TWAS
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Models
Genes
Traits
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Traits
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Medication: Simvastatin
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chr8:18,003,897-18,505,600
Best TWAS P=1.44e-09 · Best GWAS P=7.37e-11 conditioned to 0.0155
18M
18.1M
18.2M
18.3M
18.4M
18.5M
0
2
4
6
8
10
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
The Cancer Genome Atlas
Kidney Renal Clear Cell Carcinoma
NAT2
0.04
0.04
lasso
2
0.03
0.00024
6.1
-6.0
1.4e-09
-0.94
0.02
0.96
TRUE
2
The Cancer Genome Atlas
Brain Lower Grade Glioma
NAT2
0.03
0.01
lasso
2
0.01
0.02340
5.1
-5.2
1.6e-07
-0.70
0.06
0.58
FALSE