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chr1:88,453,303-90,145,331

Best TWAS P=8.69e-16 · Best GWAS P=2.25e-17 conditioned to 0.00144

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	CCBL2	0.58	0.68	lasso	7	0.69	1.4e-117	-6.4	7.0	1.8e-12	-0.75	1.00	0.00	FALSE
2	GTEx	Adipose Subcutaneous	CCBL2	0.26	0.21	enet	15	0.23	1.2e-18	-6.5	7.0	3.1e-12	-0.68	1.00	0.00	FALSE
3	GTEx	Adipose Visceral Omentum	PKN2	0.09	0.04	enet	8	0.05	1.2e-03	-7.7	-6.6	3.6e-11	0.70	0.27	0.44	FALSE
4	GTEx	Adipose Visceral Omentum	CCBL2	0.21	0.10	enet	7	0.15	5.2e-08	-6.4	7.2	4.1e-13	-0.73	0.84	0.15	FALSE
5	GTEx	Adrenal Gland	CCBL2	0.18	0.13	enet	46	0.14	1.4e-05	-7.8	6.2	4.7e-10	-0.65	0.12	0.84	FALSE
6	GTEx	Artery Aorta	CCBL2	0.29	0.20	enet	24	0.24	1.5e-13	-6.4	7.1	1.1e-12	-0.70	0.99	0.01	FALSE
7	GTEx	Artery Coronary	CCBL2	0.29	0.19	enet	5	0.14	1.6e-05	-6.1	6.3	2.1e-10	-0.72	0.51	0.35	FALSE
8	GTEx	Artery Tibial	CCBL2	0.30	0.24	lasso	8	0.29	4.9e-23	-6.4	7.6	3.9e-14	-0.74	0.99	0.01	FALSE
9	GTEx	Brain Caudate basal ganglia	CCBL2	0.27	0.21	enet	30	0.29	7.0e-09	-6.4	6.2	4.2e-10	-0.69	0.49	0.49	FALSE
10	GTEx	Brain Cerebellar Hemisphere	CCBL2	0.31	0.18	lasso	5	0.23	1.7e-06	-7.7	8.0	8.7e-16	-0.84	0.18	0.77	TRUE
11	GTEx	Brain Cerebellum	CCBL2	0.39	0.30	enet	23	0.33	1.7e-10	-6.3	6.8	7.4e-12	-0.65	0.48	0.51	FALSE
12	GTEx	Brain Cortex	CCBL2	0.59	0.39	enet	13	0.37	3.0e-11	-7.7	7.1	1.0e-12	-0.76	0.81	0.19	FALSE
13	GTEx	Brain Frontal Cortex BA9	CCBL2	0.47	0.38	enet	25	0.48	1.5e-14	-6.4	7.2	5.3e-13	-0.79	0.66	0.33	FALSE
14	GTEx	Brain Hippocampus	CCBL2	0.39	0.27	lasso	5	0.13	5.1e-04	-6.5	-6.3	2.7e-10	0.69	0.22	0.26	FALSE
15	GTEx	Brain Hypothalamus	CCBL2	0.34	0.00	enet	34	0.13	6.4e-04	-6.5	5.6	1.9e-08	-0.49	0.22	0.22	FALSE
16	GTEx	Brain Nucleus accumbens basal ganglia	CCBL2	0.38	0.44	enet	20	0.32	2.1e-09	-6.4	7.5	7.7e-14	-0.82	0.36	0.64	FALSE
17	GTEx	Brain Putamen basal ganglia	CCBL2	0.35	0.26	enet	21	0.25	1.2e-06	-6.4	7.3	2.1e-13	-0.75	0.08	0.88	FALSE
18	GTEx	Breast Mammary Tissue	CCBL2	0.15	0.11	lasso	5	0.09	1.8e-05	-6.4	6.4	1.5e-10	-0.73	0.71	0.25	FALSE
19	GTEx	Breast Mammary Tissue (Male)	CCBL2	0.14	0.03	lasso	2	0.02	8.8e-02	-6.4	6.4	1.7e-10	-0.72	0.05	0.32	FALSE
20	GTEx	Cells Transformed fibroblasts	CCBL2	0.65	0.61	enet	32	0.67	6.1e-67	-6.4	7.0	1.9e-12	-0.74	1.00	0.00	FALSE
21	GTEx	Colon Sigmoid	CCBL2	0.22	0.12	enet	4	0.09	5.2e-04	-6.3	6.2	5.7e-10	-0.71	0.16	0.71	FALSE
22	GTEx	Colon Transverse	PKN2	0.23	0.08	lasso	7	0.08	1.0e-04	4.2	6.0	2.1e-09	-0.67	0.30	0.61	FALSE
23	GTEx	Colon Transverse	CCBL2	0.30	0.19	lasso	8	0.26	1.2e-12	-6.4	7.6	2.5e-14	-0.75	0.85	0.15	FALSE
24	GTEx	Esophagus Mucosa	CCBL2	0.35	0.19	enet	27	0.30	2.7e-20	-6.4	6.7	2.6e-11	-0.58	0.97	0.03	FALSE
25	GTEx	Esophagus Muscularis	CCBL2	0.25	0.29	enet	18	0.28	1.6e-17	-6.5	7.2	6.2e-13	-0.76	1.00	0.00	FALSE
26	GTEx	Heart Atrial Appendage	CCBL2	0.30	0.20	enet	11	0.15	3.4e-07	-6.5	6.7	3.0e-11	-0.73	0.96	0.04	FALSE
27	GTEx	Lung	CCBL2	0.15	0.13	enet	13	0.17	4.8e-13	-6.3	6.9	5.9e-12	-0.70	0.94	0.06	FALSE
28	GTEx	Muscle Skeletal	CCBL2	0.12	0.15	enet	9	0.16	5.4e-15	-6.5	6.4	1.2e-10	-0.74	1.00	0.00	FALSE
29	GTEx	Nerve Tibial	CCBL2	0.42	0.33	enet	38	0.38	3.4e-28	-6.4	7.0	2.8e-12	-0.76	1.00	0.00	FALSE
30	GTEx	Pancreas	CCBL2	0.26	0.21	lasso	4	0.23	5.3e-10	-7.7	7.8	7.5e-15	-0.62	0.49	0.48	FALSE
31	GTEx	Pituitary	CCBL2	0.45	0.30	lasso	2	0.26	2.7e-07	-7.7	7.6	3.3e-14	-0.76	0.60	0.35	FALSE
32	GTEx	Skin Sun Exposed Lower leg	CCBL2	0.18	0.09	enet	12	0.17	4.0e-14	-6.4	7.2	5.2e-13	-0.66	0.75	0.25	FALSE
33	GTEx	Small Intestine Terminal Ileum	PKN2	0.26	0.34	lasso	5	0.23	7.0e-06	-5.7	5.7	1.5e-08	-0.64	0.53	0.15	FALSE
34	GTEx	Stomach	CCBL2	0.16	0.08	lasso	4	0.15	9.0e-08	-6.4	7.9	2.0e-15	-0.88	0.02	0.98	FALSE
35	GTEx	Testis	CCBL2	0.47	0.56	lasso	5	0.57	1.2e-30	-6.4	6.4	1.2e-10	-0.73	1.00	0.00	FALSE
36	GTEx	Thyroid	CCBL2	0.22	0.15	enet	22	0.22	9.8e-17	-7.7	7.6	2.4e-14	-0.66	0.76	0.24	FALSE
37	GTEx	Thyroid	RBMXL1	0.09	0.02	enet	19	0.04	2.7e-04	-3.1	7.3	2.7e-13	-0.50	0.16	0.50	FALSE
38	GTEx	Whole Blood	CCBL2	0.08	0.07	lasso	3	0.06	3.1e-06	-6.4	6.2	4.6e-10	-0.73	0.89	0.07	FALSE
39	METSIM	Adipose	CCBL2	0.27	0.14	lasso	6	0.18	6.4e-27	-6.5	7.5	5.4e-14	-0.75	0.97	0.03	FALSE
40	ROSMAP	Brain Pre-frontal Cortex	CCBL2	0.43	0.56	enet	31	0.56	1.1e-87	-6.5	7.2	6.4e-13	-0.79	1.00	0.00	FALSE
41	YFS	Blood	CCBL2	0.10	0.05	bslmm	366	0.08	2.8e-26	-6.4	5.9	4.6e-09	-0.45	1.00	0.00	FALSE
42	YFS	Blood	GTF2B	0.01	0.00	lasso	3	0.01	2.3e-04	-7.6	-7.3	3.4e-13	0.70	0.10	0.68	FALSE
43	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	CCBL2	0.14	0.09	enet	12	0.10	1.5e-08	-6.3	5.7	1.3e-08	-0.66	1.00	0.00	FALSE
44	The Cancer Genome Atlas	Breast Invasive Carcinoma	CCBL2	0.20	0.36	lasso	5	0.36	1.7e-78	-6.3	6.4	1.3e-10	-0.73	1.00	0.00	FALSE
45	The Cancer Genome Atlas	Breast Invasive Carcinoma	PKN2	0.02	0.01	enet	5	0.01	2.3e-03	-6.5	-6.5	8.3e-11	0.66	0.08	0.21	FALSE
46	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	CCBL2	0.09	0.08	blup	61	0.07	3.6e-04	-6.4	5.2	1.5e-07	-0.66	0.30	0.59	FALSE
47	The Cancer Genome Atlas	Colon Adenocarcinoma	CCBL2	0.23	0.28	lasso	3	0.26	3.9e-15	-6.4	5.8	7.2e-09	-0.69	1.00	0.00	FALSE
48	The Cancer Genome Atlas	Glioblastoma Multiforme	CCBL2	0.36	0.32	enet	37	0.33	6.4e-11	-6.4	7.0	2.2e-12	-0.67	0.18	0.82	FALSE
49	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CCBL2	0.07	0.06	lasso	2	0.05	1.2e-06	-6.4	6.2	7.6e-10	-0.67	0.34	0.64	FALSE
50	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CCBL2	0.37	0.48	enet	20	0.50	1.5e-63	-6.3	6.3	2.1e-10	-0.69	1.00	0.00	FALSE
51	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	CCBL2	0.28	0.42	enet	15	0.40	1.5e-24	-6.4	6.6	3.1e-11	-0.74	1.00	0.00	FALSE
52	The Cancer Genome Atlas	Brain Lower Grade Glioma	CCBL2	0.28	0.32	enet	24	0.31	2.5e-35	-6.4	6.4	1.7e-10	-0.68	1.00	0.00	FALSE
53	The Cancer Genome Atlas	Brain Lower Grade Glioma	PKN2	0.05	0.01	enet	8	0.02	1.6e-03	-7.7	-7.8	6.2e-15	0.91	0.02	0.97	FALSE
54	The Cancer Genome Atlas	Lung Adenocarcinoma	CCBL2	0.09	0.12	enet	10	0.11	8.7e-13	-6.4	5.9	4.3e-09	-0.68	1.00	0.00	FALSE
55	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	CCBL2	0.10	0.07	enet	12	0.08	2.0e-09	-6.4	5.8	8.0e-09	-0.58	0.97	0.02	FALSE
56	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	CCBL2	0.15	0.18	lasso	2	0.16	3.5e-07	-6.1	6.2	7.3e-10	-0.69	0.52	0.44	FALSE
57	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	CCBL2	0.37	0.47	enet	19	0.46	3.1e-20	-6.4	6.6	3.4e-11	-0.77	1.00	0.00	FALSE
58	The Cancer Genome Atlas	Prostate Adenocarcinoma	CCBL2	0.20	0.34	lasso	2	0.35	9.5e-38	-6.4	6.4	1.3e-10	-0.74	1.00	0.00	FALSE
59	The Cancer Genome Atlas	Rectum Adenocarcinoma	CCBL2	0.35	0.27	lasso	6	0.25	1.7e-06	-6.4	6.4	1.5e-10	-0.73	0.31	0.61	FALSE
60	The Cancer Genome Atlas	Soft Tissue Sarcoma	CCBL2	0.28	0.32	enet	21	0.32	8.7e-20	-6.4	6.5	8.9e-11	-0.73	1.00	0.00	FALSE
61	The Cancer Genome Atlas	Skin Cutaneous Melanoma	CCBL2	0.24	0.20	enet	12	0.17	2.7e-05	-6.4	6.2	6.6e-10	-0.72	0.31	0.18	FALSE
62	The Cancer Genome Atlas	Stomach Adenocarcinoma	CCBL2	0.11	0.13	enet	14	0.11	1.7e-08	-6.4	6.1	9.4e-10	-0.71	0.96	0.04	FALSE
63	The Cancer Genome Atlas	Thyroid Carcinoma	CCBL2	0.45	0.64	enet	13	0.66	1.4e-86	-6.4	6.5	9.5e-11	-0.75	1.00	0.00	FALSE
64	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	CCBL2	0.20	0.22	enet	16	0.18	8.6e-06	-6.4	5.2	2.2e-07	-0.65	0.26	0.66	FALSE