Best TWAS P=6.68e-15 · Best GWAS P=1.38e-32 conditioned to 8.91e-16
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Heart Atrial Appendage | SEPT7P2 | 0.15 | 0.00 | lasso | 9 | 0.08 | 1.8e-04 | -7.3 | -5.9 | 3.4e-09 | -0.07 | 0.20 | 0.04 | TRUE |
| 2 | GTEx | Skin Sun Exposed Lower leg | IGFBP3 | 0.09 | 0.00 | lasso | 6 | 0.00 | 2.7e-01 | -4.8 | -6.7 | 2.1e-11 | -0.08 | 0.14 | 0.09 | TRUE |
| 3 | NTR | Blood | IGFBP3 | 0.03 | 0.00 | bslmm | 413 | 0.01 | 1.1e-05 | 2.2 | 7.8 | 6.7e-15 | 0.27 | 0.16 | 0.04 | TRUE |
| 4 | YFS | Blood | IGFBP3 | 0.16 | 0.05 | lasso | 12 | 0.12 | 4.7e-36 | -8.8 | 7.3 | 3.1e-13 | 0.45 | 1.00 | 0.00 | FALSE |
| 5 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | IGFBP3 | 0.04 | 0.05 | blup | 47 | 0.03 | 1.2e-04 | -4.2 | -5.4 | 6.0e-08 | -0.27 | 0.17 | 0.53 | TRUE |