TWAS hub - NEXN

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells EBV-transformed lymphocytes	0.2270	0.1030	2.7e-03	0.101	NA	0.009	NA	0.081	3.7e-04	NA	1.6e-01	NA	1.4e-03
2	GTEx	Cells Transformed fibroblasts	0.1080	0.0430	1.6e-04	0.060	NA	0.050	NA	0.067	2.8e-05	NA	1.2e-04	NA	9.6e-06
3	GTEx	Nerve Tibial	0.1115	0.0470	2.2e-03	-0.004	NA	-0.003	NA	-0.004	8.5e-01	NA	6.5e-01	NA	8.4e-01
4	METSIM	Adipose	0.0599	0.0193	6.5e-06	0.037	0.032	0.023	0.030	0.017	2.2e-06	1.2e-05	1.6e-04	2.4e-05	1.2e-03
5	ROSMAP	Brain Pre-frontal Cortex	0.1129	0.0308	1.3e-12	0.068	0.105	0.099	0.096	0.098	4.3e-09	2.2e-13	1.2e-12	2.2e-12	1.3e-12
6	YFS	Blood	0.0243	0.0087	5.8e-05	0.010	0.018	0.008	0.018	0.006	2.5e-04	1.1e-06	6.5e-04	1.4e-06	2.5e-03
7	TCGA	Glioblastoma Multiforme	0.1640	0.0970	6.5e-03	0.045	0.017	0.000	NA	0.013	1.7e-02	9.7e-02	3.2e-01	NA	1.3e-01
8	TCGA	Kidney Renal Clear Cell Carcinoma	0.0267	0.0180	8.4e-03	0.011	0.012	-0.001	NA	0.005	1.9e-02	1.3e-02	4.4e-01	NA	8.8e-02
9	TCGA	Brain Lower Grade Glioma	0.0263	0.0153	8.7e-04	0.021	0.025	0.014	NA	0.019	1.6e-03	6.6e-04	7.8e-03	NA	2.5e-03
10	TCGA	Testicular Germ Cell Tumors	0.0880	0.0580	9.7e-03	0.042	0.047	0.030	NA	0.021	1.4e-02	9.3e-03	3.2e-02	NA	5.8e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Lung FEV1/FVC ratio	7.9	40.3	64.2	-7.5	-6.9	-4.0	-4.1	-6.7	4.4	-7.0	-7.5	-5.7	-8.0
Headache pain in last month	5.0	8.6	14.1	-0.3	2.9	3.6	2.6	3.8	1.6	2.8	3.8	3.1	3.1
Impedance of leg (right)	4.7	22.9	36.4	2.9	-5.2	-4.5	-4.3	-5.5	-3.3	-5.0	-6.0	-6.0	-4.1
Peak expiratory flow (PEF)	3.9	9.1	21.3	-4.6	-2.9	-1.8	-2.0	-2.9	3.3	-2.6	-3.0	-3.0	-3.2
Impedance of leg (left)	3.8	18.4	30.4	2.4	-4.5	-4.0	-4.0	-5.0	-3.0	-4.4	-5.5	-5.4	-3.6
Family relationship satisfaction	3.6	4.5	8.0	1.6	2.8	1.7	2.2	2.2	0.2	2.0	2.4	2.1	2.6
Leg predicted mass (right)	3.6	19.0	37.6	-6.1	3.7	4.4	1.8	4.5	4.6	3.5	5.5	5.1	2.6
Wears glasses or contact lenses	3.6	4.1	8.7	-0.3	-3.0	-2.4	-2.1	-2.4	-0.2	-2.1	-2.1	-1.8	-2.1
Leg fat-free mass (right)	3.5	18.9	37.6	-6.1	3.7	4.4	1.9	4.4	4.5	3.4	5.5	5.0	2.6
Leg predicted mass (left)	3.2	17.0	38.4	-6.2	3.2	4.1	1.7	4.2	4.6	3.0	5.1	4.7	2.3
Arm fat-free mass (left)	3.2	16.1	53.9	-7.3	2.6	3.8	1.1	3.4	5.8	2.4	4.2	4.0	1.3
Leg fat-free mass (left)	3.1	16.6	39.6	-6.3	3.1	4.1	1.5	4.1	4.6	2.9	5.0	4.6	2.1
Arm predicted mass (right)	3.1	15.9	61.2	-7.8	2.3	3.7	1.1	2.8	6.1	2.1	3.8	3.6	1.1
Whole body fat-free mass	3.1	17.7	50.1	-7.1	3.0	4.2	1.6	3.9	5.3	2.8	4.8	4.5	1.8
Whole body water mass	3.1	17.6	51.4	-7.2	2.9	4.1	1.6	3.9	5.4	2.8	4.8	4.4	1.7
Basal metabolic rate	3.1	17.0	50.6	-7.1	2.8	4.1	1.2	3.8	5.3	2.6	4.7	4.4	1.7
Myopia	3.1	4.4	8.1	-0.0	-2.7	-2.9	-2.1	-2.2	-1.5	-2.4	-1.6	-2.4	-1.9
Arm fat-free mass (right)	3.0	15.4	60.2	-7.8	2.2	3.7	1.0	2.9	5.9	2.0	3.7	3.5	1.0
Trunk fat-free mass	2.8	16.3	50.4	-7.1	2.6	4.1	1.6	3.6	5.4	2.5	4.3	4.1	1.4
Trunk predicted mass	2.8	15.9	49.3	-7.0	2.6	4.1	1.5	3.6	5.3	2.5	4.3	4.0	1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.8	5.9	10.2	-2.3	-2.6	-2.0	-1.0	-3.2	3.0	-2.6	-2.5	-2.5	-2.1
Arm predicted mass (left)	2.8	14.2	53.0	-7.3	2.4	3.3	0.8	3.1	5.4	2.1	3.9	3.5	1.0
Lupus	2.6	3.9	7.1	1.2	2.3	1.7	0.8	2.2	-0.3	2.2	2.7	2.2	2.6
Primary Biliary Cirrhosis	2.6	3.7	7.5	1.2	1.8	2.2	1.2	2.7	0.3	2.1	2.5	2.2	1.8
Shortness of breath walking on level ground	2.6	3.1	5.9	-2.4	-1.2	-1.1	-1.2	-2.0	1.5	-2.4	-1.6	-1.8	-1.8
Supplements: Calcium	2.6	2.9	6.0	-0.9	-2.2	-1.1	-1.4	-2.4	-0.4	-2.4	-1.2	-2.0	-1.6
Impedance of whole body	2.6	13.4	20.2	4.5	-3.4	-3.3	-3.3	-3.7	-4.4	-3.0	-4.2	-4.1	-2.1
Illnesses of father: None of the above (group 1)	2.5	3.1	6.7	-2.4	-1.5	-0.9	-0.9	-1.7	0.9	-1.9	-2.2	-1.6	-2.6
Weight	2.4	12.0	44.4	-6.7	1.8	3.0	0.2	2.9	5.1	1.8	3.5	3.4	0.9
Forced expiratory volume in 1-second (FEV1)	2.4	8.0	24.4	-4.9	-2.9	-1.3	-1.9	-2.6	3.6	-2.4	-1.9	-2.3	-2.7
Forced expiratory volume in 1-second (FEV1), Best measure	2.4	7.7	31.1	-5.6	-2.1	-1.0	-1.8	-2.0	4.3	-1.9	-1.5	-1.6	-2.5
Impedance of arm (right)	2.2	10.4	33.5	5.8	-2.3	-2.8	-2.2	-2.3	-5.4	-1.8	-2.4	-2.9	-0.9
Falls in the last year	2.2	3.0	7.1	0.3	2.7	1.5	1.4	1.4	1.4	1.7	2.3	1.8	2.0
Pulse wave reflection index	2.2	2.7	5.2	0.1	1.8	2.3	0.0	2.1	-0.0	1.9	1.6	2.3	1.4
Neck or shoulder pain in last month	2.2	3.1	5.2	-2.1	1.5	1.8	1.2	2.1	2.3	1.7	1.7	1.7	1.2
Illness, injury, bereavement, stress in last 2 years	2.2	2.7	7.6	2.4	-0.9	-2.1	-1.5	-1.2	-2.8	-0.9	-1.2	-1.4	-0.7
Ever had stillbirth, spontaneous miscarriage or termination	2.2	2.3	4.6	0.3	1.5	1.4	1.3	1.4	0.0	2.0	1.8	2.1	1.9
Commuting to job workplace: Cycle	2.2	2.7	5.5	1.6	-2.2	-1.2	-0.6	-1.9	-0.4	-1.3	-2.4	-1.9	-1.8
Father’s age at death	2.1	2.9	6.2	0.6	2.3	1.2	1.7	1.4	0.1	1.6	2.5	1.6	2.3
Leg pain on walking	2.0	2.5	5.6	-1.3	-1.7	-1.1	-2.4	-1.4	0.8	-2.0	-1.0	-1.5	-1.8
Miserableness	2.0	3.5	6.2	-0.9	1.9	2.5	1.2	2.0	2.0	2.0	2.0	1.7	2.1
BMI	1.9	11.1	36.7	-6.1	1.7	3.0	0.4	3.5	4.5	2.1	3.1	3.9	0.6
Number of treatments/medications taken	1.9	3.3	6.7	0.6	1.4	1.9	1.7	2.6	0.1	2.3	2.1	2.3	1.8
Bipolar Disorder (2011)	1.7	1.7	6.1	2.5	0.9	0.4	1.2	0.3	-0.9	1.5	1.1	0.7	1.9
Sitting height	1.7	12.2	27.7	-5.3	2.2	4.5	1.6	2.6	4.8	2.5	3.9	3.4	2.2
Financial difficulties in last 2 years	1.7	2.3	7.2	-2.3	0.8	1.2	1.1	1.2	2.7	0.6	1.5	1.4	0.8
Impedance of arm (left)	1.7	7.9	30.4	5.5	-1.7	-2.1	-1.9	-2.0	-4.7	-1.3	-2.2	-2.3	-0.3
Birth weight of first child	1.7	3.1	6.8	-1.5	-1.9	-2.2	-1.2	-2.6	1.3	-2.0	-0.7	-1.9	-1.4
Arm fat mass (left)	1.7	7.0	21.2	-4.6	1.6	2.0	0.0	2.5	3.8	1.6	3.0	2.9	0.9
Illnesses of father: High blood pressure	1.7	2.1	3.8	1.4	1.4	1.7	1.0	1.4	-0.0	1.7	1.3	1.5	1.9
Unable to work because of sickness or disability	1.7	2.2	4.5	-0.6	2.1	1.6	0.3	2.0	0.4	1.7	1.6	1.8	1.5
Pain experienced in last month	1.7	2.8	7.4	1.5	-1.6	-2.7	-0.8	-1.9	-2.0	-1.3	-1.7	-1.6	-1.1
Depressed Affect (Nagel 2018)	1.6	3.3	5.4	-1.4	1.9	2.3	1.4	1.6	2.3	1.6	2.1	1.6	1.8
Irritable Bowel Disease (IBD)	1.6	3.7	6.1	-0.9	-1.9	-2.4	-0.7	-2.3	0.9	-2.1	-2.5	-2.1	-2.2
Age at First Birth	1.6	2.3	4.7	1.5	-1.2	-1.2	-1.2	-2.2	-1.4	-1.3	-1.8	-1.7	-1.2
Hair/balding pattern: Pattern 2	1.6	2.1	4.6	1.0	1.6	0.8	1.7	1.3	0.4	1.7	1.4	1.5	2.2
Hip circumference	1.6	6.7	36.1	-6.0	0.0	1.4	-0.5	1.2	4.4	0.3	1.9	1.8	-0.4
Loud music exposure frequency	1.6	1.7	3.5	0.6	1.9	1.4	1.0	1.5	0.2	1.2	1.6	1.3	1.6
Qualifications: nursing, teaching	1.6	2.5	4.6	0.8	1.1	2.2	1.8	1.2	1.1	2.0	1.6	1.6	1.8
Alzheimer’s Disease (in mother)	1.5	1.8	9.6	3.1	-0.1	-0.1	-0.2	-0.1	-2.8	0.1	-0.1	-0.6	0.1
Chronic bronchitis/emphysema (father)	1.5	1.7	3.9	-0.4	2.0	1.0	0.7	1.4	0.7	1.6	1.5	1.2	1.9
Frequency of tiredness / lethargy in last 2 weeks	1.5	2.5	5.3	-0.5	2.1	1.3	0.7	2.3	1.0	1.4	2.3	1.4	1.6
Illnesses of mother	1.5	1.9	11.6	-3.4	0.3	0.4	1.2	-0.6	2.2	-0.4	-0.0	0.0	-0.3
Arm fat mass (right)	1.5	6.2	19.7	-4.4	1.4	1.8	-0.1	2.4	3.7	1.4	2.8	2.7	0.7
Eye problems/disorders: None of the above	1.5	1.7	3.0	-0.5	1.5	1.5	1.1	1.4	1.7	1.5	0.8	1.3	1.3
Mean time to correctly identify matches	1.5	2.9	17.1	4.1	-0.3	-1.0	1.1	-0.5	-2.5	0.0	0.5	-0.2	1.6
Forced expiratory volume in 1-second (FEV1), predicted	1.5	3.1	12.6	-3.5	0.4	2.9	-0.1	0.5	2.4	0.9	1.2	1.4	0.6
Medication: Paracetamol	1.5	2.3	4.3	1.9	1.6	2.1	1.2	0.8	1.1	1.8	0.9	1.5	1.8
Alzheimer’s Disease (in father)	1.4	1.5	3.3	0.4	-1.8	-1.1	-1.4	-1.4	-0.8	-1.2	-1.0	-1.2	-1.3
Alzheimer’s Disease (including proxy)	1.4	2.0	4.6	2.0	-1.4	-0.8	-1.3	-1.3	-2.1	-1.1	-0.9	-1.3	-1.2
Crohns Disease (2017)	1.4	3.1	7.6	-0.2	-1.6	-1.6	-0.6	-2.4	0.1	-1.8	-2.8	-2.2	-2.0
Reaction Time	1.4	2.7	14.0	3.7	-0.3	-1.3	0.8	-0.7	-2.9	-0.4	0.1	-0.6	1.2
Supplements: Zinc	1.4	1.5	2.8	-0.9	-1.5	-0.8	-1.2	-0.5	0.4	-1.7	-1.4	-1.6	-1.5
Current tobacco smoking	1.4	2.2	5.5	-2.2	1.1	1.3	0.6	1.4	2.3	0.5	1.6	1.5	1.1
Body mass index (BMI)	1.4	5.9	22.2	-4.7	1.3	1.5	0.3	2.2	4.0	1.1	2.4	2.4	0.4
Waist circumference	1.4	5.3	16.6	-4.1	1.5	1.8	0.1	2.1	3.7	1.5	2.3	2.3	0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	1.4	1.8	3.6	1.9	-0.5	-1.7	-1.6	-1.7	-1.6	-1.0	-0.7	-1.4	0.2
Guilty feelings	1.4	2.0	4.2	-1.2	-1.5	-0.4	-0.6	-2.0	1.1	-1.4	-1.7	-1.8	-1.6
Tinnitus: Yes, now most or all of the time	1.4	1.7	3.7	-1.9	-1.4	-0.6	-0.2	-1.4	1.7	-0.8	-1.3	-1.1	-1.5
Commuting to job workplace: Public transport	1.4	1.7	7.0	1.8	-1.1	-1.3	-0.8	-0.5	-2.7	-0.6	-0.8	-0.7	-0.9
Prostate Cancer	1.3	1.9	3.8	-0.8	-1.6	-0.8	-1.0	-2.0	0.2	-1.7	-1.4	-1.7	-1.4
Blood White Count	1.3	9.8	18.7	-1.7	3.1	3.1	2.5	4.1	2.1	3.1	3.6	4.3	2.7
Systolic blood pressure, automated reading	1.3	3.8	7.2	2.3	2.1	1.2	1.2	2.1	-0.0	2.7	1.7	2.2	2.3
Hand grip strength (right)	1.3	3.6	18.7	-4.3	0.8	1.2	0.5	1.0	3.1	1.2	0.7	1.4	0.2
Maternal smoking around birth	1.3	1.8	11.2	-3.3	-0.4	-0.2	0.1	0.2	2.5	-0.3	-0.2	0.0	-0.8
Fed-up feelings	1.3	2.3	6.6	-2.5	0.6	2.0	0.8	0.7	2.6	0.6	1.7	1.0	0.7
Had menopause	1.3	1.7	3.1	0.5	1.5	1.4	0.9	1.4	-0.2	1.4	1.6	1.8	1.5
Leg fat mass (left)	1.3	5.3	30.5	-5.5	0.2	1.2	-1.2	1.0	3.7	0.0	1.4	1.4	-0.6
Breast Cancer	1.2	3.0	5.2	0.4	1.6	0.6	2.0	2.1	0.8	2.1	2.0	2.3	2.0
Crohns Disease (2012)	1.2	2.0	4.0	0.5	-1.3	-1.8	-0.2	-2.0	-0.4	-1.6	-2.0	-1.8	-1.1
Average weekly spirits intake	1.2	1.5	3.2	0.2	1.3	1.1	1.0	1.8	1.0	1.4	1.3	1.4	1.2
Number of incorrect matches in round	1.2	1.9	5.6	1.5	-0.9	-1.8	0.1	-2.4	-1.1	-1.0	-1.3	-1.9	-0.4
Leg fat percentage (right)	1.2	4.4	15.1	-3.9	-1.8	-1.1	-2.4	-1.1	2.4	-2.0	-1.0	-1.1	-2.3
Comparative body size at age 10	1.2	3.4	7.3	-2.5	2.1	0.9	1.8	1.2	2.7	1.4	2.2	1.4	1.4
Number of children fathered	1.2	1.3	3.5	-1.9	1.1	1.0	1.4	0.6	1.1	1.1	0.8	1.3	0.8
Leg fat mass (right)	1.2	4.8	28.3	-5.3	-0.1	0.9	-1.4	0.8	3.6	-0.3	1.1	1.0	-0.9
Overall health rating	1.2	2.7	5.1	-1.3	1.0	1.8	1.0	2.3	2.1	1.1	2.1	1.8	1.0
Smoking status: Previous	1.2	1.8	3.5	-0.2	-1.1	-1.7	-1.9	-1.1	-0.2	-1.1	-1.5	-1.7	-1.6
Ever taken oral contraceptive pill	1.2	1.4	2.8	1.7	0.4	0.5	-0.4	1.2	-1.5	0.7	1.7	1.0	1.5
Pain type(s) experienced in last month: Hip pain	1.2	1.5	2.7	-1.4	-0.9	-0.5	-1.6	-1.6	0.7	-1.1	-0.7	-1.5	-1.2
Ulcerative Colitis (UC)	1.1	2.0	4.6	-1.3	-1.5	-2.1	-0.6	-1.6	1.2	-1.5	-1.1	-1.2	-1.4
Medication: Lansoprazole	1.1	1.2	5.2	-1.0	1.2	1.0	0.7	0.7	2.3	0.9	0.6	0.8	1.0
Tense / ‘highly strung’	1.1	1.8	11.5	3.4	-0.0	-0.1	-0.5	0.3	-2.0	0.2	-1.2	-0.7	0.0
Medication: Ibuprofen	1.1	1.3	2.6	-0.1	1.5	1.6	0.0	1.4	0.8	1.3	1.2	1.3	1.1
Comparative height size at age 10	1.1	6.3	23.0	-4.8	1.6	3.2	0.8	2.0	2.5	1.6	2.6	2.5	0.7
Mineral and other dietary supplements	1.1	1.4	4.1	0.0	1.4	0.6	1.0	2.0	-0.1	0.8	1.7	1.3	1.4
Osteoporosis (self-reported)	1.1	1.4	2.8	1.2	0.9	0.6	1.0	1.5	-0.3	1.3	1.7	1.2	1.5
Number of self-reported non-cancer illnesses	1.1	1.9	4.4	0.0	1.4	1.2	0.7	2.1	0.0	1.4	2.0	1.5	1.6
Leg fat percentage (left)	1.1	4.0	18.0	-4.2	-1.3	-0.8	-2.3	-0.8	2.5	-1.7	-0.6	-0.7	-2.0
Bipolar Disorder or Schizophrenia	1.0	2.5	9.4	3.1	-0.7	-0.6	-1.2	-1.6	-1.1	-0.9	-2.0	-2.1	-0.6
HbA1C	1.0	1.1	5.7	-2.1	-0.4	-0.4	0.3	-0.3	2.4	-0.1	-0.1	0.1	-0.4
Hand grip strength (left)	1.0	2.7	16.7	-4.1	0.4	0.4	0.2	0.3	3.1	0.3	0.1	0.6	-0.2
Multivitamins +/- minerals	1.0	1.3	3.2	-0.7	-1.0	0.1	0.0	-1.3	1.5	-1.3	-1.8	-1.4	-1.0
Pulse wave Arterial Stiffness index	1.0	1.2	2.4	-0.8	1.4	1.5	-0.2	1.1	0.7	1.4	0.7	1.6	0.4
Whole body fat mass	1.0	4.2	21.7	-4.7	0.5	1.1	-1.2	1.2	3.1	0.3	1.8	1.6	-0.2
Financial situation satisfaction	1.0	1.3	2.4	-1.3	1.3	1.4	-0.4	1.1	0.9	0.5	1.6	1.4	0.5
Rheumatoid Arthritis	0.9	1.2	5.9	-2.4	0.2	-0.0	0.0	0.4	2.3	-0.5	0.7	0.2	-0.3
Blood Eosinophil Count	0.9	6.8	11.4	2.0	3.0	2.7	1.7	2.9	-1.6	2.4	3.0	2.7	3.4
Lung FVC	0.9	4.8	20.0	-3.1	-1.9	-1.4	1.1	-2.1	4.5	-1.3	-1.2	-1.7	-1.2
Ever had hysterectomy (womb removed)	0.9	1.0	5.2	-2.3	0.7	1.1	0.5	0.2	1.4	0.5	-0.3	0.8	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.1	7.2	0.7	-1.6	-2.7	-1.8	-1.9	-0.1	-1.1	-1.0	-1.1	-0.5
Diverticular disease/diverticulitis (self-reported)	0.9	1.0	1.8	1.0	1.2	1.3	0.9	0.6	-0.9	1.3	1.0	0.7	0.9
Trunk fat mass	0.9	4.0	19.5	-4.4	0.5	1.3	-1.1	1.3	2.9	0.4	1.9	1.6	-0.0
Worrier / anxious feelings	0.9	1.8	3.4	-0.7	-1.4	-0.2	-1.2	-1.7	1.5	-1.0	-1.9	-1.4	-1.4
Noisy workplace	0.9	1.2	4.1	-0.7	0.7	1.4	1.1	2.0	0.4	1.2	0.7	1.3	0.1
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.1	2.1	-0.2	1.2	1.4	1.4	1.3	0.3	1.2	0.5	1.1	0.8
Forced vital capacity (FVC), Best measure	0.9	3.3	18.5	-4.3	-0.5	0.5	-0.6	-0.4	3.6	-0.0	0.4	-0.1	-0.6
Health satisfaction	0.9	1.2	3.4	0.9	-0.9	-0.8	-1.8	-1.1	-1.5	-1.1	-0.5	-1.0	-0.5
Medication: Seretide 50 evohaler	0.9	1.0	4.2	1.2	-0.6	-1.1	-1.3	-0.2	-2.0	-0.9	-0.0	-0.5	-0.4
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	2.6	-1.1	-0.8	-0.8	-0.7	-0.7	0.3	-1.6	-1.1	-1.3	-1.4
Knee pain experienced in last month	0.9	1.5	3.4	-1.3	1.6	0.7	-0.6	1.4	1.8	1.3	1.3	0.9	0.3
Back pain experienced in last month	0.9	1.3	4.9	-2.2	-0.5	-0.1	-0.8	-0.9	1.7	-0.7	-0.9	-1.1	-1.3
Basal cell carcinoma (self-reported)	0.9	1.1	4.9	0.5	0.9	2.2	0.2	1.1	-0.0	0.6	1.0	1.1	1.0
Bipolar Disorder (2018)	0.8	1.3	8.6	2.9	-0.2	-0.1	-0.6	-0.7	-0.9	-0.2	-1.0	-1.2	0.1
Coronary Artery Disease (CAD)	0.8	1.0	3.0	-1.7	1.2	0.3	0.6	1.3	0.9	0.8	0.8	0.9	0.5
LDL Cholesterol	0.8	1.2	6.6	-2.1	0.2	-0.3	0.7	0.3	2.6	0.4	0.1	0.6	0.1
Ulcerative Colitis	0.8	1.1	3.2	-1.3	-0.9	-1.3	-0.3	-1.2	1.8	-0.9	-0.7	-0.8	-0.8
Blood Platelet Count	0.8	9.8	38.2	-6.2	-3.3	-0.7	-1.8	-2.7	4.1	-2.2	-2.2	-1.4	-3.1
Vitamin and mineral supplements	0.8	1.0	3.4	1.1	0.6	-0.5	-0.6	0.9	-1.9	0.6	1.4	0.9	0.8
Forced vital capacity (FVC)	0.8	2.9	15.3	-3.9	-1.2	0.3	-1.0	-1.0	3.0	-0.7	0.2	-0.7	-0.7
Prospective memory result	0.8	1.0	2.7	-0.4	-0.4	-1.3	-1.1	-1.2	-0.4	-1.6	-0.8	-1.4	-0.5
Medication: Paracetamol	0.8	1.4	4.1	1.0	1.4	2.0	0.7	0.4	1.4	1.3	0.4	0.9	1.4
Hypothyroidism/myxoedema (self-reported)	0.8	1.5	7.1	-2.7	-0.2	1.7	-0.2	0.1	1.9	-0.1	0.2	1.2	-0.1
Medication: Ventolin 100micrograms inhaler	0.8	1.0	3.3	-1.8	-0.6	1.5	0.5	0.3	1.8	0.4	0.7	0.5	0.4
Pulse wave peak to peak time	0.8	1.0	2.0	0.5	-1.3	-1.4	0.0	-1.0	-0.7	-1.3	-0.5	-1.4	-0.4
Age at last live birth	0.8	1.2	7.4	2.7	0.0	-0.3	0.5	0.2	-1.6	0.3	-0.0	0.2	1.2
Commuting to job workplace: Car/motor vehicle	0.8	0.9	3.1	-1.8	0.9	0.8	0.2	0.5	1.4	0.6	0.5	0.8	0.7
Average weekly red wine intake	0.8	1.2	3.2	0.9	1.8	1.1	0.2	0.6	-1.2	1.6	0.5	0.9	1.3
Medication: Omeprazole (e.g. Zanprol)	0.8	0.9	4.0	-1.7	0.7	0.8	0.7	0.7	2.0	0.3	0.5	0.3	0.2
Schizophrenia (2018)	0.7	1.5	3.1	1.6	-0.7	-0.7	-1.0	-1.5	-0.7	-1.2	-1.8	-1.7	-0.9
Major Depression (MDD)	0.7	0.8	3.3	1.6	-0.2	0.2	-0.6	-0.4	-1.8	0.0	1.2	-0.2	0.4
Body Mass Index (BMI) (2010)	0.7	1.0	6.1	-2.5	-0.5	0.9	0.4	0.1	1.0	-0.5	0.6	0.8	-0.6
Height	0.7	13.4	63.0	-7.9	1.0	4.0	0.0	1.7	5.0	1.6	3.5	3.1	1.0
Waist Hip Ratio (WHR)	0.7	3.1	12.2	3.5	1.8	1.1	0.3	1.0	-2.1	2.0	0.7	0.7	1.9
Systolic Blood Pressure	0.7	3.4	19.4	4.4	1.5	-0.3	0.6	0.9	-1.9	2.0	0.3	0.8	1.8
Allergy or Eczema	0.7	1.9	3.7	0.7	1.4	0.7	-0.1	1.8	-1.5	1.6	1.9	1.4	1.6
Ever used hormone-replacement therapy (HRT)	0.7	0.9	2.7	1.2	0.0	-0.5	-1.6	-0.8	-1.3	-1.0	-0.5	-1.2	-0.5
Angina	0.7	0.9	2.4	-1.4	-1.1	-0.2	-1.6	-0.2	-0.2	-1.2	-0.3	-0.9	-1.1
Medication for hormone replacement therapy	0.7	0.7	2.3	-0.0	-0.6	-1.3	-1.5	-0.8	0.1	-0.9	-0.7	-0.9	-0.5
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	3.0	1.7	-0.3	-0.9	-0.8	-0.4	-1.5	-0.7	-0.5	-0.9	-0.5
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	2.5	-0.2	-1.0	-1.0	-1.6	-0.6	-0.5	-1.1	-0.9	-1.0	-1.1
Lung cancer (father)	0.7	0.9	2.0	-1.4	0.3	0.2	-1.3	1.4	1.4	0.4	0.4	0.9	-0.2
Standing height	0.7	7.2	24.6	-5.0	1.4	3.7	-0.2	1.9	2.9	1.6	2.9	2.7	1.0
Breastfed as a baby	0.7	0.9	5.1	2.3	-0.6	-0.3	-0.3	-1.0	-0.6	-0.5	-0.9	-1.0	-0.3
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	2.4	-1.5	0.4	1.6	0.6	0.6	1.5	0.7	1.0	1.0	0.4
Age at first live birth	0.7	1.2	6.8	2.6	-0.7	-0.8	0.2	-0.5	-1.5	-0.3	-1.0	-0.4	0.4
Supplements: Vitamin C	0.7	0.8	2.9	-0.5	-1.1	0.6	0.9	-1.1	1.7	-0.4	-1.1	-0.2	-0.7
Mood swings	0.7	1.3	3.0	-1.7	0.6	1.6	0.3	1.1	1.5	1.0	1.1	0.9	0.7
Commuting to job workplace: Walk	0.7	0.8	2.6	1.6	0.1	0.2	0.5	1.0	-1.3	0.9	0.9	0.6	0.6
Eye problems/disorders: Cataract	0.7	0.8	2.0	0.1	-0.7	-1.4	-0.9	-1.0	-1.0	-1.1	-0.6	-0.9	-0.8
Smoking status: Current	0.7	1.2	4.0	-1.9	0.5	0.8	0.4	1.0	2.0	-0.0	1.1	0.9	0.5
Supplements: Fish oil (including cod liver oil)	0.7	0.9	3.5	-0.8	-0.9	-0.2	-0.5	-1.9	0.8	-0.6	-1.2	-1.0	-0.9
Medication: Bendroflumethiazide	0.7	1.1	5.0	2.2	-0.7	-1.0	-0.5	-0.3	-1.7	-0.4	-0.7	-0.9	-0.2
Number of operations (self-reported)	0.7	1.0	1.5	-0.4	1.0	1.0	0.9	1.1	0.7	1.2	1.0	1.2	1.2
Ever depressed for a whole week	0.7	0.9	4.1	1.8	0.3	0.2	-1.1	0.1	-2.0	0.0	0.1	-0.2	0.3
Triglycerides	0.6	1.0	2.0	0.0	-1.4	-1.1	-1.2	-0.8	-0.6	-0.9	-0.7	-1.2	-1.2
Smoking Status	0.6	1.4	5.4	-2.1	-0.2	0.2	-1.4	-0.2	2.3	-1.0	-0.4	-0.7	-0.7
Respiratory disease	0.6	1.3	3.9	0.1	1.0	1.5	0.1	1.1	-0.4	0.7	2.0	1.0	1.7
Average weekly fortified wine intake	0.6	0.7	2.5	-1.0	-0.6	-1.6	0.0	-0.8	0.5	-0.6	-0.8	-0.9	-1.0
Stomach or abdominal pain in last month	0.6	0.7	2.1	1.4	1.5	-0.5	0.3	0.4	-0.8	0.3	0.8	0.1	1.2
Past tobacco smoking	0.6	1.1	2.7	0.0	0.8	1.4	1.6	0.3	0.3	0.8	1.0	1.3	1.4
Alcohol usually taken with meals	0.6	1.0	4.4	-2.1	-1.1	-0.0	-0.0	-1.5	0.7	-0.8	-0.8	-0.6	-0.7
Number of live births	0.6	0.9	1.9	-1.1	0.6	0.7	1.0	0.6	1.4	1.0	1.2	0.8	0.8
Exposure to tobacco smoke at home	0.6	0.7	1.9	-0.6	1.0	1.3	1.4	0.9	0.3	0.5	0.5	0.8	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	1.6	1.0	1.2	0.8	-0.3	1.0	-0.3	1.1	1.1	0.6	1.3
Chronic bronchitis/emphysema (mother)	0.6	0.7	2.9	0.9	-0.0	-0.9	-1.7	-0.5	-0.4	-1.0	-0.6	-0.6	-0.1
Number of full brothers	0.6	0.8	1.9	0.8	-0.5	-1.4	-1.0	-0.4	-0.4	-1.0	-0.8	-1.1	-0.8
Migraine (self-reported)	0.6	0.8	1.5	0.1	0.6	0.1	0.8	1.0	1.2	1.1	1.2	1.1	0.9
Friendships satisfaction	0.6	0.8	2.2	0.1	1.5	1.4	0.5	0.2	0.3	0.7	1.0	0.7	1.1
Ovarian Cancer	0.5	0.7	2.1	0.8	-0.3	-1.0	-0.6	-0.9	-1.5	-0.9	-0.4	-0.7	-0.6
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.2	1.0	1.0	0.3	0.9	0.6	0.2	0.6	1.1	0.3	1.0
Severe depression (siblings)	0.5	0.5	1.4	1.0	1.2	-0.2	1.0	0.1	-0.4	0.8	0.5	0.3	1.0
Pack years adult smoking proportion	0.5	0.7	2.7	-1.6	-0.5	-0.6	-0.9	-1.1	0.3	-0.7	-0.3	-0.3	-0.8
Relative age voice broke	0.5	0.8	1.9	0.9	-0.6	-1.2	-0.9	-0.8	-1.4	-0.8	-0.8	-0.6	-0.4
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.7	-1.0	1.0	1.3	-0.3	-0.5	0.9	0.6	-0.5	0.4	0.3
Qualifications: CSEs or equivalent	0.5	0.7	1.7	0.3	0.5	0.6	0.5	1.0	0.7	1.3	0.7	1.2	0.7
Supplements: Glucosamine	0.5	0.7	2.3	1.1	0.5	1.5	-0.1	0.3	-0.5	1.0	0.7	0.8	0.6
Medication: Levothyroxine sodium	0.5	0.8	3.7	-1.8	-0.2	0.8	0.1	-0.1	1.9	-0.1	0.0	0.8	0.2
Happiness	0.5	0.6	2.2	1.5	0.7	0.6	-0.2	-0.0	-0.9	-0.0	0.8	0.4	1.0
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	1.5	-0.5	0.9	1.2	-0.2	1.0	0.9	0.7	0.7	0.6	0.6
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	4.3	-0.4	0.4	-0.4	2.1	0.8	0.8	0.4	0.2	-0.1	0.1
Birth weight	0.5	1.0	5.3	-2.3	-0.5	0.5	0.8	-0.7	1.7	-0.3	0.6	0.3	-0.1
Exposure to tobacco smoke outside home	0.5	0.6	2.7	-1.0	0.7	0.7	0.8	0.3	1.6	0.8	-0.5	0.1	-0.3
Wheeze or whistling in the chest in last year	0.5	0.9	4.0	-2.0	1.0	1.1	-0.4	0.4	1.0	0.2	1.0	0.5	0.6
Medication for pain relief, constipation, heartburn	0.5	0.9	3.1	1.0	-0.9	-1.8	-0.6	-0.4	-1.8	-0.4	-0.1	-0.4	-0.2
Angina (self-reported)	0.5	0.6	1.6	-1.3	-0.9	0.1	-1.1	0.1	-0.3	-0.9	-0.2	-0.7	-1.0
Suffer from ‘nerves’	0.5	0.8	3.2	1.3	-0.4	-0.9	-0.8	-1.8	-0.4	-0.0	-1.1	-0.7	0.0
Illnesses of father: Heart disease	0.5	0.7	3.3	1.8	0.5	-0.3	-0.9	0.5	-1.4	0.5	0.5	0.1	0.7
Arm fat percentage (left)	0.5	1.9	6.1	-2.5	0.6	0.5	-0.6	1.3	2.1	0.6	1.7	1.5	0.3
Age started oral contraceptive pill	0.5	0.6	3.0	1.7	-0.4	-1.3	-0.0	-0.6	-0.6	0.1	-0.6	-0.3	0.0
Pack years of smoking	0.5	0.8	2.0	-1.4	-0.5	-0.8	-0.9	-1.3	0.2	-0.9	-0.5	-0.5	-0.9
Worry (Nagel 2018)	0.4	0.9	5.8	2.4	0.0	0.6	-0.7	-0.5	-0.6	0.3	-1.0	-0.4	0.4
Mean Putamen Volume	0.4	0.5	1.3	1.0	-0.0	-0.7	-0.6	-1.1	-0.3	-0.9	-0.5	-0.9	0.2
Schizophrenia (2014)	0.4	0.9	2.2	1.1	-0.5	-0.1	-0.5	-1.4	-0.2	-1.2	-1.5	-1.3	-0.6
Chronotype (morning person)	0.4	1.0	2.7	1.3	-1.2	-1.1	-1.2	-0.3	-1.6	-0.8	-0.3	-0.5	-0.9
Other serious medical condition/disability diagnosed by doctor	0.4	0.6	2.2	-0.9	-0.1	0.6	0.4	1.1	1.5	0.7	0.4	0.5	-0.0
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	1.8	-0.3	-0.1	0.6	-0.3	0.7	0.6	0.2	1.3	1.0	0.7
Medication: Co-codamol	0.4	0.4	1.1	-0.7	0.7	-0.2	1.0	0.8	0.5	0.2	1.0	0.1	0.3
Medication: Metformin	0.4	0.5	1.8	0.9	0.3	-0.0	1.3	0.9	-0.1	0.8	0.7	0.5	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	1.2	-0.8	1.1	0.8	-0.2	0.9	1.0	0.4	0.9	0.4	0.3
Age when periods started (menarche)	0.4	0.9	3.6	1.9	0.6	0.8	0.7	0.6	-0.7	1.2	-0.1	0.8	1.1
Medication: Ramipril	0.4	0.5	1.4	1.0	-0.3	-0.7	-1.2	-0.3	-1.2	-0.2	-0.3	-0.6	-0.3
Arm fat percentage (right)	0.4	1.5	5.2	-2.3	0.3	0.2	-0.6	1.3	1.9	0.5	1.6	1.4	0.0
Alcohol intake versus 10 years previously	0.4	0.6	2.5	0.0	0.7	1.1	-0.6	1.6	-0.5	-0.5	0.7	0.3	-0.2
Hair/balding pattern: Pattern 4	0.4	1.0	2.7	1.6	-1.0	-1.0	-0.4	-0.6	-1.1	-0.8	-1.1	-1.2	-0.8
Gout (self-reported)	0.4	0.5	1.6	-0.6	1.3	0.6	0.5	1.0	0.2	0.6	0.8	0.4	0.5
Medication: Amlodipine	0.4	0.6	2.4	-0.6	0.2	1.1	1.5	0.7	0.2	0.7	0.2	0.9	0.0
Body fat percentage	0.4	1.7	8.7	-3.0	-0.6	-0.3	-1.8	-0.0	1.8	-0.7	0.4	0.2	-0.9
Emphysema/chronic bronchitis	0.4	0.4	1.3	-0.6	-0.2	-0.2	0.0	-1.2	0.9	-0.7	-0.7	-0.7	-0.1
Medication: Blood pressure	0.4	0.7	1.7	0.1	-1.1	-0.6	-0.6	-0.1	-1.1	-0.9	-0.8	-0.7	-1.3
Long-standing illness, disability or infirmity	0.4	0.7	2.3	-0.8	0.1	0.7	0.3	1.5	0.5	0.4	1.5	0.7	0.3
Medication for cholesterol	0.4	0.6	1.8	-1.2	-0.4	1.3	0.8	-0.0	1.0	-0.2	0.1	0.5	-0.5
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.0	0.9	-0.8	-0.1	-0.3	-0.9	-0.7	-0.6	-0.8	-1.0	-0.2
Fractured/broken bones in last 5 years	0.4	0.5	2.1	-0.4	0.2	0.6	0.1	0.6	0.2	0.3	1.4	1.1	0.9
Neuroticism (2016)	0.3	0.4	1.6	0.6	-0.1	0.1	-0.6	-0.8	0.0	-0.4	-1.2	-0.9	-0.2
Blood Red Count	0.3	2.6	12.9	-3.2	-0.4	0.2	1.1	-0.2	3.6	-0.1	-0.9	-0.0	-0.8
Heel T-Score	0.3	2.2	4.9	2.0	-1.3	-2.2	-1.5	-1.5	-1.1	-1.2	-1.3	-1.4	-0.4
Cardiovascular Disease	0.3	1.1	2.9	1.7	1.2	0.7	-0.2	0.7	-1.1	1.1	0.5	0.6	1.4
Hypothyroidism (self reported)	0.3	0.7	2.6	-1.6	-0.6	1.4	-0.9	-0.1	0.8	-0.5	-0.2	0.6	-0.4
Diabetes (father)	0.3	0.4	1.6	-0.5	-0.4	-0.7	-0.1	-0.5	1.3	-0.7	-0.3	-0.9	-0.4
Trunk fat percentage	0.3	1.4	7.1	-2.7	-0.3	0.1	-1.6	0.4	1.6	-0.3	0.8	0.6	-0.4
Townsend deprivation index at recruitment	0.3	0.4	1.1	-0.6	-1.1	-0.5	-0.2	0.2	0.0	-1.0	-0.2	-0.5	-0.6
Taking other prescription medications	0.3	0.5	1.4	-0.2	-0.0	0.5	0.1	1.2	0.6	0.8	1.0	0.6	0.7
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.6	-0.6	-0.5	-0.6	-0.7	-0.3	-0.0	-0.5	-0.8	-0.6	-0.5
Serious illness, injury or assault to yourself	0.3	0.4	2.0	-1.4	-0.1	1.0	0.2	0.4	0.5	-0.0	0.6	0.0	-0.5
Medication: Simvastatin	0.3	0.5	1.7	-0.2	-1.3	-1.1	-0.4	-0.2	-0.6	-0.6	-0.6	-0.7	-0.4
Illnesses of siblings	0.3	0.5	2.4	-1.6	-0.3	0.4	0.5	-0.4	1.1	-0.1	-0.1	0.2	-0.6
Time employed in main current job	0.3	0.4	2.1	-0.8	0.2	0.4	0.0	-0.5	1.4	0.4	-0.1	0.4	0.7
Hair/balding pattern: Pattern 3	0.3	0.4	2.5	0.4	-0.4	0.6	-0.4	-0.0	-1.6	-0.2	-0.1	0.0	-0.6
Pulse rate	0.3	0.5	2.0	0.1	-0.4	-1.4	-0.7	-0.8	-0.6	-0.4	-0.8	-0.6	-0.6
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	1.3	-0.4	1.1	1.0	0.0	0.1	1.1	0.5	0.3	0.4	0.6
Glaucoma (self-reported)	0.3	0.4	1.1	-0.8	0.3	1.0	-0.1	0.0	0.2	0.6	0.3	1.0	0.6
Worry too long after embarrassment	0.3	0.5	2.2	-0.2	-0.6	-1.5	0.5	-0.3	0.4	-0.3	-0.3	-1.0	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	0.9	1.0	-0.7	0.1	0.0	0.8	-0.9	-0.0	-0.2	0.2	-0.5
Qualifications: College or University degree	0.3	0.8	4.8	2.2	-0.3	-1.0	0.3	-1.1	-0.5	0.5	-0.8	-0.4	-0.2
Medication: Omeprazole	0.3	0.4	1.3	-0.9	0.6	0.5	0.2	0.7	1.2	0.4	0.6	0.3	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	0.8	-0.5	0.7	0.9	-0.5	0.8	0.7	0.4	0.1	0.5	0.5
Alcohol intake frequency.	0.3	0.7	2.4	-0.6	0.4	1.0	-0.2	1.6	0.2	0.4	1.0	1.4	0.6
Medication: Aspirin	0.3	0.4	1.2	-0.2	0.1	1.0	1.0	1.1	0.1	0.4	0.3	0.6	0.3
Hypertension (Self-reported)	0.3	0.8	1.7	1.3	1.0	0.5	0.1	0.8	-0.9	0.9	0.7	0.7	1.3
Illnesses of siblings: Diabetes	0.3	0.4	1.5	0.2	0.6	0.4	-0.1	0.9	0.0	0.3	1.2	0.4	0.8
Loneliness, isolation	0.3	0.4	1.2	-0.9	-0.1	-0.3	-0.2	-0.5	1.1	-0.7	-0.6	-0.5	-0.6
Breast cancer (self-reported)	0.3	0.3	0.7	0.4	-0.7	-0.7	0.3	-0.5	-0.8	-0.5	-0.2	-0.5	-0.7
Medication: Aspirin	0.3	0.4	1.7	0.0	0.2	0.8	0.9	1.3	-0.2	0.3	0.4	0.6	0.2
Average weekly champagne plus white wine intake	0.3	0.5	1.8	1.4	0.1	-1.2	0.3	-0.4	-0.9	-0.0	0.1	-0.4	0.1
Medication: Blood pressure	0.3	0.5	2.3	1.5	0.4	-0.7	-0.2	-0.0	-1.4	0.1	-0.1	-0.3	0.5
Alcohol drinker status: Never	0.3	0.4	1.8	-0.5	-0.9	0.4	-0.6	-0.4	1.4	-0.0	-0.3	0.0	-0.5
Heart attack/myocardial infarction (self-reported)	0.3	0.4	2.4	-1.6	0.0	-0.2	0.0	0.8	-0.1	0.1	0.6	0.5	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.3	0.3	0.8	-0.2	0.6	0.1	0.7	0.8	0.2	0.7	0.7	0.9	0.4
Heart disease (siblings)	0.3	0.4	1.9	1.4	0.6	-0.1	0.1	0.6	-1.0	0.6	0.1	-0.1	-0.1
Intelligence (Savage-Jansen 2018)	0.2	0.7	3.2	0.9	-0.2	-1.8	-0.3	0.4	-0.8	0.2	-0.3	-0.9	-0.9
Neuroticism (Nagel 2018)	0.2	0.6	2.5	-0.1	0.6	1.6	0.3	0.1	1.2	0.7	0.2	0.3	0.8
Schizophrenia vs Biploar Disorder	0.2	0.2	1.4	-1.2	-0.1	0.2	-0.0	0.4	0.0	-0.4	-0.1	-0.1	-0.8
Fasting Glucose	0.2	0.2	1.3	-0.3	-1.2	0.6	0.3	0.3	-0.1	-0.2	0.3	0.2	-0.4
Type 2 Diabetes (T2D) (2018)	0.2	0.3	1.3	-0.6	-0.7	1.1	0.5	0.2	0.5	0.0	0.2	0.2	-0.3
Sensitivity / hurt feelings	0.2	0.4	1.9	-0.9	0.7	1.4	0.0	0.2	0.6	0.1	-0.1	0.1	0.4
Relative age of first facial hair	0.2	0.4	2.0	0.6	0.2	-0.6	-1.4	0.7	-1.0	0.1	-0.1	-0.0	0.1
Diabetes (mother)	0.2	0.2	0.6	0.7	0.1	0.5	-0.2	-0.1	-0.0	-0.2	-0.7	-0.8	-0.3
High blood pressure	0.2	0.5	0.8	0.8	0.8	0.5	-0.1	0.7	-0.6	0.8	0.5	0.7	0.9
Hayfever, allergic rhinitis or eczema	0.2	0.4	2.2	0.4	0.0	-0.5	-1.1	0.7	-1.5	0.1	0.5	0.0	0.1
Medication: Atenolol	0.2	0.3	0.7	0.1	-0.3	-0.3	-0.8	-0.6	-0.7	-0.6	-0.5	-0.8	0.1
High blood pressure (mother)	0.2	0.3	1.4	0.7	-0.9	-0.1	-1.2	-0.5	0.3	-0.0	-0.4	0.0	0.3
Nervous feelings	0.2	0.4	1.7	1.3	0.5	0.2	0.4	-0.3	0.2	0.8	-0.4	0.5	1.1
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.6	0.2	-0.7	0.4	-0.8	-0.7	-0.1	-0.7	-0.7	-0.7	-0.3
Hearing difficulty/problems with background noise	0.2	0.3	1.1	-1.0	0.3	0.1	-0.3	0.4	0.9	0.1	-0.1	-0.3	-0.5
Had other major operations	0.2	0.2	0.6	-0.1	0.5	0.5	0.2	0.8	0.5	0.4	0.4	0.2	0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.8	0.9	-0.4	-1.4	-0.7	-0.3	0.8	0.4	-0.1	0.1	0.5
Qualifications: None of the above	0.2	0.3	0.9	-0.9	0.3	0.6	0.4	0.9	0.3	-0.5	0.7	0.4	0.2
Heart attack	0.2	0.3	2.3	-1.5	-0.0	-0.5	-0.2	0.4	0.0	-0.1	0.4	0.2	-0.4
Allergy	0.2	0.4	1.6	1.3	0.2	0.1	1.1	-0.2	0.5	0.2	-0.6	-0.1	-0.3
Pain all over the body in last month	0.2	0.3	1.3	0.2	-0.1	0.5	-1.1	-0.7	-0.4	-0.4	-0.2	-0.1	0.1
Diabetes (self-reported)	0.2	0.3	1.2	-0.0	-0.5	0.9	1.1	0.6	0.4	0.1	0.4	0.3	0.0
Fluid intelligence score	0.2	0.4	2.7	0.1	-0.1	-1.6	0.4	0.2	-0.2	0.6	0.4	-0.0	-0.4
Asthma	0.2	0.4	1.1	0.0	-0.1	0.9	-1.0	0.3	-1.0	-0.2	0.6	0.1	0.6
Medication: Cholesterol lowering	0.2	0.3	1.2	-0.1	-0.5	-0.6	1.1	0.6	-0.4	0.0	0.7	0.2	0.2
High blood pressure (siblings)	0.2	0.3	0.8	0.7	0.0	-0.3	-0.9	-0.4	-0.7	-0.1	-0.6	-0.5	0.3
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.9	0.8	-0.4	-0.1	0.9	-0.3	-0.3	-0.0	0.2	-0.1	-0.1
Medication: Allopurinol	0.2	0.2	0.8	-0.2	0.6	-0.4	-0.2	0.6	-0.9	0.1	0.6	0.1	0.2
Number of full sisters	0.2	0.2	0.8	0.2	-0.3	0.1	-0.6	-0.9	0.1	-0.7	-0.6	-0.4	-0.1
Chest pain or discomfort	0.2	0.3	1.4	0.2	0.4	0.0	-0.9	0.8	-1.2	-0.1	0.3	-0.2	-0.1
Had major operations	0.2	0.3	0.6	0.8	-0.6	-0.8	-0.6	0.5	0.0	-0.3	-0.5	-0.3	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	1.1	1.0	0.0	0.1	-0.3	0.3	0.3	-0.5	0.1	-0.7	-0.1
Handedness (chirality/laterality): Left-handed	0.2	0.2	1.0	0.4	-0.2	-1.0	0.7	0.1	0.2	0.1	0.6	0.2	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	0.7	-0.7	0.5	0.2	-0.8	0.1	0.4	0.5	0.3	0.7	0.3
Asthma (self-reported)	0.2	0.4	1.5	0.1	0.1	1.2	-0.6	0.4	-1.0	-0.2	0.8	0.2	0.8
Osteoarthritis (self-reported)	0.2	0.2	0.8	-0.3	0.2	0.9	-0.5	-0.2	0.6	0.3	0.3	0.4	0.3
Medication: Gliclazide	0.2	0.2	1.9	1.4	-0.1	0.1	0.1	-0.1	-0.2	0.2	0.1	-0.1	-0.0
Mother’s age at death	0.2	0.3	1.8	0.2	0.0	0.4	1.3	-0.8	0.3	0.1	-0.4	0.0	-0.1
Eye problems/disorders: Glaucoma	0.2	0.3	1.5	-1.2	-0.6	0.3	-0.4	-0.4	0.3	-0.2	-0.3	0.1	-0.5
Medication: Atorvastatin	0.2	0.3	0.8	-0.3	0.6	0.3	0.9	0.1	0.1	0.4	0.9	0.5	0.5
Irritability	0.2	0.3	1.0	-0.2	-0.3	0.8	-0.0	0.8	0.4	1.0	0.6	0.7	0.1
Alcohol drinker status: Previous	0.2	0.3	0.5	0.3	0.6	0.3	0.2	0.7	-0.7	0.6	0.6	0.5	0.3
Depression (Nagel 2018)	0.1	0.2	1.1	0.2	0.5	1.1	-0.5	0.2	0.5	-0.1	0.2	0.0	0.2
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.8	-0.1	0.4	-0.5	0.6	0.8	0.1	0.9	0.5	0.2	-0.0
HDL Cholesterol	0.1	0.2	0.5	0.4	0.5	0.6	0.1	-0.0	-0.2	0.5	0.2	0.2	0.7
Neuroticism	0.1	0.3	1.4	0.7	0.3	1.2	-0.4	0.0	0.1	0.9	0.0	0.1	0.4
Hair Pigment	0.1	2.1	4.7	-0.5	1.4	1.8	0.8	1.8	-0.5	0.9	2.0	2.2	1.4
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.5	0.4	0.3	0.4	-0.3	-0.1	0.7	-0.3	-0.5	-0.6	-0.2
Mouth/teeth dental problems	0.1	0.2	0.7	-0.1	0.4	0.2	0.0	-0.1	-0.1	0.6	0.7	0.6	0.8
Neuroticism score	0.1	0.3	1.2	-0.6	-0.1	0.8	-0.4	-0.4	1.1	0.2	-0.4	-0.2	0.0
Qualifications: A levels/AS levels or equivalent	0.1	0.3	0.8	0.4	0.4	0.4	0.6	0.2	-0.2	0.9	0.8	0.3	0.2
Mouth/teeth dental problems: Dentures	0.1	0.2	0.6	0.8	-0.0	0.5	-0.7	0.4	-0.6	-0.3	0.1	0.2	0.0
Depression (self-reported)	0.1	0.1	0.3	0.4	0.3	0.5	0.2	0.0	-0.2	-0.3	-0.2	-0.6	0.2
Length of working week for main job	0.1	0.1	0.4	-0.3	0.4	0.2	0.0	-0.5	0.7	0.2	0.1	0.1	0.4
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.3	-0.3	0.1	-0.4	-0.6	0.2	-0.4	-0.3	-0.1	-0.1	-0.3
Blood clot in the leg (DVT)	0.1	0.1	0.3	-0.5	0.3	-0.1	0.2	0.4	-0.0	0.3	0.4	0.6	0.0
Heart disease (mother)	0.1	0.1	0.3	0.2	-0.2	-0.2	-0.5	0.2	0.1	0.6	-0.3	0.1	-0.2
Pulse rate, automated reading	0.1	0.4	1.4	0.6	0.4	-1.2	-0.3	0.5	-0.3	1.0	0.3	0.3	0.1
Ever had bowel cancer screening	0.1	0.1	0.3	-0.0	-0.2	-0.1	0.2	-0.4	0.6	-0.1	-0.4	-0.5	0.2
Diabetes diagnosed by doctor	0.1	0.2	0.9	-0.1	-1.0	0.3	0.5	0.0	0.3	-0.6	-0.1	-0.4	-0.8
Mouth/teeth dental problems: Mouth ulcers	0.1	0.1	0.3	-0.0	0.5	0.5	-0.6	-0.2	0.1	0.2	0.2	-0.2	0.2
Hearing aid user	0.1	0.1	0.5	0.1	0.4	-0.1	0.7	0.2	0.4	0.4	-0.2	-0.1	-0.3
High cholesterol (Self-reported)	0.1	0.2	1.8	0.3	0.1	-1.4	-0.1	-0.2	-0.1	0.3	0.0	-0.2	0.5
Medication: Lisinopril	0.1	0.1	0.5	-0.4	-0.0	0.1	-0.0	0.2	-0.3	-0.7	0.2	-0.1	0.2
Ever smoked	0.1	0.1	0.4	0.3	0.2	-0.5	-0.7	0.4	-0.1	0.2	-0.3	-0.2	-0.4
Average weekly beer plus cider intake	0.1	0.1	0.5	-0.3	0.3	0.7	0.1	0.5	0.1	-0.4	-0.3	-0.2	-0.1
Risk taking	0.1	0.1	0.4	-0.6	0.5	0.1	-0.4	-0.4	-0.3	-0.2	-0.3	-0.6	-0.2
Diastolic blood pressure, automated reading	0.1	0.4	1.6	1.0	0.3	-0.1	0.2	0.3	1.3	0.8	-0.2	0.2	0.6
Vascular/heart problems diagnosed by doctor	0.1	0.4	1.1	-0.9	-0.4	0.2	0.2	-0.7	1.0	-0.4	-0.5	-0.3	-0.5
Cholesterol lowering medication	0.1	0.1	0.3	-0.4	0.4	0.2	-0.3	0.3	0.6	0.5	-0.1	0.2	0.3
Tanning	0.0	0.4	1.1	0.0	-0.7	-0.9	-0.0	-1.1	0.9	-0.5	-0.5	-0.8	-0.1
Hearing difficulty/problems: Yes	0.0	0.1	0.2	0.1	0.1	-0.3	0.4	0.4	-0.1	0.3	-0.0	0.1	-0.4

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Trait associations