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chr2:241,978,472-243,048,760

Best TWAS P=3.77e-09 · Best GWAS P=1.32e-08 conditioned to 0.793

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	D2HGDH	0.29	0.12	enet	6	0.14	1.2e-16	-5.7	5.9	3.8e-09	-0.92	0.00	1.00	TRUE
16	GTEx	Uterus	AC093642.3	0.35	-0.01	enet	25	0.07	1.8e-02	-3.0	-5.6	2.6e-08	0.46	0.02	0.26	TRUE
12	GTEx	Muscle Skeletal	D2HGDH	0.26	0.11	lasso	2	0.14	3.0e-13	-5.7	5.7	1.3e-08	-0.94	0.00	1.00	FALSE
9	GTEx	Cells Transformed fibroblasts	AC114730.8	0.32	0.12	lasso	4	0.16	4.5e-12	4.8	5.7	1.5e-08	-0.89	0.01	0.99	FALSE
7	GTEx	Breast Mammary Tissue (Male)	AC114730.7	0.30	0.17	lasso	3	0.20	2.8e-05	5.0	5.5	3.4e-08	-0.88	0.01	0.92	FALSE
6	GTEx	Breast Mammary Tissue (Male)	D2HGDH	0.43	0.24	lasso	6	0.20	1.9e-05	5.0	5.5	3.8e-08	-0.83	0.02	0.90	FALSE
8	GTEx	Cells Transformed fibroblasts	D2HGDH	0.44	0.27	lasso	11	0.30	1.2e-22	4.8	5.5	4.2e-08	-0.86	0.08	0.91	FALSE
4	GTEx	Brain Frontal Cortex BA9	D2HGDH	0.42	0.23	lasso	4	0.26	1.7e-07	4.8	5.4	5.2e-08	-0.90	0.01	0.98	FALSE
21	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	D2HGDH	0.06	0.02	blup	28	0.04	1.3e-05	-5.7	5.4	5.4e-08	-0.86	0.00	1.00	FALSE
20	ROSMAP	Brain Pre-frontal Cortex	D2HGDH	0.44	0.33	lasso	6	0.35	2.1e-46	4.8	5.4	5.6e-08	-0.74	0.09	0.90	FALSE
13	GTEx	Pancreas	D2HGDH	0.48	0.32	lasso	11	0.31	1.4e-13	5.0	5.4	7.7e-08	-0.74	0.04	0.95	FALSE
19	METSIM	Adipose	PDCD1	0.05	0.00	blup	171	0.02	1.9e-03	-5.7	-5.3	1.4e-07	0.44	0.00	0.91	FALSE
14	GTEx	Pancreas	AC114730.8	0.20	0.15	lasso	3	0.14	1.7e-06	5.0	5.2	1.6e-07	-0.73	0.03	0.90	FALSE
11	GTEx	Esophagus Mucosa	AC114730.7	0.31	0.18	enet	6	0.18	2.3e-12	5.0	5.2	1.7e-07	-0.81	0.06	0.94	FALSE
18	GTEx	Whole Blood	AC114730.7	0.11	0.08	lasso	3	0.08	4.1e-08	5.0	5.2	1.9e-07	-0.80	0.04	0.96	FALSE
15	GTEx	Testis	AC114730.8	0.18	0.04	enet	57	0.03	2.1e-02	5.0	5.2	2.0e-07	-0.45	0.01	0.87	FALSE
10	GTEx	Colon Transverse	D2HGDH	0.48	0.27	lasso	4	0.25	2.8e-12	4.8	5.2	2.1e-07	-0.80	0.05	0.94	FALSE
3	GTEx	Brain Cerebellar Hemisphere	AC114730.7	0.54	0.37	lasso	2	0.36	3.5e-10	4.8	5.2	2.2e-07	-0.85	0.06	0.94	FALSE
5	GTEx	Brain Hypothalamus	AC114730.7	0.55	0.21	enet	17	0.22	8.6e-06	4.8	5.1	2.6e-07	-0.73	0.06	0.79	FALSE
2	GTEx	Adipose Subcutaneous	AC114730.7	0.42	0.24	lasso	6	0.22	4.9e-18	5.0	5.1	2.9e-07	-0.81	0.04	0.96	FALSE
17	GTEx	Whole Blood	D2HGDH	0.12	0.08	lasso	3	0.08	5.7e-08	4.8	5.1	2.9e-07	-0.81	0.05	0.95	FALSE