Best TWAS P=5.11e-08 · Best GWAS P=6.03e-08 conditioned to 0.374
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | C9orf43 | 0.06 | 0.05 | lasso | 3 | 0.05 | 9.0e-05 | -5.0 | 5.3 | 9.8e-08 | -0.88 | 0.04 | 0.95 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | C9orf43 | 0.12 | 0.08 | lasso | 10 | 0.06 | 3.0e-04 | -5.3 | 5.3 | 1.3e-07 | -0.98 | 0.03 | 0.96 | FALSE |
| 3 | GTEx | Cells EBV-transformed lymphocytes | C9orf43 | 0.20 | 0.21 | lasso | 2 | 0.18 | 2.4e-06 | -5.4 | 5.4 | 8.2e-08 | -1.00 | 0.03 | 0.97 | FALSE |
| 4 | GTEx | Esophagus Mucosa | C9orf43 | 0.13 | 0.13 | lasso | 4 | 0.12 | 1.4e-08 | -5.4 | 5.4 | 5.9e-08 | -1.00 | 0.03 | 0.97 | FALSE |
| 5 | METSIM | Adipose | C9orf43 | 0.05 | 0.05 | lasso | 1 | 0.03 | 5.8e-06 | -5.3 | 5.3 | 9.6e-08 | -0.98 | 0.04 | 0.96 | FALSE |
| 6 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | C9orf43 | 0.10 | 0.12 | lasso | 1 | 0.12 | 2.0e-10 | -5.3 | 5.3 | 1.5e-07 | -0.96 | 0.00 | 1.00 | FALSE |
| 7 | The Cancer Genome Atlas | Breast Invasive Carcinoma | C9orf43 | 0.08 | 0.10 | lasso | 3 | 0.10 | 2.5e-20 | -5.3 | 5.3 | 8.6e-08 | -0.97 | 0.00 | 1.00 | FALSE |
| 8 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | C9orf43 | 0.12 | 0.13 | lasso | 2 | 0.13 | 5.2e-14 | -5.3 | 5.3 | 1.3e-07 | -0.98 | 0.00 | 1.00 | FALSE |
| 9 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | C9orf43 | 0.09 | 0.10 | lasso | 2 | 0.09 | 5.9e-10 | -5.3 | 5.3 | 1.1e-07 | -0.98 | 0.00 | 1.00 | FALSE |
| 10 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | C9orf43 | 0.13 | 0.08 | blup | 57 | 0.07 | 4.9e-05 | -5.3 | 5.2 | 2.4e-07 | -0.85 | 0.00 | 0.99 | FALSE |
| 11 | The Cancer Genome Atlas | Lung Adenocarcinoma | C9orf43 | 0.12 | 0.16 | enet | 5 | 0.16 | 6.9e-18 | -5.3 | 5.1 | 2.8e-07 | -0.98 | 0.00 | 1.00 | FALSE |
| 12 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | C9orf43 | 0.21 | 0.19 | blup | 58 | 0.19 | 7.5e-21 | -5.3 | 5.1 | 3.0e-07 | -0.92 | 0.00 | 1.00 | FALSE |
| 13 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | C9orf43 | 0.11 | 0.08 | lasso | 5 | 0.06 | 3.8e-05 | -5.3 | 5.3 | 1.3e-07 | -0.96 | 0.00 | 1.00 | FALSE |
| 14 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | C9orf43 | 0.26 | 0.26 | lasso | 4 | 0.23 | 1.0e-09 | -5.3 | 5.4 | 8.4e-08 | -0.96 | 0.00 | 1.00 | FALSE |
| 15 | The Cancer Genome Atlas | Prostate Adenocarcinoma | C9orf43 | 0.18 | 0.24 | enet | 6 | 0.24 | 4.3e-25 | -5.3 | 5.4 | 6.3e-08 | -0.98 | 0.00 | 1.00 | FALSE |
| 16 | The Cancer Genome Atlas | Rectum Adenocarcinoma | C9orf43 | 0.49 | 0.17 | enet | 6 | 0.14 | 4.7e-04 | -5.3 | 5.1 | 2.9e-07 | -0.98 | 0.00 | 0.91 | FALSE |
| 17 | The Cancer Genome Atlas | Soft Tissue Sarcoma | C9orf43 | 0.11 | 0.10 | lasso | 5 | 0.09 | 4.9e-06 | -5.3 | 5.3 | 1.2e-07 | -0.99 | 0.00 | 0.99 | FALSE |
| 18 | The Cancer Genome Atlas | Stomach Adenocarcinoma | C9orf43 | 0.11 | 0.06 | lasso | 5 | 0.05 | 1.7e-04 | -5.3 | 5.5 | 5.1e-08 | -0.94 | 0.00 | 0.99 | TRUE |
| 19 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | C9orf43 | 0.13 | 0.15 | enet | 6 | 0.13 | 2.3e-05 | -5.3 | 5.4 | 7.7e-08 | -0.97 | 0.00 | 0.98 | FALSE |
| 20 | The Cancer Genome Atlas | Thyroid Carcinoma | C9orf43 | 0.13 | 0.11 | blup | 57 | 0.16 | 3.7e-15 | -4.8 | 5.2 | 2.7e-07 | -0.85 | 0.01 | 0.98 | FALSE |