[Hub]/) : Traits : Hypothyroidism/myxoedema (self-reported) : ← →

chr3:11,350,553-12,928,762

Best TWAS P=1.35e-08 · Best GWAS P=7.74e-08 conditioned to 0.453

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
2	GTEx	Brain Hypothalamus	TIMP4	0.24	0.10	lasso	4	0.11	1.7e-03	5.2	5.7	1.4e-08	0.88	0.02	0.94	TRUE
5	The Cancer Genome Atlas	Lung Adenocarcinoma	SYN2	0.03	0.02	enet	6	0.02	4.0e-03	5.2	5.7	1.5e-08	0.71	0.01	0.95	FALSE
1	GTEx	Artery Aorta	SYN2	0.14	0.08	enet	15	0.09	1.0e-05	4.4	5.3	1.2e-07	0.63	0.14	0.84	FALSE
3	GTEx	Esophagus Gastroesophageal Junction	SYN2	0.23	0.09	lasso	4	0.12	3.3e-05	4.5	5.3	1.3e-07	0.87	0.02	0.97	FALSE
4	ROSMAP	Brain Pre-frontal Cortex	TIMP4	0.07	0.05	lasso	7	0.06	5.5e-08	4.2	5.2	2.6e-07	0.78	0.07	0.92	FALSE