Best TWAS P=1.24e-56 · Best GWAS P=3.52e-124 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | MAGI3 | 0.06 | 0.00 | blup | 554 | 0.03 | 1.9e-04 | 5.89 | -8.0 | 1.1e-15 | -0.33 | 0.74 | 0.01 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | PHTF1 | 0.07 | 0.06 | blup | 517 | 0.05 | 1.2e-06 | 12.18 | -8.6 | 8.9e-18 | -0.32 | 0.99 | 0.00 | FALSE |
| 3 | CommonMind | Brain Pre-frontal Cortex | PTPN22 | 0.09 | 0.11 | lasso | 2 | 0.12 | 2.7e-14 | 11.34 | 7.8 | 6.3e-15 | 0.19 | 1.00 | 0.00 | FALSE |
| 4 | CommonMind | Brain Pre-frontal Cortex | RSBN1 | 0.05 | 0.02 | enet | 6 | 0.02 | 1.3e-03 | 5.40 | 6.2 | 7.3e-10 | 0.16 | 0.09 | 0.03 | TRUE |
| 5 | GTEx | Artery Tibial | AP4B1 | 0.09 | 0.13 | lasso | 1 | 0.13 | 4.0e-10 | -7.94 | 7.9 | 2.0e-15 | 0.14 | 1.00 | 0.00 | FALSE |
| 6 | GTEx | Artery Tibial | HIPK1 | 0.13 | 0.00 | enet | 39 | 0.00 | 1.3e-01 | -5.79 | 7.1 | 1.7e-12 | 0.16 | 0.04 | 0.40 | TRUE |
| 7 | GTEx | Artery Tibial | AP4B1-AS1 | 0.14 | 0.13 | lasso | 2 | 0.12 | 4.9e-10 | -7.94 | 8.0 | 1.4e-15 | 0.14 | 1.00 | 0.00 | FALSE |
| 8 | GTEx | Brain Cerebellar Hemisphere | AP4B1 | 0.29 | 0.22 | lasso | 5 | 0.14 | 1.8e-04 | -8.57 | 8.6 | 1.2e-17 | 0.14 | 0.26 | 0.04 | FALSE |
| 9 | GTEx | Breast Mammary Tissue | DCLRE1B | 0.19 | 0.02 | lasso | 5 | 0.03 | 9.1e-03 | 12.19 | -13.3 | 3.3e-40 | -0.39 | 0.27 | 0.37 | FALSE |
| 10 | GTEx | Cells Transformed fibroblasts | OLFML3 | 0.12 | 0.00 | enet | 23 | 0.00 | 3.0e-01 | -5.24 | -8.2 | 1.9e-16 | -0.39 | 0.04 | 0.49 | FALSE |
| 11 | GTEx | Cells Transformed fibroblasts | PHTF1 | 0.22 | 0.09 | lasso | 5 | 0.19 | 2.2e-14 | 14.47 | -9.3 | 1.1e-20 | -0.47 | 1.00 | 0.00 | FALSE |
| 12 | GTEx | Cells Transformed fibroblasts | DCLRE1B | 0.06 | 0.04 | lasso | 5 | 0.02 | 1.5e-02 | 9.03 | -6.9 | 4.0e-12 | -0.33 | 0.36 | 0.02 | TRUE |
| 13 | GTEx | Cells Transformed fibroblasts | AP4B1-AS1 | 0.12 | 0.09 | lasso | 6 | 0.10 | 4.1e-08 | 12.62 | -9.3 | 9.2e-21 | -0.27 | 0.99 | 0.00 | FALSE |
| 14 | GTEx | Colon Transverse | PTPN22 | 0.19 | 0.16 | lasso | 5 | 0.21 | 2.5e-10 | 11.34 | 8.9 | 5.7e-19 | 0.24 | 1.00 | 0.00 | FALSE |
| 15 | GTEx | Esophagus Gastroesophageal Junction | OLFML3 | 0.34 | 0.02 | enet | 68 | 0.07 | 1.5e-03 | -2.35 | 5.3 | 1.2e-07 | 0.27 | 0.14 | 0.06 | TRUE |
| 16 | GTEx | Esophagus Gastroesophageal Junction | AP4B1 | 0.13 | 0.00 | lasso | 4 | 0.01 | 2.0e-01 | -3.92 | -10.7 | 6.7e-27 | -0.47 | 0.10 | 0.19 | TRUE |
| 17 | GTEx | Nerve Tibial | AP4B1 | 0.23 | 0.09 | lasso | 4 | 0.08 | 1.8e-06 | -7.94 | 5.6 | 2.4e-08 | 0.09 | 0.64 | 0.06 | FALSE |
| 18 | GTEx | Nerve Tibial | AP4B1-AS1 | 0.17 | 0.09 | lasso | 3 | 0.07 | 8.2e-06 | -7.94 | 7.0 | 2.3e-12 | 0.12 | 0.75 | 0.03 | FALSE |
| 19 | GTEx | Pancreas | PTPN22 | 0.14 | -0.01 | enet | 28 | 0.01 | 8.8e-02 | 11.34 | 6.5 | 9.4e-11 | 0.21 | 0.16 | 0.04 | FALSE |
| 20 | GTEx | Testis | RSBN1 | 0.09 | 0.09 | enet | 6 | 0.09 | 8.9e-05 | 12.15 | -12.3 | 1.5e-34 | -0.37 | 0.51 | 0.08 | FALSE |
| 21 | GTEx | Testis | AP4B1-AS1 | 0.21 | 0.19 | lasso | 5 | 0.19 | 5.9e-09 | -8.57 | 8.7 | 3.1e-18 | 0.13 | 1.00 | 0.00 | FALSE |
| 22 | METSIM | Adipose | MAGI3 | 0.04 | 0.01 | blup | 549 | 0.03 | 5.5e-05 | 0.39 | -6.2 | 6.8e-10 | -0.31 | 0.74 | 0.01 | FALSE |
| 23 | METSIM | Adipose | PHTF1 | 0.10 | 0.03 | blup | 517 | 0.04 | 1.1e-06 | 0.88 | -6.4 | 1.6e-10 | -0.36 | 0.83 | 0.09 | TRUE |
| 24 | ROSMAP | Brain Pre-frontal Cortex | OLFML3 | 0.10 | 0.02 | enet | 27 | 0.04 | 9.7e-06 | 11.13 | -10.1 | 8.1e-24 | -0.35 | 0.86 | 0.05 | FALSE |
| 25 | ROSMAP | Brain Pre-frontal Cortex | DCLRE1B | 0.08 | 0.04 | enet | 14 | 0.05 | 2.6e-07 | 15.28 | -14.2 | 1.5e-45 | -0.50 | 0.97 | 0.03 | TRUE |
| 26 | YFS | Blood | DCLRE1B | 0.23 | 0.35 | lasso | 7 | 0.34 | 1.6e-117 | 5.62 | 5.2 | 1.9e-07 | 0.14 | 1.00 | 0.00 | FALSE |
| 27 | YFS | Blood | PTPN22 | 0.17 | 0.02 | bslmm | 497 | 0.10 | 3.8e-30 | 0.23 | 7.2 | 5.0e-13 | 0.25 | 1.00 | 0.00 | FALSE |
| 28 | The Cancer Genome Atlas | Breast Invasive Carcinoma | DCLRE1B | 0.02 | 0.00 | blup | 39 | 0.01 | 5.2e-03 | 12.64 | -14.6 | 5.0e-48 | -0.47 | 0.01 | 0.41 | FALSE |
| 29 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PHTF1 | 0.05 | 0.02 | enet | 7 | 0.03 | 3.1e-07 | 14.47 | -9.5 | 1.7e-21 | -0.48 | 0.22 | 0.63 | TRUE |
| 30 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PTPN22 | 0.02 | 0.01 | blup | 67 | 0.01 | 9.6e-03 | 15.32 | 12.8 | 1.0e-37 | 0.57 | 0.11 | 0.37 | FALSE |
| 31 | The Cancer Genome Atlas | Esophageal Carcinoma | DCLRE1B | 0.13 | 0.02 | blup | 39 | 0.08 | 1.8e-03 | -4.46 | -12.6 | 2.9e-36 | -0.46 | 0.01 | 0.50 | FALSE |
| 32 | The Cancer Genome Atlas | Glioblastoma Multiforme | DCLRE1B | 0.20 | -0.01 | blup | 39 | 0.04 | 3.0e-02 | 15.28 | -12.7 | 6.2e-37 | -0.54 | 0.00 | 0.51 | FALSE |
| 33 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | BCL2L15 | 0.09 | 0.00 | blup | 42 | 0.04 | 1.1e-02 | 11.34 | 12.1 | 1.7e-33 | 0.37 | 0.02 | 0.05 | TRUE |
| 34 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PHTF1 | 0.08 | 0.03 | blup | 62 | 0.05 | 2.1e-06 | 12.78 | -6.9 | 6.7e-12 | -0.39 | 0.75 | 0.01 | FALSE |
| 35 | The Cancer Genome Atlas | Thyroid Carcinoma | DCLRE1B | 0.06 | 0.04 | enet | 11 | 0.04 | 4.3e-05 | 15.32 | -15.9 | 1.2e-56 | -0.58 | 0.00 | 0.99 | TRUE |