TWAS hub - TRIM50

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.0394	0.0171	0.00021	0.001	0.019	0.006	0.018	0.001	0.23000	0.0007	0.04300	0.00081	0.2200
2	TCGA	Kidney Renal Clear Cell Carcinoma	0.0233	0.0271	0.00780	0.017	0.013	0.016	NA	0.015	0.00440	0.0110	0.00610	NA	0.0069
3	TCGA	Skin Cutaneous Melanoma	0.1310	0.1100	0.00120	0.114	0.111	0.108	NA	0.104	0.00059	0.0007	0.00082	NA	0.0010

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Triglycerides	6.5	10.7	11.8	2.9	-3.4	-3.4
Falls in the last year	5.6	7.6	9.7	-2.0	-3.0	-3.1
Chest pain or discomfort	5.2	7.5	13.0	-3.6	-2.2	-2.2
Father’s age at death	4.8	6.4	7.2	2.3	2.6	2.7
Ever smoked	4.8	8.4	9.8	-2.4	-3.1	-3.1
Type 2 Diabetes (T2D) (2012)	4.0	4.6	7.0	0.0	2.6	2.6
Impedance of leg (right)	3.8	18.3	23.6	-2.9	-4.8	-4.9
Hearing difficulty/problems with background noise	3.8	6.1	12.6	-3.5	-1.7	-1.6
Past tobacco smoking	3.7	6.9	7.1	2.7	2.6	2.6
Impedance of leg (left)	3.6	17.7	23.7	-2.5	-4.8	-4.9
Leg pain on walking	3.6	4.6	5.6	-1.8	-2.2	-2.4
Comparative height size at age 10	3.4	18.9	40.2	-6.3	-2.9	-2.9
Ulcerative Colitis	3.3	4.8	9.6	3.1	1.6	1.6
Standing height	3.2	32.2	61.5	-7.8	-4.1	-4.3
Impedance of whole body	3.2	16.2	23.0	-1.9	-4.7	-4.8
Gout (self-reported)	3.1	4.3	6.4	-0.3	-2.5	-2.5
LDL Cholesterol	2.8	4.4	5.2	2.3	2.0	2.0
Height	2.8	54.2	110.2	-10.5	-5.1	-5.2
Seen doctor (GP) for nerves, anxiety, tension or depression	2.6	4.0	4.3	-1.9	-2.0	-2.1
Impedance of arm (right)	2.5	11.8	17.1	-1.5	-4.0	-4.1
Impedance of arm (left)	2.5	11.8	17.1	-1.4	-4.0	-4.1
Medication: Amlodipine	2.5	3.5	5.0	-0.9	-2.2	-2.2
Illnesses of father: Heart disease	2.5	3.5	3.7	1.9	1.8	1.9
Medication: Atenolol	2.4	3.0	3.4	-1.6	-1.8	-1.8
Supplements: Vitamin C	2.4	2.9	3.4	-1.8	-1.7	-1.6
Commuting to job workplace: Public transport	2.4	2.9	3.1	1.6	1.7	1.8
Smoking Status	2.3	5.6	6.5	-2.5	-2.3	-2.3
Medication: Ventolin 100micrograms inhaler	2.3	3.0	3.2	1.8	1.7	1.7
Had major operations	2.3	2.7	3.7	-0.8	-1.9	-1.9
Ever taken oral contraceptive pill	2.3	2.5	2.7	1.5	1.7	1.6
Eye problems/disorders: Diabetes related eye disease	2.2	2.5	3.4	0.9	1.9	1.8
Hearing difficulty/problems: Yes	2.1	3.2	7.5	-2.7	-1.0	-1.0
Glaucoma (self-reported)	2.1	2.5	3.1	-1.2	-1.8	-1.7
Smoking status: Previous	2.1	3.1	4.2	-2.0	-1.6	-1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.1	4.4	5.7	1.4	2.4	2.4
Risk taking	2.1	3.1	6.8	2.6	1.2	1.1
Myopia	2.1	3.1	4.5	-0.6	-2.1	-2.1
Ulcerative Colitis (UC)	2.0	3.8	10.0	3.2	0.9	0.8
Medication: Blood pressure	2.0	3.5	5.3	-0.4	-2.3	-2.2
Back pain experienced in last month	2.0	2.8	3.5	-1.9	-1.6	-1.6
Sensitivity / hurt feelings	1.9	3.2	3.6	-1.7	-1.8	-1.9
Qualifications: None of the above	1.9	4.1	4.8	-1.7	-2.2	-2.2
Medication for cholesterol	1.9	2.9	3.3	1.5	1.8	1.8
Pain type(s) experienced in last month: Hip pain	1.9	2.4	2.9	-1.7	-1.4	-1.4
Medication for hormone replacement therapy	1.8	2.0	4.5	-2.1	-0.9	-0.9
Sitting height	1.8	12.9	31.1	-5.6	-1.8	-2.0
Fluid intelligence score	1.8	3.6	5.0	1.2	2.1	2.2
Guilty feelings	1.8	2.7	2.8	-1.6	-1.7	-1.7
Average weekly beer plus cider intake	1.8	2.5	3.8	-2.0	-1.4	-1.4
Irritability	1.8	3.1	3.9	-1.3	-1.9	-2.0
Alcohol drinker status: Previous	1.8	2.0	2.1	-1.4	-1.4	-1.5
Neuroticism (2016)	1.7	2.4	3.1	-1.2	-1.8	-1.7
Mouth/teeth dental problems	1.7	2.7	3.3	1.2	1.8	1.8
Medication: Cholesterol lowering	1.7	2.7	4.0	2.0	1.4	1.5
Verbal and Numeric Reasoning (VNR)	1.6	3.8	5.2	1.2	2.2	2.3
Prospective memory result	1.6	1.9	2.0	-1.4	-1.4	-1.3
Medication: Allopurinol	1.6	2.1	3.2	0.1	-1.8	-1.8
Medication: Seretide 50 evohaler	1.6	1.9	2.7	0.6	1.6	1.6
Alcohol drinker status: Never	1.6	1.9	4.1	-2.0	-0.9	-0.9
Irritable Bowel Disease (IBD)	1.5	3.5	10.5	3.2	0.2	0.2
Prostate Cancer	1.5	2.1	5.7	2.4	0.4	0.6
Body Mass Index (BMI) (2010)	1.5	2.1	2.4	1.6	1.4	1.4
Average weekly fortified wine intake	1.5	1.7	2.3	-0.7	-1.5	-1.5
Mouth/teeth dental problems: Dentures	1.5	2.5	2.9	-1.7	-1.6	-1.5
Hair/balding pattern: Pattern 4	1.5	3.6	4.0	1.7	2.0	2.0
Medication: Co-codamol	1.4	1.6	1.8	-1.3	-1.2	-1.2
Osteoporosis (self-reported)	1.4	1.8	1.9	-1.4	-1.3	-1.3
Lupus	1.3	2.0	3.2	-0.4	-1.8	-1.6
Hair/balding pattern: Pattern 3	1.3	1.9	2.9	-0.3	-1.7	-1.7
Unable to work because of sickness or disability	1.3	1.6	2.1	-0.9	-1.4	-1.4
Lung FVC	1.2	6.0	7.5	1.9	2.6	2.7
Average weekly spirits intake	1.2	1.5	1.7	-1.3	-1.2	-1.2
Ever unenthusiastic/disinterested for a whole week	1.2	1.5	2.2	-1.5	-1.0	-1.1
Worrier / anxious feelings	1.2	2.3	3.5	-1.9	-1.3	-1.3
Qualifications: A levels/AS levels or equivalent	1.2	2.7	3.4	1.2	1.8	1.8
Number of children fathered	1.2	1.4	1.6	-1.0	-1.3	-1.2
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.2	1.8	0.4	1.3	1.3
Age started oral contraceptive pill	1.2	1.5	1.9	1.4	1.1	1.1
Alzheimer’s Disease (in mother)	1.1	1.2	1.4	-0.9	-1.2	-1.2
Medication: Simvastatin	1.1	1.6	1.6	1.2	1.2	1.3
Alcohol intake versus 10 years previously	1.1	1.7	2.6	0.2	-1.6	-1.5
Exposure to tobacco smoke outside home	1.1	1.5	2.0	-0.8	-1.3	-1.4
Qualifications: College or University degree	1.1	3.5	6.6	2.6	1.4	1.4
Alcohol intake frequency.	1.1	2.6	4.0	-0.0	-2.0	-2.0
Age at last live birth	1.1	1.7	2.2	1.0	1.5	1.4
Wears glasses or contact lenses	1.1	1.3	1.9	0.5	1.3	1.4
Crohns Disease (2012)	1.0	1.6	1.8	1.1	-1.3	-1.3
Trunk fat percentage	1.0	3.9	4.9	-1.4	-2.2	-2.2
Age when periods started (menarche)	1.0	2.5	4.5	2.1	1.2	1.2
Serious illness, injury or assault to yourself	1.0	1.2	1.3	-1.0	-1.1	-1.1
Hip circumference	1.0	4.5	9.6	-3.1	-1.4	-1.4
Chronic bronchitis/emphysema (mother)	1.0	1.1	1.7	0.3	-1.3	-1.3
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	1.8	0.3	1.3	1.3
Emphysema/chronic bronchitis	1.0	1.1	1.6	-0.4	1.3	1.3
Neck or shoulder pain in last month	1.0	1.4	1.5	1.0	1.2	1.2
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	1.7	-0.4	-1.3	-1.3
Commuting to job workplace: Car/motor vehicle	1.0	1.1	1.8	1.3	0.9	0.9
Illnesses of father: None of the above (group 1)	1.0	1.2	1.8	-0.5	-1.3	-1.3
Heart disease (siblings)	1.0	1.3	2.5	1.6	0.8	0.8
Intelligence (Savage-Jansen 2018)	0.9	2.7	4.2	0.4	2.0	2.0
Alzheimer’s Disease (including proxy)	0.9	1.3	1.3	-1.1	-1.1	-1.1
Mean Putamen Volume	0.9	1.0	1.1	-0.9	-1.0	-1.1
Blood White Count	0.9	7.0	10.5	-0.6	-3.2	-3.2
Number of treatments/medications taken	0.9	1.6	2.2	-0.7	-1.5	-1.5
Vitamin and mineral supplements	0.9	1.3	1.7	0.7	1.3	1.3
Number of incorrect matches in round	0.9	1.4	2.5	1.6	1.0	0.9
Trunk predicted mass	0.9	4.9	14.6	-3.8	0.3	0.3
Tense / ‘highly strung’	0.9	1.5	2.4	-1.5	-1.1	-1.0
Qualifications: O levels/GCSEs or equivalent	0.9	1.4	2.0	0.6	1.3	1.4
Forced expiratory volume in 1-second (FEV1), predicted	0.9	2.0	3.2	-1.8	-1.1	-1.2
Crohns Disease (2017)	0.8	1.7	4.1	2.0	-0.7	-0.7
Primary Biliary Cirrhosis	0.8	1.1	3.4	1.8	0.0	0.2
Neuroticism	0.8	1.9	2.0	-1.3	-1.4	-1.4
Trunk fat mass	0.8	3.6	4.7	-2.2	-1.7	-1.7
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.2	1.6	-1.3	-1.0	-1.0
Trunk fat-free mass	0.8	4.8	14.0	-3.7	0.4	0.4
Asthma	0.8	1.6	2.2	0.7	1.5	1.4
Medication: Lansoprazole	0.8	0.9	1.0	-1.0	-0.9	-0.9
Arm fat-free mass (right)	0.8	4.1	11.8	-3.4	0.4	0.4
Arm predicted mass (right)	0.8	4.1	12.1	-3.5	0.3	0.3
Mood swings	0.8	1.5	2.3	-0.3	-1.5	-1.5
Eye problems/disorders: Glaucoma	0.8	0.9	1.4	0.1	-1.2	-1.1
Respiratory disease	0.7	1.6	2.4	-0.2	1.6	1.5
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.5	2.3	-0.1	1.5	1.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.3	3.5	-0.2	1.9	1.8
Mouth/teeth dental problems: Bleeding gums	0.7	0.8	1.7	1.3	0.7	0.7
Medication: Paracetamol	0.7	1.1	1.6	-0.1	-1.3	-1.3
Mouth/teeth dental problems: Loose teeth	0.7	0.8	1.2	-0.1	-1.1	-1.1
Medication for pain relief, constipation, heartburn	0.7	1.2	1.3	1.0	1.1	1.1
Mean time to correctly identify matches	0.7	1.3	1.8	0.5	1.4	1.3
Whole body fat-free mass	0.7	3.8	10.8	-3.3	0.5	0.5
Qualifications: nursing, teaching	0.7	1.1	2.5	1.6	0.6	0.6
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	1.1	-1.1	-1.0	-1.0
Asthma (self-reported)	0.7	1.5	2.2	0.3	1.5	1.4
Osteoarthritis (self-reported)	0.7	0.9	1.0	0.8	1.0	1.0
Whole body water mass	0.7	3.8	10.6	-3.2	0.6	0.6
Mother’s age at death	0.7	0.8	1.3	1.1	0.7	0.8
Basal metabolic rate	0.7	3.7	11.2	-3.3	0.1	0.1
Arm fat-free mass (left)	0.7	3.5	10.6	-3.3	0.1	0.1
Arm predicted mass (left)	0.7	3.8	11.2	-3.3	0.2	0.2
Heel T-Score	0.6	5.0	6.9	1.2	2.6	2.6
Waist Hip Ratio (WHR)	0.6	2.8	3.3	1.4	-1.8	-1.7
Cardiovascular Disease	0.6	2.0	3.0	-0.2	-1.7	-1.7
Relative age of first facial hair	0.6	1.1	1.8	1.3	0.9	0.9
Diabetes (father)	0.6	0.7	1.1	-0.4	1.0	1.1
Pack years adult smoking proportion	0.6	0.9	1.5	1.2	0.9	0.8
Supplements: Glucosamine	0.6	0.7	2.2	1.5	-0.1	-0.1
Alcohol usually taken with meals	0.6	0.9	1.8	1.4	0.6	0.7
Hair/balding pattern: Pattern 2	0.6	0.7	0.9	-0.7	-0.9	-0.9
Had menopause	0.6	0.8	0.9	-0.7	-0.9	-1.0
Forced vital capacity (FVC), Best measure	0.6	2.2	3.2	-0.6	1.8	1.7
Number of full brothers	0.6	0.7	1.1	-0.0	-1.0	-1.1
Wheeze or whistling in the chest in last year	0.6	1.0	1.6	0.4	1.2	1.3
Medication: Gliclazide	0.6	0.7	1.0	1.0	0.7	0.7
Fractured/broken bones in last 5 years	0.6	0.8	1.2	0.2	-1.0	-1.1
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	1.0	-0.7	0.9	1.0
Reaction Time	0.5	0.9	1.3	0.5	1.1	1.1
Breast Cancer	0.5	1.1	1.7	-0.3	-1.3	-1.3
HbA1C	0.5	0.6	0.6	0.7	0.8	0.8
Rheumatoid Arthritis	0.5	0.7	0.9	0.6	0.9	0.9
Blood Platelet Count	0.5	6.0	8.3	2.9	-2.2	-2.2
Systolic Blood Pressure	0.5	2.5	3.2	-1.1	-1.7	-1.8
Lung FEV1/FVC ratio	0.5	2.3	3.6	-0.1	1.9	1.9
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	0.9	1.0	0.6	0.6
Leg fat-free mass (left)	0.5	2.4	6.8	-2.6	0.5	0.5
Hand grip strength (right)	0.5	1.5	1.7	-1.1	1.3	1.3
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	0.8	-0.9	-0.6	-0.7
Leg predicted mass (left)	0.5	2.4	6.6	-2.6	0.6	0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	1.5	0.6	1.2	1.2
Allergy	0.5	1.3	1.9	-0.0	-1.4	-1.4
Weight	0.5	2.6	6.9	-2.6	-0.6	-0.6
Time employed in main current job	0.5	0.6	0.8	-0.5	-0.9	-0.8
Pulse rate	0.5	0.9	2.6	1.6	0.3	0.3
Noisy workplace	0.5	0.6	1.0	1.0	-0.6	-0.6
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	0.9	-0.5	-0.9	-0.9
Exposure to tobacco smoke at home	0.5	0.6	0.7	0.6	-0.9	-0.8
Comparative body size at age 10	0.5	1.4	3.4	1.8	0.6	0.6
Health satisfaction	0.5	0.7	2.0	-1.4	0.2	0.1
Suffer from ‘nerves’	0.5	0.8	1.4	-1.2	-0.6	-0.7
Mineral and other dietary supplements	0.5	0.7	2.0	-1.4	0.0	-0.0
Medication: Paracetamol	0.5	0.7	1.1	0.0	-1.0	-1.1
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.3	1.1	0.5	0.6
Commuting to job workplace: Cycle	0.5	0.6	1.8	-1.3	0.0	0.0
Alzheimer’s Disease (in father)	0.4	0.5	0.7	0.1	-0.8	-0.8
HDL Cholesterol	0.4	0.6	0.8	-0.6	0.9	0.9
Blood Red Count	0.4	4.3	4.6	-2.0	-2.1	-2.1
Chronotype (morning person)	0.4	0.9	1.2	0.6	1.1	1.1
Angina	0.4	0.5	0.8	-0.9	-0.6	-0.6
Townsend deprivation index at recruitment	0.4	0.5	0.5	-0.7	-0.7	-0.7
Maternal smoking around birth	0.4	0.6	0.6	0.8	0.7	0.7
Body mass index (BMI)	0.4	1.7	2.3	0.9	1.4	1.5
Waist circumference	0.4	1.5	2.0	-1.4	-1.2	-1.1
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.6	-1.3	0.1	0.1
Neuroticism score	0.4	0.9	1.1	-1.1	-0.8	-0.9
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	1.7	-1.3	0.1	0.1
Forced expiratory volume in 1-second (FEV1)	0.4	1.4	2.1	-0.3	1.4	1.4
Blood clot in the leg (DVT)	0.4	0.5	0.7	-0.8	0.6	0.7
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	0.8	-0.7	0.9	0.8
Hypothyroidism/myxoedema (self-reported)	0.4	0.9	1.1	1.1	-0.8	-0.9
Birth weight	0.4	0.8	1.7	-1.3	-0.5	-0.6
Age at first live birth	0.4	0.7	0.8	0.7	0.9	0.9
Pulse wave peak to peak time	0.4	0.4	1.3	-1.1	-0.0	0.1
Eye problems/disorders: None of the above	0.4	0.5	0.7	-0.5	-0.7	-0.8
Migraine (self-reported)	0.4	0.5	1.5	1.2	0.2	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.4	1.0	1.0	0.4	0.4
Whole body fat mass	0.4	1.6	2.7	-1.6	-1.0	-1.0
Pulse rate, automated reading	0.4	1.4	2.2	1.5	-0.9	-1.0
Number of full sisters	0.4	0.5	0.5	-0.7	-0.7	-0.7
Hypertension (Self-reported)	0.4	1.2	1.9	0.0	-1.4	-1.3
Leg fat-free mass (right)	0.4	1.9	4.7	-2.2	0.8	0.7
Commuting to job workplace: Walk	0.4	0.5	0.6	-0.8	-0.7	-0.6
Eye problems/disorders: Cataract	0.4	0.5	1.4	-1.2	-0.2	-0.1
Leg predicted mass (right)	0.4	2.0	4.8	-2.2	0.8	0.8
Medication: Blood pressure	0.4	0.8	1.1	0.5	-1.1	-1.0
Ever depressed for a whole week	0.4	0.5	0.7	0.2	0.8	0.8
Neuroticism (Nagel 2018)	0.3	0.8	1.1	-0.7	-0.9	-1.0
BMI	0.3	2.0	3.1	0.0	1.7	1.8
Allergy or Eczema	0.3	0.9	1.0	-0.8	1.0	1.0
Hypothyroidism (self reported)	0.3	0.6	0.8	0.9	-0.7	-0.7
Hand grip strength (left)	0.3	0.9	0.9	-0.9	0.9	0.9
Frequency of depressed mood in last 2 weeks	0.3	0.4	0.5	-0.7	-0.6	-0.6
Supplements: Zinc	0.3	0.4	0.5	-0.1	-0.7	-0.7
Severe depression (siblings)	0.3	0.3	0.5	0.2	0.7	0.7
High blood pressure	0.3	0.7	1.2	0.2	-1.1	-1.0
Illnesses of siblings	0.3	0.4	0.8	-0.9	-0.4	-0.4
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	0.4	0.0	0.7	0.7
Lung cancer (father)	0.3	0.4	0.9	-0.9	0.3	0.3
Breastfed as a baby	0.3	0.4	0.5	0.4	-0.7	-0.7
Pulse wave reflection index	0.3	0.4	0.8	0.9	0.6	0.4
Body fat percentage	0.3	1.2	1.7	-0.6	-1.3	-1.3
Worry too long after embarrassment	0.3	0.5	1.2	-1.1	0.4	0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	0.6	0.7	0.4	0.5
Handedness (chirality/laterality): Left-handed	0.3	0.4	0.9	-0.9	-0.4	-0.4
Ever had bowel cancer screening	0.3	0.4	0.6	-0.1	-0.8	-0.8
Smoking status: Current	0.3	0.5	0.7	-0.8	-0.6	-0.6
Financial situation satisfaction	0.3	0.4	0.6	-0.8	-0.5	-0.5
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.2	1.1	-0.3	-0.3
Medication: Lisinopril	0.3	0.4	0.7	-0.3	-0.8	-0.7
Number of operations (self-reported)	0.3	0.4	0.5	-0.4	-0.7	-0.7
Diastolic blood pressure, automated reading	0.3	1.0	1.7	1.3	-0.8	-0.9
Pack years of smoking	0.3	0.5	1.1	1.1	0.5	0.4
Worry (Nagel 2018)	0.2	0.4	0.8	-0.9	-0.5	-0.5
Age at First Birth	0.2	0.3	0.3	0.3	0.6	0.6
Schizophrenia (2014)	0.2	0.4	0.6	0.3	-0.7	-0.7
Type 2 Diabetes (T2D) (2018)	0.2	0.4	0.5	-0.7	0.6	0.6
Ever had hysterectomy (womb removed)	0.2	0.3	0.3	0.6	0.5	0.5
Medication: Metformin	0.2	0.2	0.6	-0.7	0.2	0.3
Current tobacco smoking	0.2	0.3	0.7	-0.8	-0.3	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.7	-0.8	-0.1	-0.1
Taking other prescription medications	0.2	0.2	0.4	-0.0	-0.6	-0.6
Bilateral oophorectomy (both ovaries removed)	0.2	0.3	0.5	-0.7	-0.4	-0.4
Hayfever, allergic rhinitis or eczema	0.2	0.5	0.8	-0.1	0.9	0.9
Multivitamins +/- minerals	0.2	0.2	0.3	0.6	0.4	0.3
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.6	0.8	-0.2	-0.2
Medication: Levothyroxine sodium	0.2	0.3	0.7	0.8	-0.3	-0.4
High blood pressure (mother)	0.2	0.2	0.4	0.1	-0.6	-0.6
Had other major operations	0.2	0.2	0.7	-0.8	-0.2	-0.2
Forced vital capacity (FVC)	0.2	0.9	1.1	-1.0	0.9	0.8
Diabetes (self-reported)	0.2	0.4	0.6	-0.2	0.7	0.8
Medication: Ramipril	0.2	0.3	0.6	0.8	0.4	0.4
Illnesses of mother	0.2	0.2	0.4	-0.2	0.6	0.5
Pulse wave Arterial Stiffness index	0.2	0.2	0.3	0.6	-0.3	-0.4
Birth weight of first child	0.2	0.4	0.7	-0.8	0.5	0.5
Loud music exposure frequency	0.2	0.2	0.3	0.3	0.5	0.5
High blood pressure (siblings)	0.2	0.3	0.5	0.7	-0.4	-0.4
Leg fat percentage (right)	0.2	0.6	0.8	-0.6	-0.9	-0.9
Shortness of breath walking on level ground	0.2	0.3	0.4	-0.6	0.4	0.5
Angina (self-reported)	0.2	0.3	0.7	-0.8	-0.3	-0.3
Leg fat mass (right)	0.2	0.8	1.8	-1.3	-0.5	-0.5
Overall health rating	0.2	0.5	0.9	-1.0	-0.5	-0.5
Long-standing illness, disability or infirmity	0.2	0.4	1.1	-1.0	0.1	0.1
Diabetes diagnosed by doctor	0.2	0.2	0.3	-0.4	0.5	0.6
Medication: Aspirin	0.2	0.2	0.6	0.8	0.1	0.1
Average weekly champagne plus white wine intake	0.2	0.2	0.3	0.6	0.4	0.5
Miserableness	0.2	0.4	0.9	1.0	-0.3	-0.3
Medication: Atorvastatin	0.2	0.2	0.4	0.6	-0.4	-0.4
Vascular/heart problems diagnosed by doctor	0.2	0.6	1.1	-0.0	1.0	0.9
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.3	-0.3	-0.6	-0.6
Bipolar Disorder (2018)	0.1	0.2	0.2	0.5	0.5	0.4
Depressed Affect (Nagel 2018)	0.1	0.2	0.6	0.8	-0.2	-0.2
Schizophrenia (2018)	0.1	0.2	0.2	0.4	-0.4	-0.4
Coronary Artery Disease (CAD)	0.1	0.2	0.2	0.0	0.5	0.5
Blood Eosinophil Count	0.1	0.6	1.8	-1.4	0.2	0.2
Hair Pigment	0.1	3.8	5.8	0.0	-2.3	-2.4
Tanning	0.1	1.0	3.0	-1.7	-0.2	-0.3
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.3	-0.6	-0.1	-0.1
Diabetes (mother)	0.1	0.2	0.2	0.3	-0.5	-0.4
Relative age voice broke	0.1	0.2	0.3	0.2	0.5	0.6
Stomach or abdominal pain in last month	0.1	0.1	0.2	-0.4	-0.2	-0.2
Chronic bronchitis/emphysema (father)	0.1	0.1	0.2	-0.4	0.3	0.3
Nervous feelings	0.1	0.2	0.5	-0.7	0.2	0.1
Heart attack	0.1	0.1	0.1	0.4	0.2	0.2
Happiness	0.1	0.1	0.1	0.3	0.3	0.3
Depression (self-reported)	0.1	0.2	0.5	0.7	-0.0	-0.0
Arm fat mass (right)	0.1	0.3	0.9	-0.9	-0.3	-0.2
Length of working week for main job	0.1	0.1	0.1	0.2	0.3	0.3
Peak expiratory flow (PEF)	0.1	0.3	0.4	-0.0	0.7	0.6
Ever highly irritable/argumentative for 2 days	0.1	0.2	0.4	0.7	0.2	0.2
Headache pain in last month	0.1	0.2	0.6	0.8	-0.1	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.2	0.3	-0.4	-0.4
Medication: Ibuprofen	0.1	0.1	0.1	-0.1	-0.4	-0.3
Heart disease (mother)	0.1	0.2	0.3	0.1	0.5	0.6
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.4	0.6	0.0	0.0
Medication: Aspirin	0.1	0.1	0.2	0.5	-0.2	-0.2
Average weekly red wine intake	0.1	0.2	0.3	-0.5	0.5	0.4
Loneliness, isolation	0.1	0.1	0.1	0.4	-0.2	-0.2
Friendships satisfaction	0.1	0.1	0.1	-0.2	0.3	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.2	-0.3	0.4	0.3
Arm fat mass (left)	0.1	0.3	0.6	-0.8	-0.3	-0.2
Number of self-reported non-cancer illnesses	0.1	0.1	0.2	0.2	-0.4	-0.4
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.1	0.4	0.3	0.2
High cholesterol (Self-reported)	0.1	0.2	0.5	0.7	-0.2	-0.2
Medication: Bendroflumethiazide	0.1	0.2	0.3	0.6	-0.4	-0.4
Illnesses of father: High blood pressure	0.1	0.1	0.3	0.5	-0.0	0.0
Leg fat percentage (left)	0.1	0.5	0.8	-0.2	-0.9	-0.8
Basal cell carcinoma (self-reported)	0.1	0.1	0.1	-0.3	0.2	0.3
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.3	0.5	0.2	0.3
Leg fat mass (left)	0.1	0.6	1.2	-1.1	-0.5	-0.5
Bipolar Disorder or Schizophrenia	0.0	0.1	0.3	0.6	-0.0	-0.0
Depression (Nagel 2018)	0.0	0.0	0.1	0.1	0.2	0.3
Schizophrenia vs Biploar Disorder	0.0	0.0	0.0	-0.1	-0.1	-0.0
Major Depression (MDD)	0.0	0.0	0.1	0.3	-0.1	-0.2
Ovarian Cancer	0.0	0.0	0.1	-0.4	-0.1	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Fasting Glucose	0.0	0.0	0.0	-0.0	-0.1	0.1
Systolic blood pressure, automated reading	0.0	0.0	0.1	-0.3	-0.1	-0.1
Fed-up feelings	0.0	0.0	0.1	-0.2	-0.2	-0.2
Qualifications: CSEs or equivalent	0.0	0.0	0.1	0.2	-0.1	-0.0
Financial difficulties in last 2 years	0.0	0.0	0.1	-0.2	-0.1	-0.1
Pain all over the body in last month	0.0	0.0	0.0	0.1	0.1	0.0
Arm fat percentage (right)	0.0	0.1	0.4	0.6	-0.1	-0.0
Number of live births	0.0	0.0	0.0	0.1	-0.1	-0.1
Medication: Omeprazole	0.0	0.0	0.0	-0.1	0.0	0.0
Family relationship satisfaction	0.0	0.0	0.1	-0.2	0.0	0.0
Knee pain experienced in last month	0.0	0.0	0.0	0.2	0.1	0.0
Illnesses of siblings: Diabetes	0.0	0.0	0.1	-0.3	0.0	0.0
Arm fat percentage (left)	0.0	0.2	0.5	0.7	-0.0	0.0
Breast cancer (self-reported)	0.0	0.0	0.1	0.0	-0.3	-0.2
Hearing aid user	0.0	0.0	0.0	-0.1	0.0	0.1
Cholesterol lowering medication	0.0	0.0	0.0	-0.1	0.2	0.2
Pain experienced in last month	0.0	0.0	0.0	0.1	0.1	0.1
Supplements: Calcium	0.0	0.0	0.1	0.1	-0.3	-0.3

Hub : Genes

TRIM50

Models

Trait associations