TWAS hub - TIMP4

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1070	0.0300	4.4e-07	0.055	0.054	0.050	0.061	0.058	2.9e-07	3.4e-07	9.2e-07	6.8e-08	1.2e-07
2	GTEx	Artery Tibial	0.2047	0.0442	1.1e-09	0.243	NA	0.221	NA	0.237	4.8e-19	NA	3.0e-17	NA	1.6e-18
3	GTEx	Brain Hypothalamus	0.2430	0.0810	1.6e-03	0.103	NA	0.088	NA	0.108	2.1e-03	NA	4.3e-03	NA	1.7e-03
4	GTEx	Breast Mammary Tissue	0.1670	0.0630	2.9e-03	0.064	NA	0.067	NA	0.070	3.4e-04	NA	2.5e-04	NA	1.9e-04
5	GTEx	Breast Mammary Tissue (Male)	0.1063	0.0968	1.6e-01	-0.008	NA	-0.005	NA	-0.012	5.6e-01	NA	4.4e-01	NA	8.1e-01
6	GTEx	Breast Mammary Tissue (Female)	0.4038	0.0952	2.2e-04	-0.004	NA	0.036	NA	0.064	4.5e-01	NA	3.1e-02	NA	5.7e-03
7	METSIM	Adipose	0.0564	0.0172	3.9e-06	0.029	0.028	0.012	0.026	0.016	2.7e-05	4.6e-05	6.0e-03	8.4e-05	1.4e-03
8	ROSMAP	Brain Pre-frontal Cortex	0.0672	0.0200	1.4e-06	0.054	0.039	0.051	0.044	0.058	1.5e-07	8.5e-06	3.5e-07	2.1e-06	5.5e-08
9	TCGA	Brain Lower Grade Glioma	0.0373	0.0197	1.4e-03	0.009	0.024	0.030	NA	0.025	2.8e-02	9.4e-04	2.3e-04	NA	6.8e-04
10	TCGA	Prostate Adenocarcinoma	0.0254	0.0160	9.9e-03	0.031	0.024	0.013	NA	0.023	3.1e-04	1.4e-03	1.3e-02	NA	1.7e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Hypothyroidism (self reported)	14.4	33.0	64.2	6.8	6.7	8.0	-4.2	-3.5	-4.1	-5.1	7.6	6.1	2.7
Ever unenthusiastic/disinterested for a whole week	10.6	12.9	22.2	3.7	3.4	4.7	-1.9	-2.1	-1.2	-4.4	4.6	3.9	4.2
Medication: Levothyroxine sodium	9.4	15.9	31.8	4.4	3.8	5.6	-3.4	-3.0	-3.4	-3.8	5.3	3.8	2.1
Hypothyroidism/myxoedema (self-reported)	8.7	17.0	32.3	4.5	4.4	5.7	-3.7	-3.1	-3.6	-4.0	5.2	3.9	2.3
Seen a psychiatrist for nerves, anxiety, tension or depression	8.5	11.1	16.9	3.4	3.5	4.1	-3.1	-0.9	-3.4	-3.5	3.7	3.1	3.6
Ever depressed for a whole week	7.4	9.1	18.3	3.4	2.9	3.8	-1.7	-2.2	-0.7	-4.3	3.6	3.0	2.8
Worry (Nagel 2018)	7.2	15.2	23.2	4.7	3.6	4.6	-3.2	-1.8	-2.5	-4.3	4.8	4.7	3.4
Alzheimer’s Disease (in father)	6.7	7.2	14.4	-2.9	-3.5	-3.6	0.2	0.9	0.0	2.7	-3.7	-3.8	-1.6
Tense / ‘highly strung’	6.7	11.1	18.6	4.2	3.3	4.1	-1.9	-1.5	-2.2	-3.1	4.1	4.3	3.2
Waist Hip Ratio (WHR)	6.3	28.4	47.2	6.8	6.4	6.9	5.3	5.6	1.9	-1.5	6.5	6.4	0.4
Suffer from ‘nerves’	6.2	9.8	20.1	3.1	1.9	3.3	-3.5	-1.4	-2.7	-3.5	3.8	2.3	4.5
Neuroticism score	5.3	11.2	17.4	3.9	3.3	4.2	-2.3	-1.2	-2.9	-3.4	3.9	3.8	3.4
Reaction Time	4.7	8.9	14.6	3.8	3.6	3.5	-3.0	-2.3	-2.7	-2.9	3.5	2.6	0.8
Breastfed as a baby	4.7	5.8	12.1	-2.1	-2.2	-3.5	1.1	0.0	2.5	2.1	-3.3	-2.7	-2.5
Neuroticism	4.4	10.6	18.8	3.5	2.9	4.3	-2.1	-0.9	-3.0	-3.3	3.9	3.9	3.3
Fractured/broken bones in last 5 years	4.4	5.6	12.7	-1.6	-2.0	-2.3	1.8	3.6	0.7	3.5	-2.5	-1.3	-2.8
Neuroticism (Nagel 2018)	4.2	9.9	16.5	3.4	2.5	4.1	-2.3	-0.9	-2.8	-3.3	3.8	3.9	3.2
Depression (self-reported)	4.1	5.0	8.8	2.4	1.8	2.7	-1.3	-0.9	-0.7	-3.0	2.9	2.4	2.7
Hearing difficulty/problems with background noise	4.0	6.4	13.6	-3.1	-3.1	-3.5	0.9	-0.2	-0.5	3.7	-2.7	-3.0	-1.1
Worrier / anxious feelings	4.0	7.6	14.7	3.8	2.5	3.6	-1.8	-1.0	-1.2	-2.3	3.6	3.8	1.9
Blood Eosinophil Count	3.9	30.0	56.2	7.5	3.1	6.2	-2.1	-5.0	-3.6	-7.5	6.3	3.1	7.0
Other serious medical condition/disability diagnosed by doctor	3.9	5.0	11.3	2.2	3.4	1.8	-1.6	-2.9	-1.5	-2.8	2.2	2.1	0.4
Taking other prescription medications	3.7	5.7	12.4	3.5	3.2	2.4	-1.8	-0.8	-1.3	-2.4	2.6	2.8	1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	3.6	5.5	8.0	2.8	2.6	2.5	-2.8	-1.1	-1.9	-2.7	2.1	2.2	2.2
Bipolar Disorder or Schizophrenia	3.5	8.5	21.5	2.3	2.7	3.5	-2.2	-3.5	-1.1	-4.6	3.0	2.6	2.2
Mother’s age at death	3.5	4.3	7.8	-2.8	-2.0	-2.5	1.5	0.8	2.3	2.3	-2.4	-2.2	-0.7
Type 2 Diabetes (T2D) (2018)	3.4	6.4	17.6	4.2	3.4	1.6	-1.0	-2.2	0.0	1.1	2.1	1.9	-4.2
Diabetes (mother)	3.4	4.3	13.2	3.6	2.9	1.9	-0.1	-0.5	1.3	-0.0	2.1	1.9	-2.8
Worry too long after embarrassment	3.2	5.4	13.1	0.9	0.1	2.0	-2.7	-1.5	-3.0	-3.5	1.8	1.6	3.6
Bipolar Disorder (2011)	3.1	3.0	7.1	1.7	1.2	1.9	-0.8	-1.7	-0.5	-2.7	1.9	2.2	1.8
Type 2 Diabetes (T2D) (2012)	3.1	3.6	13.7	2.5	2.5	0.1	0.6	-0.3	0.4	2.5	1.4	0.8	-3.7
Prostate Cancer	3.0	4.2	12.3	-0.4	-0.6	1.0	-3.1	-2.3	-3.5	-1.8	0.6	-0.2	3.0
Schizophrenia (2014)	3.0	6.5	11.0	2.4	2.9	3.3	-1.2	-2.8	-0.5	-3.3	3.1	2.7	1.7
Pulse wave reflection index	3.0	3.7	6.6	2.6	2.4	2.2	-2.0	-1.6	-1.2	0.0	2.4	2.0	-1.0
Overall health rating	3.0	6.3	11.6	3.2	3.4	3.0	-0.8	-1.3	-0.5	-2.8	3.2	3.1	1.5
Alzheimer’s Disease (including proxy)	2.9	4.1	9.5	-1.8	-2.5	-2.5	0.0	0.6	0.4	3.1	-2.2	-2.4	-2.4
Pain all over the body in last month	2.9	3.2	7.2	1.9	2.7	1.6	-0.8	-0.9	-0.9	-2.4	1.8	2.6	-0.4
Happiness	2.9	3.5	6.6	2.6	2.2	2.5	-1.4	-1.4	-1.1	-1.1	2.1	2.1	1.5
Schizophrenia (2018)	2.8	5.7	11.9	2.3	3.1	3.0	-0.6	-2.0	0.2	-3.4	2.8	2.9	0.9
Guilty feelings	2.8	4.2	7.9	2.7	1.5	2.1	-1.5	0.1	-2.0	-1.3	2.1	2.7	2.8
Bipolar Disorder (2018)	2.7	4.3	9.7	0.9	0.4	1.8	-2.8	-3.1	-2.0	-3.1	1.3	0.6	2.4
Triglycerides	2.7	4.5	11.6	2.9	3.4	2.0	1.8	1.7	0.4	1.4	2.1	2.2	-1.8
Ever had hysterectomy (womb removed)	2.7	3.0	8.2	2.3	2.9	1.7	0.5	0.2	0.5	-0.4	1.7	2.6	-1.8
Vitamin and mineral supplements	2.7	3.7	18.4	-1.2	-1.0	-1.1	2.9	4.3	1.1	2.0	-1.1	-0.5	-0.6
Supplements: Zinc	2.6	2.8	10.8	0.6	-0.2	0.5	-3.3	-3.3	-1.8	-0.4	0.6	-0.5	1.3
Ever highly irritable/argumentative for 2 days	2.6	3.1	7.8	2.8	0.9	1.7	-2.0	-1.6	-1.9	-1.7	1.8	1.2	1.3
Pain type(s) experienced in last month: Hip pain	2.6	3.3	6.7	-2.6	-1.5	-2.2	1.5	2.5	1.0	2.0	-2.2	-1.1	-0.2
Age started oral contraceptive pill	2.6	3.3	5.9	-1.8	-1.7	-1.9	1.5	1.8	0.7	2.2	-2.4	-1.8	-1.7
Rheumatoid Arthritis	2.5	3.4	8.1	2.2	2.8	1.7	-1.4	-0.3	1.3	-2.4	1.8	2.4	-0.2
Illnesses of father: Heart disease	2.5	3.5	7.6	-1.4	-1.1	-2.3	0.5	0.8	2.2	2.8	-2.2	-1.7	-2.3
Commuting to job workplace: Walk	2.5	2.7	7.1	-2.1	-2.2	-2.7	0.4	-0.6	0.6	0.6	-2.5	-1.7	0.6
Number of self-reported non-cancer illnesses	2.5	4.3	9.7	3.1	2.7	2.4	-0.9	-0.0	-1.7	-1.8	2.2	2.8	0.9
Primary Biliary Cirrhosis	2.4	3.4	6.7	1.9	2.4	2.6	-0.3	-0.2	0.7	-2.2	2.6	2.2	1.0
Chronotype (morning person)	2.4	5.6	17.4	-1.7	-2.1	-4.2	0.5	0.5	0.0	3.7	-2.6	-2.8	-1.5
Hearing difficulty/problems: Yes	2.4	3.6	10.5	-2.6	-3.2	-2.5	0.2	-0.5	-1.5	0.4	-2.1	-2.2	0.5
Multivitamins +/- minerals	2.4	3.1	13.2	1.5	0.7	0.9	-2.8	-3.6	-1.6	-1.1	1.2	0.4	0.8
Medication for cholesterol, blood pressure or diabetes	2.4	3.9	8.9	-2.5	-3.0	-2.3	-0.8	-1.7	0.8	-1.4	-2.2	-2.4	1.5
Nervous feelings	2.3	4.3	6.7	2.4	2.6	2.4	-1.3	-1.3	-1.2	-2.4	2.3	2.4	1.8
Verbal and Numeric Reasoning (VNR)	2.2	5.3	10.8	-3.3	-2.6	-3.3	1.4	1.6	0.7	1.3	-3.3	-2.7	-0.8
LDL Cholesterol	2.2	3.5	11.7	1.4	2.4	0.4	3.0	3.4	0.2	1.7	0.6	1.3	-1.2
Sensitivity / hurt feelings	2.2	3.7	6.5	1.9	2.1	2.5	-1.6	-1.6	-2.1	-1.5	2.2	2.2	1.1
Fed-up feelings	2.2	3.9	8.6	2.9	2.6	2.7	1.5	0.9	0.3	-1.0	2.3	2.7	-0.1
Frequency of tenseness / restlessness in last 2 weeks	2.2	3.4	7.8	2.6	2.8	2.1	-0.5	0.9	-1.2	-0.1	2.3	2.4	0.9
Mean time to correctly identify matches	2.2	4.1	6.8	2.6	2.6	2.3	-1.9	-2.0	-1.9	-1.8	2.4	1.4	0.7
Pulse rate, automated reading	2.2	7.0	13.5	-2.3	-1.8	-3.3	1.3	1.7	2.3	2.5	-3.7	-2.9	-3.5
Number of live births	2.1	2.9	6.3	1.5	1.1	1.8	-2.5	-1.7	-2.1	-1.3	1.6	1.1	1.8
Cardiovascular Disease	2.0	6.5	16.1	3.7	4.0	3.2	-0.2	1.2	-1.1	0.4	3.2	3.3	-1.0
Medication: Metformin	2.0	2.9	8.6	2.9	2.0	1.0	0.2	-1.7	0.3	0.5	1.5	1.1	-2.9
Age when periods started (menarche)	2.0	4.8	11.8	0.4	0.9	1.4	-2.5	-2.5	-2.8	-2.6	1.6	1.9	3.4
Health satisfaction	2.0	2.6	5.7	2.3	2.2	1.6	-1.2	-1.4	-0.3	-2.4	1.5	1.5	-0.2
Ever had bowel cancer screening	2.0	2.3	5.5	0.9	2.3	1.9	1.2	-0.0	0.3	-2.0	1.6	2.1	0.9
Cholesterol lowering medication	2.0	2.9	12.6	-0.7	0.1	-1.4	1.8	1.2	1.0	2.3	-1.5	-1.0	-3.5
Intelligence (Savage-Jansen 2018)	1.9	5.9	15.0	-3.9	-3.0	-3.3	0.6	1.1	-0.6	1.6	-3.1	-3.1	-0.4
Medication: Omeprazole	1.9	2.3	6.0	2.1	2.5	1.6	-0.5	-0.0	0.4	-1.3	1.6	2.1	1.2
Loneliness, isolation	1.9	2.6	6.0	1.5	1.6	2.5	-0.7	1.1	-1.9	-0.8	1.8	2.2	1.1
Medication: Gliclazide	1.9	2.1	9.0	3.0	2.0	1.0	-0.3	-0.9	0.6	0.0	1.7	1.7	-0.4
HbA1C	1.8	2.0	7.8	0.6	1.0	0.4	2.8	1.7	2.3	1.1	0.1	0.6	-0.7
Diabetes (self-reported)	1.8	2.7	9.5	2.5	2.0	0.9	-0.9	-1.7	-0.9	0.7	1.2	0.8	-3.1
Mood swings	1.8	3.2	6.6	2.6	2.4	2.5	-0.4	-0.7	-0.6	-0.9	2.5	1.8	1.6
Friendships satisfaction	1.8	2.3	4.9	1.8	1.6	1.8	-1.1	-2.2	-1.3	-1.1	1.7	1.0	0.8
Medication: Lisinopril	1.8	2.3	4.0	0.5	1.5	1.3	2.0	1.8	2.0	1.3	1.1	1.5	-1.5
Blood Platelet Count	1.7	20.1	39.8	5.0	3.9	6.3	4.5	0.5	1.0	-6.0	4.6	4.3	5.0
Father’s age at death	1.7	2.3	5.5	-1.2	-2.4	-1.9	-1.8	0.7	-1.0	0.5	-1.5	-2.2	-0.1
Pulse wave Arterial Stiffness index	1.7	1.9	5.7	1.9	2.4	1.2	-0.6	0.2	-0.4	1.0	1.3	1.3	-1.9
Pulse wave peak to peak time	1.7	2.0	5.8	-2.0	-2.4	-1.2	0.7	-0.1	0.2	-0.8	-1.3	-1.3	2.0
Neck or shoulder pain in last month	1.7	2.4	5.0	-1.1	-1.6	-1.9	0.8	2.2	0.2	2.2	-1.5	-1.4	-1.2
Qualifications: nursing, teaching	1.7	2.6	9.5	-1.8	-2.0	-3.1	1.1	0.6	0.9	0.7	-1.9	-1.3	-0.9
Tinnitus: Yes, now most or all of the time	1.7	2.0	5.0	-2.2	-1.8	-2.0	1.6	0.7	0.5	1.2	-1.3	-1.2	0.0
Coronary Artery Disease (CAD)	1.6	1.9	3.3	-1.2	-0.4	-1.6	1.3	-0.5	1.2	1.8	-1.8	-1.5	-1.5
Lupus	1.6	2.4	5.8	2.0	2.4	1.6	-0.7	0.1	1.1	-1.5	1.8	2.1	-0.5
Peak expiratory flow (PEF)	1.6	3.6	8.2	-2.9	-1.8	-1.6	1.8	2.5	0.5	1.8	-2.4	-1.8	0.4
Medication: Blood pressure	1.6	2.8	6.5	2.6	1.9	1.7	0.0	1.2	-0.2	2.3	1.9	1.2	-1.8
Number of full sisters	1.6	1.9	4.5	-1.8	-1.5	-2.1	-0.1	-0.2	0.2	1.0	-2.0	-1.8	-1.0
Ever had stillbirth, spontaneous miscarriage or termination	1.6	1.7	3.1	1.5	1.7	1.0	-1.4	-1.2	-1.8	-0.7	1.2	1.1	1.2
Medication: Atorvastatin	1.6	1.9	3.7	-1.4	-0.9	-1.5	1.6	1.5	0.1	1.7	-1.9	-1.7	-0.6
Depressed Affect (Nagel 2018)	1.5	3.3	8.8	2.1	2.1	3.0	-0.1	0.3	-1.2	-1.7	2.2	2.0	1.3
Impedance of leg (right)	1.5	7.1	17.6	-4.2	-3.3	-1.5	0.4	2.5	1.9	-1.9	-2.6	-2.8	3.6
Alcohol usually taken with meals	1.5	2.4	4.9	1.0	0.3	1.4	-1.6	-1.2	-2.2	-2.0	2.1	1.4	1.1
Hair/balding pattern: Pattern 2	1.5	1.9	7.6	-0.5	-0.7	-0.2	-2.8	-1.4	-2.4	0.0	-0.1	-1.3	1.1
Forced expiratory volume in 1-second (FEV1)	1.5	5.2	10.0	-3.0	-1.9	-2.2	2.4	3.2	1.4	2.8	-2.4	-1.9	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	1.5	4.7	9.5	-2.5	-1.8	-2.4	2.1	3.1	1.6	2.4	-2.5	-1.7	-0.3
Chronic bronchitis/emphysema (mother)	1.5	1.7	5.1	0.1	0.4	1.7	-1.3	-0.7	-2.3	-1.3	1.2	1.1	1.7
Comparative height size at age 10	1.5	8.3	20.6	-3.1	-1.8	-1.7	4.0	4.5	1.8	3.5	-3.0	-1.7	-1.9
Supplements: Vitamin C	1.5	1.8	5.8	-1.4	-1.0	-1.4	-1.3	-2.4	-0.8	-0.1	-1.8	-1.4	0.0
Diabetes diagnosed by doctor	1.5	2.4	8.8	2.3	1.8	0.6	-0.9	-1.9	-0.0	1.2	0.9	0.3	-3.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.5	3.1	4.9	-1.7	-1.6	-1.8	1.8	1.7	2.2	1.8	-1.9	-2.1	-0.1
Blood Red Count	1.4	13.1	58.7	-1.5	0.4	-1.5	3.5	-0.1	5.4	4.4	-2.1	-1.7	-7.7
Blood White Count	1.4	10.3	23.0	4.5	4.8	4.2	3.5	0.2	1.2	-2.5	3.4	3.1	-0.9
BMI	1.4	8.3	23.3	0.4	2.1	3.4	-3.1	-4.8	-4.1	-3.6	1.9	0.9	0.7
Frequency of depressed mood in last 2 weeks	1.4	2.0	5.1	2.2	1.5	1.8	-1.0	0.2	-1.1	-0.4	1.6	1.6	1.3
Forced vital capacity (FVC)	1.4	5.6	9.3	-2.9	-2.1	-2.8	2.2	2.9	1.3	3.0	-2.7	-2.0	-0.1
Heart disease (mother)	1.4	1.8	4.9	-0.5	-1.5	-1.1	0.5	0.4	2.2	2.0	-1.0	-1.2	-1.5
Commuting to job workplace: Car/motor vehicle	1.4	1.7	3.7	1.0	0.9	1.1	-1.8	-1.9	-1.3	-1.6	1.2	0.7	-0.4
Long-standing illness, disability or infirmity	1.4	2.2	5.3	1.9	2.3	0.5	-1.7	-1.7	-1.6	0.4	1.1	1.2	-1.1
Alzheimer’s Disease (in mother)	1.3	1.6	5.4	-0.9	-1.0	-1.3	0.4	0.2	0.5	2.3	-0.8	-1.2	-2.1
Lung FVC	1.3	6.5	12.0	-3.0	-2.5	-3.5	1.7	1.8	2.7	2.3	-3.3	-2.7	-0.4
Angina	1.3	1.7	8.1	-0.7	-0.3	-1.1	0.5	0.7	0.7	1.6	-1.5	-0.8	-2.8
Severe depression (siblings)	1.3	1.5	6.8	-0.1	-0.2	0.3	-1.7	-2.1	-2.6	-0.8	0.2	-0.2	0.1
Tinnitus: Yes, but not now, but have in the past	1.3	1.4	2.4	-1.3	-0.5	-1.5	1.1	1.0	0.5	1.4	-1.3	-0.9	-1.6
Fluid intelligence score	1.3	2.7	9.2	-3.0	-2.1	-1.8	0.4	1.2	-0.7	0.3	-2.0	-1.7	1.0
Loud music exposure frequency	1.3	1.4	4.4	1.1	1.3	0.7	-2.1	-0.9	-0.4	-1.9	0.4	1.1	0.6
Medication: Amlodipine	1.3	1.8	6.9	0.7	0.9	-0.5	0.8	1.7	1.7	1.9	-0.0	0.1	-2.6
Comparative body size at age 10	1.3	3.5	6.9	-1.7	-1.4	-2.0	-1.2	-2.2	0.3	0.7	-2.6	-2.5	-2.6
Eye problems/disorders: None of the above	1.3	1.4	4.3	-1.7	-1.3	-1.3	0.1	-0.3	0.7	1.0	-1.5	-2.1	-0.1
Serious illness, injury or assault to yourself	1.2	1.4	3.8	1.2	1.4	0.5	-1.7	-1.1	-1.9	-0.8	0.7	1.2	-0.1
Impedance of leg (left)	1.2	5.9	14.7	-3.8	-2.8	-1.1	0.4	2.6	1.7	-1.8	-2.2	-2.5	3.4
Waist circumference	1.2	4.2	14.5	1.2	3.1	3.8	0.5	-0.8	-1.0	-2.4	2.4	1.8	-0.4
Impedance of arm (right)	1.2	5.5	14.5	-3.8	-1.9	-0.6	0.8	2.1	0.7	-3.3	-2.1	-1.7	3.6
Family relationship satisfaction	1.2	1.5	5.8	0.4	0.3	-0.8	-1.2	-2.2	-0.2	1.0	-0.8	-0.8	-2.4
Major Depression (MDD)	1.1	1.3	5.9	0.9	1.3	1.2	-1.3	-0.5	-2.4	-0.8	0.7	0.9	-0.2
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	3.6	1.6	1.1	0.6	-1.2	-0.2	-0.8	0.7	0.9	0.7	-1.9
Townsend deprivation index at recruitment	1.1	1.5	5.4	-0.7	0.4	-1.4	0.7	0.4	-0.7	0.9	-1.7	-1.4	-2.3
Medication: Simvastatin	1.1	1.6	6.1	0.7	2.0	0.7	1.3	0.6	-0.4	1.3	0.4	0.8	-2.5
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.8	4.7	2.1	2.0	1.2	-0.4	0.2	0.1	-0.6	1.4	2.2	-0.9
Medication: Cholesterol lowering	1.1	1.7	5.3	1.2	2.3	1.4	1.5	1.1	-1.0	0.3	0.9	1.5	-0.7
Glaucoma (self-reported)	1.1	1.3	6.2	0.6	-0.2	0.9	-2.5	-0.3	-1.5	-1.1	0.4	-0.0	1.3
Age at first live birth	1.1	2.0	4.3	-1.5	-1.6	-2.1	0.7	0.7	1.7	0.6	-1.8	-1.7	-0.8
Shortness of breath walking on level ground	1.1	1.3	5.1	0.6	0.5	0.8	-0.3	-2.3	0.7	-1.7	1.0	0.2	1.4
Commuting to job workplace: Public transport	1.1	1.3	4.6	-0.8	-0.1	-0.9	2.2	1.3	0.8	1.7	-0.9	-0.5	-0.9
Commuting to job workplace: Cycle	1.1	1.3	3.6	-1.3	-1.3	-1.2	-0.2	-1.9	-0.1	-0.7	-1.3	-1.4	0.8
Medication: Omeprazole (e.g. Zanprol)	1.1	1.3	3.1	1.5	1.8	1.2	-0.5	0.3	0.0	-0.9	1.2	1.5	1.2
Supplements: Calcium	1.1	1.2	3.9	0.3	-0.8	-0.7	-0.9	-2.0	-0.5	1.5	-0.7	-0.8	-1.4
Diabetes (father)	1.0	1.3	2.9	1.2	0.7	-0.0	1.4	0.6	1.3	1.7	0.9	-0.1	-1.7
Trunk fat percentage	1.0	4.1	21.2	-2.5	1.0	2.6	-0.3	-1.2	-1.3	-4.6	0.0	-0.2	1.5
Diverticular disease/diverticulitis (self-reported)	1.0	1.2	4.2	1.7	2.0	0.9	-0.5	-0.7	0.1	-0.2	1.0	0.9	-1.1
Medication: Ramipril	1.0	1.3	3.0	1.7	1.7	1.2	0.1	1.0	0.0	0.5	1.3	1.3	-1.1
Prospective memory result	1.0	1.3	3.2	0.6	1.0	0.7	1.8	0.9	1.8	-0.3	0.7	0.8	-1.5
Birth weight	1.0	2.2	5.4	0.8	1.3	1.1	-1.4	-1.6	-1.1	-2.3	1.0	1.8	1.6
Forced vital capacity (FVC), Best measure	1.0	3.5	5.9	-2.1	-1.8	-2.3	1.5	2.4	0.9	2.2	-2.3	-1.6	0.1
Angina (self-reported)	1.0	1.3	6.1	-0.6	-0.3	-0.9	0.5	0.8	0.5	1.4	-1.4	-0.6	-2.5
Age at last live birth	1.0	1.4	2.5	-1.5	-1.4	-1.3	-1.2	-1.5	-0.0	-0.4	-1.3	-1.6	0.6
Ever taken oral contraceptive pill	1.0	1.1	4.2	0.4	-0.6	0.5	-1.7	-2.0	-1.2	-0.5	0.7	-0.6	0.8
High cholesterol (Self-reported)	1.0	1.9	2.9	1.5	1.5	0.7	1.7	1.5	-1.5	1.5	0.6	1.5	-1.2
Impedance of whole body	1.0	5.0	13.6	-3.7	-1.9	-0.6	0.6	2.8	1.4	-2.4	-2.0	-1.8	3.1
Depression (Nagel 2018)	0.9	1.4	3.2	1.6	1.8	1.4	-0.8	0.9	-0.6	-0.1	1.1	1.7	0.5
Ulcerative Colitis	0.9	1.4	6.4	-0.3	0.3	-0.3	2.0	1.3	2.5	0.1	-0.0	0.5	-0.9
Maternal smoking around birth	0.9	1.3	3.5	-1.1	-0.9	-1.8	-0.0	0.2	-0.9	0.7	-1.3	-1.0	-1.9
Qualifications: A levels/AS levels or equivalent	0.9	1.9	5.8	-2.4	-1.3	-1.6	0.4	0.2	-0.0	0.7	-2.1	-1.4	-1.4
Medication: Lansoprazole	0.9	1.0	3.2	-1.1	-0.7	-1.1	0.9	1.8	-0.3	1.3	-0.8	-0.5	-0.8
High blood pressure (siblings)	0.9	1.3	5.2	-0.1	0.4	-0.9	1.2	1.3	0.9	1.7	-0.3	-0.1	-2.3
Body fat percentage	0.9	3.7	19.4	-2.7	0.5	2.1	-0.2	-1.7	-1.0	-4.4	-0.3	-0.7	1.4
Leg fat percentage (right)	0.9	3.4	13.4	-3.1	-0.8	1.1	0.0	-1.8	-0.2	-3.7	-0.9	-1.6	1.4
Exposure to tobacco smoke outside home	0.9	1.2	2.8	1.6	0.7	-0.6	1.3	0.9	1.2	1.3	0.2	0.3	-1.7
Had major operations	0.9	1.0	3.4	-0.9	0.3	-1.4	0.8	-1.2	0.0	-0.2	-1.3	-0.1	-1.9
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	3.0	-1.6	-1.2	-0.3	1.1	0.9	1.7	-0.4	-0.6	-1.1	0.1
Hypertension (Self-reported)	0.9	2.6	5.0	2.2	2.2	1.3	0.8	1.7	0.8	1.6	1.5	1.3	-2.0
Arm fat percentage (left)	0.9	3.4	16.0	-1.2	1.4	2.6	-0.3	-2.0	-1.5	-4.0	0.8	0.6	1.0
Average weekly champagne plus white wine intake	0.9	1.2	4.3	0.1	0.1	-0.2	-1.8	-2.1	-1.0	-0.7	-0.4	-1.2	-1.2
Medication: Paracetamol	0.9	1.4	4.0	1.6	0.9	1.3	-0.4	-0.1	-0.2	-2.0	1.6	1.3	0.7
Average weekly beer plus cider intake	0.9	1.4	7.3	2.7	1.3	0.6	-0.9	0.0	-0.1	-0.2	1.4	1.2	-0.6
Age at First Birth	0.8	1.2	3.0	-0.2	-0.7	-1.3	1.4	1.7	1.4	1.3	-1.0	-0.5	-0.1
Fasting Glucose	0.8	1.0	3.6	1.9	0.7	1.1	-0.5	0.5	0.0	0.5	0.9	1.4	-1.1
HDL Cholesterol	0.8	1.3	3.9	-1.8	-1.0	-1.8	0.1	0.8	-0.5	-0.7	-2.0	-0.6	-0.0
Systolic Blood Pressure	0.8	4.0	11.5	1.6	1.2	0.3	2.1	3.0	2.7	3.4	0.8	0.9	-1.4
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	5.3	0.4	0.7	-0.0	0.8	0.3	1.3	0.3	-0.2	0.7	-2.3
High blood pressure	0.8	2.2	5.4	1.8	2.0	0.9	0.8	1.7	0.5	1.7	1.1	1.0	-2.3
Body mass index (BMI)	0.8	3.4	8.6	0.5	2.0	2.5	-1.1	-2.9	-1.9	-2.6	1.5	1.0	-0.6
Trunk fat mass	0.8	3.3	14.5	-1.8	1.2	2.6	-0.3	-1.6	-1.6	-3.8	0.3	0.0	1.1
Arm fat percentage (right)	0.8	3.2	15.7	-1.8	0.8	2.1	-0.2	-1.9	-1.6	-4.0	0.3	0.1	1.2
Hip circumference	0.8	3.4	13.2	-2.5	-0.5	0.2	-1.8	-3.6	-1.9	-1.6	-1.2	-1.7	-0.8
Pulse rate	0.8	1.4	2.5	-0.5	-0.7	-1.2	0.5	1.4	1.4	1.2	-1.6	-1.3	-1.2
Impedance of arm (left)	0.8	3.9	10.3	-3.1	-1.0	0.2	0.8	2.6	0.6	-2.9	-1.3	-0.7	3.2
Arm fat mass (right)	0.8	3.1	9.9	-0.4	1.8	2.6	-0.7	-2.1	-2.1	-3.1	1.0	0.8	0.2
Length of working week for main job	0.8	0.9	2.2	0.3	-1.3	0.4	1.0	1.4	1.1	1.5	0.4	-0.5	0.2
Medication: Paracetamol	0.8	1.4	3.0	1.7	1.2	1.1	-0.9	-0.7	-1.0	-1.6	1.5	0.9	0.2
Mouth/teeth dental problems: Loose teeth	0.8	0.9	3.0	0.5	1.7	0.7	1.2	0.7	-0.8	0.4	0.9	1.5	0.4
Mineral and other dietary supplements	0.8	1.1	4.2	0.8	1.4	1.0	-0.6	0.6	-1.1	-2.0	0.7	0.9	0.5
Illnesses of father: None of the above (group 1)	0.8	0.9	2.3	-0.7	0.4	0.6	-1.3	0.1	-1.4	-1.5	-0.1	0.3	1.5
Arm fat mass (left)	0.8	3.1	9.5	-0.4	1.8	2.8	-0.4	-1.9	-1.9	-3.1	1.2	1.0	0.4
Wears glasses or contact lenses	0.8	0.9	1.8	-0.9	-0.6	-1.0	1.3	0.1	1.4	1.2	-0.7	-0.8	-0.6
Medication: Blood pressure	0.8	1.6	7.8	1.7	1.8	0.3	0.3	0.5	0.7	0.8	0.3	0.8	-2.8
Leg fat percentage (left)	0.8	2.8	12.7	-2.6	-0.3	1.5	-0.0	-1.8	-0.4	-3.6	-0.5	-1.2	1.2
Vascular/heart problems diagnosed by doctor	0.8	2.1	6.5	-1.8	-2.1	-1.1	-0.4	-1.4	-0.3	-1.4	-1.0	-0.8	2.5
Basal cell carcinoma (self-reported)	0.8	1.0	2.1	-0.9	-0.7	-1.4	-0.8	-0.9	0.4	0.6	-1.1	-1.1	-1.5
Alcohol drinker status: Previous	0.8	0.9	3.0	-1.0	0.0	-0.2	1.4	1.7	0.7	-0.8	-0.7	0.8	-1.0
Crohns Disease (2012)	0.7	1.2	4.4	0.6	0.5	-0.3	1.7	1.1	2.1	-0.6	-0.1	1.4	-0.5
Mean Putamen Volume	0.7	0.8	3.0	-0.6	-0.6	-0.6	-1.0	-0.8	-1.7	-1.1	-1.0	-0.3	0.5
Systolic blood pressure, automated reading	0.7	1.9	6.3	-0.7	-0.1	-0.2	2.5	1.8	1.8	2.2	-0.4	-0.4	-0.8
Pack years adult smoking proportion	0.7	1.1	3.2	0.9	1.1	1.2	-1.1	-0.4	-1.8	-1.1	1.0	0.2	0.6
Illnesses of siblings	0.7	1.0	3.7	-0.5	-0.6	0.5	-1.1	-1.3	-0.5	-1.5	-0.0	-0.6	1.9
Gout (self-reported)	0.7	1.0	3.4	0.5	1.1	0.3	0.4	1.8	1.5	1.2	0.8	0.6	-0.3
Number of children fathered	0.7	0.8	2.0	1.1	1.2	1.0	0.1	-0.3	1.4	-0.9	1.1	0.8	-0.1
Migraine (self-reported)	0.7	0.9	4.2	-0.1	0.3	0.6	2.1	-0.2	1.2	-1.1	0.1	1.0	-0.6
Handedness (chirality/laterality): Left-handed	0.7	0.8	4.0	0.1	-0.8	-0.3	-1.4	-2.0	-0.8	0.1	0.0	-0.6	0.8
Medication for cholesterol	0.7	1.0	3.0	-1.5	-1.4	-0.5	-0.3	-1.1	0.2	-0.9	-0.6	-0.8	1.7
Alcohol drinker status: Never	0.7	0.8	1.8	-0.1	0.8	0.8	-0.6	-1.3	-1.3	-0.9	0.7	0.4	1.3
Number of operations (self-reported)	0.7	1.0	3.5	0.8	1.9	0.0	-0.1	-1.6	-0.7	0.1	0.6	1.3	-0.7
Risk taking	0.7	1.0	2.3	-0.6	-0.9	-1.2	0.7	0.1	0.2	1.5	-1.5	-1.3	-0.8
Breast Cancer	0.6	1.6	7.8	-0.2	-0.7	0.1	-2.8	-1.9	-1.0	0.0	-0.2	-1.6	-0.2
Smoking Status	0.6	1.5	5.6	0.2	0.0	-0.7	-1.5	-2.4	-1.7	-1.1	-1.1	-0.7	-0.6
Medication for hormone replacement therapy	0.6	0.7	2.5	0.0	-0.7	-0.3	0.9	0.8	0.9	1.6	-0.1	-0.9	-0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	3.3	1.0	1.8	0.9	-0.1	0.7	0.2	0.2	0.5	1.5	0.1
Number of incorrect matches in round	0.6	1.0	6.7	0.2	1.2	-0.8	0.4	0.1	0.2	0.8	-0.4	-0.3	-2.6
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.3	3.1	1.1	0.6	0.9	-1.5	-1.8	-0.6	0.0	1.6	0.7	1.4
Financial difficulties in last 2 years	0.6	0.8	2.2	-0.0	-0.1	-0.6	-1.5	-1.4	-1.1	-0.2	-0.8	-0.8	-0.7
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	3.0	-0.1	-1.7	-0.7	-0.9	-1.1	-0.1	-0.2	-0.7	-0.9	1.2
Noisy workplace	0.6	0.7	1.6	-1.0	-1.1	-0.6	0.1	-0.9	0.4	0.8	-1.1	-1.3	-0.5
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	3.1	-0.1	0.9	-1.0	-0.1	-0.7	-1.2	0.1	-0.4	0.2	-1.8
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.7	2.1	-1.1	-1.1	-1.4	0.7	0.0	0.2	-0.1	-1.2	-0.8	-0.1
Headache pain in last month	0.6	1.1	3.3	0.5	1.2	1.1	-1.2	-0.7	-1.8	-0.9	0.9	0.3	1.1
Emphysema/chronic bronchitis	0.6	0.7	3.3	-0.3	-0.3	-0.1	-0.8	0.5	-1.8	0.4	-0.1	-0.3	1.4
Medication: Allopurinol	0.6	0.8	4.4	-0.1	0.6	-0.2	0.6	2.1	1.2	0.9	0.1	0.9	-0.1
Whole body fat mass	0.6	2.4	10.5	-1.6	1.0	2.1	-0.3	-1.7	-1.4	-3.2	0.1	-0.1	0.5
Leg fat mass (right)	0.6	2.1	9.9	-1.6	0.5	1.8	-0.4	-1.9	-1.1	-3.1	0.1	-0.3	0.6
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.8	1.5	-0.4	-1.2	-0.4	0.4	-0.4	0.9	1.1	-1.1	-1.2	-0.9
Irritable Bowel Disease (IBD)	0.5	1.3	7.0	-0.4	0.4	-0.9	1.8	0.4	2.6	-0.4	-0.6	0.4	-0.9
Neuroticism (2016)	0.5	0.7	2.5	0.7	-0.1	1.1	-0.3	0.2	-1.3	-0.0	0.9	0.3	1.6
Heel T-Score	0.5	3.8	8.4	2.2	1.4	1.2	-2.2	-1.4	-1.4	-2.3	2.9	2.5	1.2
Average weekly spirits intake	0.5	0.6	3.8	-0.6	0.6	-0.3	0.4	2.0	0.2	0.6	-0.4	0.5	0.4
Relative age of first facial hair	0.5	1.0	2.4	-1.1	-1.2	-1.1	1.3	1.1	-0.1	1.5	-0.7	-0.1	0.9
Ever used hormone-replacement therapy (HRT)	0.5	0.6	2.4	0.3	0.6	0.7	1.5	-0.2	-0.1	0.7	0.6	0.5	-1.2
Medication: Co-codamol	0.5	0.6	2.5	0.2	-0.5	-0.8	0.5	0.5	0.4	1.6	-0.8	-0.9	-0.6
Hand grip strength (right)	0.5	1.3	4.2	-1.0	-1.4	-0.6	-2.0	0.0	-1.2	0.8	-0.8	-1.5	0.9
Average weekly fortified wine intake	0.5	0.6	2.0	0.2	0.7	0.4	-0.4	-1.0	-0.6	-1.4	0.3	0.5	1.0
Supplements: Glucosamine	0.5	0.6	2.6	-0.5	-0.0	-1.2	-0.1	-0.5	0.7	1.6	-0.9	-0.5	-0.5
Medication: Atenolol	0.5	0.6	1.6	1.3	0.8	0.8	0.8	0.4	-0.2	0.8	0.9	1.1	-0.6
Had menopause	0.5	0.7	1.8	0.3	1.3	1.1	0.9	0.2	-0.5	0.8	0.7	1.1	-0.6
Had other major operations	0.5	0.6	3.4	0.4	0.2	-1.0	-0.8	-1.8	-0.5	0.1	0.0	0.1	0.0
Weight	0.5	2.6	6.4	-0.2	1.9	2.5	-0.4	-2.0	-2.4	-2.0	1.1	0.8	-0.2
Alcohol intake versus 10 years previously	0.5	0.8	3.9	-0.1	-0.1	-0.7	0.6	-0.0	1.1	1.4	-0.2	-0.2	-2.0
Mouth/teeth dental problems: Dentures	0.5	0.8	2.3	-0.7	-0.2	0.3	1.2	1.4	1.0	-0.5	-0.3	-0.3	1.5
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	1.9	0.1	1.4	0.4	-0.4	-1.1	-0.1	-1.3	0.7	0.4	0.5
Blood clot in the leg (DVT)	0.5	0.6	2.7	0.1	-0.3	-0.6	0.2	-1.0	-1.6	-1.1	-0.7	0.3	0.7
Number of full brothers	0.5	0.6	1.4	0.7	0.9	1.1	-1.0	0.4	-0.1	0.2	0.9	1.2	0.5
Alcohol intake frequency.	0.5	1.1	3.0	0.8	0.7	0.7	0.9	0.2	1.7	0.9	1.0	0.9	-1.6
Leg pain on walking	0.5	0.7	2.0	1.0	1.4	0.5	-0.3	-0.8	0.6	-0.9	0.7	0.9	0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	2.5	-0.5	-0.1	0.2	1.2	1.6	0.3	0.8	-0.3	0.4	0.6
Leg fat-free mass (right)	0.5	2.6	5.6	1.3	2.4	1.7	-0.5	-1.6	-2.3	-0.0	1.3	1.3	-2.0
Osteoarthritis (self-reported)	0.5	0.6	2.4	-1.2	0.1	-0.4	0.8	0.6	1.6	0.8	-0.4	0.7	0.1
Medication: Aspirin	0.5	0.7	3.6	-0.6	-0.1	-0.3	0.6	0.6	0.9	0.4	-0.9	-0.8	-1.9
Leg predicted mass (right)	0.5	2.6	5.8	1.3	2.4	1.7	-0.5	-1.7	-2.3	0.0	1.3	1.3	-2.0
Miserableness	0.5	0.8	2.3	1.1	0.9	1.5	0.5	0.8	-0.1	-0.9	0.9	0.8	0.7
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	2.1	-0.1	-0.7	-0.9	0.3	-1.1	-1.4	-0.6	-0.9	-0.1	0.6
Heart disease (siblings)	0.5	0.7	2.2	0.9	1.3	0.6	0.5	0.7	-0.7	-0.2	0.7	1.5	-0.1
Leg fat mass (left)	0.5	2.1	9.0	-1.3	0.8	2.0	-0.4	-1.8	-1.3	-3.0	0.3	-0.2	0.5
Schizophrenia vs Biploar Disorder	0.4	0.5	1.5	0.4	1.2	0.2	-0.4	0.7	-0.4	1.0	0.4	0.5	-1.1
Crohns Disease (2017)	0.4	0.8	5.1	0.0	-0.1	-1.1	0.9	-0.4	2.2	-0.6	-0.6	0.3	-0.2
Ulcerative Colitis (UC)	0.4	0.7	2.4	-0.5	0.9	-0.3	1.4	0.4	1.5	0.1	-0.3	0.1	-1.2
Body Mass Index (BMI) (2010)	0.4	0.6	1.9	-0.5	0.1	1.2	1.4	-0.1	0.6	-0.6	0.6	-0.2	0.8
Respiratory disease	0.4	0.9	6.3	0.3	-0.8	-0.0	-0.8	-0.5	-0.3	-0.6	0.3	-0.7	2.5
Number of treatments/medications taken	0.4	0.7	3.4	1.9	1.3	0.5	-0.2	0.1	-0.0	0.0	0.6	0.6	-1.0
Leg fat-free mass (left)	0.4	2.2	5.3	0.9	2.1	1.7	-0.7	-1.8	-2.3	-0.5	1.1	1.2	-1.6
Stomach or abdominal pain in last month	0.4	0.4	1.3	1.0	1.2	-0.5	-0.3	-0.4	0.5	0.5	-0.0	-0.1	-1.0
Leg predicted mass (left)	0.4	2.1	4.9	0.9	2.0	1.6	-0.6	-1.7	-2.2	-0.4	1.0	1.1	-1.7
Qualifications: None of the above	0.4	0.8	2.0	1.4	1.4	1.1	0.3	0.6	-0.4	0.4	1.1	1.1	0.4
Mouth/teeth dental problems	0.4	0.6	2.3	-0.3	-1.2	-0.1	-1.4	-1.5	-0.3	-0.0	-0.1	-0.7	-0.5
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	2.4	-0.5	-0.2	-1.0	-1.5	-1.4	-0.5	-0.4	-0.5	-0.5	-0.4
Arm fat-free mass (right)	0.4	1.9	3.2	1.4	1.8	1.4	-0.6	-1.4	-1.6	1.1	1.2	1.0	-1.8
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	1.2	-1.1	-0.5	-0.1	0.9	-0.2	0.7	-0.9	-0.7	-0.7	0.7
Medication: Ibuprofen	0.4	0.5	1.2	-1.1	-1.0	-0.8	0.4	-0.0	0.2	-0.9	-0.7	-0.4	0.6
Arm predicted mass (right)	0.4	2.0	3.6	1.6	1.9	1.4	-0.6	-1.6	-1.2	1.1	1.3	1.1	-1.9
Medication: Aspirin	0.4	0.6	2.4	-0.9	-0.1	-0.2	0.3	-0.3	0.7	0.0	-0.9	-0.9	-1.6
Knee pain experienced in last month	0.4	0.7	1.4	0.6	1.0	0.7	-1.0	-0.3	-1.2	-0.7	0.7	1.1	0.7
Eye problems/disorders: Cataract	0.4	0.5	1.4	0.2	0.5	0.6	0.5	1.2	-0.8	0.2	0.8	0.9	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	1.6	0.3	0.8	-0.1	-0.1	0.9	-0.3	0.9	-0.4	-0.0	-1.2
Breast cancer (self-reported)	0.4	0.4	1.6	0.5	0.5	-0.6	-0.6	0.9	-1.3	0.1	-0.2	0.3	-0.8
Asthma (self-reported)	0.4	0.7	6.0	0.6	-0.6	0.1	-0.3	-0.5	-0.1	-0.4	0.3	-0.2	2.4
Hearing aid user	0.4	0.4	2.2	-0.2	0.1	0.1	-0.1	0.4	-1.5	1.4	0.2	-0.2	-0.0
Financial situation satisfaction	0.4	0.5	1.9	0.9	1.4	0.0	-0.6	-0.1	0.9	-0.2	0.4	0.7	-1.0
Eye problems/disorders: Glaucoma	0.4	0.5	1.3	0.9	0.6	1.0	-1.1	0.1	-0.8	-0.1	0.6	0.5	0.6
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.5	-0.5	-1.1	0.2	1.1	-0.7	1.2	0.4	0.1	-0.3	0.4
Medication: Bendroflumethiazide	0.4	0.5	2.2	0.7	-0.1	0.0	-0.7	1.4	-0.3	1.5	-0.1	-0.1	-0.4
Basal metabolic rate	0.4	2.1	5.4	0.9	1.8	1.7	-0.7	-1.9	-2.3	-0.2	1.2	1.1	-1.3
Ever had prostate specific antigen (PSA) test	0.4	0.4	0.9	0.2	0.6	0.8	-0.6	-0.6	-0.9	-0.2	0.9	0.9	0.2
Unable to work because of sickness or disability	0.4	0.5	0.9	0.7	0.8	1.0	0.6	0.9	0.7	-0.8	0.7	0.5	0.4
Myopia	0.4	0.5	2.8	-0.4	0.2	-0.3	-0.6	-1.7	0.2	-1.1	-0.5	-0.6	-0.3
Pack years of smoking	0.4	0.6	2.9	0.2	0.7	0.9	-0.7	-0.3	-1.7	-0.7	0.6	-0.1	0.7
Lung FEV1/FVC ratio	0.3	1.4	6.6	-0.5	0.2	0.5	1.9	2.6	0.6	1.3	-0.4	-0.5	-1.2
Current tobacco smoking	0.3	0.5	1.2	0.9	0.4	0.5	-1.0	-1.1	-1.0	-0.7	0.3	0.2	0.0
High blood pressure (mother)	0.3	0.5	1.2	-0.8	-1.1	-0.7	0.4	1.1	0.6	0.5	-0.2	0.2	0.2
Heart attack	0.3	0.4	1.4	0.4	0.6	1.2	-0.1	-0.1	-0.4	-1.1	0.7	0.3	0.1
Allergy	0.3	0.7	3.2	-1.3	0.3	-0.6	0.2	0.6	0.6	0.5	-0.8	0.0	-1.8
Trunk fat-free mass	0.3	1.6	4.1	1.2	1.1	1.0	-0.5	-1.6	-2.0	1.3	1.0	0.8	-1.3
Hair/balding pattern: Pattern 3	0.3	0.5	1.8	-0.0	0.4	1.4	0.2	-0.3	0.6	-0.7	0.6	0.7	1.0
Asthma	0.3	0.5	3.6	0.8	-0.3	0.2	-0.5	-0.6	0.1	-0.4	0.3	-0.2	1.9
Illnesses of mother	0.3	0.4	1.4	-0.4	0.0	-0.2	0.6	0.9	-1.2	-0.1	-0.1	-0.3	1.1
Trunk predicted mass	0.3	1.6	4.4	1.1	1.1	1.0	-0.6	-1.7	-2.1	1.3	1.0	0.8	-1.2
Birth weight of first child	0.3	0.5	1.7	-0.7	0.1	-0.3	0.1	0.4	-0.2	1.3	-0.7	-0.0	-1.2
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.9	1.0	0.5	0.2	-0.5	-0.5	-0.7	-0.5	0.7	0.7	0.5
Wheeze or whistling in the chest in last year	0.3	0.5	2.3	0.3	0.0	-0.3	-1.0	-0.5	-1.5	0.1	-0.3	-0.5	0.9
Medication for pain relief, constipation, heartburn	0.3	0.5	1.4	-0.6	-0.9	-1.0	0.4	0.2	0.4	1.2	-0.8	-0.6	-0.1
Medication: Seretide 50 evohaler	0.3	0.4	3.0	-0.1	-0.3	-0.5	-0.0	-0.3	-0.1	-0.3	-0.1	-0.3	1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	1.2	0.5	1.1	0.7	-0.5	-0.0	-0.5	-0.6	0.6	0.9	-0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	1.5	1.2	1.1	0.6	-0.8	0.4	-0.9	0.2	0.5	1.0	-0.2
Whole body fat-free mass	0.3	1.9	4.5	1.2	1.7	1.4	-0.5	-1.7	-2.1	0.6	1.2	1.1	-1.6
Smoking status: Current	0.3	0.5	1.2	1.1	0.6	0.7	-0.9	-0.9	-0.5	-0.8	0.4	0.6	0.1
Whole body water mass	0.3	2.0	4.4	1.2	1.7	1.3	-0.5	-1.8	-2.1	0.8	1.1	1.0	-1.8
Illnesses of father: High blood pressure	0.3	0.3	0.9	0.5	-0.4	-0.1	-0.1	-0.1	-0.7	0.9	0.7	0.3	-0.9
Ever smoked	0.3	0.6	1.7	-0.3	-0.8	-1.2	0.2	0.9	-0.2	1.0	-1.3	-0.6	-0.3
Arm fat-free mass (left)	0.3	1.7	3.2	1.1	1.7	1.3	-0.6	-1.6	-1.8	0.6	1.0	0.8	-1.8
Heart attack/myocardial infarction (self-reported)	0.3	0.3	1.3	0.4	0.7	1.1	0.1	-0.0	-0.4	-0.9	0.6	0.2	-0.1
Arm predicted mass (left)	0.3	1.7	3.0	1.1	1.7	1.4	-0.5	-1.7	-1.7	0.7	1.1	0.8	-1.7
Ovarian Cancer	0.2	0.2	0.9	-0.4	0.2	-0.0	0.9	-0.0	-0.2	0.5	-0.1	-0.8	0.3
Allergy or Eczema	0.2	0.6	1.7	0.9	-1.2	-0.4	-0.9	-0.5	-0.8	0.2	0.3	-0.3	1.3
Tanning	0.2	2.3	4.4	1.9	1.2	1.5	-1.3	-1.1	-1.9	-1.6	1.4	0.9	2.1
Relative age voice broke	0.2	0.4	0.8	-0.4	-0.8	-0.7	0.3	-0.2	-0.9	0.8	-0.3	-0.3	0.8
Qualifications: CSEs or equivalent	0.2	0.3	0.8	0.2	0.6	0.7	-0.1	0.6	0.2	-0.1	0.9	0.4	0.7
Hayfever, allergic rhinitis or eczema	0.2	0.4	1.7	0.4	-1.3	-0.4	-0.4	-0.8	-0.2	0.2	-0.0	-0.7	0.9
Chronic bronchitis/emphysema (father)	0.2	0.2	0.9	-0.1	-0.2	-0.5	0.2	-0.9	-0.1	0.3	-0.8	-0.5	0.4
Time employed in main current job	0.2	0.2	0.6	-0.1	-0.6	0.3	0.3	0.4	0.5	0.7	0.3	-0.2	0.8
Falls in the last year	0.2	0.2	1.3	0.3	-0.2	0.3	0.1	0.7	-0.2	-0.4	-0.1	0.2	1.1
Exposure to tobacco smoke at home	0.2	0.2	0.7	0.5	0.4	-0.4	-0.3	-0.4	-0.9	0.3	-0.4	-0.2	-0.1
Hair/balding pattern: Pattern 4	0.2	0.5	1.8	0.6	0.1	-0.6	-0.7	-1.2	-1.3	-0.6	-0.3	-0.3	-0.2
Chest pain or discomfort	0.2	0.2	0.9	-0.1	0.1	-0.2	-0.8	-0.9	0.3	-0.2	-0.4	-0.6	0.1
Illnesses of siblings: Diabetes	0.2	0.3	0.7	0.4	0.5	-0.2	0.2	0.9	-0.1	0.4	0.3	0.7	-0.7
Smoking status: Previous	0.2	0.3	0.8	0.3	0.4	-0.6	-0.5	-0.9	-0.7	-0.6	-0.7	-0.4	-0.5
Average weekly red wine intake	0.2	0.2	1.1	-0.2	-0.2	-0.2	-0.1	0.2	-1.0	-0.7	0.4	0.3	0.7
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	1.6	-0.1	-0.4	-1.3	0.4	0.4	0.1	0.9	-1.0	-0.5	-0.0
Osteoporosis (self-reported)	0.2	0.3	1.0	-0.6	-0.4	0.4	-0.4	-0.3	-1.0	0.5	-0.0	0.1	0.7
Diastolic blood pressure, automated reading	0.2	0.6	1.8	-0.2	0.8	1.1	1.3	1.2	0.8	-0.2	0.3	0.3	0.2
Height	0.1	2.6	9.4	-1.1	0.3	0.3	2.2	3.1	-1.2	2.9	-0.5	-0.2	-0.3
Hair Pigment	0.1	3.3	6.6	2.3	1.3	2.0	-1.6	-2.2	0.6	-2.6	2.2	1.0	1.1
Hand grip strength (left)	0.1	0.2	0.8	-0.1	-0.5	0.4	-0.9	0.1	-0.5	0.4	0.0	-0.2	0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	1.4	-0.3	-0.4	-0.6	-0.4	-0.5	0.7	1.2	0.2	0.1	0.3
Sitting height	0.1	0.5	1.7	0.2	0.8	0.8	-0.6	-0.3	-1.3	0.0	0.0	0.6	0.8
Past tobacco smoking	0.1	0.3	1.1	-0.3	-0.0	0.7	0.2	0.3	0.7	0.2	1.1	0.2	0.5
Lung cancer (father)	0.1	0.2	0.7	-0.2	0.9	0.2	-0.1	-0.3	-0.7	-0.2	-0.4	0.1	0.4
Standing height	0.1	1.1	3.0	-1.2	0.4	0.6	1.1	1.7	-1.7	1.0	-0.5	-0.1	0.4
Qualifications: College or University degree	0.1	0.5	1.1	-1.0	-1.0	-0.8	-0.0	-0.1	-0.4	0.5	-0.7	-0.9	0.4
Back pain experienced in last month	0.1	0.2	0.5	0.4	-0.3	-0.2	0.4	0.0	0.6	0.7	-0.3	-0.5	-0.2
Irritability	0.1	0.1	0.2	0.4	0.0	0.1	0.4	-0.3	-0.1	0.5	0.1	-0.4	0.4
Pain experienced in last month	0.1	0.1	0.4	-0.2	-0.1	-0.2	0.6	-0.3	0.4	-0.6	-0.0	-0.1	-0.5

Hub : Genes

TIMP4

Models

Trait associations