Best TWAS P=4.54e-15 · Best GWAS P=2.51e-15 conditioned to 0.0137
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | DNAJC30 | 0.13 | 0.07 | enet | 32 | 0.07 | 2.7e-09 | 5.9 | 6.2 | 7.8e-10 | 0.24 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | MLXIPL | 0.11 | 0.07 | enet | 16 | 0.07 | 1.6e-06 | 7.0 | 7.7 | 1.0e-14 | 0.88 | 0.02 | 0.98 | FALSE |
| 3 | GTEx | Adipose Visceral Omentum | MLXIPL | 0.16 | 0.02 | lasso | 3 | 0.03 | 7.8e-03 | 7.3 | 7.6 | 3.3e-14 | 0.81 | 0.06 | 0.94 | FALSE |
| 4 | GTEx | Adipose Visceral Omentum | NSUN5 | 0.07 | 0.03 | enet | 11 | 0.04 | 4.0e-03 | 6.9 | 5.8 | 5.1e-09 | 0.71 | 0.01 | 0.84 | FALSE |
| 5 | GTEx | Cells Transformed fibroblasts | MLXIPL | 0.13 | 0.06 | enet | 6 | 0.09 | 2.2e-07 | 7.8 | 7.8 | 8.1e-15 | 0.82 | 0.02 | 0.98 | FALSE |
| 6 | GTEx | Lung | MLXIPL | 0.10 | 0.07 | enet | 14 | 0.07 | 6.3e-06 | 7.0 | 6.6 | 4.5e-11 | 0.65 | 0.07 | 0.82 | FALSE |
| 7 | GTEx | Skin Not Sun Exposed Suprapubic | MLXIPL | 0.11 | 0.11 | lasso | 3 | 0.06 | 2.7e-04 | 7.8 | 7.4 | 1.8e-13 | 0.84 | 0.01 | 0.98 | FALSE |
| 8 | GTEx | Skin Sun Exposed Lower leg | MLXIPL | 0.12 | 0.09 | lasso | 4 | 0.06 | 6.1e-06 | 7.6 | 7.7 | 1.7e-14 | 0.86 | 0.03 | 0.97 | FALSE |
| 9 | GTEx | Spleen | NCF1B | 0.22 | 0.10 | enet | 9 | 0.08 | 5.1e-03 | 6.5 | -7.3 | 2.1e-13 | -0.62 | 0.05 | 0.18 | FALSE |
| 10 | GTEx | Testis | MLXIPL | 0.10 | 0.00 | lasso | 3 | 0.00 | 3.3e-01 | 4.4 | 6.8 | 1.1e-11 | 0.66 | 0.04 | 0.27 | FALSE |
| 11 | GTEx | Thyroid | MLXIPL | 0.23 | 0.14 | lasso | 7 | 0.15 | 2.1e-11 | 7.0 | 7.8 | 4.5e-15 | 0.83 | 0.02 | 0.98 | TRUE |
| 12 | METSIM | Adipose | BCL7B | 0.10 | 0.02 | enet | 20 | 0.05 | 1.2e-07 | 7.3 | 6.1 | 8.5e-10 | 0.66 | 0.01 | 0.99 | FALSE |
| 13 | METSIM | Adipose | MLXIPL | 0.12 | 0.14 | lasso | 4 | 0.13 | 1.8e-19 | 7.1 | 7.6 | 4.2e-14 | 0.80 | 0.35 | 0.65 | FALSE |
| 14 | METSIM | Adipose | TRIM50 | 0.04 | 0.00 | blup | 159 | 0.02 | 7.0e-04 | -2.2 | -5.6 | 2.4e-08 | 0.00 | 0.14 | 0.02 | TRUE |
| 15 | The Cancer Genome Atlas | Breast Invasive Carcinoma | MLXIPL | 0.06 | 0.05 | lasso | 2 | 0.05 | 5.1e-10 | 6.9 | 6.7 | 2.5e-11 | 0.67 | 0.00 | 1.00 | FALSE |
| 16 | The Cancer Genome Atlas | Lung Adenocarcinoma | MLXIPL | 0.04 | 0.03 | lasso | 1 | 0.02 | 2.3e-03 | 6.9 | 6.9 | 5.2e-12 | 0.67 | 0.00 | 0.97 | FALSE |
| 17 | The Cancer Genome Atlas | Prostate Adenocarcinoma | MLXIPL | 0.08 | 0.05 | enet | 4 | 0.05 | 5.3e-06 | 6.9 | 6.7 | 2.0e-11 | 0.64 | 0.00 | 1.00 | FALSE |
| 18 | The Cancer Genome Atlas | Thyroid Carcinoma | BCL7B | 0.05 | 0.01 | blup | 5 | 0.03 | 1.3e-03 | 6.9 | -6.0 | 2.5e-09 | -0.38 | 0.00 | 0.63 | FALSE |