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chr15:89,680,384-91,135,411

Best TWAS P=3.27e-08 · Best GWAS P=5.15e-08 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Cells Transformed fibroblasts	AP3S2	0.22	0.16	lasso	5	0.18	4.1e-13	5.3	5.2	1.6e-07	0.98	0.01	0.99	FALSE
2	GTEx	Esophagus Mucosa	AP3S2	0.19	0.16	lasso	1	0.15	4.0e-10	5.2	5.2	2.4e-07	0.96	0.00	0.99	FALSE
3	NTR	Blood	AP3S2	0.17	0.11	enet	26	0.14	2.7e-43	4.9	5.2	2.0e-07	0.90	0.01	0.99	FALSE
4	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	AP3S2	0.19	0.27	lasso	4	0.24	2.0e-20	5.2	5.2	2.6e-07	0.94	0.01	0.99	FALSE
5	The Cancer Genome Atlas	Breast Invasive Carcinoma	AP3S2	0.13	0.19	lasso	5	0.20	5.3e-40	5.3	5.2	1.6e-07	0.97	0.00	1.00	FALSE
6	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	AP3S2	0.23	0.27	lasso	1	0.26	3.8e-13	5.4	5.4	5.1e-08	1.00	0.00	1.00	FALSE
7	The Cancer Genome Atlas	Colon Adenocarcinoma	AP3S2	0.18	0.18	lasso	4	0.17	5.2e-10	5.4	5.5	3.3e-08	0.97	0.00	1.00	TRUE
8	The Cancer Genome Atlas	Esophageal Carcinoma	AP3S2	0.22	0.15	lasso	2	0.13	6.2e-05	5.4	5.4	5.3e-08	1.00	0.00	0.99	FALSE
9	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	AP3S2	0.15	0.24	enet	14	0.27	6.3e-30	5.4	5.2	1.5e-07	0.97	0.00	1.00	FALSE
10	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C15orf38	0.02	0.03	lasso	1	0.02	1.9e-03	5.3	-5.3	1.3e-07	-0.98	0.00	0.94	FALSE
11	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	AP3S2	0.27	0.38	lasso	4	0.39	3.1e-47	4.9	5.2	2.6e-07	0.98	0.02	0.98	FALSE
12	The Cancer Genome Atlas	Brain Lower Grade Glioma	AP3S2	0.23	0.27	lasso	6	0.30	3.2e-34	5.3	5.3	8.8e-08	0.97	0.01	0.99	FALSE
13	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	AP3S2	0.27	0.22	lasso	5	0.23	3.0e-11	5.2	5.2	2.0e-07	0.97	0.00	1.00	FALSE
14	The Cancer Genome Atlas	Lung Adenocarcinoma	AP3S2	0.22	0.38	lasso	4	0.39	2.3e-48	5.0	5.2	2.3e-07	0.97	0.02	0.98	FALSE
15	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	AP3S2	0.22	0.26	enet	18	0.30	1.6e-34	5.3	5.3	1.5e-07	0.95	0.01	0.99	FALSE
16	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	AP3S2	0.44	0.37	lasso	3	0.39	2.2e-17	4.9	5.1	2.7e-07	0.97	0.01	0.99	FALSE
17	The Cancer Genome Atlas	Prostate Adenocarcinoma	AP3S2	0.44	0.54	enet	13	0.55	3.3e-68	5.3	5.2	2.1e-07	0.98	0.00	1.00	FALSE
18	The Cancer Genome Atlas	Rectum Adenocarcinoma	AP3S2	0.18	0.19	lasso	5	0.15	2.1e-04	4.9	5.2	1.9e-07	0.98	0.01	0.91	FALSE
19	The Cancer Genome Atlas	Soft Tissue Sarcoma	AP3S2	0.14	0.18	enet	5	0.16	1.2e-09	5.2	5.3	1.2e-07	0.98	0.00	1.00	FALSE
20	The Cancer Genome Atlas	Stomach Adenocarcinoma	AP3S2	0.13	0.16	lasso	2	0.17	2.6e-12	5.2	5.2	1.6e-07	0.96	0.01	0.99	FALSE
21	The Cancer Genome Atlas	Thyroid Carcinoma	AP3S2	0.30	0.45	lasso	7	0.44	7.0e-47	4.9	5.1	2.9e-07	0.96	0.03	0.97	FALSE
22	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	AP3S2	0.26	0.25	lasso	4	0.25	1.4e-07	5.4	5.3	1.3e-07	0.99	0.01	0.99	FALSE