Best TWAS P=1.33e-09 · Best GWAS P=3.33e-15 conditioned to 3.57e-10
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Cells EBV-transformed lymphocytes | NEXN | 0.23 | 0.10 | lasso | 3 | 0.08 | 1.4e-03 | -5.1 | -5.3 | 1.4e-07 | -0.13 | 0.21 | 0.04 | FALSE |
2 | GTEx | Lung | GIPC2 | 0.15 | 0.09 | enet | 17 | 0.12 | 2.5e-09 | -5.8 | 6.1 | 1.3e-09 | 0.19 | 1.00 | 0.00 | TRUE |
3 | GTEx | Pancreas | GIPC2 | 0.41 | 0.13 | enet | 29 | 0.14 | 1.1e-06 | -4.6 | 5.2 | 2.4e-07 | 0.31 | 0.65 | 0.10 | FALSE |
4 | GTEx | Spleen | GIPC2 | 0.43 | 0.07 | enet | 19 | 0.22 | 2.9e-06 | -4.5 | 5.2 | 1.7e-07 | 0.22 | 0.83 | 0.02 | FALSE |
5 | ROSMAP | Brain Pre-frontal Cortex | FAM73A | 0.09 | 0.04 | enet | 19 | 0.06 | 9.6e-09 | -2.3 | 5.4 | 6.8e-08 | 0.33 | 0.99 | 0.01 | FALSE |
6 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | DNAJB4 | 0.05 | 0.03 | lasso | 3 | 0.02 | 3.3e-03 | -4.6 | -5.6 | 2.6e-08 | -0.20 | 0.00 | 0.99 | FALSE |
7 | The Cancer Genome Atlas | Colon Adenocarcinoma | GIPC2 | 0.04 | 0.01 | blup | 65 | 0.00 | 2.5e-01 | -4.2 | 5.1 | 2.7e-07 | 0.28 | 0.07 | 0.06 | FALSE |
8 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | FAM73A | 0.14 | 0.02 | enet | 14 | 0.06 | 3.8e-04 | 3.3 | 5.6 | 2.6e-08 | 0.11 | 0.01 | 0.04 | TRUE |
9 | The Cancer Genome Atlas | Thyroid Carcinoma | GIPC2 | 0.07 | 0.05 | blup | 64 | 0.06 | 1.5e-06 | -5.9 | 5.5 | 3.9e-08 | 0.28 | 0.67 | 0.02 | FALSE |