Best TWAS P=6.13e-12 · Best GWAS P=4.99e-12 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | MLXIPL | 0.11 | 0.07 | enet | 16 | 0.07 | 1.6e-06 | -6.1 | -6.3 | 3.0e-10 | 0.93 | 0.01 | 0.99 | FALSE |
2 | GTEx | Adipose Visceral Omentum | MLXIPL | 0.16 | 0.02 | lasso | 3 | 0.03 | 7.8e-03 | -6.5 | -6.6 | 5.4e-11 | 0.93 | 0.04 | 0.96 | FALSE |
3 | GTEx | Cells Transformed fibroblasts | MLXIPL | 0.13 | 0.06 | enet | 6 | 0.09 | 2.2e-07 | -6.9 | -6.7 | 2.3e-11 | 0.93 | 0.00 | 0.99 | FALSE |
4 | GTEx | Heart Left Ventricle | MLXIPL | 0.14 | 0.00 | enet | 24 | 0.01 | 1.3e-01 | -2.7 | -5.3 | 1.1e-07 | 0.59 | 0.06 | 0.70 | FALSE |
5 | GTEx | Lung | MLXIPL | 0.10 | 0.07 | enet | 14 | 0.07 | 6.3e-06 | -6.1 | -5.3 | 1.2e-07 | 0.68 | 0.03 | 0.92 | FALSE |
6 | GTEx | Skin Not Sun Exposed Suprapubic | MLXIPL | 0.11 | 0.11 | lasso | 3 | 0.06 | 2.7e-04 | -6.9 | -6.9 | 6.1e-12 | 0.99 | 0.00 | 0.99 | TRUE |
7 | GTEx | Skin Sun Exposed Lower leg | MLXIPL | 0.12 | 0.09 | lasso | 4 | 0.06 | 6.1e-06 | -6.7 | -6.8 | 1.4e-11 | 0.96 | 0.01 | 0.99 | FALSE |
8 | GTEx | Spleen | NCF1B | 0.22 | 0.10 | enet | 9 | 0.08 | 5.1e-03 | -5.1 | 5.4 | 5.9e-08 | -0.70 | 0.04 | 0.29 | FALSE |
9 | GTEx | Thyroid | MLXIPL | 0.23 | 0.14 | lasso | 7 | 0.15 | 2.1e-11 | -6.1 | -6.8 | 1.1e-11 | 0.95 | 0.01 | 0.99 | FALSE |
10 | METSIM | Adipose | MLXIPL | 0.12 | 0.14 | lasso | 4 | 0.13 | 1.8e-19 | -5.9 | -6.3 | 2.9e-10 | 0.84 | 0.26 | 0.74 | FALSE |
11 | The Cancer Genome Atlas | Breast Invasive Carcinoma | MLXIPL | 0.06 | 0.05 | lasso | 2 | 0.05 | 5.1e-10 | -5.8 | -5.6 | 2.1e-08 | 0.76 | 0.00 | 1.00 | FALSE |
12 | The Cancer Genome Atlas | Lung Adenocarcinoma | MLXIPL | 0.04 | 0.03 | lasso | 1 | 0.02 | 2.3e-03 | -5.8 | -5.8 | 6.4e-09 | 0.76 | 0.00 | 0.97 | FALSE |
13 | The Cancer Genome Atlas | Prostate Adenocarcinoma | MLXIPL | 0.08 | 0.05 | enet | 4 | 0.05 | 5.3e-06 | -5.8 | -5.5 | 3.8e-08 | 0.70 | 0.00 | 1.00 | FALSE |