TWAS hub - VAV3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0890	0.0290	6.2e-04	0.026	0.024	0.049	0.032	0.042	3.3e-04	6.2e-04	1.1e-06	7.3e-05	6.9e-06
2	GTEx	Lung	0.2470	0.0565	4.4e-06	0.231	NA	0.201	NA	0.227	1.2e-17	NA	2.3e-15	NA	2.4e-17
3	GTEx	Nerve Tibial	0.1973	0.0533	5.7e-05	0.069	NA	0.042	NA	0.088	1.3e-05	NA	5.8e-04	NA	8.8e-07
4	GTEx	Thyroid	0.3610	0.0550	9.0e-12	0.272	NA	0.281	NA	0.288	5.6e-21	NA	1.0e-21	NA	2.7e-22
5	NTR	Blood	0.0282	0.0111	5.7e-03	0.006	0.004	0.003	0.006	0.006	4.6e-03	1.2e-02	3.2e-02	4.7e-03	3.6e-03
6	ROSMAP	Brain Pre-frontal Cortex	0.0761	0.0247	3.7e-04	0.044	0.040	0.031	0.044	0.044	2.2e-06	6.7e-06	5.7e-05	2.3e-06	2.3e-06
7	TCGA	Thyroid Carcinoma	0.0860	0.0310	1.4e-03	0.022	0.021	0.050	NA	0.039	3.1e-03	3.6e-03	1.3e-05	NA	1.1e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Hypothyroidism (self reported)	54.9	126.1	225.0	5.2	13.6	9.3	15.0	13.2	4.9	12.7
Hypothyroidism/myxoedema (self-reported)	43.7	85.3	158.8	3.6	11.3	7.7	12.6	10.9	3.4	10.4
Medication: Levothyroxine sodium	37.5	63.5	125.4	3.5	9.7	6.3	11.2	9.4	3.4	8.5
Eye problems/disorders: Cataract	6.6	7.7	10.6	-1.9	-3.0	-3.2	-2.8	-3.1	-2.2	-2.9
Shortness of breath walking on level ground	5.5	6.5	11.3	-0.1	-3.0	-2.3	-3.4	-2.8	-0.8	-3.3
Eye problems/disorders: None of the above	4.9	5.7	10.3	0.5	2.7	3.2	2.6	2.8	1.4	2.3
Angina (self-reported)	4.5	5.9	11.4	-1.1	-3.4	-2.6	-2.9	-2.8	-0.5	-2.3
Angina	4.0	5.2	10.0	-0.7	-3.2	-2.6	-2.8	-2.6	-0.3	-2.3
Ever smoked	3.7	6.4	13.0	-0.2	-2.9	-3.0	-2.6	-2.7	-0.7	-3.6
Bipolar Disorder or Schizophrenia	3.5	8.6	15.7	-1.4	-2.7	-2.2	-3.8	-2.7	-3.0	-4.0
Taking other prescription medications	3.5	5.3	10.5	0.7	2.6	2.1	3.2	2.5	2.0	2.3
Age at first live birth	3.0	5.2	11.2	0.1	-2.9	-1.8	-3.4	-2.0	-2.3	-2.0
Bipolar Disorder (2018)	2.9	4.6	6.4	-1.7	-1.9	-2.5	-2.2	-2.4	-1.8	-2.3
Worry too long after embarrassment	2.9	4.8	10.7	0.8	2.1	3.3	2.1	2.5	-0.0	2.7
Fasting Glucose	2.8	3.3	6.4	-1.7	-1.4	-2.1	-1.8	-0.9	-2.5	-2.0
Guilty feelings	2.6	3.9	9.1	-1.0	1.6	3.0	1.9	1.8	-1.1	2.6
Ulcerative Colitis (UC)	2.4	4.4	6.3	-0.6	-2.4	-2.5	-2.5	-2.4	-0.4	-2.5
Coronary Artery Disease (CAD)	2.4	2.8	4.8	-0.5	-1.6	-2.2	-1.8	-1.6	-2.0	-1.6
Mean time to correctly identify matches	2.4	4.5	6.9	-0.6	-2.1	-2.3	-2.2	-2.6	-2.1	-2.4
Had major operations	2.4	2.8	6.8	1.1	1.4	2.6	1.7	1.4	1.2	1.8
Relative age voice broke	2.3	3.6	6.7	0.3	2.2	1.9	2.6	1.8	0.3	2.5
Serious illness, injury or assault to yourself	2.3	2.7	5.6	-1.5	-2.0	-1.3	-1.7	-1.7	-0.3	-2.4
Schizophrenia (2018)	2.2	4.6	10.4	-0.4	-2.0	-0.8	-3.0	-1.5	-2.4	-3.2
Qualifications: CSEs or equivalent	2.2	2.9	4.7	0.0	1.6	2.1	2.1	2.2	-0.4	2.1
Number of full sisters	2.2	2.7	6.0	-1.1	-1.7	-1.1	-2.2	-1.6	-0.2	-2.4
Alcohol usually taken with meals	2.1	3.4	6.9	-2.6	-2.0	-1.6	-1.1	-1.6	-2.5	-0.8
Heart attack	2.1	2.7	5.6	-1.4	-1.6	-2.1	-1.6	-1.1	-0.7	-2.4
Severe depression (siblings)	2.0	2.3	4.4	-0.1	2.0	0.6	2.1	2.1	1.3	1.1
Ever unenthusiastic/disinterested for a whole week	2.0	2.4	6.0	1.2	1.8	2.4	1.5	1.0	1.6	0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.0	4.1	8.6	2.9	1.8	1.4	1.9	2.0	1.1	2.5
Reaction Time	1.9	3.5	6.7	0.0	-1.7	-2.0	-2.4	-2.6	-1.3	-2.0
Hand grip strength (left)	1.9	5.1	6.3	2.4	2.5	2.0	2.0	2.5	2.5	1.9
Past tobacco smoking	1.9	3.5	6.9	0.5	1.9	2.5	1.9	1.9	0.6	2.6
Impedance of arm (right)	1.9	8.7	15.0	-1.4	-2.7	-3.3	-3.8	-2.9	-1.8	-3.9
Unable to work because of sickness or disability	1.9	2.5	4.0	-1.9	-1.8	-0.9	-1.3	-1.8	-2.0	-1.0
Bipolar Disorder (2011)	1.8	1.7	2.6	-0.9	-1.4	-1.6	-1.0	-1.5	-1.0	-1.5
Ulcerative Colitis	1.8	2.6	4.5	-0.2	-1.9	-2.0	-2.1	-1.6	-0.9	-1.6
Ever used hormone-replacement therapy (HRT)	1.8	2.2	6.4	-0.4	-1.4	-1.9	-1.2	-1.4	-0.6	-2.5
Number of incorrect matches in round	1.8	3.0	4.5	-0.3	-1.6	-2.1	-1.8	-2.1	-1.6	-1.9
Time employed in main current job	1.8	2.1	3.8	-1.7	-1.0	-1.6	-1.2	-1.1	-1.2	-2.0
BMI	1.7	9.6	21.0	3.3	2.4	2.8	3.3	2.0	4.6	2.6
Lung FVC	1.7	8.5	13.2	2.1	3.6	3.0	3.5	3.6	0.4	2.8
Chronotype (morning person)	1.7	3.9	9.2	0.3	1.6	2.1	2.3	2.1	0.8	3.0
Body mass index (BMI)	1.7	7.3	13.0	2.3	2.2	2.5	3.6	2.2	3.0	2.8
Chest pain or discomfort	1.7	2.4	4.5	-0.6	-1.8	-1.2	-1.8	-2.1	-1.7	-1.1
Heart attack/myocardial infarction (self-reported)	1.7	2.3	4.8	-1.5	-1.5	-1.9	-1.4	-0.9	-0.3	-2.2
Pack years of smoking	1.7	2.5	5.4	-0.5	-1.7	-2.3	-1.3	-1.9	0.4	-1.9
Schizophrenia (2014)	1.6	3.6	7.8	-1.2	-1.4	-1.4	-2.5	-1.1	-2.2	-2.8
Ever highly irritable/argumentative for 2 days	1.6	1.9	4.4	2.1	0.8	2.1	1.2	0.5	0.4	1.6
Neck or shoulder pain in last month	1.6	2.3	4.3	0.5	-2.0	-1.3	-1.3	-2.1	-1.2	-1.5
Age at last live birth	1.6	2.3	6.2	0.9	-2.4	-0.6	-2.5	-1.4	-0.2	-1.1
Alzheimer’s Disease (in father)	1.5	1.6	6.2	2.5	0.6	0.4	0.6	0.5	1.5	1.2
Irritable Bowel Disease (IBD)	1.5	3.6	6.3	-1.3	-2.0	-2.2	-2.0	-2.5	-0.4	-2.0
Type 2 Diabetes (T2D) (2012)	1.5	1.8	3.9	-0.1	-1.4	-2.0	-1.3	-1.4	0.1	-1.6
Hand grip strength (right)	1.5	4.0	4.8	2.0	2.0	1.9	1.8	2.0	2.2	2.1
Gout (self-reported)	1.5	2.1	8.4	2.9	0.5	0.4	1.0	0.4	2.2	-0.1
Eye problems/disorders: Glaucoma	1.5	1.8	3.0	-0.6	-1.0	-1.7	-1.2	-1.1	-1.7	-1.6
Lupus	1.4	2.2	3.5	-1.2	1.7	1.9	1.6	0.9	-0.8	1.8
Pack years adult smoking proportion	1.4	2.1	3.6	-0.6	-1.7	-1.9	-1.4	-1.8	0.2	-1.6
Pulse wave Arterial Stiffness index	1.4	1.7	2.4	-1.0	-1.6	-1.4	-1.2	-1.5	-1.0	-1.3
Emphysema/chronic bronchitis	1.4	1.5	2.8	0.0	-1.6	-1.7	-1.1	-1.5	-0.2	-1.4
Qualifications: nursing, teaching	1.4	2.2	8.2	-2.6	-0.2	0.5	0.4	0.3	-2.9	0.3
HbA1C	1.3	1.4	2.8	1.3	-1.0	-1.7	-0.2	-1.6	0.0	-1.2
Smoking Status	1.3	3.2	6.2	0.7	-2.2	-1.9	-2.5	-1.8	0.3	-1.9
Average weekly spirits intake	1.3	1.6	5.4	0.3	-1.0	-2.3	-1.0	-1.4	-0.7	-1.0
Chronic bronchitis/emphysema (father)	1.3	1.5	3.5	-0.9	-0.9	-1.4	-1.5	-1.3	-0.1	-1.9
Neuroticism score	1.3	2.8	8.2	0.6	1.5	2.9	1.7	1.3	0.3	2.1
Tense / ‘highly strung’	1.3	2.1	3.8	1.2	1.7	1.9	0.9	1.9	0.0	1.6
Loud music exposure frequency	1.3	1.4	4.0	-0.5	-0.9	0.8	-2.0	-0.9	-1.1	-1.3
Medication: Allopurinol	1.3	1.8	5.5	2.3	1.3	0.3	1.1	0.9	1.8	0.1
Smoking status: Previous	1.3	2.0	4.9	-1.0	-1.3	-2.2	-1.1	-1.3	-0.8	-1.6
Medication: Gliclazide	1.3	1.5	3.6	-0.5	-1.9	-1.3	-1.2	-1.8	0.2	-0.5
Happiness	1.2	1.4	3.2	0.8	1.1	1.1	1.7	0.9	0.0	1.8
Noisy workplace	1.2	1.5	2.3	-1.2	-1.3	-0.6	-1.5	-1.5	-1.0	-1.4
Pulse wave peak to peak time	1.2	1.4	2.3	1.0	1.4	1.5	0.9	1.4	0.9	1.1
Medication: Blood pressure	1.2	2.1	7.0	2.6	-0.9	-0.8	-0.9	-0.7	2.1	-0.6
Average weekly red wine intake	1.2	1.8	5.7	-2.1	-0.6	-1.1	-0.3	-0.8	-2.4	-0.6
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.2	2.3	-0.8	-1.5	-0.9	-1.3	-1.4	-0.4	-1.1
Impedance of whole body	1.2	5.9	9.5	-1.8	-1.8	-3.0	-2.9	-2.0	-1.8	-3.1
Alzheimer’s Disease (including proxy)	1.1	1.6	6.2	2.5	-0.6	0.4	0.4	-0.4	1.9	0.7
Bilateral oophorectomy (both ovaries removed)	1.1	1.2	3.0	-1.5	-0.5	-1.7	-0.9	-0.1	-1.2	-0.9
Had other major operations	1.1	1.3	3.1	1.4	-0.9	-0.1	-1.3	-1.4	-0.3	-1.8
Qualifications: None of the above	1.1	2.4	5.2	1.7	-1.4	-1.5	-0.7	-1.5	2.3	-1.4
Medication: Ramipril	1.1	1.4	4.6	0.7	-1.5	-2.1	-0.8	-1.0	0.2	-0.9
Hip circumference	1.1	4.6	11.1	2.9	0.8	1.9	2.0	0.8	3.3	2.0
Falls in the last year	1.1	1.5	3.7	0.5	-1.9	-0.8	-1.0	-1.7	0.8	-0.9
Forced expiratory volume in 1-second (FEV1)	1.1	3.6	6.2	1.5	1.9	2.3	1.7	2.1	0.2	2.5
Impedance of arm (left)	1.1	5.3	9.7	-1.0	-1.9	-2.9	-2.9	-2.0	-1.3	-3.1
Birth weight of first child	1.1	2.0	4.8	0.5	-1.8	-1.0	-1.5	-1.5	0.2	-2.2
Qualifications: O levels/GCSEs or equivalent	1.1	1.7	6.6	-2.1	-0.1	-0.8	-0.1	0.1	-2.6	-0.2
Glaucoma (self-reported)	1.1	1.3	3.4	-0.7	-0.7	-0.8	-1.1	-0.7	-1.8	-1.5
Arm fat-free mass (right)	1.1	5.4	9.2	1.7	1.5	3.0	1.9	1.8	2.9	2.9
Number of full brothers	1.1	1.4	2.8	1.7	1.0	0.7	1.4	0.7	1.6	0.6
Arm predicted mass (right)	1.1	5.6	9.9	1.6	1.4	3.1	2.0	1.7	2.8	3.1
Diabetes diagnosed by doctor	1.1	1.9	3.7	-0.3	-1.7	-1.9	-1.6	-1.8	0.1	-1.0
Arm fat mass (left)	1.1	4.3	9.2	2.1	1.4	1.7	2.5	1.4	3.0	2.0
Commuting to job workplace: Public transport	1.1	1.4	2.7	-1.6	-1.5	-0.5	-1.2	-1.3	-0.8	-0.5
Age started oral contraceptive pill	1.1	1.3	2.6	-0.1	-1.3	-1.6	-1.2	-1.4	-0.3	-1.2
Medication: Co-codamol	1.0	1.1	2.2	-1.5	-0.1	-1.1	0.1	-0.7	-1.3	-1.5
Impedance of leg (right)	1.0	4.9	7.4	-1.7	-1.7	-2.5	-2.7	-1.6	-2.2	-2.6
Hearing difficulty/problems with background noise	1.0	1.6	2.4	0.7	-1.2	-1.6	-1.4	-1.1	-1.4	-1.5
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	2.6	1.0	1.3	0.7	1.2	1.2	0.3	1.6
Weight	1.0	5.0	10.3	2.3	1.3	2.3	2.3	1.4	3.2	2.3
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.2	6.3	1.4	1.6	2.2	1.9	1.7	-0.1	2.5
Arm fat mass (right)	1.0	4.0	9.7	1.9	1.2	1.7	2.4	1.2	3.1	1.9
Breastfed as a baby	1.0	1.2	4.2	-1.0	-0.9	-1.3	-0.1	-0.9	-2.1	-0.1
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	3.3	-0.4	-1.3	-0.5	-1.8	-1.0	-1.2	-0.9
Arm fat percentage (left)	1.0	3.9	8.2	1.8	1.5	1.2	2.7	1.3	2.9	1.7
Osteoarthritis (self-reported)	1.0	1.4	2.2	-0.7	-1.4	-1.5	-0.8	-1.4	-0.6	-1.4
Smoking status: Current	1.0	1.5	3.6	0.7	-1.5	-0.6	-1.9	-1.1	-0.2	-1.6
Leg predicted mass (right)	1.0	5.1	9.7	1.5	1.3	3.1	1.8	1.5	2.9	2.8
Illnesses of father: High blood pressure	1.0	1.2	2.0	1.0	1.1	1.4	1.3	0.9	0.8	1.1
Ever had hysterectomy (womb removed)	0.9	1.0	3.3	-1.8	0.1	-0.7	-0.1	0.1	-1.8	-0.6
Leg fat-free mass (left)	0.9	4.9	8.9	1.6	1.2	3.0	1.8	1.4	2.9	2.8
Current tobacco smoking	0.9	1.5	3.3	0.9	-1.4	-0.7	-1.8	-1.1	0.1	-1.6
Age when periods started (menarche)	0.9	2.1	3.4	1.8	-1.5	-1.3	-1.5	-1.5	0.8	-1.4
Supplements: Glucosamine	0.9	1.2	3.7	-1.9	1.0	0.4	1.0	0.6	-1.3	0.5
Impedance of leg (left)	0.9	4.3	6.9	-1.7	-1.5	-2.3	-2.6	-1.5	-2.0	-2.5
Leg predicted mass (left)	0.9	4.8	8.9	1.6	1.2	3.0	1.8	1.3	2.9	2.7
Pain all over the body in last month	0.9	0.9	2.3	1.5	-0.7	0.1	-0.7	-0.0	1.0	-1.5
Qualifications: A levels/AS levels or equivalent	0.9	1.9	9.4	-1.2	0.7	0.8	0.4	0.8	-3.1	0.8
Mouth/teeth dental problems: Dentures	0.9	1.4	3.8	-0.4	-0.9	-1.5	-1.3	-1.0	-0.5	-1.9
Leg fat-free mass (right)	0.9	4.9	9.1	1.5	1.3	3.0	1.8	1.4	2.9	2.7
Wears glasses or contact lenses	0.9	1.0	3.8	1.9	0.5	0.9	1.1	0.2	0.7	0.8
Basal metabolic rate	0.9	5.0	8.8	1.9	1.2	2.9	1.8	1.4	3.0	2.7
Leg fat percentage (left)	0.9	3.1	7.8	1.3	1.6	1.3	2.8	1.2	2.0	1.6
Medication: Omeprazole (e.g. Zanprol)	0.9	1.0	5.3	1.1	0.1	-0.5	0.4	-0.3	2.3	0.5
Leg fat mass (left)	0.9	3.4	6.1	1.6	1.3	1.6	2.4	1.3	2.5	1.9
Major Depression (MDD)	0.8	0.9	3.9	0.9	0.4	0.5	-0.5	0.5	2.0	-0.9
Neuroticism	0.8	2.0	5.3	0.3	1.2	2.3	1.3	1.1	0.2	1.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.1	1.9	-0.6	-1.4	-0.6	-0.8	-1.4	-1.3	-0.9
Pulse rate	0.8	1.4	4.8	-0.3	-1.3	-2.2	-0.6	-1.7	0.1	-0.6
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	3.2	-1.6	-0.3	-0.2	-0.3	-0.5	-1.8	-0.4
Medication: Amlodipine	0.8	1.2	3.0	1.7	0.8	-0.5	0.9	0.4	1.7	0.7
Medication: Omeprazole	0.8	1.0	4.6	0.6	-0.7	-0.5	-0.2	-1.2	2.1	-0.0
Leg fat mass (right)	0.8	3.1	5.7	1.5	1.1	1.5	2.3	1.2	2.4	1.8
Leg pain on walking	0.8	1.0	3.1	0.9	0.8	0.6	1.2	0.8	1.8	0.2
Whole body fat-free mass	0.8	4.5	9.0	1.7	1.1	3.0	1.5	1.4	2.7	2.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	5.5	-2.3	-0.4	0.4	-0.0	-0.3	-0.9	-0.4
Illnesses of father: None of the above (group 1)	0.8	1.0	2.5	-0.3	0.9	0.9	0.9	1.0	1.6	0.9
Whole body water mass	0.8	4.4	8.5	1.8	0.9	2.9	1.5	1.2	2.8	2.6
Arm fat-free mass (left)	0.8	4.0	7.5	1.7	1.1	2.7	1.6	1.3	2.6	2.3
Fractured/broken bones in last 5 years	0.8	1.1	3.3	1.6	-0.7	0.3	-0.8	-0.6	1.8	-0.3
Alcohol drinker status: Previous	0.8	0.9	1.9	-0.9	-1.0	-0.8	-0.9	-1.4	-0.1	-1.2
Arm predicted mass (left)	0.8	3.8	7.4	1.6	0.9	2.7	1.4	1.1	2.7	2.4
Crohns Disease (2017)	0.7	1.6	3.6	-1.8	-1.0	-1.2	-0.8	-1.9	-0.2	-1.2
Age at First Birth	0.7	1.0	3.3	-0.5	0.2	1.8	0.4	0.9	-1.3	0.8
Crohns Disease (2012)	0.7	1.1	2.8	-1.0	-1.1	-1.1	-0.7	-1.7	-0.0	-1.0
Frequency of depressed mood in last 2 weeks	0.7	1.0	5.2	-0.8	-0.4	0.3	-0.8	-0.5	-2.3	0.0
Eye problems/disorders: Diabetes related eye disease	0.7	0.7	2.1	0.4	-1.0	-1.2	-0.5	-0.4	1.4	-0.0
Diabetes (mother)	0.7	0.9	3.9	-2.0	-0.3	-0.4	-0.3	-0.1	-1.4	-0.4
Medication: Atenolol	0.7	0.9	2.2	-1.3	-1.4	-0.2	-1.5	-0.7	-0.2	-0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.7	4.9	1.0	1.2	2.2	1.1	0.8	1.2	1.0
Arm fat percentage (right)	0.7	2.7	7.4	1.8	0.9	0.9	2.2	0.8	2.7	1.2
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	3.7	-1.9	0.6	0.6	0.0	0.7	-1.9	0.2
Leg fat percentage (right)	0.7	2.5	6.5	1.2	1.4	0.9	2.6	1.0	1.8	1.5
Whole body fat mass	0.7	3.0	7.8	1.4	1.0	1.4	2.1	1.0	2.8	1.7
Commuting to job workplace: Car/motor vehicle	0.7	0.7	2.3	1.0	-0.2	-1.2	0.3	-0.5	-0.1	-1.5
Long-standing illness, disability or infirmity	0.7	1.1	3.6	1.9	-0.2	0.8	0.2	-0.3	1.9	-0.0
Ever taken oral contraceptive pill	0.7	0.8	3.0	-1.7	-0.5	-0.7	-0.5	-0.5	-1.1	-0.2
Vascular/heart problems diagnosed by doctor	0.7	1.9	3.1	-1.7	1.8	1.8	1.2	1.3	-0.6	0.8
Schizophrenia vs Biploar Disorder	0.6	0.8	2.7	1.6	0.5	0.6	0.8	1.1	0.3	0.5
Respiratory disease	0.6	1.2	2.1	1.2	-1.2	-0.6	-1.1	-1.5	0.9	-1.1
Hearing difficulty/problems: Yes	0.6	1.0	2.4	0.4	-0.9	-1.2	-1.0	-0.4	-0.9	-1.5
Hayfever, allergic rhinitis or eczema	0.6	1.3	3.1	0.6	1.2	1.1	1.2	1.2	0.7	1.8
Trunk fat mass	0.6	2.6	7.9	1.3	0.9	1.3	1.9	0.8	2.8	1.4
Waist circumference	0.6	2.3	7.4	1.4	0.5	1.3	1.6	0.4	2.7	1.4
Trunk fat-free mass	0.6	3.3	7.3	1.7	0.7	2.7	1.0	1.1	2.2	2.2
Trunk predicted mass	0.6	3.2	7.1	1.7	0.6	2.7	0.9	1.0	2.2	2.2
Medication: Paracetamol	0.6	1.1	4.7	-2.2	-0.1	-0.0	-0.1	-1.0	-1.2	0.6
Forced vital capacity (FVC), Best measure	0.6	2.1	5.0	1.2	1.0	2.2	1.4	1.0	0.0	2.0
Body fat percentage	0.6	2.3	6.1	1.1	1.1	0.8	2.2	0.9	2.5	1.1
Comparative body size at age 10	0.6	1.5	2.7	0.2	1.4	1.6	1.5	1.2	0.0	1.6
Overall health rating	0.6	1.2	3.1	0.7	-1.7	-0.7	-0.5	-1.8	1.0	-0.3
Illnesses of father: Heart disease	0.6	0.8	2.6	-0.4	-0.9	-0.6	-1.0	-0.7	-1.6	-0.7
Average weekly champagne plus white wine intake	0.6	0.8	2.8	1.7	0.3	1.2	0.5	0.5	0.2	0.7
Ever depressed for a whole week	0.6	0.8	2.2	0.5	1.1	1.5	0.8	0.6	0.5	0.8
Supplements: Calcium	0.6	0.7	1.1	1.1	0.8	0.5	0.8	1.0	0.7	0.6
Prostate Cancer	0.5	0.7	1.4	-0.4	-1.2	-0.6	-0.4	-0.9	-0.7	-1.0
Body Mass Index (BMI) (2010)	0.5	0.7	4.2	0.8	0.1	-0.1	0.3	-0.3	2.1	-0.1
Mean Putamen Volume	0.5	0.6	1.3	-1.1	-0.7	-0.3	-0.4	-0.6	-1.0	-0.9
Blood Eosinophil Count	0.5	3.6	5.7	0.4	-2.4	-1.8	-2.2	-2.4	1.1	-2.1
Blood White Count	0.5	3.8	7.6	0.7	-2.0	-2.4	-1.9	-2.8	1.5	-1.9
Medication: Metformin	0.5	0.7	1.2	0.4	-0.9	-1.0	-0.7	-1.0	1.1	-0.5
Trunk fat percentage	0.5	2.0	6.9	0.9	0.9	0.7	1.9	0.7	2.6	0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	3.1	1.1	0.7	1.8	0.5	0.5	1.1	1.0
High blood pressure	0.5	1.4	6.7	2.6	-0.7	-0.7	-0.4	-0.3	1.4	0.1
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	3.1	-0.9	-0.3	1.3	-0.3	0.2	-1.8	-0.0
Forced vital capacity (FVC)	0.5	2.0	3.8	1.4	1.2	1.9	1.2	1.4	0.6	1.9
Diabetes (self-reported)	0.5	0.8	1.7	-0.4	-1.2	-1.2	-0.7	-1.3	0.0	-0.3
Father’s age at death	0.5	0.6	2.6	-0.9	0.3	-0.3	0.4	0.6	-1.6	0.6
Hair/balding pattern: Pattern 3	0.5	0.8	1.2	-0.7	1.1	1.1	0.6	1.0	-1.1	0.3
Exposure to tobacco smoke at home	0.5	0.6	1.2	0.6	-1.0	-1.0	-0.6	-1.1	-0.1	-0.3
Pulse wave reflection index	0.5	0.7	2.7	-0.5	-0.5	-0.1	-0.8	-0.0	-1.6	-0.9
Birth weight	0.5	1.0	4.2	2.0	-0.3	-0.5	-0.3	-0.8	-0.3	-1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	1.7	1.3	-0.7	-0.2	-0.4	-1.1	0.7	-0.6
Medication: Ibuprofen	0.5	0.6	1.9	0.3	-0.9	-0.6	-0.7	-1.4	0.8	-0.5
Suffer from ‘nerves’	0.5	0.8	1.6	0.2	0.6	0.9	1.1	0.5	1.0	1.3
Medication: Aspirin	0.5	0.7	2.6	1.4	0.1	-0.1	-0.1	-0.0	1.6	-0.6
Hypertension (Self-reported)	0.5	1.4	5.6	2.4	-0.7	-0.8	-0.4	-0.4	1.7	-0.2
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.3	-0.5	-0.8	-0.6	-1.1	-0.7	-0.7	-0.9
Mouth/teeth dental problems: Mouth ulcers	0.5	0.7	1.9	1.2	-0.1	1.1	0.7	-0.1	0.4	1.4
Medication: Aspirin	0.5	0.6	2.0	1.4	-0.3	-0.0	-0.6	-0.3	1.2	-0.7
Miserableness	0.5	0.8	3.6	0.3	0.7	1.9	0.8	0.8	-0.2	0.6
Hearing aid user	0.5	0.6	1.3	1.1	-0.2	-0.1	-0.8	-0.2	1.1	-0.9
Medication: Bendroflumethiazide	0.5	0.7	1.9	1.4	0.5	1.4	0.6	0.4	-0.1	0.8
Medication: Atorvastatin	0.5	0.7	2.4	-0.5	-0.9	-1.6	-0.6	-0.7	-0.3	-0.6
Myopia	0.5	0.7	2.0	0.3	0.7	-0.1	0.9	1.0	-1.4	0.6
Pain experienced in last month	0.5	0.8	4.4	-2.1	0.4	-0.6	-0.2	0.4	-0.8	-0.2
Neuroticism (Nagel 2018)	0.4	0.9	1.6	-0.4	1.1	1.2	1.2	0.5	-0.4	1.3
Systolic blood pressure, automated reading	0.4	1.2	3.3	-1.1	-0.8	-1.1	-0.8	-0.7	-1.8	-0.9
Supplements: Zinc	0.4	0.4	1.4	-0.7	-0.4	-0.6	0.4	-0.5	1.2	0.1
Townsend deprivation index at recruitment	0.4	0.6	2.7	0.9	0.0	0.5	-0.2	-0.0	1.6	-0.3
Worrier / anxious feelings	0.4	0.7	2.5	1.6	0.8	0.3	0.6	0.3	0.5	1.1
Depression (self-reported)	0.4	0.5	1.5	-1.2	0.3	0.8	0.3	0.1	-1.0	0.5
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.7	-0.3	0.7	0.5	0.2	0.8	-1.3	-0.1
Headache pain in last month	0.4	0.6	2.4	0.8	0.1	1.6	0.7	-0.0	0.2	1.0
Number of children fathered	0.4	0.5	1.6	0.5	-0.5	-0.2	-0.7	-0.6	0.5	-1.3
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.4	1.8	-1.4	-0.4	-0.9	-0.4	-0.1	-0.0	-0.4
Migraine (self-reported)	0.4	0.4	1.0	1.0	0.8	0.8	-0.4	0.7	0.1	0.3
Heart disease (mother)	0.4	0.5	2.0	-0.1	0.1	1.4	1.0	0.7	-0.5	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.4	-0.7	0.4	0.4	0.1	0.2	1.2	-1.0
Commuting to job workplace: Walk	0.4	0.4	1.5	-0.7	0.1	0.0	0.5	0.1	-0.8	1.2
Breast cancer (self-reported)	0.4	0.5	1.0	0.7	-0.4	-0.9	-0.6	-0.1	-1.0	-0.7
Number of self-reported non-cancer illnesses	0.4	0.8	1.7	1.2	0.8	-0.1	1.3	1.1	0.3	0.5
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.2	0.1	-0.7	-0.4	-0.4	-1.1	-0.9	-0.7
High cholesterol (Self-reported)	0.4	0.8	1.8	-0.3	1.3	0.2	1.3	1.1	0.5	0.6
Average weekly beer plus cider intake	0.4	0.6	2.1	1.4	0.0	0.0	0.2	-0.6	1.2	-0.4
Irritability	0.4	0.6	1.5	0.6	1.2	0.8	0.3	1.2	0.3	-0.1
Risk taking	0.4	0.6	1.5	-0.2	-1.0	-0.4	-1.1	-0.7	-0.4	-1.2
Cholesterol lowering medication	0.4	0.6	3.0	-1.7	-0.0	-0.4	0.1	0.2	-0.9	-0.2
Basal cell carcinoma (self-reported)	0.4	0.4	2.0	1.4	-0.0	0.7	-0.2	0.6	0.5	-0.1
Heart disease (siblings)	0.4	0.5	2.4	-0.5	0.5	0.4	1.6	-0.4	0.7	0.1
Alzheimer’s Disease (in mother)	0.3	0.3	0.6	0.8	-0.7	0.4	0.5	-0.6	0.2	0.6
Verbal and Numeric Reasoning (VNR)	0.3	0.7	1.9	-0.6	-1.1	-0.2	-0.7	-0.6	-1.4	-0.6
Ovarian Cancer	0.3	0.4	1.1	0.4	0.8	0.3	0.6	1.1	0.3	0.6
HDL Cholesterol	0.3	0.5	1.5	-0.2	0.7	1.0	0.8	1.2	0.2	0.4
Triglycerides	0.3	0.5	0.8	0.8	0.9	0.4	0.7	0.2	0.9	0.4
Lung FEV1/FVC ratio	0.3	1.4	2.6	0.3	1.5	-0.1	1.4	1.6	-0.8	1.4
Number of treatments/medications taken	0.3	0.5	1.3	1.0	0.3	-0.1	1.1	0.1	1.0	0.5
Vitamin and mineral supplements	0.3	0.4	1.3	-1.1	0.5	-0.1	-0.1	0.5	-0.9	0.3
Diabetes (father)	0.3	0.3	1.0	0.5	-1.0	0.2	-0.5	-0.6	0.3	-0.4
Average weekly fortified wine intake	0.3	0.3	1.1	1.0	-0.6	0.2	-0.2	-0.5	0.7	0.3
Fed-up feelings	0.3	0.6	1.5	0.6	0.6	1.2	0.9	-0.3	0.3	0.9
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	1.2	1.1	-0.1	0.5	0.1	0.2	0.6	-0.5
Stomach or abdominal pain in last month	0.3	0.4	1.2	-0.5	-1.0	-0.2	-0.5	-1.1	-0.1	-0.4
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	0.9	-0.9	0.4	0.7	0.6	-0.1	0.7	0.6
Had menopause	0.3	0.4	1.3	-0.2	0.6	0.3	0.9	0.3	1.2	0.5
Fluid intelligence score	0.3	0.6	1.1	-1.1	-0.7	-0.1	-0.8	-0.1	-0.9	-1.0
Alcohol intake versus 10 years previously	0.3	0.5	1.0	-0.8	-0.7	-0.9	-0.7	0.0	-0.6	-1.0
Number of live births	0.3	0.4	0.9	-1.0	-0.2	-0.7	-0.9	0.4	0.6	-0.3
Lung cancer (father)	0.3	0.3	0.6	0.8	-0.4	-0.4	-0.6	-0.7	0.6	-0.4
Illnesses of mother	0.3	0.4	1.4	0.6	0.3	0.6	0.2	0.1	0.7	1.2
Blood clot in the leg (DVT)	0.3	0.4	0.8	0.9	-0.7	-0.1	-0.8	-0.4	-0.3	-0.8
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.9	0.4	0.8	0.8	0.2	0.9	0.3	0.7
Exposure to tobacco smoke outside home	0.3	0.3	1.2	-0.0	0.4	-0.8	-0.2	0.4	-0.4	-1.1
Health satisfaction	0.3	0.4	1.6	1.2	-0.5	0.3	0.1	-0.5	0.7	-0.2
Mouth/teeth dental problems: Loose teeth	0.3	0.3	1.1	1.0	-0.3	0.4	0.2	-0.1	0.9	-0.0
Comparative height size at age 10	0.3	1.9	5.6	0.1	-1.6	-0.3	-2.4	-1.4	0.2	-1.6
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	0.9	0.8	0.5	0.2	0.5	0.4	0.9	0.1
Supplements: Vitamin C	0.3	0.3	0.6	0.8	-0.4	-0.3	0.6	-0.6	0.8	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	1.1	-0.4	0.0	-1.0	-0.4	-0.2	-0.0	-0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	2.5	0.1	-0.3	1.6	-1.1	-0.1	0.0	0.8
Loneliness, isolation	0.3	0.4	1.2	0.0	0.3	0.9	0.8	-0.4	0.3	1.1
Ever had bowel cancer screening	0.3	0.3	1.2	-0.0	-0.7	-0.4	-0.0	-0.4	-1.1	-0.6
Friendships satisfaction	0.3	0.3	0.6	0.6	0.4	0.7	0.8	0.5	0.1	0.7
Mineral and other dietary supplements	0.3	0.3	1.4	0.4	-0.4	-0.5	-1.2	-0.6	-0.2	-0.2
Osteoporosis (self-reported)	0.3	0.4	1.3	1.0	0.1	-0.3	-0.5	-0.5	1.1	-0.2
Mother’s age at death	0.3	0.3	0.8	-0.9	0.1	-0.4	0.5	0.7	-0.1	-0.7
Financial situation satisfaction	0.3	0.4	0.8	0.7	-0.8	0.2	-0.7	-0.9	0.4	-0.3
Medication: Paracetamol	0.3	0.5	2.4	-1.5	0.1	0.4	0.0	-0.6	-0.6	0.6
Number of operations (self-reported)	0.3	0.5	2.0	-0.7	0.3	0.0	0.2	-0.1	-1.4	-0.9
Depression (Nagel 2018)	0.2	0.4	2.1	-0.1	-0.2	-0.3	-0.4	-0.4	-1.5	-0.2
Neuroticism (2016)	0.2	0.2	0.6	0.4	0.3	0.5	0.1	0.5	0.8	0.5
Rheumatoid Arthritis	0.2	0.3	0.4	0.3	0.4	0.6	0.6	0.6	-0.3	-0.6
Blood Platelet Count	0.2	2.2	6.8	-2.6	-0.8	-1.3	-0.1	-1.6	-1.9	0.1
Height	0.2	2.9	8.2	0.3	-2.3	-0.2	-2.9	-1.7	1.0	-1.7
Type 2 Diabetes (T2D) (2018)	0.2	0.4	0.9	0.3	-0.7	-0.3	-0.9	-0.9	1.0	-0.1
Relative age of first facial hair	0.2	0.3	1.2	-0.1	0.5	0.1	0.2	0.5	0.7	1.1
Maternal smoking around birth	0.2	0.3	1.2	-1.1	-0.1	-0.8	-0.4	0.0	0.0	-0.4
High blood pressure (mother)	0.2	0.3	0.8	0.2	0.9	-0.4	0.0	0.7	0.1	-0.9
Nervous feelings	0.2	0.4	0.8	0.2	0.9	0.4	0.8	0.7	-0.3	0.9
Financial difficulties in last 2 years	0.2	0.3	0.9	-0.4	0.0	-0.3	0.1	0.1	-0.9	0.9
Mouth/teeth dental problems	0.2	0.3	0.6	-0.8	0.4	0.4	0.4	0.6	0.6	0.7
Allergy	0.2	0.5	1.1	-1.0	-0.5	-0.6	-0.4	-0.5	-0.9	-0.5
Medication: Simvastatin	0.2	0.2	0.8	0.5	0.3	-0.0	0.9	0.0	0.7	0.2
Illnesses of siblings	0.2	0.2	0.7	0.6	0.4	0.4	-0.3	0.8	0.2	0.1
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	1.3	0.8	-0.1	1.1	0.3	0.3	0.6	0.2
Medication: Cholesterol lowering	0.2	0.3	0.8	-0.4	-0.6	-0.9	-0.1	-0.6	-0.3	-0.5
Medication: Lansoprazole	0.2	0.3	1.2	-0.3	0.3	-1.1	0.3	-0.0	0.5	-0.4
Prospective memory result	0.2	0.2	1.2	1.1	-0.2	0.0	0.1	-0.3	0.6	0.2
Standing height	0.2	2.1	7.5	-0.1	-1.9	-0.2	-2.7	-1.4	0.4	-1.0
Hair/balding pattern: Pattern 4	0.2	0.5	1.1	-0.7	-1.0	-0.0	-0.4	-0.7	-1.1	0.0
Chronic bronchitis/emphysema (mother)	0.2	0.3	0.6	0.1	0.6	0.3	0.8	0.4	0.3	0.7
High blood pressure (siblings)	0.2	0.2	0.7	-0.1	-0.0	0.6	0.4	-0.0	0.5	0.8
Wheeze or whistling in the chest in last year	0.2	0.3	0.6	-0.3	-0.4	0.8	-0.3	-0.8	0.2	-0.7
Qualifications: College or University degree	0.2	0.6	2.0	0.0	0.5	1.4	0.4	0.2	-0.6	1.2
Medication for pain relief, constipation, heartburn	0.2	0.4	1.5	0.0	-0.1	-0.2	-0.7	0.5	-1.2	-0.8
Pulse rate, automated reading	0.2	0.6	2.3	0.2	-1.0	-0.9	-0.4	-1.5	0.1	-0.4
Knee pain experienced in last month	0.2	0.3	0.9	0.5	-0.4	1.0	0.0	-0.5	0.8	0.2
Illnesses of siblings: Diabetes	0.2	0.2	0.5	0.4	0.3	-0.7	0.7	0.2	0.4	0.0
Back pain experienced in last month	0.2	0.3	1.1	0.0	-0.1	-0.1	-0.4	-0.2	-1.0	-0.8
Asthma (self-reported)	0.2	0.4	1.7	1.3	-0.3	0.0	-0.2	-0.6	0.5	-0.2
Tinnitus: Yes, now most or all of the time	0.2	0.3	0.6	-0.3	-0.8	-0.2	-0.8	-0.5	0.4	-0.5
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.7	-0.5	-0.8	-0.3	-0.1	-0.3	-0.4	-0.6
Alcohol drinker status: Never	0.2	0.2	0.8	0.3	0.5	0.9	0.1	0.5	0.3	0.5
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.6	-0.8	-0.1	0.5	-0.1	-0.2	-0.6	0.2
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.5	0.0	-0.7	-0.2	-0.2	-0.7	-0.3	-0.0
Worry (Nagel 2018)	0.1	0.2	0.5	0.1	0.5	0.7	0.1	0.0	-0.4	0.7
Breast Cancer	0.1	0.3	0.8	-0.7	-0.3	-0.9	-0.2	0.2	0.2	-0.8
LDL Cholesterol	0.1	0.1	0.3	0.2	0.3	0.1	0.4	0.5	0.2	0.6
Primary Biliary Cirrhosis	0.1	0.2	0.5	-0.4	-0.4	0.1	0.5	-0.7	-0.4	-0.5
Heel T-Score	0.1	0.8	4.2	0.3	-0.4	0.7	-0.2	0.7	-2.0	-0.0
Waist Hip Ratio (WHR)	0.1	0.5	1.0	-0.9	-0.4	-0.1	-1.0	-0.9	0.6	-0.5
Allergy or Eczema	0.1	0.4	1.1	0.6	0.4	-0.2	1.0	0.2	0.3	0.9
Cardiovascular Disease	0.1	0.4	0.8	0.4	0.5	0.1	0.4	0.7	0.9	0.9
Tanning	0.1	0.9	2.0	1.4	0.8	1.4	1.0	0.3	0.5	0.5
Sensitivity / hurt feelings	0.1	0.2	0.5	0.3	-0.1	0.5	0.7	-0.2	0.4	0.5
Other serious medical condition/disability diagnosed by doctor	0.1	0.2	0.6	-0.7	-0.3	0.2	-0.0	-0.2	-0.8	-0.1
Medication for hormone replacement therapy	0.1	0.2	0.5	0.0	0.0	-0.6	-0.0	0.0	-0.7	-0.5
Multivitamins +/- minerals	0.1	0.1	0.3	0.4	-0.0	0.5	-0.4	-0.0	-0.3	-0.4
Sitting height	0.1	0.5	2.4	-0.1	0.1	1.5	-0.3	0.2	-0.6	0.9
Hair/balding pattern: Pattern 2	0.1	0.2	0.6	0.5	0.2	-0.2	-0.1	0.4	0.8	0.3
Asthma	0.1	0.3	1.1	1.1	-0.2	-0.1	-0.1	-0.6	0.4	-0.1
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.3	0.2	-0.1	0.2	0.1	-0.6	0.4	-0.0
Length of working week for main job	0.1	0.2	0.5	-0.3	-0.7	0.2	-0.2	-0.6	0.0	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.5	0.2	0.5	-0.0	0.7	-0.0	0.0	0.7
Peak expiratory flow (PEF)	0.1	0.3	0.7	0.2	0.3	0.5	0.2	0.6	-0.9	0.8
Medication: Seretide 50 evohaler	0.1	0.1	0.4	-0.2	0.3	-0.0	0.4	0.0	0.1	-0.6
Alcohol intake frequency.	0.1	0.3	2.1	-1.4	-0.1	0.0	-0.3	0.2	-0.0	-0.3
Family relationship satisfaction	0.1	0.1	0.3	0.5	-0.0	0.6	0.5	-0.1	-0.1	0.3
Mood swings	0.1	0.2	0.7	-0.7	0.3	0.8	0.5	-0.3	0.2	0.2
Medication for cholesterol	0.1	0.2	0.3	-0.4	-0.6	0.2	-0.5	-0.6	0.2	-0.4
Medication: Blood pressure	0.1	0.2	0.5	0.5	0.1	-0.7	0.4	0.3	-0.2	0.6
Medication: Lisinopril	0.1	0.2	0.6	0.6	-0.1	-0.5	-0.8	-0.1	0.2	-0.3
Diastolic blood pressure, automated reading	0.1	0.4	1.0	0.5	1.0	0.2	0.9	0.6	-0.5	0.6
Commuting to job workplace: Cycle	0.1	0.1	0.2	0.4	-0.4	-0.0	-0.4	-0.3	0.2	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.5	0.7	-0.2	-0.0	-0.4	-0.1	-0.4	-0.5
Depressed Affect (Nagel 2018)	0.0	0.1	0.2	-0.3	0.1	0.3	0.5	-0.5	0.2	0.0
Blood Red Count	0.0	0.4	0.9	-0.6	-0.9	-0.2	-0.9	-0.1	0.0	-0.7
Systolic Blood Pressure	0.0	0.1	0.3	-0.2	-0.1	-0.0	-0.6	0.2	-0.1	0.1
Hair Pigment	0.0	1.3	7.7	2.8	1.0	-0.1	0.2	0.3	-0.1	0.2

Hub : Genes

VAV3

Models

Trait associations