[Hub]/) : Traits : Hypothyroidism/myxoedema (self-reported) :

chr1:107,418,424-109,188,382

Best TWAS P=2.65e-36 · Best GWAS P=1.62e-36 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Lung VAV3 0.25 0.23 lasso 2 0.23 2.4e-17 11.4 11.3 1.4e-29 0.90 0.98 0.02 FALSE
2 GTEx Nerve Tibial VAV3 0.20 0.07 lasso 5 0.09 8.8e-07 8.1 7.7 1.3e-14 0.77 0.13 0.86 FALSE
3 GTEx Thyroid VAV3 0.36 0.27 lasso 5 0.29 2.7e-22 12.6 12.6 2.6e-36 1.00 0.00 1.00 TRUE
4 NTR Blood VAV3 0.03 0.01 lasso 4 0.01 3.6e-03 11.4 10.9 1.6e-27 0.82 0.10 0.72 FALSE
5 The Cancer Genome Atlas Thyroid Carcinoma VAV3 0.09 0.02 enet 13 0.05 1.3e-05 11.8 10.4 3.2e-25 0.87 0.01 0.99 FALSE