4	0.8	1.1	0.7
Waist circumference	0.8	2.9	5.8	-1.5	-1.2	-1.5	-2.2	-2.4	-1.9	-0.1
Weight	0.8	4.0	7.8	-2.0	-1.6	-1.5	-2.8	-2.5	-2.2	-0.4
Hip circumference	0.8	3.3	5.2	-1.3	-1.4	-1.8	-2.2	-2.2	-2.3	-1.1
Prospective memory result	0.8	1.0	2.9	1.5	0.7	-0.1	1.7	0.4	1.0	-0.2
Hair/balding pattern: Pattern 4	0.8	1.9	3.2	-1.8	-1.4	-1.3	-1.6	-1.3	-1.4	-0.9
Forced vital capacity (FVC), Best measure	0.8	2.9	8.0	-2.8	-2.4	0.2	-0.6	-0.9	-2.2	-0.7
Pulse rate, automated reading	0.8	2.7	8.2	-0.3	-0.8	-2.9	-1.6	-2.2	-0.9	-1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	3.1	-0.3	-0.2	1.8	0.2	0.9	0.9	1.3
Smoking status: Previous	0.8	1.2	3.1	-1.1	-0.2	1.4	-1.3	0.4	0.2	1.8
Smoking status: Current	0.8	1.3	1.7	-1.1	-1.1	-1.3	-0.7	-0.9	-1.2	-1.3
Supplements: Fish oil (including cod liver oil)	0.8	1.1	3.5	-0.1	-0.0	-1.9	0.1	-0.8	-1.3	-1.3
Medication: Atorvastatin	0.8	1.0	2.5	-1.6	-1.2	-0.4	-0.7	-0.8	-1.2	0.5
Average weekly beer plus cider intake	0.8	1.2	6.8	-0.0	0.2	-0.6	-2.6	-0.9	0.2	0.5
Unable to work because of sickness or disability	0.8	1.0	2.4	1.1	1.5	-1.2	1.1	0.6	0.1	0.9
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	2.0	1.4	1.2	-1.4	0.6	-0.5	-0.2	-0.6
Ever used hormone-replacement therapy (HRT)	0.7	0.9	4.0	0.7	0.5	0.7	2.0	0.2	0.4	0.9
Medication: Metformin	0.7	0.9	1.9	-0.6	-0.7	-1.3	0.6	-1.0	-1.4	-0.8
Diabetes (father)	0.7	0.9	4.6	-0.0	0.7	1.0	-0.5	0.3	0.2	2.1
Nervous feelings	0.7	1.3	2.4	-1.4	-1.4	-0.4	-1.5	-0.9	-0.8	-0.8
Forced vital capacity (FVC)	0.7	2.7	7.9	-2.8	-2.1	0.7	-1.3	-0.7	-2.0	-0.2
Medication: Simvastatin	0.7	1.0	2.7	0.2	0.3	1.6	0.9	1.5	0.7	0.9
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.8	3.6	-0.1	0.1	-0.3	-1.9	-1.2	-0.2	0.9
Medication: Cholesterol lowering	0.7	1.1	2.8	0.5	0.3	1.3	1.2	1.7	1.0	0.8
Arm fat mass (right)	0.7	3.0	8.1	-1.2	-1.0	-1.7	-2.8	-2.3	-1.6	-0.4
Pulse wave reflection index	0.7	0.9	1.8	-0.0	0.3	1.2	1.3	1.3	0.1	1.1
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	2.4	-1.5	-1.6	0.2	-0.4	-1.1	-1.0	-0.3
Blood clot in the leg (DVT)	0.7	0.9	2.0	0.5	0.6	1.1	1.4	0.6	0.7	1.3
Arm fat percentage (left)	0.7	3.0	8.4	-1.1	-1.0	-1.9	-2.9	-2.1	-1.4	-0.5
Long-standing illness, disability or infirmity	0.7	1.1	3.5	1.4	1.9	-1.3	-0.1	0.3	0.4	0.4
Back pain experienced in last month	0.7	1.0	3.0	1.4	1.0	-0.4	1.7	0.2	1.0	0.1
Breast cancer (self-reported)	0.7	0.8	2.4	0.3	0.0	-1.3	0.8	-0.5	-0.6	-1.6
Arm fat mass (left)	0.7	2.9	7.8	-1.3	-1.1	-1.6	-2.8	-2.2	-1.5	-0.2
Commuting to job workplace: Public transport	0.7	0.8	3.1	-0.7	-0.5	1.8	0.1	0.9	0.2	0.9
Ever smoked	0.7	1.2	3.2	-1.5	-1.1	0.1	-1.8	-0.7	-1.1	0.3
Supplements: Calcium	0.7	0.8	2.2	1.0	0.4	0.6	1.5	1.1	0.7	-0.2
Fasting Glucose	0.6	0.8	2.2	0.2	0.1	1.5	0.1	0.7	1.3	0.9
Lung FVC	0.6	2.9	5.3	-2.3	-2.3	-1.0	-0.0	-1.3	-2.2	-1.4
Average weekly spirits intake	0.6	0.7	1.2	0.9	0.9	1.1	-0.4	0.6	1.0	1.0
Current tobacco smoking	0.6	1.0	2.3	-0.6	-0.8	-1.3	-0.2	-1.0	-1.0	-1.5
Age when periods started (menarche)	0.6	1.5	2.5	-1.6	-1.4	-0.6	-1.5	-0.7	-1.0	-1.4
Sitting height	0.6	4.4	13.2	-3.6	-2.6	0.6	-2.1	-0.7	-2.3	0.5
Impedance of arm (right)	0.6	2.7	5.5	-2.3	-2.1	-0.3	-1.4	-1.3	-2.2	-0.9
Qualifications: A levels/AS levels or equivalent	0.6	1.4	3.6	-0.0	0.1	1.9	1.9	0.7	0.6	1.3
Asthma	0.6	1.2	3.3	1.1	1.4	0.8	1.8	0.7	0.5	0.9
Medication: Lansoprazole	0.6	0.7	2.3	0.2	-0.4	-0.9	1.5	-0.5	-0.6	-0.9
Wheeze or whistling in the chest in last year	0.6	1.0	2.5	0.1	0.7	1.3	1.0	1.0	0.5	1.6
Leg pain on walking	0.6	0.7	1.6	1.3	1.2	-0.2	0.2	0.4	1.1	0.7
Illnesses of father: Heart disease	0.6	0.8	1.9	-1.4	-1.2	0.2	-0.6	-0.9	-1.0	0.3
Loneliness, isolation	0.6	0.9	2.1	-0.1	0.3	1.4	0.3	1.1	0.7	1.4
Ever had bowel cancer screening	0.6	0.7	1.4	1.0	0.6	-0.0	1.1	1.2	0.9	-0.6
Diabetes diagnosed by doctor	0.6	1.0	2.8	1.4	1.2	-0.2	1.7	0.3	0.1	0.5
Eye problems/disorders: Cataract	0.6	0.6	1.5	-0.2	0.1	1.2	-0.8	0.6	0.9	1.1
Cholesterol lowering medication	0.6	1.0	2.5	-1.6	-1.3	-0.2	-0.6	-1.0	-1.0	0.6
Pain experienced in last month	0.6	1.1	2.6	-1.2	-1.3	0.8	-1.6	-0.7	-0.4	-0.6
Heart attack/myocardial infarction (self-reported)	0.6	0.7	1.6	1.2	1.3	-0.5	0.6	0.6	1.0	0.5
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	1.8	0.3	0.5	1.0	1.4	0.6	0.5	1.3
Prostate Cancer	0.5	0.7	1.8	-1.1	-1.1	-0.3	-1.3	-0.3	-0.2	-0.5
Primary Biliary Cirrhosis	0.5	0.7	2.5	-0.2	0.1	0.4	-1.6	1.2	0.8	0.2
Triglycerides	0.5	0.8	3.2	-1.6	-1.8	0.0	0.0	0.0	0.0	0.0
Blood Platelet Count	0.5	5.4	10.4	-3.2	-2.4	2.8	-3.1	-0.3	-0.5	1.9
Smoking Status	0.5	1.2	3.2	-1.6	-1.2	-0.1	-1.8	-0.5	-0.9	-0.3
Cardiovascular Disease	0.5	1.5	5.2	-0.7	-0.2	1.7	0.1	1.1	0.7	2.3
Ever had hysterectomy (womb removed)	0.5	0.6	1.1	0.9	0.8	-1.0	1.0	0.4	-0.6	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	1.0	0.9	1.0	-1.0	0.9	0.6	0.6	0.4
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	1.1	0.9	0.7	0.0	1.0	0.3	0.9	0.6
Body mass index (BMI)	0.5	2.3	6.0	-0.6	-0.7	-1.9	-2.5	-2.1	-1.1	-0.5
Number of incorrect matches in round	0.5	0.8	4.0	0.9	0.7	-0.2	2.0	0.1	0.5	0.1
Diabetes (self-reported)	0.5	0.8	2.6	1.2	1.1	-0.2	1.6	0.3	-0.1	0.5
Medication: Ramipril	0.5	0.6	2.9	0.2	0.2	-0.4	1.7	-0.1	-0.7	0.7
Depression (self-reported)	0.5	0.5	1.5	1.0	1.2	-0.8	-0.7	0.3	0.5	0.0
Illnesses of mother	0.5	0.6	2.2	-0.5	-0.2	1.5	0.1	0.6	0.1	1.1
Exposure to tobacco smoke at home	0.5	0.6	1.1	-0.3	0.3	0.8	-0.5	0.9	1.0	1.0
Birth weight of first child	0.5	1.0	3.2	-0.3	-0.9	-0.1	-1.8	-1.1	0.2	-1.1
Loud music exposure frequency	0.5	0.6	1.8	-0.2	-0.2	1.3	0.3	0.4	0.8	1.2
Emphysema/chronic bronchitis	0.5	0.5	2.4	-0.1	0.5	0.2	1.5	0.7	0.4	0.5
Neck or shoulder pain in last month	0.5	0.7	3.1	0.4	0.5	0.6	1.8	0.7	0.4	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	0.9	0.8	0.7	0.5	1.0	0.6	0.9	0.8
Overall health rating	0.5	1.1	5.7	0.2	0.6	-2.4	-0.3	-0.9	-0.8	0.4
Age at last live birth	0.5	0.7	2.4	0.1	-0.8	0.4	-1.0	0.4	0.7	-1.5
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.2	-1.1	-1.0	-0.8	-0.6	-0.5	-0.8	0.2
Knee pain experienced in last month	0.5	0.7	2.5	0.6	0.5	-1.6	-0.1	-0.2	-0.8	-1.2
Medication: Aspirin	0.5	0.7	1.9	0.9	0.9	0.1	1.4	1.0	0.3	0.5
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.7	-1.3	-1.0	0.7	-0.9	-0.4	0.0	0.2
Eye problems/disorders: Glaucoma	0.5	0.6	1.7	-0.4	-0.7	-0.9	0.0	-0.8	-0.6	-1.3
High cholesterol (Self-reported)	0.5	1.0	2.5	-1.6	-1.6	1.1	-0.4	-0.2	-0.1	0.5
Alcohol drinker status: Never	0.5	0.6	1.9	-0.0	0.4	0.8	0.8	0.5	0.8	1.4
Ever had prostate specific antigen (PSA) test	0.5	0.5	1.5	-0.1	-0.1	-0.7	1.0	-0.1	-1.2	-0.7
Diastolic blood pressure, automated reading	0.5	1.6	4.0	-0.9	-1.3	-1.4	-2.0	-1.5	-0.5	-0.7
Ever depressed for a whole week	0.5	0.7	1.6	0.1	0.4	1.0	-0.6	0.7	1.3	1.0
Commuting to job workplace: Cycle	0.5	0.6	3.6	0.3	-0.0	0.6	1.9	0.3	0.2	-0.3
Bipolar Disorder (2018)	0.4	0.7	3.1	1.8	1.2	0.0	0.0	0.0	0.0	0.0
Breast Cancer	0.4	0.9	2.2	0.5	0.7	1.0	-1.1	1.5	0.9	0.4
Schizophrenia (2014)	0.4	0.9	4.8	2.2	1.3	0.0	0.0	0.0	0.0	0.0
BMI	0.4	2.5	5.6	-1.4	-1.2	-1.4	-2.4	-1.8	-1.8	-0.5
Type 2 Diabetes (T2D) (2018)	0.4	0.8	2.5	0.9	1.0	-0.3	1.6	0.2	0.1	1.0
Hearing difficulty/problems: Yes	0.4	0.7	1.4	-1.1	-0.8	0.8	-1.2	0.3	0.4	0.7
Medication for hormone replacement therapy	0.4	0.5	1.4	0.3	-0.1	-0.8	0.2	-1.2	-0.4	-1.0
Severe depression (siblings)	0.4	0.4	2.4	-0.1	-0.1	0.4	1.6	0.3	0.2	0.3
Multivitamins +/- minerals	0.4	0.5	1.3	-0.2	-0.4	-1.1	0.5	-0.7	-0.6	-1.0
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	2.1	0.0	0.6	0.5	-0.3	1.0	0.8	1.4
Hearing difficulty/problems with background noise	0.4	0.7	1.8	0.2	0.6	0.6	-0.3	1.1	1.3	1.0
Financial difficulties in last 2 years	0.4	0.5	0.8	-0.8	-0.4	-0.8	-0.9	-0.5	-0.7	0.8
Mouth/teeth dental problems	0.4	0.5	2.3	0.1	0.2	1.5	0.4	0.9	-0.3	0.7
Neuroticism score	0.4	0.8	1.6	-1.3	-1.1	-0.7	-0.8	-0.8	-0.7	-0.4
Father’s age at death	0.4	0.5	1.5	1.2	1.2	-0.4	0.4	-0.4	0.6	0.0
Mouth/teeth dental problems: Dentures	0.4	0.8	1.9	-0.7	-0.1	-1.4	-1.3	-0.8	-0.6	-0.4
Impedance of arm (left)	0.4	1.6	3.2	-1.8	-1.7	-0.4	-0.9	-0.9	-1.7	-0.8
Standing height	0.4	3.6	10.2	-3.2	-2.2	0.7	-1.0	-1.3	-2.7	-0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.7	1.3	1.0	-1.1	-0.3	-0.3	0.2	-0.6
Medication: Amlodipine	0.4	0.5	1.5	1.2	0.9	-1.2	0.1	0.3	-0.2	-0.3
Comparative body size at age 10	0.4	1.1	2.5	-1.6	-1.2	-0.4	-0.4	-1.1	-1.3	0.8
Age at first live birth	0.4	0.6	2.0	0.2	-0.6	0.3	-1.2	0.0	0.6	-1.4
Medication: Blood pressure	0.4	0.8	2.2	1.5	1.1	-0.6	1.0	0.7	0.5	-0.2
Medication: Ibuprofen	0.4	0.4	1.1	-0.2	-0.1	-0.1	-1.0	-0.8	-0.2	1.1
Commuting to job workplace: Car/motor vehicle	0.4	0.5	2.9	-0.0	-0.3	0.4	-1.7	-0.3	0.4	-0.0
Medication: Aspirin	0.4	0.5	2.0	0.7	0.5	-0.0	1.4	0.7	0.0	0.2
Mineral and other dietary supplements	0.4	0.6	1.2	-0.7	-0.5	1.1	-0.9	0.4	0.5	0.9
Asthma (self-reported)	0.4	0.8	2.6	0.8	1.1	0.6	1.6	0.5	0.4	0.7
Wears glasses or contact lenses	0.4	0.4	1.1	-0.4	-0.4	-0.6	0.0	-0.7	-0.8	-1.0
Financial situation satisfaction	0.4	0.4	1.6	-0.5	-0.2	-0.6	-0.9	-1.3	-0.0	0.1
Medication: Bendroflumethiazide	0.4	0.7	1.5	-1.0	-1.2	-0.5	0.3	-0.3	-0.9	-0.9
Age started oral contraceptive pill	0.4	0.5	1.8	0.1	-0.0	1.0	1.3	0.4	0.4	0.1
Bipolar Disorder or Schizophrenia	0.3	0.8	4.4	2.1	1.1	0.0	0.0	0.0	0.0	0.0
Alzheimer’s Disease (in father)	0.3	0.3	1.4	0.3	-0.0	-0.8	0.2	-0.0	0.4	-1.2
HbA1C	0.3	0.3	0.8	0.5	0.5	0.9	0.3	0.6	0.4	-0.4
Height	0.3	5.7	18.1	-4.2	-2.6	-0.3	-1.0	-1.0	-3.4	-1.1
Waist Hip Ratio (WHR)	0.3	1.4	3.6	-1.8	-1.0	0.5	-0.7	-0.9	-0.9	1.9
Systolic blood pressure, automated reading	0.3	0.8	2.4	-0.4	-0.6	-1.2	-1.5	-1.1	-0.1	-0.1
Impedance of leg (right)	0.3	1.3	2.5	-1.3	-1.3	0.3	-1.6	-1.5	-0.6	-0.7
Leg fat-free mass (left)	0.3	1.4	3.2	-1.8	-1.3	-0.1	-1.4	-0.8	-1.5	0.2
Hand grip strength (right)	0.3	0.7	1.6	-0.3	-0.7	-0.3	-1.2	-1.1	0.5	-1.3
Townsend deprivation index at recruitment	0.3	0.5	0.9	-1.0	-0.6	-0.7	-0.8	0.1	-0.9	-0.2
Average weekly fortified wine intake	0.3	0.4	1.5	-0.4	-0.3	-0.5	-0.5	-0.6	-1.2	-0.5
Fed-up feelings	0.3	0.5	1.6	-0.2	0.5	-1.0	-1.3	-0.1	0.2	0.7
High blood pressure (mother)	0.3	0.5	1.1	0.7	1.0	-0.9	0.5	0.6	0.4	0.5
Leg predicted mass (left)	0.3	1.3	3.1	-1.8	-1.2	-0.0	-1.4	-0.9	-1.4	0.3
Heart attack	0.3	0.4	1.0	0.9	1.0	-0.7	0.1	0.2	0.7	0.3
Falls in the last year	0.3	0.4	1.8	0.6	0.3	-0.5	1.4	0.3	0.1	-0.5
Noisy workplace	0.3	0.4	0.8	0.7	0.5	-0.9	-0.1	-0.6	-0.5	-0.7
Lung cancer (father)	0.3	0.4	0.8	-0.9	-0.8	0.2	-0.2	-0.9	-0.7	0.0
Tense / ‘highly strung’	0.3	0.5	1.6	-0.3	-0.3	-1.2	0.1	-0.8	-0.4	-0.9
Glaucoma (self-reported)	0.3	0.4	1.6	-0.1	-0.3	-0.8	0.1	-0.3	-0.3	-1.3
Birth weight	0.3	0.7	1.3	0.8	1.1	0.1	1.0	-0.0	1.0	1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	1.1	-0.8	-1.1	0.1	0.5	-0.3	-0.4	-0.7
Medication: Allopurinol	0.3	0.4	1.6	0.4	0.0	0.6	-0.2	1.2	0.7	0.1
Medication: Omeprazole	0.3	0.3	0.7	-0.6	-0.5	-0.6	0.2	-0.7	-0.3	-0.8
Number of full sisters	0.3	0.3	0.6	-0.5	-0.7	-0.0	0.6	-0.1	-0.7	-0.8
Illnesses of siblings: Diabetes	0.3	0.3	0.7	0.8	0.9	-0.2	0.3	0.9	0.2	-0.2
Handedness (chirality/laterality): Left-handed	0.3	0.4	1.7	0.2	0.1	0.7	1.3	0.8	0.0	-0.2
Qualifications: nursing, teaching	0.3	0.5	1.3	-0.1	-0.5	-0.1	1.1	-0.6	-0.7	-1.1
Medication: Gliclazide	0.3	0.3	1.3	-1.2	-0.7	-0.2	-0.1	-0.2	-0.6	-0.0
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.2	0.0	0.5	-1.1	0.8	0.5	-0.6	0.2
Myopia	0.3	0.4	1.1	0.5	0.9	-0.4	0.2	1.1	-0.6	-0.5
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	0.7	-0.9	-0.8	-0.2	-0.3	-0.5	-0.1	-0.9
Impedance of whole body	0.3	1.3	2.8	-1.7	-1.6	0.1	-0.7	-1.2	-1.3	-0.5
Schizophrenia vs Biploar Disorder	0.2	0.2	0.9	0.9	0.9	0.0	0.0	0.0	0.0	0.0
Heel T-Score	0.2	2.0	4.7	-1.4	-1.1	-2.0	-0.6	-1.0	-2.2	-0.7
Hand grip strength (left)	0.2	0.4	1.1	-0.0	-0.4	0.5	-0.6	-0.3	1.0	-1.0
Sensitivity / hurt feelings	0.2	0.3	0.4	-0.6	-0.6	-0.6	0.5	-0.6	-0.5	-0.1
Supplements: Zinc	0.2	0.2	0.7	0.2	0.2	-0.8	0.0	0.6	-0.3	0.4
Supplements: Glucosamine	0.2	0.3	0.9	0.5	0.4	0.9	0.5	0.7	0.3	0.3
Chronic bronchitis/emphysema (father)	0.2	0.2	0.6	-0.7	-0.8	-0.1	0.4	0.4	-0.4	-0.2
Impedance of leg (left)	0.2	0.8	1.7	-1.0	-1.0	0.2	-1.2	-1.3	-0.5	-0.3
Alcohol usually taken with meals	0.2	0.3	1.5	-0.1	-0.2	0.6	1.2	0.1	-0.1	-0.6
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.6	0.3	0.6	-0.0	-0.0	0.6	0.6	0.8
Hair/balding pattern: Pattern 3	0.2	0.3	0.6	-0.8	-0.7	0.3	0.1	-0.2	-0.6	0.4
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.6	0.1	0.4	-0.6	-0.7	-0.3	-0.8	-0.0
Breastfed as a baby	0.2	0.3	0.7	-0.2	0.2	-0.6	0.4	-0.2	-0.7	-0.8
Number of children fathered	0.2	0.2	0.7	0.8	0.2	-0.4	0.5	-0.5	-0.0	-0.4
Health satisfaction	0.2	0.2	1.1	0.0	0.6	-0.2	-0.4	-0.2	0.1	1.0
Qualifications: College or University degree	0.2	0.7	2.2	0.6	0.6	1.5	1.1	0.5	0.4	0.7
Medication: Seretide 50 evohaler	0.2	0.3	0.6	0.8	0.7	0.2	0.8	-0.1	0.3	0.2
Alcohol intake frequency.	0.2	0.4	0.9	0.1	0.9	-0.6	0.7	0.8	0.1	0.6
Comparative height size at age 10	0.2	0.9	2.1	-1.2	-0.4	1.5	-0.2	0.3	-0.7	1.3
Hypertension (Self-reported)	0.2	0.6	1.0	0.7	1.0	-0.6	0.8	0.8	0.2	0.9
Leg fat-free mass (right)	0.2	0.9	2.2	-1.5	-1.0	0.0	-0.9	-0.4	-1.3	0.6
Mood swings	0.2	0.4	1.3	0.2	0.5	0.6	-0.0	-0.2	0.8	1.1
Medication for cholesterol	0.2	0.4	1.1	-0.4	-0.7	0.3	-0.8	-0.2	-0.2	-1.1
Illnesses of father: None of the above (group 1)	0.2	0.2	1.1	0.5	0.3	0.1	0.2	-0.1	1.1	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	1.5	-0.9	-0.9	0.1	0.5	-0.0	-1.2	-0.5
Leg predicted mass (right)	0.2	0.9	2.3	-1.5	-1.0	0.0	-0.9	-0.5	-1.3	0.5
Miserableness	0.2	0.4	0.7	-0.8	-0.2	-0.8	0.3	-0.5	-0.7	0.7
Hearing aid user	0.2	0.2	0.6	-0.5	-0.5	0.8	-0.2	0.2	0.5	0.2
Mother’s age at death	0.2	0.2	0.5	0.6	0.7	-0.1	0.2	0.4	0.3	-0.5
Medication: Lisinopril	0.2	0.2	1.1	-0.0	0.1	-1.1	0.2	-0.1	-0.6	0.2
Basal metabolic rate	0.2	1.3	2.6	-1.5	-1.0	-0.2	-1.6	-1.2	-1.4	0.3
Arm fat-free mass (left)	0.2	1.0	1.7	-1.3	-0.9	0.0	-1.1	-1.2	-1.1	0.4
Vascular/heart problems diagnosed by doctor	0.2	0.6	1.3	-0.7	-1.1	0.9	-0.5	-0.5	-0.1	-1.1
Arm predicted mass (left)	0.2	1.1	2.1	-1.4	-0.9	-0.2	-1.2	-1.4	-1.3	0.2
Depressed Affect (Nagel 2018)	0.1	0.2	1.0	-0.7	-0.1	0.1	-0.2	-0.0	0.3	1.0
Schizophrenia (2018)	0.1	0.3	1.6	1.3	0.4	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.1	0.1	0.5	-0.5	-0.7	0.0	0.0	0.0	0.0	0.0
Blood White Count	0.1	1.0	1.8	-1.3	-1.0	-0.3	-0.6	-1.1	-1.4	0.7
Systolic Blood Pressure	0.1	0.4	2.6	-0.4	-0.3	-0.1	0.1	0.3	0.3	1.6
Chronotype (morning person)	0.1	0.3	1.1	-0.6	-0.6	0.7	1.1	0.2	0.0	0.0
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.4	-0.2	-0.1	-0.6	-0.4	-0.3	0.1	0.7
Maternal smoking around birth	0.1	0.1	0.1	-0.3	-0.3	-0.0	-0.3	-0.3	0.4	0.3
High blood pressure	0.1	0.4	0.9	0.3	0.6	-1.0	0.6	0.4	-0.2	0.7
Diverticular disease/diverticulitis (self-reported)	0.1	0.2	0.4	0.3	-0.2	-0.6	0.4	-0.2	-0.4	-0.6
Trunk fat-free mass	0.1	0.8	1.5	-1.2	-0.7	0.1	-1.1	-0.9	-1.1	0.2
Pulse wave Arterial Stiffness index	0.1	0.1	0.3	-0.3	-0.1	-0.1	0.2	-0.1	-0.6	0.2
Trunk predicted mass	0.1	0.6	1.2	-1.1	-0.6	0.2	-0.9	-0.9	-1.0	0.3
Length of working week for main job	0.1	0.2	0.3	-0.3	-0.5	-0.4	-0.0	-0.5	-0.3	-0.6
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.4	0.3	0.4	-0.1	0.6	0.2	-0.0	0.3
Arm fat-free mass (right)	0.1	0.3	0.7	-0.7	-0.3	0.5	-0.6	-0.5	-0.2	0.8
Worry too long after embarrassment	0.1	0.2	0.7	-0.8	-0.7	0.6	0.2	-0.1	-0.1	0.1
Pulse wave peak to peak time	0.1	0.1	0.2	0.2	0.0	0.3	-0.4	0.2	0.5	-0.0
Medication for pain relief, constipation, heartburn	0.1	0.2	0.4	-0.6	-0.5	0.5	-0.2	-0.2	-0.4	-0.1
Arm predicted mass (right)	0.1	0.4	0.7	-0.8	-0.4	0.1	-0.7	-0.7	-0.6	0.6
Family relationship satisfaction	0.1	0.2	0.5	-0.1	-0.1	-0.7	0.6	-0.1	0.5	-0.1
Whole body fat-free mass	0.1	0.8	1.7	-1.3	-0.8	0.2	-1.1	-0.8	-1.1	0.4
Osteoarthritis (self-reported)	0.1	0.2	0.4	0.4	0.6	-0.2	-0.1	0.3	0.3	0.6
Whole body water mass	0.1	0.7	1.6	-1.3	-0.7	0.2	-1.0	-0.7	-1.1	0.3
Irritability	0.1	0.1	0.4	-0.3	-0.2	-0.6	-0.5	-0.4	-0.1	-0.3
Major Depression (MDD)	0.0	0.0	0.2	0.0	0.4	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.0	0.0	0.2	0.5	0.2	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
HDL Cholesterol	0.0	0.0	0.3	0.1	0.5	0.0	0.0	0.0	0.0	0.0
LDL Cholesterol	0.0	0.1	0.4	-0.6	-0.4	0.0	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.2	0.4	0.0	0.0	0.0	0.0	0.0	0.0
Blood Eosinophil Count	0.0	0.3	0.6	0.8	0.7	0.6	-0.2	0.4	-0.0	0.7
Hair Pigment	0.0	0.8	2.7	-0.1	-0.4	-1.2	-0.6	-0.5	-0.8	-1.6
Tanning	0.0	0.5	1.4	-0.4	-0.6	-0.5	-0.3	-0.5	-1.2	-1.0
Relative age of first facial hair	0.0	0.1	0.2	0.2	-0.0	0.1	0.3	0.5	0.2	-0.5
Happiness	0.0	0.1	0.1	-0.1	0.4	-0.4	-0.0	0.2	-0.1	-0.0
Average weekly red wine intake	0.0	0.1	0.2	-0.2	-0.2	0.5	-0.3	-0.3	-0.1	-0.1

Hub : Genes

CPT1C

Models

Trait associations