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chr9:96,440,728-101,477,500

Best TWAS P=9.27e-40 · Best GWAS P=2.03e-53 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	LOC441454	0.05	0.01	lasso	3	0.02	1.5e-03	10.10	9.3	1.2e-20	-0.01	0.03	0.70	FALSE
2	GTEx	Adipose Subcutaneous	HSD17B3	0.21	0.01	enet	31	0.04	1.9e-04	9.56	8.3	1.1e-16	0.10	0.27	0.34	FALSE
3	GTEx	Adipose Subcutaneous	ERCC6L2	0.14	0.14	lasso	9	0.12	7.7e-10	6.48	6.3	3.8e-10	-0.01	1.00	0.00	FALSE
4	GTEx	Adipose Visceral Omentum	LINC00476	0.34	0.30	lasso	5	0.36	2.1e-19	5.53	5.5	3.8e-08	-0.04	1.00	0.00	FALSE
5	GTEx	Artery Aorta	ERCC6L2	0.26	0.20	lasso	12	0.18	4.2e-10	6.49	6.5	7.2e-11	0.00	1.00	0.00	FALSE
6	GTEx	Artery Tibial	HIATL1	0.24	0.15	lasso	7	0.17	1.7e-13	-3.11	5.5	3.0e-08	-0.01	1.00	0.00	FALSE
7	GTEx	Artery Tibial	ERCC6L2	0.22	0.18	enet	39	0.18	5.2e-14	6.50	5.9	3.1e-09	-0.05	1.00	0.00	FALSE
8	GTEx	Artery Tibial	RP11-435O5.5	0.09	0.04	lasso	2	0.02	7.3e-03	13.57	-13.2	9.3e-40	-0.44	0.25	0.05	TRUE
9	GTEx	Brain Caudate basal ganglia	LINC00476	0.50	0.42	lasso	8	0.39	3.4e-12	5.53	5.5	4.5e-08	-0.06	0.99	0.00	FALSE
10	GTEx	Brain Frontal Cortex BA9	LINC00476	0.27	0.14	lasso	4	0.24	5.1e-07	-3.71	5.1	2.9e-07	-0.02	0.67	0.03	FALSE
11	GTEx	Breast Mammary Tissue	CDC14B	0.16	0.02	enet	21	0.02	3.7e-02	12.38	-10.3	5.3e-25	-0.02	0.03	0.94	FALSE
12	GTEx	Breast Mammary Tissue	ERCC6L2	0.17	0.02	lasso	4	0.03	1.2e-02	6.50	8.5	2.2e-17	-0.03	0.28	0.03	TRUE
13	GTEx	Breast Mammary Tissue (Female)	C9orf156	0.42	0.22	lasso	10	0.23	1.5e-07	-3.99	-5.9	4.6e-09	0.01	0.05	0.89	FALSE
14	GTEx	Cells EBV-transformed lymphocytes	AAED1	0.17	0.02	lasso	3	0.04	2.4e-02	12.26	10.7	6.1e-27	0.01	0.03	0.64	FALSE
15	GTEx	Cells Transformed fibroblasts	HIATL1	0.45	0.23	enet	50	0.33	1.6e-25	-3.24	7.1	1.3e-12	0.00	1.00	0.00	TRUE
16	GTEx	Cells Transformed fibroblasts	ERCC6L2	0.19	0.02	enet	34	0.16	4.1e-12	6.38	7.1	1.2e-12	0.02	0.98	0.00	FALSE
17	GTEx	Cells Transformed fibroblasts	RP11-435O5.5	0.14	0.04	lasso	4	0.02	7.9e-03	5.36	-5.3	1.4e-07	0.22	0.20	0.47	FALSE
18	GTEx	Esophagus Mucosa	HIATL1	0.19	0.16	enet	19	0.17	1.7e-11	-3.25	6.2	5.5e-10	0.00	1.00	0.00	FALSE
19	GTEx	Esophagus Muscularis	ERCC6L2	0.15	0.10	lasso	6	0.08	8.8e-06	6.53	7.7	2.0e-14	-0.01	0.87	0.01	FALSE
20	GTEx	Heart Atrial Appendage	ERCC6L2	0.16	0.05	enet	22	0.10	4.6e-05	6.53	6.8	1.5e-11	0.02	0.59	0.02	FALSE
21	GTEx	Heart Atrial Appendage	RP11-435O5.4	0.18	0.00	lasso	5	0.00	6.2e-01	2.01	-5.6	1.9e-08	0.06	0.07	0.06	TRUE
22	GTEx	Liver	LINC00476	0.29	0.24	enet	11	0.27	3.2e-08	6.00	5.2	1.7e-07	-0.03	0.87	0.01	FALSE
23	GTEx	Liver	PTCH1	0.25	0.06	enet	11	0.03	4.9e-02	15.39	12.5	5.0e-36	0.91	0.01	0.94	TRUE
24	GTEx	Muscle Skeletal	HIATL1	0.15	0.04	enet	26	0.07	1.4e-07	-3.04	-5.1	2.9e-07	-0.01	0.98	0.00	FALSE
25	GTEx	Nerve Tibial	HSD17B3	0.14	0.00	enet	20	0.00	2.4e-01	12.14	10.1	5.7e-24	0.03	0.04	0.69	FALSE
26	GTEx	Nerve Tibial	ZNF367	0.10	0.05	lasso	3	0.02	7.9e-03	12.21	11.6	5.1e-31	0.03	0.09	0.86	FALSE
27	GTEx	Nerve Tibial	ERCC6L2	0.15	0.11	lasso	6	0.10	2.2e-07	6.51	6.5	8.6e-11	0.03	1.00	0.00	TRUE
28	GTEx	Pancreas	ERCC6L2	0.23	0.19	enet	18	0.22	9.7e-10	4.25	5.2	2.4e-07	-0.02	1.00	0.00	FALSE
29	GTEx	Skin Sun Exposed Lower leg	ERCC6L2	0.21	0.19	lasso	8	0.17	4.3e-14	6.37	6.3	2.6e-10	0.00	1.00	0.00	FALSE
30	GTEx	Spleen	PTCH1	0.33	0.08	lasso	8	0.18	1.9e-05	-0.61	9.9	4.1e-23	0.64	0.04	0.81	FALSE
31	GTEx	Testis	HABP4	0.19	0.22	lasso	9	0.21	1.1e-09	12.24	12.3	1.2e-34	0.03	0.03	0.97	FALSE
32	GTEx	Testis	C9orf3	0.15	0.00	enet	18	0.00	2.4e-01	-0.39	-6.3	2.2e-10	-0.10	0.06	0.14	TRUE
33	GTEx	Testis	LINC00476	0.51	0.47	lasso	6	0.50	4.1e-25	5.53	6.0	1.7e-09	-0.05	1.00	0.00	FALSE
34	GTEx	Thyroid	CDC14B	0.15	0.10	lasso	5	0.08	5.3e-07	12.01	-11.5	8.4e-31	-0.03	0.10	0.90	FALSE
35	GTEx	Thyroid	C9orf3	0.25	0.00	enet	45	0.02	1.8e-02	-0.71	-5.1	2.9e-07	-0.06	0.08	0.03	TRUE
36	GTEx	Thyroid	ERCC6L2	0.09	0.07	lasso	2	0.05	6.9e-05	6.53	6.5	1.0e-10	-0.01	0.85	0.01	FALSE
37	GTEx	Whole Blood	ERCC6L2	0.07	0.03	lasso	2	0.02	3.7e-03	4.04	5.3	1.5e-07	0.03	0.59	0.02	FALSE
38	METSIM	Adipose	ANP32B	0.05	0.03	lasso	6	0.02	1.1e-03	-6.82	6.8	1.3e-11	0.01	0.00	1.00	TRUE
39	METSIM	Adipose	HABP4	0.05	0.00	bslmm	355	0.01	1.5e-02	12.19	7.0	3.6e-12	0.03	0.04	0.49	FALSE
40	NTR	Blood	C9orf3	0.02	0.02	lasso	1	0.01	2.5e-05	-5.12	-5.1	3.0e-07	0.00	0.98	0.00	FALSE
41	NTR	Blood	PTCH1	0.04	0.02	blup	433	0.02	4.1e-08	13.71	11.2	5.3e-29	0.65	0.01	0.99	TRUE
42	YFS	Blood	ANP32B	0.03	0.02	lasso	9	0.02	1.9e-08	-6.82	6.6	3.7e-11	-0.02	0.00	1.00	FALSE
43	YFS	Blood	HABP4	0.08	0.09	enet	24	0.11	5.9e-34	12.15	-12.0	2.1e-33	-0.04	0.24	0.76	FALSE
44	YFS	Blood	PTCH1	0.09	0.05	lasso	8	0.05	1.2e-15	13.70	12.7	8.4e-37	0.95	0.10	0.90	FALSE
45	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	C9orf130	0.24	0.34	lasso	7	0.39	1.5e-34	5.53	6.5	9.8e-11	-0.03	0.56	0.44	FALSE
46	The Cancer Genome Atlas	Breast Invasive Carcinoma	C9orf102	0.13	0.00	enet	10	0.03	4.5e-06	-0.59	5.5	3.1e-08	0.05	0.06	0.80	FALSE
47	The Cancer Genome Atlas	Breast Invasive Carcinoma	C9orf130	0.27	0.41	enet	24	0.44	6.2e-101	5.53	6.8	1.2e-11	-0.04	0.84	0.16	FALSE
48	The Cancer Genome Atlas	Breast Invasive Carcinoma	CDC14B	0.02	0.01	lasso	1	0.01	3.0e-03	12.39	-12.4	3.0e-35	-0.03	0.02	0.76	FALSE
49	The Cancer Genome Atlas	Breast Invasive Carcinoma	HSD17B3	0.02	0.01	enet	7	0.01	7.3e-03	-3.49	6.2	7.4e-10	0.07	0.19	0.30	FALSE
50	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	C9orf130	0.30	0.30	blup	73	0.30	3.6e-15	5.53	5.7	1.5e-08	-0.04	0.38	0.62	FALSE
51	The Cancer Genome Atlas	Colon Adenocarcinoma	C9orf130	0.36	0.38	enet	13	0.38	3.7e-23	5.53	6.0	1.7e-09	-0.02	0.59	0.41	FALSE
52	The Cancer Genome Atlas	Esophageal Carcinoma	C9orf130	0.39	0.22	enet	10	0.42	1.8e-14	6.51	6.2	5.7e-10	-0.03	0.02	0.98	FALSE
53	The Cancer Genome Atlas	Glioblastoma Multiforme	C9orf130	0.39	0.20	blup	73	0.21	5.8e-07	5.68	5.8	7.2e-09	-0.01	0.04	0.94	FALSE
54	The Cancer Genome Atlas	Glioblastoma Multiforme	CDC14B	0.16	0.17	blup	41	0.19	2.6e-06	12.26	-11.2	6.4e-29	0.00	0.02	0.96	FALSE
55	The Cancer Genome Atlas	Glioblastoma Multiforme	HABP4	0.08	0.06	blup	44	0.05	1.6e-02	11.91	-12.8	2.1e-37	-0.05	0.03	0.53	FALSE
56	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C9orf130	0.31	0.43	enet	9	0.45	9.0e-56	5.53	6.1	8.1e-10	-0.06	0.84	0.16	FALSE
57	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	HABP4	0.02	0.02	blup	44	0.02	7.1e-03	12.26	12.5	1.1e-35	0.03	0.02	0.79	FALSE
58	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C9orf102	0.07	0.05	blup	78	0.06	5.2e-07	6.53	6.0	1.9e-09	0.01	0.01	0.99	FALSE
59	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C9orf130	0.36	0.43	lasso	6	0.52	6.8e-69	6.14	6.7	2.3e-11	0.01	0.13	0.87	FALSE
60	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CDC14B	0.03	0.02	blup	42	0.02	2.1e-03	12.26	-12.7	1.0e-36	-0.03	0.02	0.79	FALSE
61	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	FAM22F	0.03	0.02	blup	26	0.01	2.8e-02	-5.87	-6.2	4.2e-10	0.01	0.00	0.88	FALSE
62	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	HSD17B3	0.03	0.00	blup	98	0.01	1.7e-02	-3.49	6.2	4.0e-10	0.09	0.06	0.04	FALSE
63	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PTCH1	0.04	0.00	blup	56	0.02	1.6e-03	13.70	7.8	8.2e-15	0.73	0.02	0.52	FALSE
64	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	C9orf130	0.34	0.27	blup	73	0.36	7.6e-22	5.68	6.1	1.2e-09	-0.07	0.59	0.41	FALSE
65	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	HIATL1	0.07	0.02	blup	44	0.04	2.3e-03	5.07	6.2	4.7e-10	-0.02	0.11	0.08	FALSE
66	The Cancer Genome Atlas	Brain Lower Grade Glioma	C9orf130	0.29	0.49	lasso	7	0.51	7.5e-67	5.53	5.7	9.7e-09	-0.05	0.84	0.16	FALSE
67	The Cancer Genome Atlas	Brain Lower Grade Glioma	CDC14B	0.05	0.06	lasso	5	0.06	6.5e-07	12.31	-11.4	4.5e-30	-0.02	0.03	0.97	FALSE
68	The Cancer Genome Atlas	Brain Lower Grade Glioma	HABP4	0.05	0.08	lasso	5	0.08	6.9e-09	12.10	-12.3	1.2e-34	-0.04	0.04	0.96	FALSE
69	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	C9orf130	0.32	0.31	blup	73	0.32	9.9e-16	6.14	6.7	1.8e-11	0.00	0.06	0.94	FALSE
70	The Cancer Genome Atlas	Lung Adenocarcinoma	C9orf130	0.43	0.47	lasso	6	0.52	5.1e-71	5.53	6.5	8.2e-11	-0.03	0.83	0.17	FALSE
71	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	C9orf130	0.27	0.33	lasso	4	0.36	1.9e-42	5.53	6.5	8.9e-11	-0.04	0.74	0.26	FALSE
72	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	HIATL1	0.04	0.01	blup	44	0.03	8.8e-05	-3.24	5.7	1.1e-08	-0.05	0.22	0.12	FALSE
73	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	C9orf130	0.21	0.25	lasso	8	0.29	7.6e-20	5.53	6.1	1.2e-09	-0.04	0.73	0.27	FALSE
74	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	C9orf130	0.49	0.46	enet	13	0.52	2.8e-25	5.68	6.2	7.1e-10	-0.03	0.11	0.89	FALSE
75	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	C9orf130	0.43	0.33	blup	73	0.34	3.7e-14	6.14	6.3	2.9e-10	-0.03	0.20	0.80	FALSE
76	The Cancer Genome Atlas	Prostate Adenocarcinoma	C9orf102	0.06	0.02	blup	78	0.03	2.3e-04	6.51	5.8	5.3e-09	0.00	0.01	0.98	FALSE
77	The Cancer Genome Atlas	Prostate Adenocarcinoma	C9orf130	0.37	0.58	enet	17	0.64	9.7e-88	5.53	6.3	3.7e-10	-0.03	0.84	0.16	FALSE
78	The Cancer Genome Atlas	Prostate Adenocarcinoma	HIATL1	0.18	0.05	blup	44	0.12	3.9e-12	4.35	5.8	4.8e-09	0.05	0.98	0.00	FALSE
79	The Cancer Genome Atlas	Prostate Adenocarcinoma	PTCH1	0.02	0.01	blup	54	0.02	1.1e-03	13.17	-10.8	2.6e-27	-0.19	0.06	0.04	FALSE
80	The Cancer Genome Atlas	Rectum Adenocarcinoma	C9orf130	0.28	0.16	blup	73	0.18	4.6e-05	6.47	5.6	2.5e-08	-0.01	0.02	0.93	FALSE
81	The Cancer Genome Atlas	Soft Tissue Sarcoma	C9orf130	0.18	0.15	blup	73	0.17	2.6e-10	6.14	6.1	1.3e-09	0.01	0.07	0.93	FALSE
82	The Cancer Genome Atlas	Skin Cutaneous Melanoma	C9orf130	0.26	0.10	lasso	2	0.17	2.4e-05	6.14	6.8	1.0e-11	0.02	0.04	0.80	FALSE
83	The Cancer Genome Atlas	Stomach Adenocarcinoma	C9orf130	0.31	0.28	blup	73	0.37	7.7e-28	5.53	6.8	1.5e-11	-0.05	0.03	0.97	FALSE
84	The Cancer Genome Atlas	Stomach Adenocarcinoma	CDC14B	0.08	0.02	blup	41	0.04	1.0e-03	10.10	-12.9	2.4e-38	-0.05	0.02	0.70	TRUE
85	The Cancer Genome Atlas	Stomach Adenocarcinoma	HIATL1	0.04	0.01	blup	44	0.02	2.1e-02	5.05	6.6	3.1e-11	-0.03	0.02	0.17	FALSE
86	The Cancer Genome Atlas	Testicular Germ Cell Tumors	C9orf130	0.36	0.35	lasso	10	0.41	1.2e-15	6.46	6.6	3.3e-11	0.00	0.02	0.98	FALSE
87	The Cancer Genome Atlas	Testicular Germ Cell Tumors	SLC35D2	0.18	0.04	blup	74	0.07	1.8e-03	-6.64	-7.7	2.0e-14	-0.07	0.03	0.12	FALSE
88	The Cancer Genome Atlas	Thyroid Carcinoma	C9orf130	0.56	0.60	enet	14	0.68	1.2e-89	5.53	6.4	1.2e-10	-0.02	0.83	0.17	FALSE
89	The Cancer Genome Atlas	Thyroid Carcinoma	C9orf3	0.03	0.02	lasso	4	0.02	4.0e-03	-4.92	-5.8	6.1e-09	-0.05	0.26	0.10	FALSE
90	The Cancer Genome Atlas	Thyroid Carcinoma	CDC14B	0.05	0.07	blup	42	0.08	4.8e-08	12.40	-12.1	8.3e-34	-0.02	0.02	0.98	FALSE
91	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	C9orf130	0.18	0.01	blup	73	0.03	5.3e-02	6.50	5.9	3.4e-09	-0.03	0.02	0.57	FALSE