[Hub]/) : Traits : Hypothyroidism/myxoedema (self-reported) : ← →

chr3:36,339,386-38,174,470

Best TWAS P=4.39e-09 · Best GWAS P=1.23e-08 conditioned to 0.0573

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	LRRFIP2	0.04	0.00	bslmm	481	0.02	3.5e-03	-5.6	-5.9	4.4e-09	0.76	0.09	0.83	TRUE
6	GTEx	Muscle Skeletal	LRRFIP2	0.11	0.10	enet	15	0.13	1.1e-12	-5.5	-5.7	1.3e-08	0.93	0.07	0.93	FALSE
7	GTEx	Nerve Tibial	LRRFIP2	0.09	0.10	lasso	2	0.07	5.8e-06	-5.5	-5.6	1.7e-08	0.96	0.05	0.94	FALSE
14	The Cancer Genome Atlas	Breast Invasive Carcinoma	LRRFIP2	0.02	0.03	blup	73	0.03	3.0e-06	-5.4	-5.6	1.8e-08	0.97	0.06	0.94	FALSE
11	GTEx	Whole Blood	LRRFIP2	0.04	0.05	lasso	3	0.04	1.4e-04	-5.7	5.6	2.2e-08	-0.99	0.04	0.95	FALSE
2	GTEx	Artery Tibial	LRRFIP2	0.08	0.08	lasso	5	0.08	1.0e-06	-5.5	-5.6	2.7e-08	0.91	0.09	0.91	FALSE
12	NTR	Blood	LRRFIP2	0.03	0.03	lasso	5	0.04	8.6e-12	-5.6	5.5	3.2e-08	-0.97	0.05	0.94	FALSE
10	GTEx	Thyroid	LRRFIP2	0.38	0.55	enet	31	0.60	3.8e-56	-5.5	-5.5	4.1e-08	0.98	0.05	0.95	FALSE
5	GTEx	Muscle Skeletal	MLH1	0.04	0.04	lasso	2	0.01	1.5e-02	-5.5	-5.5	4.3e-08	0.99	0.05	0.94	FALSE
13	ROSMAP	Brain Pre-frontal Cortex	LRRFIP2	0.09	0.09	lasso	5	0.08	7.4e-11	-5.3	-5.5	4.4e-08	0.92	0.09	0.91	FALSE
3	GTEx	Colon Sigmoid	LRRFIP2	0.13	0.00	lasso	5	0.00	2.1e-01	-5.5	-5.5	4.9e-08	0.81	0.08	0.66	FALSE
17	The Cancer Genome Atlas	Thyroid Carcinoma	EPM2AIP1	0.04	0.04	blup	31	0.04	8.3e-05	4.8	-5.4	5.5e-08	0.99	0.02	0.98	FALSE
4	GTEx	Esophagus Muscularis	LRRFIP2	0.16	0.17	enet	11	0.13	4.7e-08	-5.2	-5.4	6.2e-08	0.94	0.09	0.91	FALSE
18	The Cancer Genome Atlas	Thyroid Carcinoma	LRRFIP2	0.24	0.38	enet	14	0.38	2.1e-38	-5.5	-5.4	7.4e-08	0.98	0.04	0.96	FALSE
15	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	LRRFIP2	0.02	0.01	blup	73	0.02	5.7e-03	-5.5	-5.3	1.3e-07	0.98	0.05	0.89	FALSE
8	GTEx	Testis	LRRFIP2	0.12	0.05	enet	25	0.11	1.6e-05	4.0	-5.2	1.8e-07	0.75	0.06	0.93	FALSE
16	The Cancer Genome Atlas	Brain Lower Grade Glioma	LRRFIP2	0.03	0.01	enet	7	0.01	1.8e-02	-5.3	-5.2	1.8e-07	0.96	0.04	0.60	FALSE
9	GTEx	Testis	C3orf35	0.18	0.02	enet	9	0.04	6.4e-03	4.0	5.1	2.7e-07	-0.67	0.09	0.71	FALSE