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chr7:76,609,573-78,122,616

Best TWAS P=2.12e-09 · Best GWAS P=1.01e-08 conditioned to 0.384

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	RSBN1L	0.09	0.09	enet	9	0.09	2.0e-11	-5.6	-5.3	1.4e-07	0.94	0.02	0.98	FALSE
2	GTEx	Adipose Subcutaneous	TMEM60	0.08	0.05	lasso	4	0.05	7.3e-05	-5.1	-5.6	1.9e-08	0.96	0.02	0.98	FALSE
3	GTEx	Adipose Visceral Omentum	TMEM60	0.20	0.13	lasso	8	0.11	2.3e-06	-5.7	-5.6	2.4e-08	0.90	0.02	0.98	FALSE
4	GTEx	Cells Transformed fibroblasts	TMEM60	0.25	0.20	lasso	4	0.20	1.5e-14	-5.3	-5.2	1.9e-07	0.99	0.02	0.98	FALSE
5	GTEx	Colon Sigmoid	RSBN1L	0.17	0.09	lasso	2	0.05	5.5e-03	-5.2	-5.5	4.6e-08	0.95	0.04	0.86	FALSE
6	GTEx	Colon Sigmoid	RSBN1L-AS1	0.46	0.48	lasso	6	0.50	5.0e-20	-5.0	-5.3	1.2e-07	0.92	0.03	0.97	FALSE
7	GTEx	Esophagus Gastroesophageal Junction	RSBN1L-AS1	0.38	0.41	lasso	12	0.44	1.2e-17	-5.7	-5.5	2.8e-08	0.98	0.01	0.98	FALSE
8	GTEx	Esophagus Mucosa	TMEM60	0.06	0.04	lasso	2	0.04	1.0e-03	-5.3	-5.2	2.3e-07	0.99	0.02	0.98	FALSE
9	GTEx	Esophagus Muscularis	RSBN1L-AS1	0.35	0.51	lasso	5	0.52	3.8e-36	-5.0	-5.2	1.6e-07	0.91	0.04	0.96	FALSE
10	GTEx	Muscle Skeletal	TMEM60	0.11	0.12	lasso	4	0.12	4.6e-12	-5.3	5.3	1.3e-07	-0.98	0.02	0.98	FALSE
11	GTEx	Nerve Tibial	TMEM60	0.14	0.14	lasso	8	0.12	1.1e-08	-5.3	-5.3	8.9e-08	0.99	0.02	0.98	FALSE
12	GTEx	Ovary	RSBN1L-AS1	0.21	0.22	enet	20	0.16	8.1e-05	-5.0	-5.5	4.8e-08	0.93	0.03	0.90	FALSE
13	GTEx	Skin Sun Exposed Lower leg	TMEM60	0.10	0.10	lasso	3	0.09	1.4e-07	-5.3	-5.3	1.1e-07	0.99	0.02	0.98	FALSE
14	GTEx	Testis	RSBN1L-AS1	0.16	0.12	lasso	8	0.16	1.5e-07	-5.4	-6.0	2.1e-09	0.89	0.03	0.97	TRUE
15	GTEx	Whole Blood	TMEM60	0.05	0.04	enet	7	0.03	5.4e-04	-5.6	-5.4	5.5e-08	0.94	0.02	0.98	FALSE
16	The Cancer Genome Atlas	Breast Invasive Carcinoma	TMEM60	0.02	0.02	lasso	1	0.02	2.3e-05	5.5	-5.5	4.5e-08	0.94	0.01	0.99	FALSE
17	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	TMEM60	0.08	0.06	blup	29	0.05	2.1e-03	5.5	-5.3	8.6e-08	0.81	0.01	0.71	FALSE
18	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	TMEM60	0.05	0.02	blup	29	0.03	7.9e-03	5.5	-5.6	2.4e-08	0.87	0.01	0.75	FALSE
19	The Cancer Genome Atlas	Brain Lower Grade Glioma	RSBN1L	0.02	0.02	blup	58	0.02	3.4e-03	-5.3	5.3	1.1e-07	-0.91	0.02	0.82	FALSE
20	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TMEM60	0.02	0.03	blup	29	0.02	6.8e-03	5.5	-5.9	3.9e-09	0.94	0.01	0.90	FALSE