Best TWAS P=4.86e-15 · Best GWAS P=1.88e-15 conditioned to 4.47e-05
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 4 | GTEx | Muscle Skeletal | C1QTNF6 | 0.18 | 0.14 | lasso | 3 | 0.12 | 7.1e-12 | 7.6 | 7.8 | 4.9e-15 | 0.60 | 0.03 | 0.97 | TRUE |
| 5 | GTEx | Muscle Skeletal | RP1-151B14.6 | 0.21 | 0.14 | lasso | 4 | 0.12 | 3.0e-12 | 7.6 | 7.7 | 1.6e-14 | 0.58 | 0.03 | 0.97 | FALSE |
| 7 | GTEx | Whole Blood | RP1-151B14.6 | 0.10 | 0.07 | lasso | 2 | 0.04 | 6.4e-05 | 7.5 | 7.6 | 3.6e-14 | 0.58 | 0.04 | 0.96 | FALSE |
| 3 | GTEx | Liver | C1QTNF6 | 0.32 | 0.18 | lasso | 4 | 0.11 | 6.4e-04 | 7.6 | 7.2 | 7.9e-13 | 0.51 | 0.05 | 0.83 | FALSE |
| 2 | GTEx | Breast Mammary Tissue (Male) | RP1-151B14.6 | 0.23 | -0.01 | lasso | 4 | 0.01 | 1.4e-01 | 7.6 | 6.9 | 4.6e-12 | 0.45 | 0.06 | 0.14 | FALSE |
| 8 | The Cancer Genome Atlas | Breast Invasive Carcinoma | C1QTNF6 | 0.05 | 0.04 | lasso | 3 | 0.04 | 5.0e-09 | -6.0 | -6.0 | 1.5e-09 | -0.82 | 0.02 | 0.98 | FALSE |
| 1 | GTEx | Breast Mammary Tissue | RP1-151B14.6 | 0.18 | 0.07 | enet | 37 | 0.04 | 2.4e-03 | 7.6 | 5.4 | 5.6e-08 | 0.22 | 0.04 | 0.83 | FALSE |
| 6 | GTEx | Whole Blood | C1QTNF6 | 0.18 | 0.12 | enet | 20 | 0.16 | 7.8e-15 | 7.6 | 5.3 | 9.1e-08 | 0.18 | 0.03 | 0.97 | FALSE |