TWAS hub - IGFBP3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Liver	0.2260	0.0800	0.00260	0.032	NA	-0.001	NA	0.045	4.4e-02	NA	3.4e-01	NA	2.2e-02
2	GTEx	Skin Sun Exposed Lower leg	0.0870	0.0390	0.00420	-0.003	NA	0.000	NA	0.001	8.8e-01	NA	3.3e-01	NA	2.7e-01
3	NTR	Blood	0.0261	0.0102	0.00053	0.002	0.013	0.012	0.015	0.006	4.5e-02	3.6e-05	5.0e-05	1.1e-05	2.6e-03
4	YFS	Blood	0.1563	0.0306	0.00000	0.048	0.093	0.114	0.095	0.117	2.6e-15	1.1e-28	2.1e-35	2.0e-29	4.7e-36
5	TCGA	Kidney Renal Clear Cell Carcinoma	0.0407	0.0188	0.00035	0.045	0.033	0.021	NA	0.033	6.8e-06	1.2e-04	1.6e-03	NA	1.2e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Sitting height	5.4	38.5	60.7	2.1	-6.7	7.8	7.3	-5.4
Average weekly spirits intake	3.8	4.7	12.4	-1.1	-1.2	-2.5	-3.5	1.5
Birth weight	3.5	7.5	33.5	-0.6	-5.8	1.1	0.4	-1.6
Forced expiratory volume in 1-second (FEV1)	3.4	11.4	29.5	1.4	-4.3	5.4	0.8	2.4
Diastolic blood pressure, automated reading	3.4	10.4	27.8	-2.7	0.1	-4.1	-0.5	-5.3
Forced vital capacity (FVC)	3.3	12.8	31.6	2.0	-4.7	5.6	1.1	2.4
Prospective memory result	3.3	4.0	9.4	-1.6	-0.9	-3.1	-1.3	-2.4
Ever had stillbirth, spontaneous miscarriage or termination	3.2	3.5	8.1	-0.0	-2.8	-0.8	2.0	-2.1
Type 2 Diabetes (T2D) (2012)	3.1	3.6	7.4	0.3	2.7	2.5	0.5	1.9
Impedance of leg (right)	3.1	14.9	40.3	2.2	6.3	0.9	2.3	4.9
Birth weight of first child	3.0	5.5	20.2	-1.7	-4.5	-1.2	-1.7	-0.4
Illnesses of father: None of the above (group 1)	3.0	3.7	10.5	1.3	-1.9	-3.2	-1.8	0.1
HbA1C	2.8	3.1	7.0	0.6	1.6	1.1	2.1	-2.6
Comparative height size at age 10	2.8	15.6	28.2	-2.1	-3.9	5.3	2.1	5.0
Eye problems/disorders: Cataract	2.8	3.3	11.3	-0.7	3.4	1.4	1.6	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.8	3.2	7.1	0.0	-2.5	2.7	-0.1	1.7
Illnesses of father: High blood pressure	2.8	3.5	10.6	-0.0	2.0	3.2	1.5	0.7
Waist Hip Ratio (WHR)	2.7	12.1	44.9	-0.1	6.7	-2.6	-0.6	2.9
Systolic Blood Pressure	2.7	13.7	56.2	-0.4	2.2	1.7	-2.0	7.5
Systolic blood pressure, automated reading	2.7	7.7	32.2	-0.3	0.4	1.2	-2.2	5.7
Unable to work because of sickness or disability	2.7	3.4	6.4	2.0	-2.5	1.9	0.7	1.6
Relative age of first facial hair	2.6	5.3	15.8	4.0	-1.5	2.6	1.2	0.1
Impedance of leg (left)	2.5	12.1	35.9	1.6	6.0	0.4	1.8	4.3
Forced expiratory volume in 1-second (FEV1), Best measure	2.5	7.9	22.4	0.4	-4.7	3.6	0.1	2.0
Osteoarthritis (self-reported)	2.5	3.2	6.6	1.9	1.8	2.6	1.1	1.1
Myopia	2.5	3.6	7.9	-1.6	-1.8	-2.8	-2.1	0.2
Medication for hormone replacement therapy	2.4	2.7	6.7	0.3	2.3	0.7	-0.9	2.6
Heart attack	2.4	3.1	9.3	-0.9	0.1	-2.2	-0.8	-3.1
Medication: Paracetamol	2.4	3.9	13.0	-1.6	-1.6	-0.8	0.9	-3.6
Heart attack/myocardial infarction (self-reported)	2.4	3.0	9.4	-1.0	0.3	-2.0	-0.9	-3.1
Prostate Cancer	2.3	3.2	12.6	-1.7	0.4	-0.4	-0.2	-3.6
Forced vital capacity (FVC), Best measure	2.2	8.1	23.6	0.6	-4.9	3.7	0.5	1.5
Medication for pain relief, constipation, heartburn	2.2	3.8	12.3	1.6	1.2	0.9	-1.3	3.5
Leg predicted mass (right)	2.2	11.7	48.0	-1.6	-6.9	2.4	-0.2	-1.5
Trunk predicted mass	2.1	12.0	47.5	-1.2	-6.9	3.2	0.5	-0.4
Exposure to tobacco smoke outside home	2.1	2.8	6.6	-1.9	0.3	0.8	1.7	-2.6
Eye problems/disorders: None of the above	2.1	2.5	4.5	-0.4	-2.0	-2.1	-1.8	-0.7
Whole body fat-free mass	2.1	11.8	47.7	-1.4	-6.9	3.0	0.2	-0.7
Leg fat-free mass (right)	2.1	11.4	46.2	-1.6	-6.8	2.4	-0.2	-1.5
Whole body water mass	2.1	12.0	48.4	-1.4	-7.0	3.0	0.2	-0.8
Type 2 Diabetes (T2D) (2018)	2.0	3.7	10.7	-1.7	3.3	2.0	0.8	0.6
Hand grip strength (right)	2.0	5.5	18.5	0.6	-4.3	2.7	-1.0	0.5
Trunk fat-free mass	2.0	11.8	47.3	-1.1	-6.9	3.1	0.4	-0.4
Commuting to job workplace: Car/motor vehicle	2.0	2.3	7.0	0.9	1.3	0.2	-1.5	2.6
Pain type(s) experienced in last month: Hip pain	2.0	2.5	10.2	3.2	-0.5	0.8	0.8	0.9
Medication: Blood pressure	1.9	3.4	7.2	-2.3	0.6	-2.7	-1.4	-1.6
Angina (self-reported)	1.9	2.5	6.7	-0.9	-1.5	-2.6	-0.9	-1.4
Medication: Seretide 50 evohaler	1.9	2.2	4.1	0.3	1.6	-1.7	-2.0	1.0
Eye problems/disorders: Glaucoma	1.9	2.2	5.8	2.4	-1.5	-0.3	-0.7	1.6
Number of operations (self-reported)	1.9	2.9	11.9	0.0	1.5	0.4	-0.2	-3.4
Height	1.8	33.9	82.1	-0.4	-9.1	7.6	3.7	4.1
Leg fat-free mass (left)	1.8	9.6	38.9	-1.2	-6.2	2.6	-0.0	-0.9
Leg predicted mass (left)	1.8	9.7	39.3	-1.3	-6.3	2.5	-0.0	-0.9
Father’s age at death	1.8	2.4	10.8	3.3	-0.5	0.8	0.4	-0.3
Standing height	1.8	18.1	48.0	-0.9	-6.9	5.5	2.8	1.9
Medication for cholesterol, blood pressure or diabetes	1.8	2.9	7.7	1.9	-1.2	2.8	1.2	0.6
Arm fat-free mass (right)	1.8	9.3	38.3	-1.6	-6.2	2.3	-0.5	-0.3
Arm predicted mass (right)	1.8	9.0	37.1	-1.5	-6.1	2.3	-0.4	-0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.8	3.9	12.1	0.8	-3.5	2.5	0.3	0.1
Impedance of whole body	1.8	9.3	29.8	1.0	5.5	0.7	2.2	3.2
Knee pain experienced in last month	1.7	2.6	4.9	2.2	1.7	1.8	0.0	1.6
Commuting to job workplace: Walk	1.7	1.9	4.9	2.2	-1.5	-1.1	-0.5	-0.9
Mouth/teeth dental problems: Mouth ulcers	1.7	2.6	4.2	1.5	1.9	2.0	1.4	-1.0
Medication for cholesterol	1.7	2.6	7.1	0.2	-2.7	-0.4	0.8	-2.2
Basal metabolic rate	1.7	9.5	36.8	-1.3	-6.1	3.0	0.2	-0.3
Ovarian Cancer	1.6	2.1	4.4	-2.1	-1.2	-1.1	-0.2	-1.8
Angina	1.6	2.1	5.7	-0.7	-1.5	-2.4	-0.6	-1.2
Headache pain in last month	1.6	2.7	8.8	-0.6	-0.7	-3.0	-1.7	-1.0
Glaucoma (self-reported)	1.6	1.9	5.7	2.4	-1.2	-0.1	-0.4	1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.6	1.9	5.3	0.6	2.3	-1.7	-0.5	-0.7
Medication: Paracetamol	1.6	2.5	8.2	-0.6	-1.6	-1.1	0.5	-2.9
Arm fat-free mass (left)	1.6	8.1	30.0	-1.3	-5.5	2.9	0.3	-0.4
Mean Putamen Volume	1.5	1.7	4.3	2.1	0.6	1.7	0.9	0.2
Respiratory disease	1.5	3.4	6.1	-1.2	1.5	-2.5	-1.3	-2.4
Frequency of unenthusiasm / disinterest in last 2 weeks	1.5	2.0	3.9	0.3	-2.0	-2.0	0.8	-1.2
Relative age voice broke	1.5	2.3	9.7	3.1	-0.9	-0.2	0.8	0.2
Hair/balding pattern: Pattern 3	1.5	2.3	5.1	-0.4	1.2	0.5	2.1	2.3
Had major operations	1.5	1.8	4.9	-1.0	-1.1	1.2	0.6	-2.2
Forced expiratory volume in 1-second (FEV1), predicted	1.5	3.2	8.2	-0.8	-2.9	1.9	1.3	1.2
Medication: Aspirin	1.5	1.9	4.7	-1.6	-0.3	-1.4	-0.6	-2.2
Arm predicted mass (left)	1.5	7.6	27.2	-1.2	-5.2	3.0	0.3	-0.2
Medication: Metformin	1.4	1.9	5.7	-2.4	0.9	0.3	-0.7	1.6
Average weekly fortified wine intake	1.4	1.7	4.3	-1.7	-1.1	-0.4	-2.1	-0.1
Hayfever/allergic rhinitis (self-reported)	1.4	1.9	3.2	-0.3	1.8	-1.6	-1.7	0.6
Noisy workplace	1.4	1.7	3.1	-1.8	-1.7	-1.1	-1.1	0.2
Pulse wave Arterial Stiffness index	1.4	1.7	5.6	-0.6	0.4	1.1	-1.0	2.4
Pulse wave reflection index	1.4	1.7	3.0	-0.5	-1.7	-1.0	-1.6	-1.2
Worry too long after embarrassment	1.4	2.4	9.1	0.5	-1.1	-3.0	-0.7	-1.0
Medication: Allopurinol	1.4	1.8	6.1	-0.2	2.5	0.5	-1.6	0.2
Osteoporosis (self-reported)	1.4	1.8	4.2	0.4	-2.0	1.8	0.2	1.0
Major Depression (MDD)	1.3	1.6	5.5	0.7	-0.1	0.6	2.4	-1.3
Bipolar Disorder (2011)	1.3	1.2	2.7	-0.9	-0.1	-0.6	-1.6	1.5
Allergy or Eczema	1.3	3.4	7.8	-1.3	1.1	-2.8	-2.5	-0.1
Other serious medical condition/disability diagnosed by doctor	1.3	1.7	5.0	1.1	-0.9	1.2	2.2	-0.4
Impedance of arm (right)	1.3	6.0	15.9	0.9	4.0	0.8	2.5	2.6
Pulse rate	1.3	2.2	5.0	-0.6	2.2	0.3	1.2	-2.0
Length of working week for main job	1.3	1.4	3.2	1.8	-0.9	0.4	-1.7	0.2
Medication: Ventolin 100micrograms inhaler	1.3	1.7	3.7	-0.7	1.4	-1.6	-1.9	0.2
Age at last live birth	1.3	1.8	5.5	0.8	-0.8	0.9	2.3	-1.2
Medication: Aspirin	1.3	1.7	5.2	-1.4	-0.4	-0.8	-0.5	-2.3
Asthma (self-reported)	1.3	2.6	4.4	-0.6	1.9	-1.6	-1.4	-2.1
Commuting to job workplace: Public transport	1.3	1.5	4.4	-0.9	-1.0	-1.1	-0.3	-2.1
Alcohol drinker status: Never	1.3	1.6	4.6	2.1	1.6	-0.8	0.1	-0.6
Schizophrenia vs Biploar Disorder	1.2	1.5	2.6	-1.4	0.7	-0.7	1.4	-1.6
HDL Cholesterol	1.2	1.9	3.5	-0.7	-1.9	-0.4	-1.8	1.5
Hand grip strength (left)	1.2	3.2	8.1	0.6	-2.7	2.9	0.3	0.7
Ever used hormone-replacement therapy (HRT)	1.2	1.6	6.4	0.5	0.3	0.2	-1.0	2.5
Hair/balding pattern: Pattern 2	1.2	1.6	3.5	0.0	-0.9	-0.9	-1.7	-1.9
Asthma	1.2	2.3	3.7	-0.4	1.9	-1.4	-1.4	-1.9
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.5	3.9	0.0	-0.9	-0.9	1.4	-2.0
Depression (self-reported)	1.2	1.4	2.6	1.2	-1.6	0.9	1.3	0.6
Hypothyroidism/myxoedema (self-reported)	1.2	2.3	7.4	-0.1	1.1	2.7	0.5	1.6
High blood pressure (siblings)	1.2	1.7	4.2	-2.1	1.0	-1.2	-1.4	0.3
Leg fat percentage (right)	1.2	4.4	15.8	-0.6	4.0	0.3	-0.2	2.3
Number of full brothers	1.2	1.5	3.9	-1.0	-0.5	-1.6	-2.0	0.1
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	5.6	-0.5	-2.4	0.2	-0.2	0.9
Smoking status: Previous	1.2	1.8	6.4	-0.2	0.3	-2.5	-0.9	-1.3
Diabetes diagnosed by doctor	1.2	2.0	5.5	-1.3	2.4	1.6	0.3	0.4
Medication: Gliclazide	1.2	1.3	3.4	-1.8	0.3	-1.1	-1.2	-0.7
Commuting to job workplace: Cycle	1.2	1.5	5.9	2.4	0.3	0.4	1.1	-0.1
Depression (Nagel 2018)	1.1	1.7	3.0	0.1	-1.2	-1.7	1.3	-1.6
Cardiovascular Disease	1.1	3.7	9.8	-0.8	1.2	-0.9	-3.1	2.4
Hearing difficulty/problems with background noise	1.1	1.7	3.6	0.3	-1.9	-0.6	-1.8	1.2
Hair/balding pattern: Pattern 4	1.1	2.8	7.5	-1.3	0.6	2.7	2.0	-0.7
Pulse wave peak to peak time	1.1	1.3	3.5	0.6	-0.6	-0.7	1.3	-1.9
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.3	3.3	-1.8	-0.8	-0.2	-1.2	1.0
Illnesses of siblings: Diabetes	1.1	1.3	5.4	-2.3	0.0	-0.8	0.0	0.7
Cholesterol lowering medication	1.1	1.6	2.9	0.2	1.6	1.7	1.6	-0.0
Bipolar Disorder (2018)	1.0	1.5	5.5	0.6	-2.4	-0.3	-1.0	0.9
Lupus	1.0	1.5	4.7	-0.5	0.7	0.7	2.2	-1.1
Triglycerides	1.0	1.7	3.5	1.5	1.9	0.8	1.4	0.0
Hearing difficulty/problems: Yes	1.0	1.5	5.0	0.6	-1.5	-0.0	-2.2	0.0
Diabetes (mother)	1.0	1.2	3.9	-2.0	0.9	0.6	1.1	0.0
Tinnitus: Yes, but not now, but have in the past	1.0	1.0	2.7	-1.6	0.6	1.1	-0.2	-1.0
Supplements: Glucosamine	1.0	1.2	3.9	1.2	-2.0	0.5	-0.7	0.2
Medication: Atenolol	1.0	1.2	3.4	-0.7	1.4	-1.9	0.1	-0.0
Nervous feelings	1.0	1.9	4.7	-1.3	-0.4	-2.2	-0.3	-1.7
Impedance of arm (left)	1.0	4.4	12.0	0.7	3.5	0.2	1.7	2.6
Gout (self-reported)	1.0	1.3	4.6	0.4	2.1	0.9	-0.9	-0.5
Pulse rate, automated reading	1.0	3.2	6.6	0.6	2.3	1.4	2.6	-1.3
Number of full sisters	1.0	1.3	3.1	0.2	-1.3	-0.9	-1.8	0.8
Ever taken oral contraceptive pill	1.0	1.1	3.2	1.8	0.6	1.1	-0.1	0.8
Hearing aid user	1.0	1.2	2.9	0.1	-1.7	-0.7	-1.4	-0.5
Leg fat percentage (left)	1.0	3.6	12.4	-1.1	3.5	-0.1	-0.8	2.0
Heart disease (siblings)	1.0	1.2	3.3	-1.3	-1.8	-1.0	-0.4	-0.5
Lung FVC	0.9	4.3	12.2	2.2	-3.5	2.2	-0.0	0.0
Frequency of depressed mood in last 2 weeks	0.9	1.3	2.8	-0.1	-0.5	-1.7	0.8	-1.7
Current tobacco smoking	0.9	1.5	4.7	2.2	0.8	-0.2	0.6	1.4
Had other major operations	0.9	1.1	3.3	-0.6	1.3	-0.4	0.1	-1.8
Allergy	0.9	2.1	7.0	0.7	-1.3	1.2	2.6	-0.1
Diabetes (self-reported)	0.9	1.4	2.8	-1.7	1.6	1.1	-0.1	0.4
Time employed in main current job	0.9	1.1	2.7	-1.6	1.4	-0.1	-0.6	-0.5
Worrier / anxious feelings	0.9	1.8	3.6	-0.8	-1.2	-1.1	-1.3	-1.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.2	2.7	-0.0	-1.6	-1.4	-1.0	0.6
Wheeze or whistling in the chest in last year	0.9	1.6	3.8	-0.3	1.0	-1.5	-2.0	-0.7
Loneliness, isolation	0.9	1.3	3.7	-1.3	-1.9	-0.9	0.4	-0.3
Qualifications: nursing, teaching	0.9	1.4	3.1	0.7	-0.8	0.8	1.8	-1.5
Smoking status: Current	0.9	1.5	5.1	2.3	0.4	-0.4	1.1	1.0
Medication: Lisinopril	0.9	1.1	2.4	-1.5	0.8	-0.8	-1.3	0.5
Ever had prostate specific antigen (PSA) test	0.9	1.1	1.7	-1.3	-1.2	0.9	-0.1	1.1
Basal cell carcinoma (self-reported)	0.9	1.1	4.5	0.0	2.1	-0.3	-0.4	0.9
Ever had hysterectomy (womb removed)	0.8	0.9	3.8	0.0	-0.6	-0.5	-1.9	-0.3
Supplements: Zinc	0.8	0.8	2.4	0.9	-1.5	-0.7	-0.6	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.9	4.4	0.3	2.1	0.7	-0.6	2.1
Serious illness, injury or assault to yourself	0.8	0.9	1.5	1.2	-0.7	1.1	0.3	-1.2
Had menopause	0.8	1.0	2.1	-0.5	-1.3	-0.7	-1.4	0.6
Pain all over the body in last month	0.8	0.9	2.8	-0.7	-0.4	1.7	0.5	-0.9
Mouth/teeth dental problems: Dentures	0.8	1.3	4.7	1.0	-0.6	-0.7	-2.2	0.2
Medication: Cholesterol lowering	0.8	1.3	2.8	-1.4	1.0	-1.7	-0.7	-0.2
Exposure to tobacco smoke at home	0.8	0.9	2.4	-0.4	-0.2	-1.6	-1.1	1.0
Peak expiratory flow (PEF)	0.8	1.8	5.6	-0.0	-1.6	2.4	1.0	0.0
Medication: Ibuprofen	0.8	1.0	2.8	0.2	-0.5	-1.1	0.8	-1.7
Average weekly red wine intake	0.8	1.2	2.6	1.6	-1.5	0.5	0.4	0.9
Average weekly beer plus cider intake	0.8	1.1	4.5	-0.4	2.1	0.6	-0.8	0.2
Schizophrenia (2018)	0.7	1.5	4.0	1.5	0.5	-1.0	0.3	-2.0
Crohns Disease (2012)	0.7	1.2	2.8	1.5	-0.8	1.7	0.1	0.3
LDL Cholesterol	0.7	1.1	3.4	1.9	-0.8	0.3	0.4	1.2
Schizophrenia (2014)	0.7	1.5	5.3	-0.1	0.2	-1.3	0.6	-2.3
Heel T-Score	0.7	5.4	18.5	0.1	4.3	0.5	-1.3	2.6
Smoking Status	0.7	1.6	2.2	1.5	1.4	-1.5	1.2	-0.2
Number of treatments/medications taken	0.7	1.2	2.0	-1.2	0.6	-1.4	-1.3	0.8
Medication: Co-codamol	0.7	0.8	2.6	-1.6	0.2	0.2	-0.0	-1.2
Diabetes (father)	0.7	0.8	1.2	-0.2	0.9	0.9	1.1	1.1
Qualifications: CSEs or equivalent	0.7	0.9	3.8	-0.1	2.0	-0.2	-0.6	-0.4
Past tobacco smoking	0.7	1.4	4.9	-1.0	-0.1	2.2	0.1	1.0
Medication: Simvastatin	0.7	1.0	4.0	-0.5	2.0	-0.6	-0.3	-0.4
Illnesses of siblings	0.7	0.9	3.2	1.8	-0.2	0.8	0.8	-0.3
Weight	0.7	3.5	10.5	-1.0	-3.2	2.3	-0.1	0.9
Lung cancer (father)	0.7	0.8	2.4	-0.7	1.5	-0.0	-0.3	0.9
Loud music exposure frequency	0.7	0.8	1.7	-1.1	-0.5	-0.8	-0.2	-1.3
Chronic bronchitis/emphysema (mother)	0.7	0.9	1.6	1.3	1.0	-0.7	-0.9	0.6
Comparative body size at age 10	0.7	2.0	9.4	-0.2	-3.1	-0.2	0.2	-0.7
Heart disease (mother)	0.7	0.8	1.9	-0.8	1.4	-0.6	0.9	0.7
Hypertension (Self-reported)	0.7	2.0	5.2	-0.8	0.1	-1.8	-2.3	1.1
Ever had bowel cancer screening	0.7	0.9	1.9	-0.6	-1.4	-0.8	-0.7	-0.9
Friendships satisfaction	0.7	0.9	1.5	0.6	-1.0	-1.1	-1.2	-0.7
Miserableness	0.7	1.2	2.6	1.6	-1.4	-0.2	-0.8	1.0
Medication: Bendroflumethiazide	0.7	1.0	2.4	-1.5	-0.2	-0.9	-1.2	0.7
Age started oral contraceptive pill	0.7	0.9	1.8	-1.3	-0.8	0.9	-1.2	0.1
Supplements: Calcium	0.7	0.8	3.3	-0.4	-1.8	-0.6	0.2	-0.3
Alzheimer’s Disease (in mother)	0.6	0.7	1.4	1.2	0.3	-0.7	-0.8	-0.9
Ulcerative Colitis (UC)	0.6	1.1	3.7	-0.0	0.6	-1.9	-1.0	-0.8
Age at First Birth	0.6	0.9	2.5	1.6	-0.2	1.1	0.7	0.0
Ulcerative Colitis	0.6	0.9	2.4	0.5	-0.3	-1.4	-0.2	-1.5
Blood White Count	0.6	4.1	7.6	0.6	2.6	2.4	2.8	0.2
Hypothyroidism (self reported)	0.6	1.5	4.5	0.5	1.2	2.1	0.9	0.7
Lung FEV1/FVC ratio	0.6	3.0	9.7	-1.3	-0.4	0.1	-1.9	3.1
Sensitivity / hurt feelings	0.6	1.1	1.8	1.1	-1.4	-1.3	-0.8	-0.4
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	2.4	-0.1	-1.6	-0.2	-0.7	0.7
Number of incorrect matches in round	0.6	0.9	2.9	-1.7	-1.1	-0.6	0.0	0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.3	2.9	0.7	1.7	0.9	-0.2	1.4
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.6	1.2	-0.8	0.5	-0.0	-1.1	-1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	1.6	1.1	0.4	0.7	0.9	1.3
Ever highly irritable/argumentative for 2 days	0.6	0.7	1.9	-1.4	0.0	0.5	0.3	-1.2
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	2.6	-0.8	1.6	0.5	0.3	-0.7
Body fat percentage	0.6	2.4	6.2	-1.1	2.5	-0.2	-0.6	2.1
Shortness of breath walking on level ground	0.6	0.7	1.3	-0.2	0.7	-0.6	-1.1	1.1
Suffer from ‘nerves’	0.6	0.9	1.5	-1.1	-1.1	-0.9	0.2	-1.2
Chest pain or discomfort	0.6	0.9	2.3	-0.9	-0.4	-1.0	-0.2	-1.5
Family relationship satisfaction	0.6	0.7	2.5	-0.3	-0.4	-0.8	-0.6	-1.6
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	2.3	-0.1	0.7	0.4	0.8	1.5
Back pain experienced in last month	0.6	0.9	2.0	1.4	-0.2	-0.8	0.4	-1.2
Guilty feelings	0.6	0.8	2.0	-0.3	-1.3	0.5	0.4	-1.4
Fractured/broken bones in last 5 years	0.6	0.8	1.8	-0.5	-1.4	0.5	0.9	-1.0
Bipolar Disorder or Schizophrenia	0.5	1.1	2.4	1.5	-1.1	-1.0	-0.3	-1.0
Reaction Time	0.5	1.0	3.5	-1.0	1.9	-0.4	0.5	-0.0
Chronotype (morning person)	0.5	1.0	3.3	-0.1	-1.8	-0.7	-1.2	-0.3
Trunk fat percentage	0.5	1.9	4.3	-1.0	2.0	0.0	-0.5	2.1
Townsend deprivation index at recruitment	0.5	0.6	1.3	-0.7	-0.7	-0.1	1.0	-1.1
Maternal smoking around birth	0.5	0.8	3.0	-0.2	0.7	0.4	-0.2	1.7
Age when periods started (menarche)	0.5	1.3	3.1	0.2	-0.8	-1.8	-1.5	-0.4
Bilateral oophorectomy (both ovaries removed)	0.5	0.5	1.1	-0.7	1.1	0.8	-0.2	0.7
Hayfever, allergic rhinitis or eczema	0.5	1.2	3.2	-0.6	0.9	-1.1	-1.8	0.4
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	2.1	1.4	-0.6	0.3	0.6	-0.3
Mouth/teeth dental problems	0.5	0.7	2.0	-0.2	-1.4	-0.8	1.0	-0.1
Hip circumference	0.5	2.0	5.8	0.0	-2.4	1.5	-0.3	1.5
Alcohol intake versus 10 years previously	0.5	0.7	2.3	-0.0	0.3	1.5	0.7	-0.8
Blood clot in the leg (DVT)	0.5	0.6	1.2	-0.8	-1.1	-0.0	-1.0	0.4
Neck or shoulder pain in last month	0.5	0.7	1.4	1.2	-0.8	0.3	-1.2	-0.2
Mean time to correctly identify matches	0.5	1.0	2.5	-1.1	1.6	-0.9	-0.6	0.6
Leg pain on walking	0.5	0.7	1.5	-0.2	-1.2	-1.1	-0.6	-0.2
Long-standing illness, disability or infirmity	0.5	0.8	1.6	1.0	0.4	1.1	1.3	0.3
Mineral and other dietary supplements	0.5	0.7	2.1	-0.8	1.5	-0.3	0.1	0.8
Mother’s age at death	0.5	0.6	1.3	-0.2	0.6	0.1	-1.1	1.1
Ever smoked	0.5	0.9	2.7	1.6	0.3	-1.3	0.3	-0.1
Ever depressed for a whole week	0.5	0.7	2.0	-0.6	-0.1	-1.0	1.4	0.2
Vascular/heart problems diagnosed by doctor	0.5	1.4	2.5	1.4	-0.3	1.5	1.6	-0.4
Pain experienced in last month	0.5	0.8	1.9	-1.4	0.4	0.3	-1.1	0.7
Alcohol drinker status: Previous	0.5	0.6	1.8	-0.3	-0.5	-1.3	-0.4	-0.7
Alzheimer’s Disease (in father)	0.4	0.4	0.7	-0.5	-0.8	0.1	-0.6	-0.8
Verbal and Numeric Reasoning (VNR)	0.4	0.8	2.5	-0.9	0.2	-0.9	-0.3	-1.6
Neuroticism (2016)	0.4	0.6	1.4	-1.1	-1.2	-0.1	-0.2	-0.6
Tanning	0.4	4.7	17.3	-0.8	-4.2	-1.3	-1.9	-0.1
High blood pressure	0.4	1.2	2.7	-0.9	0.5	-1.2	-1.6	1.0
Multivitamins +/- minerals	0.4	0.5	1.3	-0.5	-1.1	-0.0	-1.1	0.3
Medication: Levothyroxine sodium	0.4	0.7	2.2	-0.6	0.0	1.5	0.6	0.7
Waist circumference	0.4	1.5	5.2	-0.5	0.7	-0.5	-1.1	2.3
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.9	0.3	-0.3	-0.5	0.7	-1.4
Ever unenthusiastic/disinterested for a whole week	0.4	0.4	1.1	0.2	0.6	-1.0	0.6	-0.6
Medication: Ramipril	0.4	0.5	1.0	-0.7	-0.8	0.5	-0.0	1.0
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	2.2	0.0	-1.5	-0.6	-0.0	-0.6
Medication: Lansoprazole	0.4	0.4	1.3	-0.4	-0.7	-0.3	-1.1	0.3
Illnesses of mother	0.4	0.5	1.6	-0.1	-0.6	1.3	0.3	-0.5
Breastfed as a baby	0.4	0.5	1.2	0.2	-1.1	-0.4	0.7	-0.8
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	2.4	-0.4	-0.4	-0.1	1.5	-0.3
Age at first live birth	0.4	0.8	1.8	0.6	-0.2	1.2	1.4	-0.4
Health satisfaction	0.4	0.5	1.0	-0.0	-1.0	-0.8	-1.0	-0.1
Qualifications: College or University degree	0.4	1.4	4.9	0.7	-2.2	0.4	0.9	-0.7
Illnesses of father: Heart disease	0.4	0.5	1.1	-1.0	0.5	0.8	0.1	-0.7
Breast cancer (self-reported)	0.4	0.5	1.5	0.6	0.5	0.6	-0.0	-1.2
Tinnitus: Yes, now most or all of the time	0.4	0.4	0.9	0.6	-0.9	0.5	0.3	-0.8
Medication: Blood pressure	0.4	0.7	2.1	-0.2	0.8	0.3	-0.8	1.4
Medication: Atorvastatin	0.4	0.5	1.6	-0.1	-0.5	1.3	0.6	0.3
Neuroticism (Nagel 2018)	0.3	0.6	1.3	-0.6	-0.9	-1.1	-0.7	0.2
Worry (Nagel 2018)	0.3	0.6	1.8	-1.3	-0.9	-0.4	-0.4	-0.2
Alzheimer’s Disease (including proxy)	0.3	0.4	0.8	0.2	0.1	-0.8	-0.9	-0.7
Irritable Bowel Disease (IBD)	0.3	0.6	1.4	0.6	1.0	-0.7	-1.2	0.1
Body Mass Index (BMI) (2010)	0.3	0.4	1.0	-0.5	0.6	0.1	1.0	-0.6
Fasting Glucose	0.3	0.4	1.2	0.4	-0.1	0.7	1.1	-0.2
Primary Biliary Cirrhosis	0.3	0.5	1.4	-0.9	0.3	-0.2	-1.2	0.2
Rheumatoid Arthritis	0.3	0.4	1.0	1.0	-0.5	0.5	-0.0	0.6
Taking other prescription medications	0.3	0.5	1.2	1.1	0.7	-0.5	0.3	0.5
Trunk fat mass	0.3	1.1	2.8	-1.4	-0.1	0.8	-0.5	1.7
Fluid intelligence score	0.3	0.7	2.1	-1.5	0.8	-0.3	-0.2	-0.7
Arm fat percentage (right)	0.3	1.2	3.9	-0.9	2.0	0.3	-0.2	1.1
Tense / ‘highly strung’	0.3	0.5	1.5	-0.5	1.2	-0.1	-0.8	-0.2
Medication: Amlodipine	0.3	0.4	0.7	-0.3	0.6	-0.8	-0.5	-0.7
Number of children fathered	0.3	0.4	1.3	-0.1	-0.5	-1.1	-0.5	0.0
Alcohol intake frequency.	0.3	0.8	2.1	0.4	0.7	1.0	-0.0	-1.4
Supplements: Vitamin C	0.3	0.4	1.1	-1.0	-0.7	0.3	-0.5	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	1.4	-0.6	1.2	0.2	-0.1	0.5
Arm fat percentage (left)	0.3	1.3	3.0	-1.2	1.7	-0.2	-0.8	1.2
Handedness (chirality/laterality): Left-handed	0.3	0.4	1.3	0.7	0.0	0.3	0.3	1.1
Wears glasses or contact lenses	0.3	0.4	0.7	-0.6	-0.7	-0.5	-0.8	-0.4
Irritability	0.3	0.4	0.8	0.9	-0.5	0.7	-0.1	0.8
Risk taking	0.3	0.4	1.4	0.7	-1.2	-0.3	-0.2	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.3	0.3	0.5	-0.5	-0.5	0.7	-0.7	0.5
Pack years of smoking	0.3	0.5	1.5	0.2	0.4	-0.8	-1.2	0.0
Depressed Affect (Nagel 2018)	0.2	0.4	1.2	0.0	-1.1	-0.4	-0.7	0.5
Intelligence (Savage-Jansen 2018)	0.2	0.7	2.4	-1.5	0.1	-0.6	-0.3	-0.9
Crohns Disease (2017)	0.2	0.5	1.2	0.5	0.5	0.8	-1.1	0.5
Breast Cancer	0.2	0.6	0.8	-0.7	-0.2	-0.8	0.9	-0.9
Blood Eosinophil Count	0.2	1.6	5.0	-0.6	0.9	-1.3	-2.2	0.4
Blood Red Count	0.2	2.0	4.8	1.1	2.2	0.5	-0.2	1.9
Neuroticism	0.2	0.4	0.9	-0.5	0.0	-0.9	-0.9	-0.1
Vitamin and mineral supplements	0.2	0.3	1.3	0.1	1.1	0.1	0.6	-0.1
Severe depression (siblings)	0.2	0.2	0.5	0.4	0.2	-0.6	-0.3	0.7
Fed-up feelings	0.2	0.4	0.9	0.9	0.1	-0.1	-0.2	-0.9
Stomach or abdominal pain in last month	0.2	0.2	0.8	-0.0	0.1	0.0	0.5	-0.9
High blood pressure (mother)	0.2	0.3	0.6	0.7	0.4	-0.2	0.2	0.8
Body mass index (BMI)	0.2	0.7	2.3	-0.9	-0.2	-0.3	-1.5	0.1
Alcohol usually taken with meals	0.2	0.4	0.9	0.7	-1.0	0.7	0.3	0.3
Qualifications: None of the above	0.2	0.3	0.9	0.9	-0.1	0.1	-0.8	0.5
Financial difficulties in last 2 years	0.2	0.3	0.5	-0.2	-0.1	-0.7	-0.3	-0.7
Neuroticism score	0.2	0.5	1.3	0.1	-0.7	-1.2	-0.5	-0.6
Falls in the last year	0.2	0.3	1.1	0.0	-1.0	0.2	0.5	-0.2
Happiness	0.2	0.3	1.2	1.1	0.1	0.1	0.1	0.3
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.7	0.0	-1.3	0.2	-0.1	-0.3
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.3	-0.2	-0.3	-0.5	0.5	0.5
Emphysema/chronic bronchitis	0.2	0.3	0.6	-0.3	0.7	-0.8	-0.4	-0.1
Migraine (self-reported)	0.2	0.3	0.8	0.9	-0.2	0.4	0.4	-0.6
Medication: Omeprazole	0.2	0.2	0.8	0.9	-0.2	-0.1	0.4	-0.3
Whole body fat mass	0.2	1.0	3.0	-0.9	-0.2	0.8	-0.6	1.7
Leg fat mass (right)	0.2	0.9	2.3	-1.0	0.5	0.9	-0.3	1.5
Mood swings	0.2	0.4	0.9	1.0	-0.6	0.5	-0.3	0.5
Arm fat mass (left)	0.2	0.8	1.7	-1.3	-0.5	0.8	-0.8	0.9
Number of self-reported non-cancer illnesses	0.2	0.3	0.9	0.5	1.0	-0.4	0.4	-0.5
Average weekly champagne plus white wine intake	0.2	0.3	0.5	0.6	0.1	-0.7	0.6	-0.2
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.6	0.6	0.2	-0.5	-0.8	-0.4
High cholesterol (Self-reported)	0.2	0.3	1.3	-0.3	1.1	-0.4	0.2	-0.2
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.6	-0.3	-0.8	-0.1	0.3	-0.5
Leg fat mass (left)	0.2	0.9	1.8	-1.3	0.3	0.6	-0.7	1.3
Coronary Artery Disease (CAD)	0.1	0.1	0.3	0.4	0.6	-0.4	0.2	-0.1
Blood Platelet Count	0.1	1.2	2.7	1.0	1.6	0.8	1.2	-0.3
BMI	0.1	0.8	3.1	-0.8	-0.3	0.4	-1.8	-0.0
Pack years adult smoking proportion	0.1	0.2	0.5	0.4	0.3	-0.3	-0.7	-0.2
Number of live births	0.1	0.1	0.2	0.4	0.3	-0.0	0.0	0.3
Arm fat mass (right)	0.1	0.5	0.8	-0.9	-0.6	0.9	-0.4	0.8
Overall health rating	0.1	0.3	1.2	0.1	0.2	-1.1	-0.2	-0.4
Financial situation satisfaction	0.1	0.1	0.3	0.3	-0.1	-0.5	-0.3	-0.1
Hair Pigment	0.0	1.2	3.2	0.4	1.8	-1.2	-0.7	0.6
Chronic bronchitis/emphysema (father)	0.0	0.0	0.1	0.1	-0.2	-0.2	0.1	-0.3

Hub : Genes

IGFBP3

Models

Trait associations