Hub : Traits :

Medication: Levothyroxine sodium

386 significantly associated models · 95 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 752566 1941929 1 1 2.3e-08 1.0e-07 1.4e-01 92 PUSL1
2 1 2288852 2761863 1 1 2.2e-08 4.4e-07 1.1e-01 90 MMEL1
3 1 18972776 20503710 1 1 1.3e-08 7.7e-08 4.0e-05 42 CAPZB
4 1 107418424 109188382 1 2 2.9e-29 2.1e-29 1.0e+00 100 VAV3
5 1 113236087 115222434 10 8 9.3e-37 9.0e-84 NaN NaN BCL2L15 DCLRE1B HIPK1 OLFML3 PHTF1 PTPN22
6 2 190818878 192254289 1 1 7.4e-08 8.4e-19 3.7e-15 21 NAB1
7 3 11350553 12928762 2 1 1.6e-08 1.0e-07 1.0e+00 100 TIMP4
8 4 148303195 150060844 1 1 1.7e-15 1.6e-16 1.0e+00 100 NR3C2
9 5 101392473 103061825 1 1 6.0e-09 4.2e-09 1.1e-01 93 PAM
10 6 25296606 26689223 1 1 1.3e-08 6.0e-14 1.4e-08 43 U91328.19
11 6 34026489 35542476 2 1 3.9e-08 1.5e-08 1.2e-01 92 UHRF1BP1
12 6 89941356 91704536 1 1 6.2e-25 4.0e-25 1.0e+00 100 BACH2
13 6 166651581 167841508 5 8 3.4e-20 3.6e-20 1.0e+00 100 AL133458.1 GPR31 RNASET2
14 7 99591418 100979310 1 1 2.2e-07 2.9e-07 1.0e+00 100 GIGYF1
15 8 8092025 8939373 4 1 2.9e-10 7.2e-12 1.0e+00 100 SGK223
16 8 60736025 62220903 1 1 8.8e-08 9.3e-08 1.0e+00 100 RAB2A
17 8 133633829 134394277 1 1 2.8e-07 2.0e-09 2.2e-04 62 TG
18 9 99581811 102081250 8 12 1.4e-38 2.8e-51 NaN NaN ANP32B C9orf156 COL15A1 FOXE1 NCBP1 TMOD1 TSTD2
19 10 5027660 6504126 2 2 5.5e-13 8.8e-14 1.1e-02 88 FAM208B IL15RA
20 11 35028935 35689490 1 1 1.1e-13 2.0e-15 2.7e-04 79 SLC1A2
21 11 60549966 62346131 7 1 4.7e-09 1.7e-08 7.2e-01 100 FADS2
22 12 55677395 57125879 5 1 2.6e-10 3.5e-10 1.0e+00 100 RAB5B
23 12 110233500 113517494 20 8 3.3e-38 1.7e-63 NaN NaN ADAM1A ALDH2 HECTD4 RP3-462E2.3 VPS29
24 15 38088200 39556796 1 1 4.7e-12 1.7e-13 1.0e+00 100 RASGRP1
25 17 39589083 41265776 3 1 1.6e-11 1.4e-11 1.0e+00 100 HSPB9
26 17 44788310 46474610 4 2 5.0e-10 2.4e-10 4.6e-04 69 EFCAB13 NPEPPS
27 19 4118871 5529588 2 2 7.2e-10 3.2e-16 2.2e-06 66 FEM1A TICAM1
28 19 49279612 50652095 1 1 3.1e-07 5.6e-07 1.3e-02 76 ALDH16A1
29 22 30233446 30820707 1 1 3.9e-08 4.3e-10 1.6e-03 74 HORMAD2
30 22 36867133 38292974 2 1 4.9e-15 1.9e-15 4.5e-05 74 C1QTNF6

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Bipolar Disorder (2018) 1.18 1 0 0.0 0.00 1.0e+00 FADS2
Bipolar Disorder or Schizophrenia 1.32 1 0 0.0 0.00 1.0e+00 SGK223
Depressed Affect (Nagel 2018) 2.02 2 0 0.0 0.00 1.0e+00 HECTD4 HORMAD2
Intelligence (Savage-Jansen 2018) 0.80 3 0 0.0 0.00 1.0e+00 FADS2 PAM RAB5B
Neuroticism (Nagel 2018) 2.13 4 0 0.0 0.99 1.5e-04 AL133458.1 HORMAD2 RNASET2 TIMP4
Schizophrenia (2018) 1.30 1 0 0.0 0.00 1.0e+00 U91328.19
Schizophrenia vs Biploar Disorder 1.01 1 0 0.0 0.00 1.0e+00 VPS29
Worry (Nagel 2018) 1.78 5 0 0.0 0.67 2.2e-01 HORMAD2 PAM RNASET2 TIMP4 U91328.19
Crohns Disease (2017) 5.00 10 3 6.7 0.11 7.2e-01 AL133458.1 BCL2L15 DCLRE1B FADS2 GIGYF1 GPR31 HIPK1 HORMAD2 PTPN22 RNASET2
Irritable Bowel Disease (IBD) 3.25 4 2 4.4 0.90 6.5e-03 AL133458.1 HECTD4 HORMAD2 RNASET2
Reaction Time 2.47 4 2 4.4 0.75 8.4e-02 ALDH2 HECTD4 RAB5B RP3-462E2.3
Verbal and Numeric Reasoning (VNR) 1.18 3 0 0.0 0.00 1.0e+00 FADS2 PAM RAB5B
Breast Cancer 1.40 4 2 4.4 -0.98 3.0e-03 BCL2L15 DCLRE1B PHTF1 PTPN22
Coronary Artery Disease (CAD) 2.80 3 0 0.0 0.95 5.3e-02 HECTD4 UHRF1BP1 VPS29
Crohns Disease (2012) 4.28 5 2 4.4 0.20 6.4e-01 AL133458.1 FADS2 HIPK1 HORMAD2 RNASET2
Fasting Glucose 1.51 1 0 0.0 0.00 1.0e+00 FADS2
HbA1C 1.13 1 0 0.0 0.00 1.0e+00 ADAM1A
HDL Cholesterol 1.99 2 1 2.2 0.00 1.0e+00 FADS2 UHRF1BP1
LDL Cholesterol 2.73 3 2 4.4 0.86 6.2e-02 ALDH2 FADS2 HECTD4
Lupus 3.48 4 1 2.2 0.78 1.2e-01 DCLRE1B HECTD4 NAB1 SGK223
Neuroticism (2016) 1.63 1 1 2.2 0.00 1.0e+00 SGK223
Primary Biliary Cirrhosis 3.15 3 0 0.0 0.86 1.4e-01 HECTD4 MMEL1 NAB1
Rheumatoid Arthritis 12.81 13 8 17.8 0.94 2.3e-07 BCL2L15 DCLRE1B FAM208B GPR31 HECTD4 HIPK1 MMEL1 NAB1 OLFML3 PAM PHTF1 PTPN22 RASGRP1
Schizophrenia (2014) 1.05 2 0 0.0 0.00 1.0e+00 GIGYF1 SGK223
Triglycerides 1.90 1 1 2.2 0.00 1.0e+00 FADS2
Blood Eosinophil Count 12.02 17 13 28.9 0.72 3.0e-04 ADAM1A ALDH2 BACH2 EFCAB13 FADS2 FAM208B GIGYF1 GPR31 HECTD4 NAB1 NPEPPS RAB5B RASGRP1 RP3-462E2.3 SLC1A2 TIMP4 VPS29
Blood Platelet Count 6.36 15 10 22.2 0.28 2.2e-01 ADAM1A C1QTNF6 C9orf156 CAPZB FADS2 FOXE1 HECTD4 NAB1 PAM RP3-462E2.3 TIMP4 TMOD1 TSTD2 UHRF1BP1 VPS29
Blood Red Count 2.96 15 11 24.4 0.59 1.0e-02 ADAM1A ALDH2 ANP32B BACH2 C9orf156 FADS2 GIGYF1 HECTD4 NAB1 NPEPPS PAM RAB5B RP3-462E2.3 TG VPS29
Blood White Count 5.85 18 15 33.3 0.37 8.3e-02 ADAM1A ALDH2 BACH2 BCL2L15 DCLRE1B FADS2 HECTD4 HORMAD2 HSPB9 OLFML3 PAM PHTF1 PTPN22 RAB2A RNASET2 RP3-462E2.3 TIMP4 VPS29
Heel T-Score 0.84 8 4 8.9 0.09 8.3e-01 ANP32B BACH2 CAPZB DCLRE1B FADS2 NAB1 PUSL1 RAB5B
BMI 1.33 4 2 4.4 -0.54 3.5e-01 HECTD4 RAB5B UHRF1BP1 VPS29
Height 1.21 20 16 35.6 -0.51 7.0e-03 ADAM1A ALDH2 ANP32B C9orf156 CAPZB COL15A1 EFCAB13 FADS2 HECTD4 HORMAD2 HSPB9 NAB1 NCBP1 NPEPPS NR3C2 PAM PUSL1 RP3-462E2.3 SLC1A2 UHRF1BP1
Waist Hip Ratio (WHR) 1.26 6 4 8.9 0.65 1.6e-01 ADAM1A BACH2 HECTD4 PAM TIMP4 UHRF1BP1
Systolic Blood Pressure 2.42 7 7 15.6 0.87 2.3e-03 ADAM1A ALDH2 HECTD4 NAB1 PUSL1 RP3-462E2.3 VPS29
Smoking Status 1.22 3 1 2.2 0.00 1.0e+00 ADAM1A PTPN22 RAB5B
Allergy or Eczema 2.23 5 4 8.9 -0.38 4.5e-01 ADAM1A BACH2 COL15A1 HECTD4 RAB5B
Cardiovascular Disease 2.20 6 3 6.7 0.82 1.2e-02 ADAM1A ALDH2 HECTD4 RAB5B UHRF1BP1 VPS29
Hypothyroidism (self reported) 40.36 48 44 97.8 0.99 2.5e-57 ADAM1A AL133458.1 ALDH16A1 ALDH2 ANP32B BACH2 BCL2L15 C1QTNF6 C9orf156 CAPZB DCLRE1B EFCAB13 FADS2 FAM208B FEM1A FOXE1 GIGYF1 GPR31 HECTD4 HIPK1 HORMAD2 HSPB9 IL15RA MMEL1 NAB1 NCBP1 NPEPPS NR3C2 OLFML3 PAM PHTF1 PTPN22 PUSL1 RAB2A RAB5B RASGRP1 RNASET2 RP3-462E2.3 SGK223 SLC1A2 TG TICAM1 TIMP4 TMOD1 TSTD2 UHRF1BP1 VAV3 VPS29
Respiratory disease 2.27 4 3 6.7 -0.98 1.7e-02 BACH2 FADS2 FAM208B RAB5B
Type 2 Diabetes (T2D) (2018) 1.70 2 0 0.0 0.00 1.0e+00 ADAM1A PAM
Lung FEV1/FVC ratio 1.16 5 3 6.7 -0.65 2.4e-01 ANP32B C9orf156 NCBP1 RAB5B SLC1A2
Lung FVC 1.16 7 1 2.2 0.13 7.7e-01 ALDH2 HECTD4 HORMAD2 HSPB9 PAM RAB5B RP3-462E2.3
Neuroticism 1.80 4 0 0.0 0.43 5.7e-01 AL133458.1 C9orf156 HORMAD2 TIMP4
Chronotype (morning person) 1.45 4 0 0.0 0.48 4.1e-01 ALDH2 HECTD4 HORMAD2 TIMP4
Hair Pigment 0.54 9 7 15.6 0.33 2.2e-01 ALDH2 ANP32B C9orf156 EFCAB13 FADS2 GIGYF1 HECTD4 RP3-462E2.3 TSTD2
Tanning 0.30 3 0 0.0 0.98 2.2e-02 ALDH2 HECTD4 RP3-462E2.3
Number of treatments/medications taken 3.73 9 2 4.4 0.98 4.6e-09 ADAM1A AL133458.1 BCL2L15 DCLRE1B FADS2 FAM208B HECTD4 PTPN22 RNASET2
Sensitivity / hurt feelings 1.59 1 1 2.2 0.00 1.0e+00 SGK223
Frequency of depressed mood in last 2 weeks 1.22 1 0 0.0 0.00 1.0e+00 HSPB9
Other serious medical condition/disability diagnosed by doctor 2.51 1 0 0.0 0.00 1.0e+00 DCLRE1B
Systolic blood pressure, automated reading 1.71 5 4 8.9 0.19 6.8e-01 ALDH2 HECTD4 NAB1 PUSL1 SGK223
Vitamin and mineral supplements 1.26 1 0 0.0 0.00 1.0e+00 U91328.19
Impedance of leg (right) 1.16 4 3 6.7 0.57 4.3e-01 PAM RAB5B SGK223 UHRF1BP1
Leg fat-free mass (left) 1.86 10 8 17.8 -0.45 1.6e-01 ALDH2 ANP32B EFCAB13 HECTD4 HORMAD2 RAB5B SGK223 U91328.19 UHRF1BP1 VPS29
Trunk fat percentage 1.38 2 2 4.4 0.00 1.0e+00 U91328.19 UHRF1BP1
Fed-up feelings 2.14 4 1 2.2 -0.78 6.6e-02 ALDH2 HECTD4 HORMAD2 SGK223
Relative age voice broke 0.97 1 0 0.0 0.00 1.0e+00 ADAM1A
Taking other prescription medications 6.41 11 7 15.6 0.98 7.8e-10 ADAM1A AL133458.1 BCL2L15 DCLRE1B FAM208B HECTD4 HIPK1 HSPB9 PTPN22 RNASET2 UHRF1BP1
Heel bone mineral density (BMD) T-score, automated (left) 1.74 3 1 2.2 0.00 1.0e+00 FADS2 SGK223 U91328.19
Serious illness, injury or assault to yourself 1.26 1 0 0.0 0.00 1.0e+00 PTPN22
High blood pressure 2.05 5 3 6.7 0.28 5.5e-01 ADAM1A ALDH2 HECTD4 RAB5B SGK223
Hayfever, allergic rhinitis or eczema 2.41 6 3 6.7 -0.36 4.8e-01 ADAM1A BACH2 COL15A1 HECTD4 RAB5B U91328.19
Medication: Atenolol 2.46 2 1 2.2 0.00 1.0e+00 ALDH2 HECTD4
Sitting height 1.00 8 4 8.9 -0.32 4.1e-01 ANP32B C9orf156 CAPZB COL15A1 FADS2 HORMAD2 U91328.19 UHRF1BP1
Body mass index (BMI) 1.80 6 4 8.9 -0.38 4.6e-01 HECTD4 RAB5B SGK223 U91328.19 UHRF1BP1 VPS29
Impedance of leg (left) 1.09 4 3 6.7 0.56 4.4e-01 PAM RAB5B SGK223 UHRF1BP1
Leg predicted mass (left) 1.86 10 7 15.6 -0.45 1.7e-01 ALDH2 ANP32B EFCAB13 HECTD4 HORMAD2 RAB5B SGK223 U91328.19 UHRF1BP1 VPS29
Trunk fat mass 1.70 3 2 4.4 0.00 1.0e+00 ANP32B U91328.19 UHRF1BP1
Waist circumference 1.35 5 2 4.4 -0.51 3.9e-01 ALDH2 HECTD4 RAB5B U91328.19 UHRF1BP1
Past tobacco smoking 1.88 5 0 0.0 0.16 7.6e-01 ADAM1A ALDH2 HECTD4 PTPN22 RAB5B
Nervous feelings 1.62 3 2 4.4 0.00 1.0e+00 HORMAD2 SGK223 U91328.19
Hearing difficulty/problems with background noise 1.04 1 0 0.0 0.00 1.0e+00 U91328.19
Forced vital capacity (FVC) 0.89 2 1 2.2 0.00 1.0e+00 HORMAD2 RAB5B
Heel bone mineral density (BMD) T-score, automated (right) 1.74 4 1 2.2 -0.39 6.1e-01 CAPZB FADS2 SGK223 U91328.19
Ever unenthusiastic/disinterested for a whole week 1.71 1 0 0.0 0.00 1.0e+00 TIMP4
Qualifications: None of the above 1.07 1 1 2.2 0.00 1.0e+00 RAB5B
Allergy 1.97 6 3 6.7 0.13 8.1e-01 ADAM1A BACH2 COL15A1 FADS2 RAB5B U91328.19
Diabetes (self-reported) 1.88 1 0 0.0 0.00 1.0e+00 PTPN22
Hayfever/allergic rhinitis (self-reported) 1.96 2 0 0.0 0.00 1.0e+00 RAB5B U91328.19
Medication: Ramipril 1.50 1 0 0.0 0.00 1.0e+00 ADAM1A
Medication: Simvastatin 1.05 1 0 0.0 0.00 1.0e+00 FADS2
Fluid intelligence score 1.05 2 0 0.0 0.00 1.0e+00 FADS2 RAB5B
Illnesses of siblings 1.26 2 0 0.0 0.00 1.0e+00 ADAM1A HECTD4
Neuroticism score 2.38 4 1 2.2 0.53 4.7e-01 HORMAD2 SGK223 TIMP4 U91328.19
Weight 2.07 9 5 11.1 -0.53 1.1e-01 ALDH2 ANP32B HECTD4 HORMAD2 RAB5B SGK223 U91328.19 UHRF1BP1 VPS29
Impedance of arm (right) 1.39 7 4 8.9 0.55 2.0e-01 ADAM1A HECTD4 NR3C2 RAB5B SGK223 UHRF1BP1 VPS29
Arm fat percentage (right) 1.29 3 2 4.4 0.00 1.0e+00 SGK223 U91328.19 UHRF1BP1
Trunk fat-free mass 1.71 11 7 15.6 -0.72 5.4e-03 ADAM1A ALDH2 ANP32B HECTD4 HORMAD2 PUSL1 RAB5B RP3-462E2.3 U91328.19 UHRF1BP1 VPS29
Hip circumference 2.24 9 5 11.1 -0.40 2.3e-01 ALDH2 EFCAB13 HECTD4 RAB5B RP3-462E2.3 SGK223 U91328.19 UHRF1BP1 VPS29
Father's age at death 1.62 1 0 0.0 0.00 1.0e+00 HECTD4
Worrier / anxious feelings 1.82 2 1 2.2 0.00 1.0e+00 PAM SGK223
Frequency of tiredness / lethargy in last 2 weeks 1.52 1 0 0.0 0.00 1.0e+00 ALDH2
Number of live births 1.79 2 0 0.0 0.00 1.0e+00 FADS2 HORMAD2
Forced expiratory volume in 1-second (FEV1) 1.10 4 2 4.4 -0.59 4.1e-01 HORMAD2 RAB5B SGK223 U91328.19
Pulse rate 1.88 2 2 4.4 0.00 1.0e+00 FADS2 GIGYF1
Qualifications: A levels/AS levels or equivalent 1.28 1 0 0.0 0.00 1.0e+00 RAB5B
Mouth/teeth dental problems: Dentures 1.35 2 1 2.2 0.00 1.0e+00 SGK223 U91328.19
Asthma 1.99 3 3 6.7 0.00 1.0e+00 BACH2 FADS2 RAB5B
Medication: Ibuprofen (e.g. Nurofen) 1.59 1 0 0.0 0.00 1.0e+00 HECTD4
Forced expiratory volume in 1-second (FEV1), Best measure 0.95 3 1 2.2 0.00 1.0e+00 HORMAD2 RAB5B SGK223
Pulse wave Arterial Stiffness index 1.70 1 1 2.2 0.00 1.0e+00 ADAM1A
Impedance of arm (left) 1.41 8 4 8.9 0.66 5.5e-02 ADAM1A HECTD4 NR3C2 RAB5B RP3-462E2.3 SGK223 UHRF1BP1 VPS29
Arm fat mass (right) 1.73 5 4 8.9 -0.41 4.9e-01 HECTD4 RAB5B SGK223 U91328.19 UHRF1BP1
Trunk predicted mass 1.73 12 7 15.6 -0.73 3.2e-03 ADAM1A ALDH2 ANP32B COL15A1 HECTD4 HORMAD2 PUSL1 RAB5B RP3-462E2.3 U91328.19 UHRF1BP1 VPS29
Standing height 1.24 14 9 20.0 -0.29 2.1e-01 ALDH2 ANP32B C9orf156 CAPZB COL15A1 EFCAB13 FADS2 HECTD4 HORMAD2 HSPB9 NAB1 NPEPPS SGK223 U91328.19
Exposure to tobacco smoke at home 1.18 1 0 0.0 0.00 1.0e+00 UHRF1BP1
Breastfed as a baby 1.45 1 1 2.2 0.00 1.0e+00 PUSL1
Tense / 'highly strung' 1.65 2 1 2.2 0.00 1.0e+00 SGK223 TIMP4
Hair/balding pattern: Pattern 4 0.81 1 0 0.0 0.00 1.0e+00 FADS2
Birth weight of first child 2.74 6 1 2.2 -0.72 4.3e-02 ADAM1A ALDH2 HECTD4 RAB2A RAB5B RP3-462E2.3
Peak expiratory flow (PEF) 1.18 2 2 4.4 0.00 1.0e+00 PUSL1 SGK223
Medication: Paracetamol 1.51 1 0 0.0 0.00 1.0e+00 RAB5B
Headache pain in last month 1.97 4 1 2.2 -0.92 2.7e-02 ALDH2 HECTD4 RAB5B U91328.19
Medication for cholesterol, blood pressure or diabetes 1.55 1 0 0.0 0.00 1.0e+00 ADAM1A
Gout (self-reported) 1.36 1 0 0.0 0.00 1.0e+00 HECTD4
Hypothyroidism/myxoedema (self-reported) 34.42 50 46 102.2 1.00 2.3e-67 ADAM1A AL133458.1 ALDH16A1 ALDH2 ANP32B BACH2 BCL2L15 C1QTNF6 C9orf156 CAPZB COL15A1 DCLRE1B EFCAB13 FADS2 FAM208B FEM1A FOXE1 GIGYF1 GPR31 HECTD4 HIPK1 HORMAD2 HSPB9 IL15RA MMEL1 NAB1 NCBP1 NPEPPS NR3C2 OLFML3 PAM PHTF1 PTPN22 PUSL1 RAB2A RAB5B RASGRP1 RNASET2 RP3-462E2.3 SGK223 SLC1A2 TG TICAM1 TIMP4 TMOD1 TSTD2 U91328.19 UHRF1BP1 VAV3 VPS29
Medication: Ventolin 100micrograms inhaler 1.08 2 0 0.0 0.00 1.0e+00 BACH2 RAB5B
Birth weight 2.57 6 2 4.4 -0.97 2.6e-04 ADAM1A ALDH2 DCLRE1B HECTD4 HORMAD2 VPS29
High blood pressure (siblings) 1.46 1 0 0.0 0.00 1.0e+00 HECTD4
Forced vital capacity (FVC), Best measure 0.73 2 1 2.2 0.00 1.0e+00 HORMAD2 RAB5B
Body fat percentage 1.44 2 2 4.4 0.00 1.0e+00 U91328.19 UHRF1BP1
Leg fat percentage (right) 1.69 3 2 4.4 0.00 1.0e+00 SGK223 U91328.19 UHRF1BP1
Arm fat-free mass (right) 1.94 11 8 17.8 -0.69 1.4e-02 ADAM1A ALDH2 ANP32B HECTD4 HORMAD2 RAB5B RP3-462E2.3 SGK223 U91328.19 UHRF1BP1 VPS29
Comparative body size at age 10 1.24 4 2 4.4 -0.59 4.1e-01 HORMAD2 SGK223 U91328.19 UHRF1BP1
Worry too long after embarrassment 2.00 1 1 2.2 0.00 1.0e+00 SGK223
Seen a psychiatrist for nerves, anxiety, tension or depression 1.64 2 0 0.0 0.00 1.0e+00 TIMP4 U91328.19
Wheeze or whistling in the chest in last year 1.07 1 0 0.0 0.00 1.0e+00 FADS2
Age at first live birth 1.13 1 0 0.0 0.00 1.0e+00 RAB5B
Pulse wave peak to peak time 1.69 1 1 2.2 0.00 1.0e+00 ADAM1A
Qualifications: College or University degree 1.00 3 1 2.2 0.00 1.0e+00 PAM RAB5B U91328.19
Emphysema/chronic bronchitis 1.68 1 0 0.0 0.00 1.0e+00 SGK223
Medication for pain relief, constipation, heartburn 1.70 1 1 2.2 0.00 1.0e+00 UHRF1BP1
Medication: Blood pressure 1.72 3 1 2.2 0.88 1.2e-01 ADAM1A ALDH2 HECTD4
Medication: Omeprazole 1.51 1 0 0.0 0.00 1.0e+00 UHRF1BP1
Mean time to correctly identify matches 2.25 3 2 4.4 0.98 3.2e-03 ALDH2 HECTD4 RP3-462E2.3
Whole body fat mass 1.77 8 2 4.4 -0.36 3.9e-01 ALDH2 ANP32B HECTD4 RAB5B SGK223 U91328.19 UHRF1BP1 VPS29
Leg fat mass (right) 1.97 7 3 6.7 -0.47 2.4e-01 ALDH2 HECTD4 RAB5B SGK223 U91328.19 UHRF1BP1 VPS29
Arm predicted mass (right) 1.98 11 8 17.8 -0.68 1.5e-02 ADAM1A ALDH2 ANP32B HECTD4 HORMAD2 RAB5B RP3-462E2.3 SGK223 U91328.19 UHRF1BP1 VPS29
Pulse rate, automated reading 2.48 6 3 6.7 -0.51 3.0e-01 FADS2 GIGYF1 NAB1 RAB5B UHRF1BP1 VPS29
Alcohol intake frequency. 0.97 2 0 0.0 0.00 1.0e+00 NPEPPS RAB5B
Comparative height size at age 10 1.63 7 4 8.9 -0.95 1.4e-07 ALDH2 ANP32B C9orf156 CAPZB HECTD4 HORMAD2 NR3C2
Suffer from 'nerves' 1.73 1 0 0.0 0.00 1.0e+00 SGK223
Overall health rating 1.59 4 0 0.0 0.46 5.4e-01 BCL2L15 PTPN22 SGK223 UHRF1BP1
Qualifications: NVQ or HND or HNC or equivalent 1.49 1 0 0.0 0.00 1.0e+00 ALDH2
Supplements: Vitamin C 1.30 1 0 0.0 0.00 1.0e+00 U91328.19
Hypertension (Self-reported) 1.85 5 3 6.7 0.23 6.2e-01 ADAM1A ALDH2 HECTD4 RAB5B SGK223
Illnesses of father: Heart disease 1.63 1 0 0.0 0.00 1.0e+00 HECTD4
Smoking status: Previous 1.91 3 0 0.0 0.74 1.5e-01 ALDH2 HECTD4 RAB5B
Whole body fat-free mass 1.82 13 6 13.3 -0.57 3.2e-02 ADAM1A ALDH2 ANP32B EFCAB13 HECTD4 HORMAD2 PUSL1 RAB5B RP3-462E2.3 SGK223 U91328.19 UHRF1BP1 VPS29
Leg fat-free mass (right) 1.85 9 8 17.8 -0.43 2.2e-01 ANP32B EFCAB13 HECTD4 HORMAD2 RAB5B SGK223 U91328.19 UHRF1BP1 VPS29
Arm fat percentage (left) 1.32 3 3 6.7 0.00 1.0e+00 SGK223 U91328.19 UHRF1BP1
Mood swings 1.66 2 1 2.2 0.00 1.0e+00 HORMAD2 SGK223
Loneliness, isolation 2.30 1 0 0.0 0.00 1.0e+00 RNASET2
Long-standing illness, disability or infirmity 3.88 7 2 4.4 0.99 2.7e-08 AL133458.1 BCL2L15 DCLRE1B FAM208B PTPN22 RNASET2 UHRF1BP1
Diabetes diagnosed by doctor 2.03 1 0 0.0 0.00 1.0e+00 PTPN22
Friendships satisfaction 1.04 1 0 0.0 0.00 1.0e+00 VPS29
Mouth/teeth dental problems: Mouth ulcers 2.14 2 1 2.2 0.00 1.0e+00 FEM1A PAM
Medication for cholesterol 2.01 1 0 0.0 0.00 1.0e+00 HECTD4
Mineral and other dietary supplements 1.26 1 0 0.0 0.00 1.0e+00 SGK223
Asthma (self-reported) 2.10 3 3 6.7 0.00 1.0e+00 BACH2 FADS2 RAB5B
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.99 2 1 2.2 0.00 1.0e+00 RAB5B U91328.19
Whole body water mass 1.83 13 6 13.3 -0.58 3.0e-02 ADAM1A ALDH2 ANP32B EFCAB13 HECTD4 HORMAD2 PUSL1 RAB5B RP3-462E2.3 SGK223 U91328.19 UHRF1BP1 VPS29
Leg predicted mass (right) 1.85 9 8 17.8 -0.43 2.2e-01 ANP32B EFCAB13 HECTD4 HORMAD2 RAB5B SGK223 U91328.19 UHRF1BP1 VPS29
Arm fat mass (left) 1.71 5 4 8.9 -0.39 5.1e-01 HECTD4 RAB5B SGK223 U91328.19 UHRF1BP1
Number of self-reported non-cancer illnesses 3.54 6 1 2.2 0.98 1.5e-05 AL133458.1 ALDH2 FAM208B HECTD4 RNASET2 UHRF1BP1
Average weekly champagne plus white wine intake 1.19 1 0 0.0 0.00 1.0e+00 FADS2
Miserableness 2.08 2 1 2.2 0.00 1.0e+00 HORMAD2 SGK223
Guilty feelings 1.54 1 0 0.0 0.00 1.0e+00 SGK223
Medication: Blood pressure 2.04 3 2 4.4 0.76 1.4e-01 ALDH2 HECTD4 SGK223
Supplements: Fish oil (including cod liver oil) 1.31 1 0 0.0 0.00 1.0e+00 SGK223
High cholesterol (Self-reported) 1.28 1 0 0.0 0.00 1.0e+00 FADS2
Medication: Bendroflumethiazide 1.27 1 0 0.0 0.00 1.0e+00 SGK223
Medication: Lisinopril 1.64 1 0 0.0 0.00 1.0e+00 HECTD4
Ever smoked 1.69 2 0 0.0 0.00 1.0e+00 HECTD4 PTPN22
Basal metabolic rate 1.95 13 7 15.6 -0.55 4.2e-02 ADAM1A ALDH2 ANP32B EFCAB13 HECTD4 HORMAD2 PUSL1 RAB5B RP3-462E2.3 SGK223 U91328.19 UHRF1BP1 VPS29
Leg fat percentage (left) 1.72 3 2 4.4 0.00 1.0e+00 SGK223 U91328.19 UHRF1BP1
Arm fat-free mass (left) 2.00 11 9 20.0 -0.70 7.2e-03 ADAM1A ALDH2 ANP32B HECTD4 HORMAD2 RAB5B RP3-462E2.3 SGK223 U91328.19 UHRF1BP1 VPS29
Average weekly beer plus cider intake 1.16 1 0 0.0 0.00 1.0e+00 SGK223
Irritability 1.67 2 1 2.2 0.00 1.0e+00 FADS2 SGK223
Age started oral contraceptive pill 1.81 2 0 0.0 0.00 1.0e+00 RAB5B RNASET2
Diastolic blood pressure, automated reading 3.27 7 7 15.6 0.71 2.1e-02 ADAM1A ALDH2 GIGYF1 HECTD4 RP3-462E2.3 SGK223 VPS29
Unable to work because of sickness or disability 1.06 1 0 0.0 0.00 1.0e+00 UHRF1BP1
Commuting to job workplace: Cycle 1.19 1 0 0.0 0.00 1.0e+00 UHRF1BP1
Myopia 1.54 1 0 0.0 0.00 1.0e+00 FADS2
Vascular/heart problems diagnosed by doctor 2.08 5 4 8.9 -0.74 5.5e-02 ADAM1A ALDH2 HECTD4 SGK223 VPS29
Pain experienced in last month 1.35 3 0 0.0 0.00 1.0e+00 ALDH2 HECTD4 RAB5B
Impedance of whole body 1.26 6 4 8.9 0.72 1.1e-01 ADAM1A HECTD4 RAB5B SGK223 UHRF1BP1 VPS29
Leg fat mass (left) 2.00 6 3 6.7 -0.45 3.1e-01 HECTD4 RAB5B SGK223 U91328.19 UHRF1BP1 VPS29
Arm predicted mass (left) 2.03 11 8 17.8 -0.70 8.1e-03 ADAM1A ALDH2 ANP32B HECTD4 HORMAD2 RAB5B RP3-462E2.3 SGK223 U91328.19 UHRF1BP1 VPS29

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 6 0.172 1.7
GTEx Adipose Visceral Omentum 4 0.196 1.6
GTEx Adrenal Gland 4 0.275 1.8
GTEx Artery Aorta 3 0.101 1.7
GTEx Artery Coronary 4 0.338 1.7
GTEx Artery Tibial 10 0.266 1.8
GTEx Brain Caudate basal ganglia 1 0.109 1.7
GTEx Brain Cerebellar Hemisphere 7 0.470 1.9
GTEx Brain Cerebellum 7 0.353 1.9
GTEx Brain Cortex 3 0.290 1.7
GTEx Brain Frontal Cortex BA9 5 0.541 1.9
GTEx Brain Hippocampus 1 0.191 1.7
GTEx Brain Hypothalamus 1 0.169 1.5
GTEx Brain Nucleus accumbens basal ganglia 1 0.116 1.6
GTEx Brain Putamen basal ganglia 2 0.321 1.9
GTEx Breast Mammary Tissue 5 0.253 1.7
GTEx Breast Mammary Tissue (Male) 4 0.335 1.6
GTEx Breast Mammary Tissue (Female) 4 0.243 1.7
GTEx Cells EBV-transformed lymphocytes 1 0.070 1.7
GTEx Cells Transformed fibroblasts 10 0.238 1.7
GTEx Colon Sigmoid 4 0.274 1.7
GTEx Colon Transverse 10 0.484 1.7
GTEx Esophagus Gastroesophageal Junction 7 0.484 1.8
GTEx Esophagus Mucosa 7 0.211 1.7
GTEx Esophagus Muscularis 7 0.217 1.7
GTEx Heart Atrial Appendage 4 0.253 1.7
GTEx Heart Left Ventricle 5 0.327 1.6
GTEx Liver 1 0.139 1.7
GTEx Lung 8 0.278 1.8
GTEx Muscle Skeletal 9 0.311 1.7
GTEx Nerve Tibial 12 0.278 1.8
GTEx Ovary 4 0.441 1.8
GTEx Pancreas 2 0.123 1.6
GTEx Pituitary 2 0.179 1.7
GTEx Prostate 2 0.240 1.7
GTEx Skin Not Sun Exposed Suprapubic 8 0.325 1.8
GTEx Skin Sun Exposed Lower leg 10 0.275 1.7
GTEx Small Intestine Terminal Ileum 0 0.000 1.8
GTEx Spleen 1 0.071 1.7
GTEx Stomach 7 0.481 1.8
GTEx Testis 12 0.380 1.8
GTEx Thyroid 13 0.325 1.8
GTEx Uterus 2 0.353 1.9
GTEx Vagina 0 0.000 1.8
GTEx Whole Blood 7 0.351 1.9
METSIM Adipose 12 0.260 1.6
NTR Blood 6 0.250 1.9
ROSMAP Brain Pre-frontal Cortex 8 0.182 1.6
YFS Blood 11 0.238 1.8
CommonMind Brain Pre-frontal Cortex 12 0.223 1.6
The Cancer Genome Atlas Bladder Urothelial Carcinoma 3 0.181 1.6
The Cancer Genome Atlas Breast Invasive Carcinoma 11 0.250 1.7
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 2 0.182 1.6
The Cancer Genome Atlas Colon Adenocarcinoma 7 0.339 1.6
The Cancer Genome Atlas Esophageal Carcinoma 4 0.584 1.9
The Cancer Genome Atlas Glioblastoma Multiforme 3 0.294 1.6
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 7 0.257 1.7
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 3 0.073 1.5
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 4 0.195 1.6
The Cancer Genome Atlas Brain Lower Grade Glioma 9 0.209 1.7
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 4 0.362 1.7
The Cancer Genome Atlas Lung Adenocarcinoma 6 0.204 1.7
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 3 0.120 1.7
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 4 0.251 1.6
The Cancer Genome Atlas Pancreatic Adenocarcinoma 4 0.241 1.8
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 8 0.603 1.8
The Cancer Genome Atlas Prostate Adenocarcinoma 6 0.130 1.6
The Cancer Genome Atlas Rectum Adenocarcinoma 2 0.289 1.7
The Cancer Genome Atlas Soft Tissue Sarcoma 3 0.281 1.7
The Cancer Genome Atlas Skin Cutaneous Melanoma 1 0.187 1.6
The Cancer Genome Atlas Stomach Adenocarcinoma 2 0.119 1.6
The Cancer Genome Atlas Testicular Germ Cell Tumors 2 0.156 1.7
The Cancer Genome Atlas Thyroid Carcinoma 10 0.194 1.7
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 2 0.394 1.8