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Medication: Ventolin 100micrograms inhaler

84 significantly associated models · 24 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	2	102118712	103767612	4	1	8.1e-23	1.6e-17	1.3e-01	97	IL1RL1
2	2	241978472	243048760	5	2	3.8e-09	1.3e-08	7.9e-01	100	AC093642.3 D2HGDH
3	4	122842267	123530993	1	1	1.2e-07	3.2e-07	7.5e-04	56	KIAA1109
4	9	5833337	7345304	1	1	2.2e-10	7.0e-21	2.1e-12	44	GLDC
5	13	40440805	41928314	1	1	3.0e-07	1.4e-05	7.7e-01	100	FOXO1
6	15	67111296	67736023	1	1	7.8e-09	4.6e-11	1.5e-03	77	SMAD3
7	17	37083464	39048774	11	1	1.7e-14	3.1e-14	1.0e+00	100	ORMDL3

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr	corr P	genes
Respiratory disease	66.23	8	7	15.6	0.98	1.2e-05	AC093642.3 D2HGDH FOXO1 GLDC IL1RL1 KIAA1109 ORMDL3 SMAD3
Asthma (self-reported)	63.83	8	7	15.6	0.98	1.4e-05	AC093642.3 D2HGDH FOXO1 GLDC IL1RL1 KIAA1109 ORMDL3 SMAD3
Asthma	63.43	8	7	15.6	0.98	1.3e-05	AC093642.3 D2HGDH FOXO1 GLDC IL1RL1 KIAA1109 ORMDL3 SMAD3
Allergy	60.41	8	8	17.8	-0.99	1.1e-06	AC093642.3 D2HGDH FOXO1 GLDC IL1RL1 KIAA1109 ORMDL3 SMAD3
Blood Eosinophil Count	53.03	7	7	15.6	0.95	1.1e-03	AC093642.3 D2HGDH FOXO1 GLDC IL1RL1 KIAA1109 SMAD3
Allergy or Eczema	50.31	8	8	17.8	0.97	5.3e-05	AC093642.3 D2HGDH FOXO1 GLDC IL1RL1 KIAA1109 ORMDL3 SMAD3
Hayfever, allergic rhinitis or eczema	44.11	8	8	17.8	0.97	4.9e-05	AC093642.3 D2HGDH FOXO1 GLDC IL1RL1 KIAA1109 ORMDL3 SMAD3
Hayfever/allergic rhinitis (self-reported)	29.09	7	6	13.3	0.98	6.1e-05	AC093642.3 D2HGDH GLDC IL1RL1 KIAA1109 ORMDL3 SMAD3
Wheeze or whistling in the chest in last year	27.99	7	7	15.6	0.99	4.8e-06	AC093642.3 D2HGDH GLDC IL1RL1 KIAA1109 ORMDL3 SMAD3
Blood White Count	14.56	2	1	2.2	0.00	1.0e+00	IL1RL1 ORMDL3
Medication: Seretide 50 evohaler	13.05	4	1	2.2	0.98	1.6e-02	D2HGDH IL1RL1 KIAA1109 SMAD3
Irritable Bowel Disease (IBD)	11.11	3	3	6.7	0.00	1.0e+00	KIAA1109 ORMDL3 SMAD3
Ulcerative Colitis	8.86	3	2	4.4	0.00	1.0e+00	KIAA1109 ORMDL3 SMAD3
Crohns Disease (2017)	8.63	3	2	4.4	0.00	1.0e+00	KIAA1109 ORMDL3 SMAD3
Crohns Disease (2012)	7.82	3	1	2.2	0.00	1.0e+00	KIAA1109 ORMDL3 SMAD3
Taking other prescription medications	7.62	3	0	0.0	0.00	1.0e+00	D2HGDH IL1RL1 ORMDL3
Number of self-reported non-cancer illnesses	7.46	4	0	0.0	0.99	1.0e-02	D2HGDH IL1RL1 KIAA1109 ORMDL3
Ulcerative Colitis (UC)	7.27	3	2	4.4	0.00	1.0e+00	KIAA1109 ORMDL3 SMAD3
Rheumatoid Arthritis	5.70	2	0	0.0	0.00	1.0e+00	KIAA1109 ORMDL3
Lung FEV1/FVC ratio	5.39	6	3	6.7	-0.98	4.0e-04	D2HGDH FOXO1 GLDC IL1RL1 ORMDL3 SMAD3
Primary Biliary Cirrhosis	5.36	1	1	2.2	0.00	1.0e+00	ORMDL3
Chest pain or discomfort	4.45	2	0	0.0	0.00	1.0e+00	IL1RL1 ORMDL3
HDL Cholesterol	3.58	1	1	2.2	0.00	1.0e+00	ORMDL3
Medication: Atenolol	3.20	1	0	0.0	0.00	1.0e+00	IL1RL1
Long-standing illness, disability or infirmity	2.97	1	0	0.0	0.00	1.0e+00	KIAA1109
Heart disease (siblings)	2.63	1	0	0.0	0.00	1.0e+00	SMAD3
Supplements: Vitamin C	2.57	1	0	0.0	0.00	1.0e+00	ORMDL3
Lupus	2.52	1	0	0.0	0.00	1.0e+00	ORMDL3
Hypothyroidism/myxoedema (self-reported)	2.52	1	0	0.0	0.00	1.0e+00	KIAA1109
Hypothyroidism (self reported)	2.34	1	0	0.0	0.00	1.0e+00	KIAA1109
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.14	1	0	0.0	0.00	1.0e+00	ORMDL3
Ever smoked	2.10	1	0	0.0	0.00	1.0e+00	GLDC
Past tobacco smoking	2.04	1	0	0.0	0.00	1.0e+00	GLDC
Myopia	1.91	1	0	0.0	0.00	1.0e+00	ORMDL3
Mouth/teeth dental problems: Mouth ulcers	1.85	1	0	0.0	0.00	1.0e+00	ORMDL3
Supplements: Glucosamine	1.81	1	0	0.0	0.00	1.0e+00	GLDC
Blood Platelet Count	1.66	2	1	2.2	0.00	1.0e+00	FOXO1 ORMDL3
Chronotype (morning person)	1.63	1	0	0.0	0.00	1.0e+00	KIAA1109
Birth weight of first child	1.55	1	0	0.0	0.00	1.0e+00	SMAD3
Bipolar Disorder or Schizophrenia	1.37	1	0	0.0	0.00	1.0e+00	ORMDL3
Mouth/teeth dental problems: Dentures	1.25	1	0	0.0	0.00	1.0e+00	ORMDL3
Birth weight	1.25	1	0	0.0	0.00	1.0e+00	SMAD3
Blood Red Count	0.88	1	1	2.2	0.00	1.0e+00	FOXO1
Waist circumference	0.82	1	0	0.0	0.00	1.0e+00	FOXO1
Impedance of arm (right)	0.79	1	0	0.0	0.00	1.0e+00	ORMDL3
Hip circumference	0.74	1	0	0.0	0.00	1.0e+00	FOXO1
Arm fat mass (right)	0.65	1	0	0.0	0.00	1.0e+00	FOXO1
Arm fat mass (left)	0.62	1	0	0.0	0.00	1.0e+00	FOXO1
Weight	0.60	1	0	0.0	0.00	1.0e+00	FOXO1
Waist Hip Ratio (WHR)	0.59	1	0	0.0	0.00	1.0e+00	SMAD3
Whole body fat mass	0.59	1	0	0.0	0.00	1.0e+00	FOXO1
Arm predicted mass (left)	0.59	1	0	0.0	0.00	1.0e+00	FOXO1
Arm fat percentage (right)	0.56	1	0	0.0	0.00	1.0e+00	FOXO1
Leg fat mass (right)	0.56	1	0	0.0	0.00	1.0e+00	FOXO1
Arm fat-free mass (left)	0.55	1	0	0.0	0.00	1.0e+00	FOXO1
Leg fat mass (left)	0.54	1	0	0.0	0.00	1.0e+00	FOXO1
Leg predicted mass (left)	0.53	1	0	0.0	0.00	1.0e+00	FOXO1
Body mass index (BMI)	0.52	1	0	0.0	0.00	1.0e+00	FOXO1
Basal metabolic rate	0.51	1	0	0.0	0.00	1.0e+00	FOXO1
Leg fat-free mass (left)	0.50	1	0	0.0	0.00	1.0e+00	FOXO1
Heel T-Score	0.47	1	0	0.0	0.00	1.0e+00	GLDC
Whole body fat-free mass	0.47	1	0	0.0	0.00	1.0e+00	FOXO1
Trunk fat mass	0.45	1	0	0.0	0.00	1.0e+00	FOXO1
Whole body water mass	0.45	1	0	0.0	0.00	1.0e+00	FOXO1
Leg fat-free mass (right)	0.44	1	0	0.0	0.00	1.0e+00	FOXO1
Leg predicted mass (right)	0.44	1	0	0.0	0.00	1.0e+00	FOXO1
Trunk fat-free mass	0.43	1	0	0.0	0.00	1.0e+00	FOXO1
Trunk predicted mass	0.43	1	0	0.0	0.00	1.0e+00	FOXO1
Arm fat percentage (left)	0.43	1	0	0.0	0.00	1.0e+00	FOXO1
Height	0.33	3	0	0.0	0.00	1.0e+00	FOXO1 IL1RL1 KIAA1109

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Brain Nucleus accumbens basal ganglia	1	0.116	1.5
GTEx	Brain Cortex	0	0.000	1.4
GTEx	Brain Frontal Cortex BA9	1	0.108	1.4
GTEx	Brain Putamen basal ganglia	0	0.000	1.4
GTEx	Cells Transformed fibroblasts	3	0.071	1.4
GTEx	Spleen	2	0.142	1.4
NTR	Blood	3	0.125	1.4
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	1	0.060	1.4
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	1	0.049	1.4
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	0	0.000	1.4
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	2	0.120	1.4
The Cancer Genome Atlas	Rectum Adenocarcinoma	2	0.289	1.4
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.4
GTEx	Adipose Subcutaneous	1	0.029	1.3
GTEx	Adipose Visceral Omentum	0	0.000	1.3
GTEx	Adrenal Gland	0	0.000	1.3
GTEx	Artery Aorta	0	0.000	1.3
GTEx	Artery Tibial	0	0.000	1.3
GTEx	Brain Caudate basal ganglia	0	0.000	1.3
GTEx	Brain Cerebellar Hemisphere	1	0.067	1.3
GTEx	Brain Cerebellum	0	0.000	1.3
GTEx	Brain Hypothalamus	1	0.169	1.3
GTEx	Breast Mammary Tissue	1	0.051	1.3
GTEx	Breast Mammary Tissue (Male)	2	0.168	1.3
GTEx	Colon Sigmoid	0	0.000	1.3
GTEx	Colon Transverse	4	0.194	1.3
GTEx	Esophagus Gastroesophageal Junction	0	0.000	1.3
GTEx	Esophagus Mucosa	3	0.090	1.3
GTEx	Esophagus Muscularis	1	0.031	1.3
GTEx	Heart Atrial Appendage	2	0.127	1.3
GTEx	Lung	2	0.070	1.3
GTEx	Muscle Skeletal	2	0.069	1.3
GTEx	Nerve Tibial	0	0.000	1.3
GTEx	Pancreas	3	0.184	1.3
GTEx	Skin Not Sun Exposed Suprapubic	0	0.000	1.3
GTEx	Skin Sun Exposed Lower leg	1	0.027	1.3
GTEx	Small Intestine Terminal Ileum	0	0.000	1.3
GTEx	Testis	1	0.032	1.3
GTEx	Thyroid	1	0.025	1.3
GTEx	Whole Blood	5	0.251	1.3
METSIM	Adipose	3	0.065	1.3
ROSMAP	Brain Pre-frontal Cortex	3	0.068	1.3
YFS	Blood	4	0.087	1.3
CommonMind	Brain Pre-frontal Cortex	2	0.037	1.3
The Cancer Genome Atlas	Colon Adenocarcinoma	1	0.048	1.3
The Cancer Genome Atlas	Esophageal Carcinoma	1	0.146	1.3
The Cancer Genome Atlas	Glioblastoma Multiforme	0	0.000	1.3
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	1	0.037	1.3
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	4	0.098	1.3
The Cancer Genome Atlas	Brain Lower Grade Glioma	1	0.023	1.3
The Cancer Genome Atlas	Lung Adenocarcinoma	2	0.068	1.3
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	3	0.120	1.3
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	0	0.000	1.3
The Cancer Genome Atlas	Stomach Adenocarcinoma	3	0.178	1.3
The Cancer Genome Atlas	Testicular Germ Cell Tumors	0	0.000	1.3
The Cancer Genome Atlas	Thyroid Carcinoma	4	0.078	1.3
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.3
GTEx	Artery Coronary	0	0.000	1.2
GTEx	Brain Hippocampus	0	0.000	1.2
GTEx	Breast Mammary Tissue (Female)	0	0.000	1.2
GTEx	Cells EBV-transformed lymphocytes	0	0.000	1.2
GTEx	Heart Left Ventricle	0	0.000	1.2
GTEx	Liver	1	0.139	1.2
GTEx	Ovary	0	0.000	1.2
GTEx	Pituitary	0	0.000	1.2
GTEx	Prostate	1	0.120	1.2
GTEx	Stomach	0	0.000	1.2
GTEx	Uterus	1	0.176	1.2
GTEx	Vagina	0	0.000	1.2
The Cancer Genome Atlas	Breast Invasive Carcinoma	2	0.045	1.2
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Prostate Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.2