Best TWAS P=1.35e-08 · Best GWAS P=7.74e-08 conditioned to 0.453
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | SYN2 | 0.14 | 0.08 | enet | 15 | 0.09 | 1.0e-05 | 4.4 | 5.3 | 1.2e-07 | 0.63 | 0.14 | 0.84 | FALSE |
| 2 | GTEx | Brain Hypothalamus | TIMP4 | 0.24 | 0.10 | lasso | 4 | 0.11 | 1.7e-03 | 5.2 | 5.7 | 1.4e-08 | 0.88 | 0.02 | 0.94 | TRUE |
| 3 | GTEx | Esophagus Gastroesophageal Junction | SYN2 | 0.23 | 0.09 | lasso | 4 | 0.12 | 3.3e-05 | 4.5 | 5.3 | 1.3e-07 | 0.87 | 0.02 | 0.97 | FALSE |
| 4 | ROSMAP | Brain Pre-frontal Cortex | TIMP4 | 0.07 | 0.05 | lasso | 7 | 0.06 | 5.5e-08 | 4.2 | 5.2 | 2.6e-07 | 0.78 | 0.07 | 0.92 | FALSE |
| 5 | The Cancer Genome Atlas | Lung Adenocarcinoma | SYN2 | 0.03 | 0.02 | enet | 6 | 0.02 | 4.0e-03 | 5.2 | 5.7 | 1.5e-08 | 0.71 | 0.01 | 0.95 | FALSE |