Best TWAS P=5.38e-10 · Best GWAS P=1.82e-07 conditioned to 0.603
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | PIGV | 0.04 | 0.03 | bslmm | 295 | 0.03 | 4.2e-05 | 5.0 | -5.2 | 1.9e-07 | -0.97 | 0.04 | 0.96 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | PIGV | 0.04 | 0.04 | lasso | 6 | 0.03 | 2.6e-03 | 5.2 | -5.5 | 2.9e-08 | -0.98 | 0.03 | 0.95 | FALSE |
| 3 | GTEx | Artery Aorta | PIGV | 0.11 | 0.10 | lasso | 9 | 0.08 | 2.7e-05 | 5.0 | -5.4 | 7.5e-08 | -0.93 | 0.04 | 0.96 | FALSE |
| 4 | GTEx | Esophagus Mucosa | PIGV | 0.16 | 0.15 | lasso | 6 | 0.14 | 7.0e-10 | 5.2 | -5.3 | 9.1e-08 | -1.00 | 0.03 | 0.97 | FALSE |
| 5 | GTEx | Esophagus Muscularis | PIGV | 0.09 | 0.07 | enet | 25 | 0.13 | 3.4e-08 | 5.0 | -6.2 | 5.4e-10 | -0.88 | 0.03 | 0.97 | TRUE |
| 6 | GTEx | Prostate | RP1-50O24.6 | 0.15 | 0.02 | lasso | 9 | 0.02 | 1.1e-01 | 5.0 | 5.1 | 3.0e-07 | 0.97 | 0.03 | 0.60 | FALSE |
| 7 | GTEx | Skin Sun Exposed Lower leg | PIGV | 0.05 | 0.07 | lasso | 2 | 0.06 | 5.0e-06 | 5.2 | -5.2 | 2.3e-07 | -0.99 | 0.03 | 0.97 | FALSE |
| 8 | GTEx | Spleen | PIGV | 0.16 | 0.13 | lasso | 13 | 0.16 | 6.6e-05 | 4.0 | -5.5 | 3.9e-08 | -0.69 | 0.03 | 0.90 | FALSE |
| 9 | METSIM | Adipose | PIGV | 0.03 | 0.02 | enet | 25 | 0.04 | 2.8e-06 | -2.2 | -5.2 | 2.4e-07 | -0.63 | 0.04 | 0.93 | FALSE |
| 10 | METSIM | Adipose | ZDHHC18 | 0.04 | 0.03 | lasso | 2 | 0.04 | 3.8e-06 | 4.8 | 6.0 | 2.0e-09 | 0.82 | 0.03 | 0.97 | FALSE |
| 11 | NTR | Blood | ARID1A | 0.03 | 0.03 | enet | 20 | 0.03 | 7.8e-11 | 5.2 | -6.1 | 1.1e-09 | -0.95 | 0.03 | 0.97 | FALSE |
| 12 | The Cancer Genome Atlas | Prostate Adenocarcinoma | FAM46B | 0.04 | 0.00 | blup | 23 | 0.01 | 3.5e-02 | -2.1 | -5.4 | 7.5e-08 | -0.54 | 0.00 | 0.17 | FALSE |