Best TWAS P=7.7e-12 · Best GWAS P=4e-11 conditioned to 0.25
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Esophagus Gastroesophageal Junction | RP11-181G12.2 | 0.16 | 0.02 | enet | 18 | 0.01 | 1.1e-01 | 6.6 | 6.8 | 7.7e-12 | 0.93 | 0.02 | 0.80 | TRUE |
| 2 | GTEx | Esophagus Muscularis | RP11-181G12.2 | 0.23 | 0.14 | lasso | 4 | 0.19 | 1.0e-11 | 5.8 | 6.0 | 1.8e-09 | 0.87 | 0.10 | 0.90 | FALSE |
| 3 | GTEx | Lung | AL590822.2 | 0.09 | 0.00 | lasso | 3 | 0.00 | 2.0e-01 | 5.1 | 5.8 | 9.1e-09 | 0.65 | 0.03 | 0.63 | FALSE |
| 4 | GTEx | Muscle Skeletal | RP11-181G12.2 | 0.12 | 0.13 | enet | 8 | 0.14 | 7.6e-14 | -4.8 | 5.4 | 7.7e-08 | 0.78 | 0.92 | 0.08 | FALSE |
| 5 | YFS | Blood | PUSL1 | 0.02 | 0.00 | blup | 139 | 0.01 | 8.6e-04 | 4.9 | -5.1 | 3.0e-07 | 0.03 | 0.00 | 0.45 | TRUE |
| 6 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | C1orf86 | 0.03 | 0.02 | blup | 49 | 0.01 | 1.3e-02 | 6.6 | 6.1 | 1.2e-09 | 0.96 | 0.01 | 0.87 | FALSE |
| 7 | The Cancer Genome Atlas | Prostate Adenocarcinoma | C1orf86 | 0.04 | 0.02 | lasso | 5 | 0.02 | 1.5e-03 | 6.6 | 5.6 | 2.1e-08 | 0.92 | 0.01 | 0.79 | FALSE |