Best TWAS P=8.05e-23 · Best GWAS P=1.58e-17 conditioned to 0.126
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Colon Transverse | IL18R1 | 0.14 | 0.00 | enet | 41 | 0.00 | 2.1e-01 | 3.4 | 6.5 | 8.7e-11 | -0.33 | 0.06 | 0.27 | FALSE |
| 2 | GTEx | Whole Blood | IL18R1 | 0.06 | 0.00 | enet | 14 | 0.01 | 2.1e-02 | -8.2 | 5.5 | 4.0e-08 | -0.51 | 0.04 | 0.80 | FALSE |
| 3 | ROSMAP | Brain Pre-frontal Cortex | IL1RL2 | 0.08 | 0.02 | enet | 33 | 0.03 | 2.3e-04 | 3.4 | -6.1 | 1.2e-09 | 0.27 | 0.19 | 0.10 | FALSE |
| 4 | YFS | Blood | IL18RAP | 0.41 | 0.55 | bslmm | 562 | 0.62 | 4.2e-269 | 7.0 | -5.2 | 2.5e-07 | 0.46 | 1.00 | 0.00 | FALSE |
| 5 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | IL1RL1 | 0.04 | 0.03 | lasso | 7 | 0.03 | 8.1e-04 | -8.2 | -7.7 | 1.0e-14 | 0.67 | 0.02 | 0.92 | FALSE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | IL18R1 | 0.05 | 0.01 | blup | 108 | 0.03 | 1.8e-07 | -8.3 | 5.7 | 1.1e-08 | -0.43 | 0.02 | 0.98 | FALSE |
| 7 | The Cancer Genome Atlas | Breast Invasive Carcinoma | IL1RL1 | 0.02 | 0.01 | blup | 78 | 0.01 | 1.5e-03 | 7.3 | -7.5 | 6.3e-14 | 0.61 | 0.10 | 0.48 | FALSE |
| 8 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | IL1RL1 | 0.04 | 0.04 | lasso | 8 | 0.04 | 1.7e-05 | -8.5 | -9.5 | 1.7e-21 | 0.78 | 0.02 | 0.96 | FALSE |
| 9 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | IL18RAP | 0.03 | 0.02 | blup | 94 | 0.02 | 1.2e-03 | -8.3 | 8.6 | 9.6e-18 | -0.71 | 0.00 | 0.93 | FALSE |
| 10 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | IL1RL1 | 0.08 | 0.08 | enet | 9 | 0.08 | 1.2e-09 | -8.3 | -9.1 | 6.1e-20 | 0.71 | 0.01 | 0.99 | FALSE |
| 11 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | IL1RL2 | 0.04 | 0.04 | enet | 5 | 0.03 | 1.9e-04 | -6.7 | -6.9 | 6.9e-12 | 0.39 | 0.06 | 0.42 | FALSE |
| 12 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | IL1RL1 | 0.18 | 0.06 | blup | 78 | 0.15 | 3.7e-09 | 7.3 | -9.0 | 2.0e-19 | 0.64 | 0.03 | 0.97 | FALSE |
| 13 | The Cancer Genome Atlas | Lung Adenocarcinoma | IL1RL1 | 0.03 | 0.01 | blup | 78 | 0.02 | 4.7e-03 | -7.7 | -9.8 | 8.1e-23 | 0.77 | 0.02 | 0.88 | TRUE |
| 14 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | IL1RL1 | 0.19 | 0.05 | blup | 78 | 0.10 | 7.1e-05 | 7.5 | -9.0 | 3.1e-19 | 0.68 | 0.06 | 0.84 | FALSE |
| 15 | The Cancer Genome Atlas | Thyroid Carcinoma | IL1RL1 | 0.05 | 0.03 | enet | 6 | 0.03 | 9.7e-04 | -8.3 | -8.3 | 1.2e-16 | 0.66 | 0.02 | 0.98 | FALSE |