Hub : Traits :

Medication: Ventolin 100micrograms inhaler

84 significantly associated models · 24 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 2 102118712 103767612 4 1 8.1e-23 1.6e-17 1.3e-01 97 IL1RL1
2 2 241978472 243048760 5 2 3.8e-09 1.3e-08 7.9e-01 100 AC093642.3 D2HGDH
3 4 122842267 123530993 1 1 1.2e-07 3.2e-07 7.5e-04 56 KIAA1109
4 9 5833337 7345304 1 1 2.2e-10 7.0e-21 2.1e-12 44 GLDC
5 13 40440805 41928314 1 1 3.0e-07 1.4e-05 7.7e-01 100 FOXO1
6 15 67111296 67736023 1 1 7.8e-09 4.6e-11 1.5e-03 77 SMAD3
7 17 37083464 39048774 11 1 1.7e-14 3.1e-14 1.0e+00 100 ORMDL3

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Bipolar Disorder or Schizophrenia 1.37 1 0 0.0 0.00 1.0e+00 ORMDL3
Crohns Disease (2017) 8.63 3 2 4.4 0.00 1.0e+00 KIAA1109 ORMDL3 SMAD3
Irritable Bowel Disease (IBD) 11.11 3 3 6.7 0.00 1.0e+00 KIAA1109 ORMDL3 SMAD3
Ulcerative Colitis (UC) 7.27 3 2 4.4 0.00 1.0e+00 KIAA1109 ORMDL3 SMAD3
Crohns Disease (2012) 7.82 3 1 2.2 0.00 1.0e+00 KIAA1109 ORMDL3 SMAD3
HDL Cholesterol 3.58 1 1 2.2 0.00 1.0e+00 ORMDL3
Lupus 2.52 1 0 0.0 0.00 1.0e+00 ORMDL3
Primary Biliary Cirrhosis 5.36 1 1 2.2 0.00 1.0e+00 ORMDL3
Rheumatoid Arthritis 5.70 2 0 0.0 0.00 1.0e+00 KIAA1109 ORMDL3
Ulcerative Colitis 8.86 3 2 4.4 0.00 1.0e+00 KIAA1109 ORMDL3 SMAD3
Blood Eosinophil Count 53.03 7 7 15.6 0.95 1.1e-03 AC093642.3 D2HGDH FOXO1 GLDC IL1RL1 KIAA1109 SMAD3
Blood Platelet Count 1.66 2 1 2.2 0.00 1.0e+00 FOXO1 ORMDL3
Blood Red Count 0.88 1 1 2.2 0.00 1.0e+00 FOXO1
Blood White Count 14.56 2 1 2.2 0.00 1.0e+00 IL1RL1 ORMDL3
Heel T-Score 0.47 1 0 0.0 0.00 1.0e+00 GLDC
Height 0.33 3 0 0.0 0.00 1.0e+00 FOXO1 IL1RL1 KIAA1109
Waist Hip Ratio (WHR) 0.59 1 0 0.0 0.00 1.0e+00 SMAD3
Allergy or Eczema 50.31 8 8 17.8 0.97 5.3e-05 AC093642.3 D2HGDH FOXO1 GLDC IL1RL1 KIAA1109 ORMDL3 SMAD3
Hypothyroidism (self reported) 2.34 1 0 0.0 0.00 1.0e+00 KIAA1109
Respiratory disease 66.23 8 7 15.6 0.98 1.2e-05 AC093642.3 D2HGDH FOXO1 GLDC IL1RL1 KIAA1109 ORMDL3 SMAD3
Lung FEV1/FVC ratio 5.39 6 3 6.7 -0.98 4.0e-04 D2HGDH FOXO1 GLDC IL1RL1 ORMDL3 SMAD3
Chronotype (morning person) 1.63 1 0 0.0 0.00 1.0e+00 KIAA1109
Leg fat-free mass (left) 0.50 1 0 0.0 0.00 1.0e+00 FOXO1
Taking other prescription medications 7.62 3 0 0.0 0.00 1.0e+00 D2HGDH IL1RL1 ORMDL3
Hayfever, allergic rhinitis or eczema 44.11 8 8 17.8 0.97 4.9e-05 AC093642.3 D2HGDH FOXO1 GLDC IL1RL1 KIAA1109 ORMDL3 SMAD3
Supplements: Glucosamine 1.81 1 0 0.0 0.00 1.0e+00 GLDC
Medication: Atenolol 3.20 1 0 0.0 0.00 1.0e+00 IL1RL1
Body mass index (BMI) 0.52 1 0 0.0 0.00 1.0e+00 FOXO1
Leg predicted mass (left) 0.53 1 0 0.0 0.00 1.0e+00 FOXO1
Trunk fat mass 0.45 1 0 0.0 0.00 1.0e+00 FOXO1
Waist circumference 0.82 1 0 0.0 0.00 1.0e+00 FOXO1
Past tobacco smoking 2.04 1 0 0.0 0.00 1.0e+00 GLDC
Allergy 60.41 8 8 17.8 -0.99 1.1e-06 AC093642.3 D2HGDH FOXO1 GLDC IL1RL1 KIAA1109 ORMDL3 SMAD3
Hayfever/allergic rhinitis (self-reported) 29.09 7 6 13.3 0.98 6.1e-05 AC093642.3 D2HGDH GLDC IL1RL1 KIAA1109 ORMDL3 SMAD3
Weight 0.60 1 0 0.0 0.00 1.0e+00 FOXO1
Impedance of arm (right) 0.79 1 0 0.0 0.00 1.0e+00 ORMDL3
Arm fat percentage (right) 0.56 1 0 0.0 0.00 1.0e+00 FOXO1
Trunk fat-free mass 0.43 1 0 0.0 0.00 1.0e+00 FOXO1
Hip circumference 0.74 1 0 0.0 0.00 1.0e+00 FOXO1
Mouth/teeth dental problems: Dentures 1.25 1 0 0.0 0.00 1.0e+00 ORMDL3
Asthma 63.43 8 7 15.6 0.98 1.3e-05 AC093642.3 D2HGDH FOXO1 GLDC IL1RL1 KIAA1109 ORMDL3 SMAD3
Arm fat mass (right) 0.65 1 0 0.0 0.00 1.0e+00 FOXO1
Trunk predicted mass 0.43 1 0 0.0 0.00 1.0e+00 FOXO1
Birth weight of first child 1.55 1 0 0.0 0.00 1.0e+00 SMAD3
Hypothyroidism/myxoedema (self-reported) 2.52 1 0 0.0 0.00 1.0e+00 KIAA1109
Birth weight 1.25 1 0 0.0 0.00 1.0e+00 SMAD3
Wheeze or whistling in the chest in last year 27.99 7 7 15.6 0.99 4.8e-06 AC093642.3 D2HGDH GLDC IL1RL1 KIAA1109 ORMDL3 SMAD3
Medication: Seretide 50 evohaler 13.05 4 1 2.2 0.98 1.6e-02 D2HGDH IL1RL1 KIAA1109 SMAD3
Whole body fat mass 0.59 1 0 0.0 0.00 1.0e+00 FOXO1
Leg fat mass (right) 0.56 1 0 0.0 0.00 1.0e+00 FOXO1
Chest pain or discomfort 4.45 2 0 0.0 0.00 1.0e+00 IL1RL1 ORMDL3
Supplements: Vitamin C 2.57 1 0 0.0 0.00 1.0e+00 ORMDL3
Whole body fat-free mass 0.47 1 0 0.0 0.00 1.0e+00 FOXO1
Leg fat-free mass (right) 0.44 1 0 0.0 0.00 1.0e+00 FOXO1
Arm fat percentage (left) 0.43 1 0 0.0 0.00 1.0e+00 FOXO1
Long-standing illness, disability or infirmity 2.97 1 0 0.0 0.00 1.0e+00 KIAA1109
Mouth/teeth dental problems: Mouth ulcers 1.85 1 0 0.0 0.00 1.0e+00 ORMDL3
Asthma (self-reported) 63.83 8 7 15.6 0.98 1.4e-05 AC093642.3 D2HGDH FOXO1 GLDC IL1RL1 KIAA1109 ORMDL3 SMAD3
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.14 1 0 0.0 0.00 1.0e+00 ORMDL3
Whole body water mass 0.45 1 0 0.0 0.00 1.0e+00 FOXO1
Leg predicted mass (right) 0.44 1 0 0.0 0.00 1.0e+00 FOXO1
Arm fat mass (left) 0.62 1 0 0.0 0.00 1.0e+00 FOXO1
Number of self-reported non-cancer illnesses 7.46 4 0 0.0 0.99 1.0e-02 D2HGDH IL1RL1 KIAA1109 ORMDL3
Ever smoked 2.10 1 0 0.0 0.00 1.0e+00 GLDC
Basal metabolic rate 0.51 1 0 0.0 0.00 1.0e+00 FOXO1
Arm fat-free mass (left) 0.55 1 0 0.0 0.00 1.0e+00 FOXO1
Myopia 1.91 1 0 0.0 0.00 1.0e+00 ORMDL3
Heart disease (siblings) 2.63 1 0 0.0 0.00 1.0e+00 SMAD3
Leg fat mass (left) 0.54 1 0 0.0 0.00 1.0e+00 FOXO1
Arm predicted mass (left) 0.59 1 0 0.0 0.00 1.0e+00 FOXO1

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 1 0.029 1.3
GTEx Adipose Visceral Omentum 0 0.000 1.3
GTEx Adrenal Gland 0 0.000 1.3
GTEx Artery Aorta 0 0.000 1.3
GTEx Artery Coronary 0 0.000 1.2
GTEx Artery Tibial 0 0.000 1.3
GTEx Brain Caudate basal ganglia 0 0.000 1.3
GTEx Brain Cerebellar Hemisphere 1 0.067 1.3
GTEx Brain Cerebellum 0 0.000 1.3
GTEx Brain Cortex 0 0.000 1.4
GTEx Brain Frontal Cortex BA9 1 0.108 1.4
GTEx Brain Hippocampus 0 0.000 1.2
GTEx Brain Hypothalamus 1 0.169 1.3
GTEx Brain Nucleus accumbens basal ganglia 1 0.116 1.5
GTEx Brain Putamen basal ganglia 0 0.000 1.4
GTEx Breast Mammary Tissue 1 0.051 1.3
GTEx Breast Mammary Tissue (Male) 2 0.168 1.3
GTEx Breast Mammary Tissue (Female) 0 0.000 1.2
GTEx Cells EBV-transformed lymphocytes 0 0.000 1.2
GTEx Cells Transformed fibroblasts 3 0.071 1.4
GTEx Colon Sigmoid 0 0.000 1.3
GTEx Colon Transverse 4 0.194 1.3
GTEx Esophagus Gastroesophageal Junction 0 0.000 1.3
GTEx Esophagus Mucosa 3 0.090 1.3
GTEx Esophagus Muscularis 1 0.031 1.3
GTEx Heart Atrial Appendage 2 0.127 1.3
GTEx Heart Left Ventricle 0 0.000 1.2
GTEx Liver 1 0.139 1.2
GTEx Lung 2 0.070 1.3
GTEx Muscle Skeletal 2 0.069 1.3
GTEx Nerve Tibial 0 0.000 1.3
GTEx Ovary 0 0.000 1.2
GTEx Pancreas 3 0.184 1.3
GTEx Pituitary 0 0.000 1.2
GTEx Prostate 1 0.120 1.2
GTEx Skin Not Sun Exposed Suprapubic 0 0.000 1.3
GTEx Skin Sun Exposed Lower leg 1 0.027 1.3
GTEx Small Intestine Terminal Ileum 0 0.000 1.3
GTEx Spleen 2 0.142 1.4
GTEx Stomach 0 0.000 1.2
GTEx Testis 1 0.032 1.3
GTEx Thyroid 1 0.025 1.3
GTEx Uterus 1 0.176 1.2
GTEx Vagina 0 0.000 1.2
GTEx Whole Blood 5 0.251 1.3
METSIM Adipose 3 0.065 1.3
NTR Blood 3 0.125 1.4
ROSMAP Brain Pre-frontal Cortex 3 0.068 1.3
YFS Blood 4 0.087 1.3
CommonMind Brain Pre-frontal Cortex 2 0.037 1.3
The Cancer Genome Atlas Bladder Urothelial Carcinoma 1 0.060 1.4
The Cancer Genome Atlas Breast Invasive Carcinoma 2 0.045 1.2
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Colon Adenocarcinoma 1 0.048 1.3
The Cancer Genome Atlas Esophageal Carcinoma 1 0.146 1.3
The Cancer Genome Atlas Glioblastoma Multiforme 0 0.000 1.3
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 1 0.037 1.3
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 4 0.098 1.3
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 1 0.049 1.4
The Cancer Genome Atlas Brain Lower Grade Glioma 1 0.023 1.3
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 0 0.000 1.4
The Cancer Genome Atlas Lung Adenocarcinoma 2 0.068 1.3
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 3 0.120 1.3
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Pancreatic Adenocarcinoma 2 0.120 1.4
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 0 0.000 1.3
The Cancer Genome Atlas Prostate Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Rectum Adenocarcinoma 2 0.289 1.4
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.2
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.4
The Cancer Genome Atlas Stomach Adenocarcinoma 3 0.178 1.3
The Cancer Genome Atlas Testicular Germ Cell Tumors 0 0.000 1.3
The Cancer Genome Atlas Thyroid Carcinoma 4 0.078 1.3
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.3