Best TWAS P=6.21e-23 · Best GWAS P=4.88e-23 conditioned to 0.0381
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Visceral Omentum | INADL | 0.22 | 0.03 | lasso | 6 | 0.05 | 1.3e-03 | -9.8 | 8.2 | 2.5e-16 | -0.74 | 0.06 | 0.60 | FALSE |
| 2 | GTEx | Artery Aorta | DOCK7 | 0.14 | 0.08 | lasso | 4 | 0.09 | 1.2e-05 | -9.8 | 9.4 | 8.0e-21 | -0.91 | 0.05 | 0.94 | FALSE |
| 3 | GTEx | Artery Tibial | DOCK7 | 0.07 | 0.07 | enet | 20 | 0.07 | 3.5e-06 | -9.8 | 9.5 | 3.0e-21 | -0.95 | 0.06 | 0.94 | FALSE |
| 4 | GTEx | Brain Cerebellum | ATG4C | 0.23 | 0.12 | lasso | 4 | 0.18 | 6.4e-06 | -3.7 | -5.4 | 7.5e-08 | 0.55 | 0.42 | 0.40 | FALSE |
| 5 | GTEx | Cells Transformed fibroblasts | DOCK7 | 0.23 | 0.21 | lasso | 5 | 0.28 | 4.9e-21 | -9.1 | 9.1 | 8.6e-20 | -0.93 | 0.20 | 0.80 | FALSE |
| 6 | GTEx | Esophagus Mucosa | DOCK7 | 0.15 | 0.04 | lasso | 5 | 0.02 | 1.0e-02 | -9.8 | 8.5 | 2.2e-17 | -0.79 | 0.08 | 0.81 | FALSE |
| 7 | GTEx | Skin Not Sun Exposed Suprapubic | DOCK7 | 0.17 | 0.01 | lasso | 2 | 0.00 | 2.5e-01 | -9.7 | 9.7 | 3.2e-22 | -0.97 | 0.06 | 0.58 | FALSE |
| 8 | GTEx | Skin Sun Exposed Lower leg | DOCK7 | 0.09 | 0.10 | lasso | 3 | 0.10 | 2.7e-08 | -9.7 | 9.7 | 2.3e-22 | -0.97 | 0.06 | 0.94 | FALSE |
| 9 | GTEx | Spleen | DOCK7 | 0.28 | 0.14 | enet | 33 | 0.22 | 2.1e-06 | -9.7 | 8.3 | 7.3e-17 | -0.69 | 0.07 | 0.84 | FALSE |
| 10 | GTEx | Whole Blood | DOCK7 | 0.06 | 0.00 | lasso | 6 | 0.00 | 1.6e-01 | -9.1 | 9.3 | 1.5e-20 | -0.96 | 0.08 | 0.84 | FALSE |
| 11 | GTEx | Whole Blood | USP1 | 0.05 | 0.02 | lasso | 1 | 0.02 | 1.0e-02 | -9.7 | 9.7 | 2.2e-22 | -0.97 | 0.05 | 0.91 | FALSE |
| 12 | NTR | Blood | DOCK7 | 0.02 | 0.00 | blup | 647 | 0.01 | 1.5e-03 | -9.8 | 8.1 | 5.8e-16 | -0.83 | 0.05 | 0.95 | FALSE |
| 13 | ROSMAP | Brain Pre-frontal Cortex | DOCK7 | 0.06 | 0.06 | lasso | 6 | 0.06 | 3.7e-08 | -9.8 | -9.0 | 2.6e-19 | 0.91 | 0.06 | 0.94 | FALSE |
| 14 | YFS | Blood | DOCK7 | 0.05 | 0.04 | lasso | 8 | 0.05 | 1.3e-14 | -9.7 | 9.3 | 1.1e-20 | -0.95 | 0.05 | 0.95 | FALSE |
| 15 | The Cancer Genome Atlas | Breast Invasive Carcinoma | DOCK7 | 0.01 | 0.01 | blup | 85 | 0.01 | 1.1e-03 | -9.8 | 9.8 | 7.7e-23 | -0.98 | 0.05 | 0.93 | FALSE |
| 16 | The Cancer Genome Atlas | Colon Adenocarcinoma | DOCK7 | 0.07 | 0.06 | blup | 83 | 0.06 | 2.1e-04 | -9.8 | 9.5 | 3.0e-21 | -0.94 | 0.04 | 0.94 | FALSE |
| 17 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | DOCK7 | 0.12 | 0.05 | lasso | 8 | 0.07 | 9.2e-09 | -9.7 | 8.3 | 7.9e-17 | -0.87 | 0.10 | 0.90 | FALSE |
| 18 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ANGPTL3 | 0.04 | 0.04 | lasso | 2 | 0.04 | 3.0e-05 | -9.7 | 9.2 | 4.9e-20 | -0.92 | 0.02 | 0.97 | FALSE |
| 19 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | DOCK7 | 0.04 | 0.01 | enet | 11 | 0.04 | 5.6e-05 | -9.7 | 8.2 | 3.1e-16 | -0.69 | 0.05 | 0.88 | FALSE |
| 20 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | DOCK7 | 0.06 | 0.07 | blup | 86 | 0.07 | 1.0e-04 | -9.8 | 9.4 | 6.4e-21 | -0.96 | 0.05 | 0.95 | FALSE |
| 21 | The Cancer Genome Atlas | Lung Adenocarcinoma | DOCK7 | 0.04 | 0.01 | enet | 3 | 0.02 | 3.0e-03 | -9.8 | 9.8 | 1.7e-22 | -0.99 | 0.04 | 0.74 | FALSE |
| 22 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | DOCK7 | 0.08 | 0.05 | enet | 29 | 0.10 | 7.8e-05 | -9.8 | 8.8 | 1.0e-18 | -0.91 | 0.06 | 0.93 | FALSE |
| 23 | The Cancer Genome Atlas | Thyroid Carcinoma | DOCK7 | 0.05 | 0.03 | blup | 86 | 0.02 | 1.6e-03 | -8.2 | 9.9 | 6.2e-23 | -0.92 | 0.07 | 0.89 | TRUE |