TWAS hub - PUSL1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Testis	0.1900	0.0600	2.5e-04	0.022	NA	0.040	NA	0.047	3.6e-02	NA	7.2e-03	NA	3.8e-03
2	GTEx	Whole Blood	0.1080	0.0420	6.1e-03	0.013	NA	0.018	NA	0.015	2.2e-02	NA	8.0e-03	NA	1.4e-02
3	METSIM	Adipose	0.0483	0.0187	4.3e-04	0.028	0.028	0.032	0.027	0.010	3.8e-05	3.7e-05	1.2e-05	4.9e-05	1.0e-02
4	ROSMAP	Brain Pre-frontal Cortex	0.0951	0.0335	3.5e-05	0.056	0.039	0.048	0.052	0.056	9.3e-08	7.7e-06	8.1e-07	2.4e-07	9.9e-08
5	YFS	Blood	0.0217	0.0089	1.4e-03	0.000	0.008	0.003	0.007	0.000	5.3e-01	8.6e-04	3.0e-02	1.3e-03	4.6e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Peak expiratory flow (PEF)	9.6	22.4	36.8	-6.0	-3.8	-4.9	-6.1	-0.8
Breastfed as a baby	8.9	11.0	26.8	-5.2	-0.0	-2.3	-2.9	3.8
Medication: Levothyroxine sodium	8.7	14.7	31.2	5.6	2.1	3.6	5.0	0.0
Hypothyroidism/myxoedema (self-reported)	5.9	11.4	23.1	4.7	1.8	2.9	4.8	0.1
Hypothyroidism (self reported)	5.8	13.3	26.0	4.9	2.7	3.0	5.1	0.7
Ulcerative Colitis (UC)	4.4	8.2	20.6	-2.2	-1.3	-3.5	-4.5	-1.3
Systolic blood pressure, automated reading	4.4	12.9	39.1	6.2	1.0	0.9	3.6	-3.3
Irritable Bowel Disease (IBD)	4.3	10.3	25.5	-2.0	-2.0	-3.6	-5.0	-2.2
Systolic Blood Pressure	4.0	20.0	76.0	8.7	0.1	-0.7	3.3	-3.5
Birth weight of first child	3.9	7.1	13.6	-3.7	-1.0	-0.8	-2.6	3.6
Lupus	3.2	4.9	14.3	1.7	1.7	3.8	2.1	-0.1
Medication: Seretide 50 evohaler	2.9	3.4	9.4	-1.8	-1.7	-1.1	-3.1	-0.2
Heel T-Score	2.8	22.0	30.7	-4.3	-4.7	-4.3	-4.5	-5.5
Supplements: Calcium	2.8	3.1	8.0	-1.2	-1.6	-2.8	-1.5	1.0
Heel bone mineral density (BMD) T-score, automated (right)	2.7	6.2	9.5	-2.7	-2.0	-1.4	-2.9	-3.1
Hayfever/allergic rhinitis (self-reported)	2.6	3.5	7.5	-1.6	0.1	-2.1	-2.7	-1.6
Supplements: Vitamin C	2.6	3.1	8.0	-2.8	-0.1	-2.0	-1.8	0.5
Had other major operations	2.5	3.0	5.1	-2.3	-2.0	-0.9	-2.1	0.8
Illnesses of father: High blood pressure	2.5	3.1	9.6	1.7	-1.2	-1.0	0.6	-3.1
Supplements: Zinc	2.4	2.6	6.5	-1.7	-0.3	-2.6	-1.9	-0.1
Asthma (self-reported)	2.4	4.8	11.0	-2.0	-1.6	-2.1	-3.3	-1.3
Depressed Affect (Nagel 2018)	2.3	4.7	10.9	3.3	0.8	2.2	2.2	1.5
Relative age voice broke	2.3	3.5	6.5	-2.5	-1.3	-1.5	-2.4	-0.8
Heel bone mineral density (BMD) T-score, automated (left)	2.3	5.3	8.5	-2.3	-2.2	-1.7	-2.2	-2.9
Prospective memory result	2.3	2.8	7.0	-0.9	-1.4	-2.6	-1.8	-1.1
Glaucoma (self-reported)	2.3	2.8	5.2	2.1	1.0	2.3	1.7	-0.4
Eye problems/disorders: Glaucoma	2.3	2.7	5.8	2.4	1.1	1.8	1.9	0.3
Number of operations (self-reported)	2.3	3.4	8.1	-2.9	-1.5	-0.6	-2.3	1.1
Medication: Co-codamol	2.2	2.6	4.4	-2.1	-1.8	-1.2	-1.6	-1.2
Alzheimer’s Disease (including proxy)	2.1	3.0	4.2	-1.7	-1.1	-2.0	-1.9	-1.8
Crohns Disease (2017)	2.1	4.5	11.1	-1.2	-1.6	-2.1	-3.3	-1.7
Respiratory disease	2.1	4.7	11.1	-2.4	-0.9	-2.3	-3.3	-0.1
Illnesses of mother	2.1	2.6	5.3	0.0	2.3	2.1	1.3	1.2
Family relationship satisfaction	2.1	2.6	6.1	-2.3	-0.8	-1.0	-2.5	-0.1
Heart disease (siblings)	2.1	2.5	4.0	1.2	1.7	1.2	1.7	-2.0
Father’s age at death	2.0	2.7	5.0	1.4	1.0	2.2	2.2	-0.8
Tense / ‘highly strung’	2.0	3.3	7.8	-0.0	-2.1	-2.8	-1.5	-1.4
Breast cancer (self-reported)	2.0	2.4	5.4	0.5	-2.3	-1.8	-1.2	-1.4
Alzheimer’s Disease (in father)	1.8	2.0	3.7	-1.9	-1.4	-0.9	-1.9	-0.0
Falls in the last year	1.8	2.5	8.7	1.0	2.9	1.0	1.3	0.1
Health satisfaction	1.8	2.3	8.2	1.1	2.9	-0.5	0.9	1.1
Emphysema/chronic bronchitis	1.8	2.1	4.5	-1.0	-0.7	-1.6	-2.1	-1.3
Fed-up feelings	1.7	3.0	10.0	3.2	0.8	0.6	1.9	-0.6
Hair/balding pattern: Pattern 3	1.7	2.6	4.1	2.0	0.5	1.9	1.6	1.5
Alzheimer’s Disease (in mother)	1.6	1.9	4.2	-0.6	-0.3	-1.7	-1.4	-2.0
Qualifications: CSEs or equivalent	1.6	2.1	6.1	0.2	2.5	1.0	1.1	1.4
Multivitamins +/- minerals	1.6	2.0	4.1	-2.0	-0.8	-1.8	-1.2	0.5
Mineral and other dietary supplements	1.6	2.1	3.9	2.0	0.1	1.5	1.8	-1.2
Vitamin and mineral supplements	1.5	2.1	4.8	2.2	0.3	1.5	1.3	-1.2
Supplements: Glucosamine	1.5	1.9	7.0	-2.6	-0.3	-0.8	-1.4	0.4
Qualifications: None of the above	1.5	3.3	6.9	2.6	1.9	-0.2	2.5	-0.0
Forced expiratory volume in 1-second (FEV1)	1.5	4.9	9.6	-1.2	-2.4	-3.1	-2.6	-1.0
Asthma	1.5	3.0	8.0	-1.6	-1.3	-1.6	-2.8	-0.5
Length of working week for main job	1.5	1.7	5.5	2.3	-0.1	0.6	1.6	0.4
Medication: Lisinopril	1.5	1.9	4.8	0.3	1.6	-1.4	0.6	-2.2
Irritability	1.5	2.5	4.8	-0.6	-1.5	-1.8	-2.2	-1.3
Depression (Nagel 2018)	1.4	2.1	2.8	1.7	1.7	0.9	1.5	1.3
Frequency of depressed mood in last 2 weeks	1.4	2.0	3.3	1.3	1.8	1.2	1.7	0.7
Hearing difficulty/problems: Yes	1.4	2.1	7.6	-1.2	-1.2	-0.2	-0.6	2.8
Serious illness, injury or assault to yourself	1.4	1.7	5.0	-0.6	-0.7	-0.0	-1.6	-2.2
Sitting height	1.4	9.8	26.2	-0.3	-2.7	-1.6	-3.6	-5.1
Had menopause	1.4	1.8	2.8	-1.6	-1.4	-1.7	-1.2	-0.1
High blood pressure (siblings)	1.4	2.1	4.2	2.0	-0.6	0.6	1.8	-1.5
Number of full brothers	1.4	1.7	5.9	-2.4	-0.0	0.1	-1.4	1.0
Mood swings	1.4	2.5	7.4	2.7	-0.3	1.2	1.9	0.0
Ever had stillbirth, spontaneous miscarriage or termination	1.4	1.5	3.1	-1.1	-0.7	-1.8	-1.6	-0.2
Average weekly champagne plus white wine intake	1.4	1.9	7.9	-1.1	0.0	-0.3	-0.6	2.8
Diabetes (father)	1.3	1.6	3.1	1.3	-1.2	-1.4	0.2	-1.8
High blood pressure (mother)	1.3	1.8	5.0	1.7	-0.3	-1.0	-0.1	-2.2
Allergy	1.3	3.0	10.5	1.3	0.9	0.8	3.2	1.2
Medication: Cholesterol lowering	1.3	2.0	7.3	1.1	-0.7	-0.8	-0.2	-2.7
Shortness of breath walking on level ground	1.3	1.5	2.9	-1.1	0.2	-1.7	-1.6	-0.9
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	2.8	0.1	1.3	1.4	1.7	1.2
Ever had bowel cancer screening	1.3	1.6	2.9	-0.2	1.6	-0.2	1.7	1.5
Mouth/teeth dental problems: Mouth ulcers	1.3	2.1	3.6	-1.1	-1.9	-1.7	-1.4	-0.9
Osteoarthritis (self-reported)	1.3	1.7	3.2	-1.8	-0.6	-1.8	-0.7	-1.2
Miserableness	1.3	2.3	7.9	2.8	1.0	0.9	1.2	-0.6
Ovarian Cancer	1.2	1.6	5.0	-0.5	-2.2	-1.4	-0.9	-0.2
Stomach or abdominal pain in last month	1.2	1.4	2.9	0.4	-1.4	1.5	0.2	-1.7
Forced vital capacity (FVC)	1.2	4.4	9.2	-1.2	-1.7	-3.0	-2.8	-0.8
Trunk fat-free mass	1.2	6.7	18.1	-4.3	0.9	-2.0	-2.2	-2.4
Qualifications: A levels/AS levels or equivalent	1.2	2.6	4.8	-1.9	-2.2	0.3	-1.9	-1.0
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.3	2.8	-0.3	-0.5	-1.7	-1.4	-1.3
Forced expiratory volume in 1-second (FEV1), Best measure	1.2	3.7	7.0	-1.0	-2.6	-2.1	-2.0	-1.5
Trunk predicted mass	1.2	6.6	18.1	-4.2	0.9	-1.9	-2.2	-2.5
Standing height	1.2	11.9	19.9	-2.8	-1.7	-3.6	-4.0	-4.5
Chronic bronchitis/emphysema (mother)	1.2	1.4	6.4	-0.7	-0.0	0.1	0.4	2.5
Ever had hysterectomy (womb removed)	1.1	1.2	2.7	-0.6	-1.5	1.6	-0.6	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.5	3.6	1.9	1.5	-0.0	1.2	-0.4
Illnesses of siblings	1.1	1.6	4.4	-1.3	0.9	-0.2	-1.1	2.1
Depression (self-reported)	1.1	1.3	1.8	1.3	-0.1	1.3	1.0	-1.4
Medication: Lansoprazole	1.1	1.2	2.9	-1.7	-0.6	-0.4	-1.2	1.1
Qualifications: O levels/GCSEs or equivalent	1.1	1.8	4.2	-1.4	-1.3	0.1	-2.0	-1.1
Blood clot in the leg (DVT)	1.1	1.4	3.3	-1.8	1.2	1.0	-0.7	0.9
Forced vital capacity (FVC), Best measure	1.1	3.9	5.7	-1.1	-2.4	-2.1	-2.2	-1.7
Had major operations	1.1	1.3	4.9	-2.2	-0.1	0.0	-1.3	0.0
Illnesses of siblings: Diabetes	1.1	1.4	3.4	-0.5	-1.9	-1.4	-1.1	0.3
Eye problems/disorders: Cataract	1.1	1.2	3.0	-1.7	-1.0	-0.8	-1.1	0.5
Illnesses of father: None of the above (group 1)	1.1	1.4	3.4	-1.3	-0.4	0.2	-1.3	1.9
Whole body water mass	1.1	6.0	17.1	-4.1	1.1	-2.0	-1.8	-2.2
Supplements: Fish oil (including cod liver oil)	1.1	1.4	4.1	-1.3	0.0	-1.0	-0.5	2.0
Basal metabolic rate	1.1	6.1	16.5	-4.1	1.1	-2.2	-1.7	-2.3
Prostate Cancer	1.0	1.3	3.4	0.8	-0.9	-1.2	-0.8	-1.9
Height	1.0	20.0	31.2	-4.9	-1.9	-4.5	-5.6	-4.6
Average weekly spirits intake	1.0	1.3	2.4	-1.6	-0.2	-1.3	-0.9	-1.3
Ever used hormone-replacement therapy (HRT)	1.0	1.3	2.2	-1.5	-1.4	-1.2	-1.0	0.2
High blood pressure	1.0	2.7	5.7	2.0	-0.4	-2.4	-0.4	-1.9
Hayfever, allergic rhinitis or eczema	1.0	2.2	8.4	-1.0	-0.7	-0.2	-2.9	-0.9
Weight	1.0	4.9	11.1	-3.3	1.2	-2.2	-1.0	-2.5
Medication for cholesterol, blood pressure or diabetes	1.0	1.7	4.7	-1.7	0.6	0.9	-0.1	2.2
Neck or shoulder pain in last month	1.0	1.4	1.9	-1.4	-0.9	-1.2	-1.1	-1.2
Heart disease (mother)	1.0	1.3	4.7	2.2	-0.1	-0.4	1.0	0.7
Whole body fat-free mass	1.0	5.9	16.3	-4.0	1.0	-2.0	-1.8	-2.2
Ever taken oral contraceptive pill	1.0	1.1	2.5	-0.6	-0.2	-1.0	-1.4	-1.6
Commuting to job workplace: Public transport	1.0	1.1	2.7	0.8	0.5	1.6	0.4	-1.4
Vascular/heart problems diagnosed by doctor	1.0	2.8	5.2	-2.2	0.4	2.3	0.6	1.8
Mean Putamen Volume	0.9	1.0	2.6	1.6	-0.9	0.9	0.5	-0.6
Smoking Status	0.9	2.1	4.2	-2.0	0.4	-1.2	-2.0	-0.9
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	3.2	0.4	-1.1	-1.8	-0.2	0.7
Severe depression (siblings)	0.9	1.0	2.5	0.7	1.6	0.6	1.0	-0.7
Townsend deprivation index at recruitment	0.9	1.3	5.2	-0.9	2.3	-0.6	-0.2	-0.2
Average weekly fortified wine intake	0.9	1.0	1.7	-0.2	1.3	1.1	1.0	1.0
Leg predicted mass (left)	0.9	4.5	12.0	-3.5	0.9	-2.1	-1.2	-1.9
Trunk fat mass	0.9	3.7	6.6	-2.6	0.3	-2.4	-1.1	-2.1
Number of live births	0.9	1.3	4.4	-0.2	-0.3	-1.2	-0.9	-2.1
Arm fat mass (right)	0.9	3.5	9.7	-3.1	1.3	-1.7	-0.7	-1.7
Arm fat-free mass (right)	0.9	4.7	13.8	-3.7	0.9	-1.9	-1.6	-1.7
Comparative body size at age 10	0.9	2.5	7.6	-2.8	0.9	1.8	-0.5	0.6
Arm predicted mass (right)	0.9	4.5	12.7	-3.6	1.0	-1.9	-1.4	-1.8
Long-standing illness, disability or infirmity	0.9	1.3	2.5	-0.9	-0.4	-1.4	-1.6	-1.1
Commuting to job workplace: Walk	0.9	1.0	1.7	1.1	-0.5	1.0	0.9	-1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	1.9	5.1	-1.0	-2.3	-1.4	-1.2	-0.5
Leg predicted mass (right)	0.9	4.6	12.5	-3.5	1.1	-2.2	-1.2	-1.7
Medication: Blood pressure	0.9	1.7	7.5	1.0	-0.2	-2.7	-0.4	-0.2
Arm fat-free mass (left)	0.9	4.8	12.9	-3.6	1.4	-1.8	-1.3	-2.1
Myopia	0.9	1.3	3.0	-1.7	0.8	0.1	-0.4	-1.7
Cholesterol lowering medication	0.9	1.4	4.4	-0.7	-0.1	-2.1	-1.3	0.5
Arm predicted mass (left)	0.9	4.7	12.8	-3.6	1.6	-1.5	-1.3	-2.1
Neuroticism (Nagel 2018)	0.8	2.0	6.2	2.5	0.1	0.9	1.6	0.6
Cardiovascular Disease	0.8	2.8	9.2	3.0	0.0	-2.0	0.8	0.0
Number of treatments/medications taken	0.8	1.4	3.0	0.2	-0.3	-1.7	-0.8	-1.7
Leg fat-free mass (left)	0.8	4.5	12.0	-3.5	1.0	-2.2	-1.2	-1.8
Diverticular disease/diverticulitis (self-reported)	0.8	0.9	1.8	-1.2	-0.0	-1.0	-0.7	-1.3
Chronic bronchitis/emphysema (father)	0.8	1.0	3.1	0.1	0.5	0.4	1.2	1.8
Waist circumference	0.8	3.0	7.7	-2.8	1.9	-1.5	-0.2	-1.1
Hip circumference	0.8	3.4	10.8	-3.3	0.9	-1.6	-1.0	-1.4
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	2.3	-1.5	-0.3	-0.6	0.4	-1.5
Loud music exposure frequency	0.8	0.9	2.6	0.1	1.6	-0.0	-0.0	1.3
Medication: Amlodipine	0.8	1.1	2.4	1.5	-0.5	-1.6	0.0	-0.5
Qualifications: College or University degree	0.8	2.4	7.3	-2.7	-1.3	-0.2	-1.6	0.4
Comparative height size at age 10	0.8	4.1	17.5	1.1	-0.3	-1.2	-0.6	-4.2
Medication: Aspirin	0.8	1.1	2.3	1.1	-0.1	-1.3	-0.4	-1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	1.0	2.6	0.7	-1.3	-1.6	-0.2	0.4
Leg fat-free mass (right)	0.8	4.2	11.4	-3.4	1.1	-2.1	-1.1	-1.6
Loneliness, isolation	0.8	1.1	1.6	-1.3	1.2	-0.3	-1.1	1.0
Arm fat mass (left)	0.8	3.4	9.3	-3.1	1.1	-1.9	-0.7	-1.5
Wears glasses or contact lenses	0.8	0.9	2.5	-1.6	-1.1	-0.7	-0.5	-0.5
Financial situation satisfaction	0.8	1.0	3.5	0.1	1.9	0.7	-0.8	-0.6
Medication: Paracetamol	0.8	1.2	2.8	0.2	0.7	-1.6	0.2	-1.7
Ever smoked	0.8	1.5	3.4	-1.8	0.7	-1.6	-1.1	0.1
Diastolic blood pressure, automated reading	0.8	2.5	6.3	2.5	-0.0	-1.0	1.1	-2.0
Deep venous thrombosis (DVT) (self-reported)	0.8	1.1	2.5	-1.6	1.1	0.9	-0.8	0.5
Impedance of whole body	0.8	4.1	11.0	2.0	-3.3	-1.1	-1.9	-0.9
Neuroticism (2016)	0.7	1.0	2.4	1.6	-0.0	0.9	1.2	0.7
Allergy or Eczema	0.7	1.9	6.4	-0.8	-0.5	-0.0	-2.5	-1.5
Chronotype (morning person)	0.7	1.6	2.8	-1.7	-0.7	-1.4	-1.6	-0.2
Impedance of leg (right)	0.7	3.3	9.0	1.3	-3.0	-0.7	-1.8	-1.5
Past tobacco smoking	0.7	1.4	2.7	1.6	-0.3	1.2	1.6	0.1
Nervous feelings	0.7	1.3	3.9	2.0	0.4	-0.9	1.1	-0.9
Mouth/teeth dental problems: Dentures	0.7	1.1	2.1	0.5	1.5	0.6	1.0	-1.4
Medication for pain relief, constipation, heartburn	0.7	1.2	4.9	-0.4	-0.3	0.8	-0.4	2.2
Medication: Ibuprofen	0.7	0.8	2.3	-1.5	0.0	-0.6	0.4	-1.2
Whole body fat mass	0.7	3.0	6.0	-2.5	0.8	-2.0	-0.8	-2.0
Leg fat mass (right)	0.7	2.7	5.6	-2.4	1.2	-1.6	-0.2	-2.0
Commuting to job workplace: Car/motor vehicle	0.7	0.8	2.3	-0.6	0.3	-0.9	-0.5	1.5
Hypertension (Self-reported)	0.7	2.0	4.2	1.9	-0.3	-2.1	-0.3	-1.3
Smoking status: Previous	0.7	1.0	2.2	-1.5	-0.4	-0.7	-1.4	0.2
Medication for cholesterol	0.7	1.1	4.6	-0.5	0.1	2.1	0.5	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.9	4.0	2.0	-0.1	0.1	0.5	0.2
Smoking status: Current	0.7	1.1	2.2	-1.2	1.5	-1.0	-0.7	-0.7
Number of self-reported non-cancer illnesses	0.7	1.2	3.0	1.7	0.6	0.3	0.8	-1.3
Alcohol drinker status: Never	0.7	0.8	2.8	-0.5	0.7	-1.7	-0.4	0.4
Pain experienced in last month	0.7	1.2	2.4	0.8	1.3	1.6	1.0	-0.0
Leg fat mass (left)	0.7	2.6	5.9	-2.4	1.3	-1.7	-0.3	-1.6
BMI	0.6	3.3	6.3	-2.5	2.5	0.2	2.0	-0.4
Trunk fat percentage	0.6	2.3	4.8	-1.9	0.0	-2.2	-0.8	-1.6
Current tobacco smoking	0.6	1.0	2.3	-1.1	1.5	-1.0	-0.5	-0.7
Tinnitus: Yes, but not now, but have in the past	0.6	0.7	1.3	1.2	0.5	0.1	1.2	-0.6
Number of incorrect matches in round	0.6	1.0	2.5	-0.1	-1.6	-1.5	-0.3	-0.2
Impedance of arm (right)	0.6	2.8	6.7	1.1	-2.6	-1.2	-1.9	-1.1
Alcohol intake versus 10 years previously	0.6	0.8	3.1	1.8	0.0	-0.2	1.0	-0.3
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	2.8	1.7	0.5	0.2	0.9	-1.1
Happiness	0.6	0.8	2.3	-0.6	1.5	-0.0	-0.5	1.0
Impedance of arm (left)	0.6	3.0	7.7	1.3	-2.8	-1.4	-1.8	-0.6
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	3.1	-0.2	-0.3	-0.6	-0.6	-1.8
Medication: Paracetamol	0.6	1.0	2.6	0.2	0.7	-1.3	0.2	-1.6
Exposure to tobacco smoke outside home	0.6	0.8	1.9	-1.4	1.1	0.5	0.2	0.8
Eye problems/disorders: None of the above	0.6	0.6	1.7	-0.1	1.0	1.3	0.0	0.7
Medication: Blood pressure	0.6	1.0	3.1	1.8	0.2	-0.4	0.1	-1.3
Overall health rating	0.6	1.3	4.2	1.1	2.0	0.1	1.1	-0.3
Chest pain or discomfort	0.6	0.8	3.5	1.9	0.2	-0.1	0.1	-0.7
Osteoporosis (self-reported)	0.6	0.8	2.1	1.5	0.4	0.6	0.9	0.7
Medication: Aspirin	0.6	0.7	2.0	0.8	0.2	-0.8	-0.6	-1.4
Hearing aid user	0.6	0.6	1.6	-0.1	-0.7	0.9	0.4	1.2
Mother’s age at death	0.6	0.7	2.2	0.1	-1.1	1.5	0.5	-0.2
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.4	0.7	1.2	0.8	0.9	-0.5
Risk taking	0.6	0.9	2.8	-0.4	-0.1	-1.1	-0.5	-1.7
Unable to work because of sickness or disability	0.6	0.7	1.5	-0.8	1.2	0.0	-0.9	0.8
Commuting to job workplace: Cycle	0.6	0.7	1.1	-1.1	-0.2	1.1	-0.9	-0.6
Neuroticism	0.5	1.1	3.4	1.9	0.4	-0.3	1.4	-0.2
Relative age of first facial hair	0.5	1.0	2.9	-1.7	-0.3	0.4	-1.2	-0.5
Diabetes (mother)	0.5	0.6	1.4	-0.1	-1.2	0.4	-0.4	-1.2
Maternal smoking around birth	0.5	0.7	3.2	-0.3	-0.1	0.3	-0.2	1.8
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.4	-0.9	-0.7	-0.0	-0.4	-1.2
Medication: Atenolol	0.5	0.7	1.7	1.3	-0.4	-1.2	0.3	0.4
Body mass index (BMI)	0.5	2.1	5.0	-2.2	2.0	-0.6	0.8	-0.5
Impedance of leg (left)	0.5	2.6	6.8	1.5	-2.6	-0.6	-1.7	-0.9
Heart attack	0.5	0.6	1.1	0.6	1.1	-1.0	-0.7	-0.4
Arm fat percentage (right)	0.5	1.9	5.0	-2.2	1.1	-1.3	-0.3	-1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.7	1.8	-0.8	-0.4	-1.4	-0.7	-0.7
Gout (self-reported)	0.5	0.7	2.5	-0.4	1.6	-0.1	-0.5	-0.8
Body fat percentage	0.5	2.0	3.5	-1.8	0.4	-1.9	-0.5	-1.6
Leg fat percentage (right)	0.5	1.9	3.4	-1.9	0.7	-1.7	-0.1	-1.6
Angina (self-reported)	0.5	0.6	1.4	0.7	0.9	0.4	0.5	1.2
Medication: Omeprazole	0.5	0.6	0.9	1.0	0.5	-0.5	0.8	-0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.0	0.8	-0.4	-1.0	-0.8	0.8
Age at last live birth	0.5	0.8	2.0	-0.5	1.2	-0.1	-0.6	-1.4
Arm fat percentage (left)	0.5	1.9	4.7	-2.2	0.9	-1.7	-0.3	-1.0
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.2	0.7	0.9	0.0	0.8	-1.1
Friendships satisfaction	0.5	0.6	2.3	-0.1	0.8	-0.5	-0.1	-1.5
Medication: Bendroflumethiazide	0.5	0.8	2.9	1.7	0.5	-0.5	0.1	-0.9
Leg fat percentage (left)	0.5	1.7	3.3	-1.8	1.1	-1.7	0.1	-1.1
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.4	-1.2	-0.4	0.0	-1.1	0.5
Age started oral contraceptive pill	0.5	0.6	1.2	1.1	0.5	1.1	0.6	-0.1
Ever depressed for a whole week	0.5	0.6	1.8	0.8	-0.7	0.2	-0.5	-1.3
Basal cell carcinoma (self-reported)	0.5	0.6	2.1	-0.2	-0.0	-0.6	0.5	-1.5
Heart attack/myocardial infarction (self-reported)	0.5	0.7	1.3	0.4	1.1	-1.0	-0.8	-0.3
Intelligence (Savage-Jansen 2018)	0.4	1.1	3.4	-0.3	-0.7	-0.0	-1.2	-1.9
Reaction Time	0.4	0.8	2.0	-1.4	1.0	0.1	-0.7	0.8
Verbal and Numeric Reasoning (VNR)	0.4	1.1	2.9	-0.3	-1.3	0.1	-0.8	-1.7
Fasting Glucose	0.4	0.4	2.1	0.0	0.0	0.0	0.0	-1.5
Primary Biliary Cirrhosis	0.4	0.5	2.7	0.0	0.0	0.0	0.0	1.6
Blood Eosinophil Count	0.4	3.2	6.0	-2.5	-0.4	-1.8	-2.0	-1.6
Type 2 Diabetes (T2D) (2018)	0.4	0.8	1.8	0.8	-0.9	-1.0	0.1	-1.3
Angina	0.4	0.5	2.0	0.5	0.6	0.2	0.2	1.4
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.8	0.8	1.4	0.0	0.6	0.2
Financial difficulties in last 2 years	0.4	0.5	1.1	-0.2	1.1	0.2	-1.0	0.5
Mouth/teeth dental problems	0.4	0.7	2.2	0.5	0.0	0.8	0.5	1.5
Diabetes (self-reported)	0.4	0.6	2.2	0.6	-0.1	-0.8	-0.1	-1.5
Fluid intelligence score	0.4	0.7	2.9	0.0	-0.6	0.6	0.4	-1.7
Worrier / anxious feelings	0.4	0.8	2.2	1.5	0.3	-0.1	1.2	-0.1
Pulse rate	0.4	0.8	1.1	-0.7	-0.7	-1.0	-1.1	0.8
Pulse wave reflection index	0.4	0.5	1.3	-0.2	1.1	0.6	1.0	-0.2
Birth weight	0.4	0.8	1.5	-1.0	-1.1	0.2	-1.2	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.1	0.1	-0.1	-0.9	1.0	-0.9
Number of full sisters	0.4	0.5	1.2	0.4	1.1	0.9	0.4	0.3
Leg pain on walking	0.4	0.4	1.3	0.5	1.1	0.1	0.6	-0.5
Illnesses of father: Heart disease	0.4	0.6	1.2	1.0	0.5	0.4	0.7	-1.1
Diabetes diagnosed by doctor	0.4	0.7	2.7	0.5	-0.5	-0.5	-0.4	-1.6
Back pain experienced in last month	0.4	0.6	1.3	-0.5	0.3	-1.1	-1.0	0.6
Medication: Gliclazide	0.4	0.5	1.3	1.1	-0.7	-0.6	-0.1	-0.4
High cholesterol (Self-reported)	0.4	0.7	2.5	-0.2	-0.7	-1.6	-0.6	-0.5
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	0.9	1.0	0.3	-0.2	0.9	-0.9
Worry (Nagel 2018)	0.3	0.5	1.1	1.0	-0.4	-1.1	0.6	0.1
Breast Cancer	0.3	0.7	2.5	-0.9	0.4	-0.3	-0.0	1.6
Schizophrenia (2014)	0.3	0.6	2.8	0.0	0.0	0.0	0.0	-1.7
Blood Platelet Count	0.3	3.5	8.8	0.5	3.0	0.6	1.4	2.4
Waist Hip Ratio (WHR)	0.3	1.4	5.9	0.5	2.4	-0.7	0.6	0.1
Lung FEV1/FVC ratio	0.3	1.6	2.8	-0.5	-1.6	-1.2	-0.9	-1.7
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.7	-0.2	-0.4	-0.7	-0.7	-0.8
Medication for hormone replacement therapy	0.3	0.4	0.6	-0.7	-0.6	-0.8	-0.5	-0.4
Hand grip strength (right)	0.3	0.8	2.0	-1.0	-0.4	-0.9	-0.2	1.4
Age when periods started (menarche)	0.3	0.7	2.0	-0.6	1.4	-0.2	0.2	1.1
Medication: Ramipril	0.3	0.3	0.7	0.8	0.7	-0.7	0.2	-0.2
Neuroticism score	0.3	0.7	1.6	0.9	-0.3	-1.3	0.2	-1.0
Time employed in main current job	0.3	0.3	1.3	0.1	-0.1	-0.3	0.4	1.1
Noisy workplace	0.3	0.3	1.1	-1.0	0.3	-0.0	-0.5	-0.4
Lung cancer (father)	0.3	0.3	0.9	-0.3	-0.6	0.3	0.4	-1.0
Ever highly irritable/argumentative for 2 days	0.3	0.3	0.8	0.9	0.4	0.1	0.7	0.2
Headache pain in last month	0.3	0.4	1.2	0.3	1.1	-0.4	0.9	-0.2
Migraine (self-reported)	0.3	0.3	0.7	0.8	-0.0	0.7	0.5	0.5
Medication: Allopurinol	0.3	0.4	1.6	0.4	1.3	-0.5	-0.1	-0.1
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	0.8	-0.2	-0.9	-0.1	-0.1	0.9
Medication: Atorvastatin	0.3	0.3	1.3	0.5	0.1	-1.2	-0.3	-0.2
Age at First Birth	0.2	0.4	1.8	0.0	0.0	0.0	0.0	-1.3
HbA1C	0.2	0.2	1.0	0.0	0.0	0.0	0.0	-1.0
Blood Red Count	0.2	1.6	4.5	-2.1	-0.8	-0.3	-0.7	-1.5
Hair Pigment	0.2	6.7	10.8	-3.3	-2.3	-1.5	-3.3	-2.0
Medication: Metformin	0.2	0.2	0.5	0.6	0.7	-0.1	0.0	-0.6
Pack years adult smoking proportion	0.2	0.3	0.8	0.0	0.9	0.2	0.7	0.2
Taking other prescription medications	0.2	0.3	0.5	-0.3	-0.3	-0.7	-0.6	-0.6
Hair/balding pattern: Pattern 2	0.2	0.3	0.7	0.2	-0.8	0.2	0.6	-0.6
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.7	0.8	0.7	0.4	-0.0	0.1
Pain all over the body in last month	0.2	0.2	0.8	0.1	0.2	-0.9	-0.2	0.5
Medication: Simvastatin	0.2	0.3	0.8	0.9	0.1	0.1	0.0	-0.7
Exposure to tobacco smoke at home	0.2	0.2	0.4	-0.5	0.2	-0.7	-0.4	0.5
Worry too long after embarrassment	0.2	0.3	1.0	0.3	0.4	0.3	0.4	-1.0
Wheeze or whistling in the chest in last year	0.2	0.3	0.8	-0.1	0.5	-0.7	0.0	-0.9
Number of children fathered	0.2	0.3	0.6	0.4	-0.2	0.8	0.5	0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.6	0.4	-0.4	0.5	-0.3	-0.8
Age at first live birth	0.2	0.3	0.8	-0.6	0.5	-0.2	-0.0	-0.9
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.7	-0.0	-0.8	-0.8	-0.2	-0.1
Mean time to correctly identify matches	0.2	0.5	1.3	-0.7	1.1	0.7	0.1	0.3
Suffer from ‘nerves’	0.2	0.2	0.6	0.8	0.3	0.7	-0.3	-0.1
Knee pain experienced in last month	0.2	0.3	0.9	-0.9	0.7	0.5	0.1	-0.0
Average weekly red wine intake	0.2	0.2	0.6	-0.1	-0.7	0.1	0.3	0.8
Qualifications: nursing, teaching	0.2	0.4	1.6	-1.3	-0.1	0.4	-0.1	-0.3
Fractured/broken bones in last 5 years	0.2	0.3	0.8	0.2	0.3	-0.2	0.6	0.9
Alcohol drinker status: Previous	0.2	0.2	0.8	0.4	-0.9	0.1	-0.4	-0.1
Pack years of smoking	0.2	0.2	0.6	-0.1	0.7	0.1	0.7	0.2
Schizophrenia (2018)	0.1	0.1	0.6	0.0	0.0	0.0	0.0	-0.8
Blood White Count	0.1	0.7	1.5	0.5	0.4	-1.2	1.1	-0.5
Lung FVC	0.1	0.7	1.8	-0.2	-0.7	-1.3	-1.1	0.2
Tanning	0.1	1.7	4.7	2.2	1.1	1.2	1.1	0.2
Hand grip strength (left)	0.1	0.3	0.8	-0.1	0.6	-0.9	-0.0	0.7
Sensitivity / hurt feelings	0.1	0.2	0.7	0.1	-0.6	-0.2	-0.1	-0.8
Alcohol usually taken with meals	0.1	0.2	0.5	0.7	-0.2	0.1	-0.3	-0.5
Hearing difficulty/problems with background noise	0.1	0.1	0.3	-0.4	-0.2	0.2	-0.3	-0.5
Pulse wave Arterial Stiffness index	0.1	0.1	0.3	-0.5	0.3	-0.2	0.5	0.0
Hair/balding pattern: Pattern 4	0.1	0.1	0.5	-0.7	0.3	-0.0	-0.2	-0.3
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.6	0.5	0.2	0.7	0.0	0.2
Pulse wave peak to peak time	0.1	0.1	0.5	0.4	-0.1	0.2	-0.7	-0.2
Pulse rate, automated reading	0.1	0.3	0.9	0.0	-0.9	-0.6	0.3	-0.7
Alcohol intake frequency.	0.1	0.2	0.4	0.5	-0.0	-0.5	0.5	0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.6	-0.2	0.5	0.5	-0.1	-0.8
Guilty feelings	0.1	0.2	0.8	0.9	0.1	-0.2	0.1	-0.2
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.3	-0.6	0.4	0.2	-0.2	0.4
Average weekly beer plus cider intake	0.1	0.2	0.4	-0.6	-0.5	-0.4	-0.3	-0.3
Bipolar Disorder (2018)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder or Schizophrenia	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Schizophrenia vs Biploar Disorder	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
HDL Cholesterol	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
LDL Cholesterol	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Rheumatoid Arthritis	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Triglycerides	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ulcerative Colitis	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0

Hub : Genes

PUSL1

Models

Trait associations