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chr10:76,664,253-80,383,574

Best TWAS P=4.98e-15 · Best GWAS P=4.06e-12 conditioned to 0.325

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	DLG5	0.10	0.07	lasso	5	0.06	3.3e-08	-6.9	-6.9	4.9e-12	0.98	0.01	0.99	FALSE
2	GTEx	Adipose Subcutaneous	C10orf11	0.24	0.21	lasso	9	0.20	3.3e-16	5.1	-5.1	3.0e-07	0.00	0.00	1.00	FALSE
3	GTEx	Adipose Subcutaneous	DLG5	0.39	0.40	lasso	12	0.43	1.9e-38	-6.9	-6.6	4.4e-11	0.97	0.00	1.00	FALSE
4	GTEx	Adipose Subcutaneous	RP13-39P12.3	0.31	0.27	lasso	12	0.34	1.1e-28	-6.8	-5.9	3.3e-09	0.90	0.00	1.00	FALSE
5	GTEx	Adipose Visceral Omentum	DLG5	0.26	0.23	lasso	8	0.21	5.7e-11	-6.8	-6.6	3.8e-11	0.97	0.01	0.99	FALSE
6	GTEx	Adipose Visceral Omentum	RP13-39P12.3	0.18	0.07	lasso	7	0.06	3.3e-04	-6.8	-5.7	9.5e-09	0.87	0.01	0.99	FALSE
7	GTEx	Adrenal Gland	DLG5	0.22	0.14	lasso	6	0.11	8.5e-05	-6.8	-7.8	5.0e-15	0.94	0.01	0.99	TRUE
8	GTEx	Artery Aorta	DLG5	0.26	0.19	enet	10	0.22	2.6e-12	-6.7	-6.8	1.5e-11	0.98	0.01	0.99	FALSE
9	GTEx	Artery Aorta	RP13-39P12.3	0.14	0.13	enet	9	0.12	2.2e-07	-6.7	-7.0	3.6e-12	0.97	0.01	0.99	FALSE
10	GTEx	Artery Coronary	DLG5	0.33	0.25	lasso	4	0.27	1.4e-09	-6.4	-6.0	1.7e-09	0.91	0.01	0.99	FALSE
11	GTEx	Artery Coronary	RP13-39P12.3	0.21	0.03	lasso	4	0.09	7.2e-04	-6.4	-5.6	2.4e-08	0.85	0.03	0.93	FALSE
12	GTEx	Artery Tibial	DLG5	0.24	0.18	lasso	5	0.18	9.7e-14	-6.9	-6.8	1.4e-11	0.98	0.01	0.99	FALSE
13	GTEx	Artery Tibial	RP13-39P12.3	0.14	0.04	lasso	7	0.05	7.3e-05	-6.9	-5.5	4.8e-08	0.85	0.02	0.98	FALSE
14	GTEx	Brain Cerebellum	DLG5	0.36	0.28	lasso	7	0.36	1.6e-11	-6.9	-6.1	1.1e-09	0.90	0.01	0.99	FALSE
15	GTEx	Breast Mammary Tissue	DLG5	0.15	0.09	lasso	7	0.08	6.7e-05	-6.4	-6.2	7.7e-10	0.93	0.02	0.96	FALSE
16	GTEx	Cells Transformed fibroblasts	DLG5	0.25	0.18	lasso	11	0.16	2.0e-12	-6.6	-6.6	4.9e-11	0.96	0.02	0.98	FALSE
17	GTEx	Cells Transformed fibroblasts	RP13-39P12.3	0.19	0.13	lasso	7	0.15	4.5e-11	-6.6	-6.0	1.9e-09	0.90	0.02	0.98	FALSE
18	GTEx	Colon Sigmoid	DLG5	0.23	0.11	lasso	5	0.15	4.6e-06	2.5	-5.2	2.5e-07	0.82	0.03	0.93	FALSE
19	GTEx	Colon Transverse	DLG5	0.23	0.17	lasso	8	0.19	1.4e-09	-6.4	-6.2	4.6e-10	0.94	0.01	0.99	FALSE
20	GTEx	Esophagus Gastroesophageal Junction	DLG5	0.27	0.03	enet	13	0.06	3.9e-03	-5.7	-5.8	6.1e-09	0.73	0.02	0.95	FALSE
21	GTEx	Esophagus Mucosa	DLG5	0.21	0.16	lasso	5	0.18	5.2e-12	-6.9	-6.3	3.6e-10	0.94	0.00	1.00	FALSE
22	GTEx	Esophagus Muscularis	C10orf11	0.45	0.39	enet	42	0.38	5.1e-24	5.1	-5.5	3.4e-08	-0.01	0.00	1.00	TRUE
23	GTEx	Heart Atrial Appendage	DLG5	0.32	0.23	lasso	4	0.24	3.9e-11	-6.4	-6.5	8.4e-11	0.97	0.01	0.99	FALSE
24	GTEx	Heart Left Ventricle	DLG5	0.13	0.10	lasso	4	0.09	1.2e-05	-6.4	-6.6	5.4e-11	0.97	0.01	0.99	FALSE
25	GTEx	Liver	DLG5	0.42	0.31	lasso	5	0.28	2.1e-08	-6.6	-6.5	6.1e-11	0.97	0.01	0.99	FALSE
26	GTEx	Liver	RP13-39P12.3	0.29	0.03	enet	21	0.07	4.6e-03	-6.6	-5.7	1.1e-08	0.76	0.02	0.93	FALSE
27	GTEx	Lung	C10orf11	0.30	0.26	lasso	5	0.24	2.0e-18	5.1	-5.1	2.8e-07	0.00	0.00	1.00	FALSE
28	GTEx	Lung	DLG5	0.41	0.38	lasso	8	0.37	7.9e-30	-6.8	-6.7	2.8e-11	0.98	0.01	0.99	FALSE
29	GTEx	Lung	RP13-39P12.3	0.36	0.28	enet	27	0.31	2.5e-24	-6.8	-5.5	4.5e-08	0.90	0.01	0.99	FALSE
30	GTEx	Nerve Tibial	DLG5	0.51	0.44	lasso	6	0.50	1.4e-39	-6.9	-6.8	1.1e-11	0.97	0.00	1.00	FALSE
31	GTEx	Nerve Tibial	RP13-39P12.3	0.31	0.25	lasso	7	0.36	1.3e-26	-6.8	-5.7	1.2e-08	0.86	0.01	0.99	FALSE
32	GTEx	Ovary	DLG5	0.62	0.38	lasso	6	0.40	5.3e-11	-6.6	-7.5	5.5e-14	0.96	0.01	0.99	FALSE
33	GTEx	Ovary	RP13-39P12.3	0.42	0.29	lasso	5	0.33	7.5e-09	-6.6	-7.4	1.1e-13	0.94	0.02	0.98	FALSE
34	GTEx	Pancreas	DLG5	0.39	0.43	enet	11	0.44	3.5e-20	-6.9	-6.7	2.1e-11	0.99	0.01	0.99	FALSE
35	GTEx	Pancreas	RP13-39P12.3	0.20	0.24	lasso	3	0.23	3.8e-10	-6.8	-6.8	8.0e-12	0.98	0.01	0.99	FALSE
36	GTEx	Pituitary	DLG5	0.45	0.36	lasso	11	0.31	1.9e-08	-6.6	-6.6	4.5e-11	0.97	0.01	0.99	FALSE
37	GTEx	Pituitary	RP13-39P12.3	0.38	0.22	lasso	11	0.17	3.8e-05	-6.6	-6.5	1.1e-10	0.95	0.02	0.96	FALSE
38	GTEx	Skin Sun Exposed Lower leg	DLG5	0.12	0.06	lasso	4	0.06	4.9e-06	-6.8	-6.6	4.9e-11	0.97	0.01	0.99	FALSE
39	GTEx	Spleen	DLG5	0.51	0.46	lasso	4	0.44	1.1e-12	-6.9	-6.8	9.6e-12	0.98	0.01	0.99	FALSE
40	GTEx	Spleen	RP13-39P12.3	0.38	0.34	lasso	2	0.35	8.8e-10	-6.9	-6.3	2.8e-10	0.94	0.01	0.99	FALSE
41	GTEx	Stomach	DLG5	0.20	0.12	lasso	7	0.08	1.3e-04	-6.9	-6.7	1.6e-11	0.98	0.01	0.99	FALSE
42	GTEx	Thyroid	DLG5	0.39	0.43	lasso	5	0.43	1.5e-35	-6.8	-6.8	8.6e-12	0.98	0.01	0.99	FALSE
43	GTEx	Thyroid	RP13-39P12.3	0.28	0.30	lasso	8	0.29	3.3e-22	-6.8	-6.8	8.1e-12	0.98	0.01	0.99	FALSE
44	GTEx	Whole Blood	DLG5	0.10	0.06	lasso	9	0.10	2.3e-09	2.6	-5.3	1.3e-07	0.79	0.08	0.92	FALSE
45	METSIM	Adipose	DLG5	0.18	0.19	lasso	11	0.22	2.2e-32	-6.8	-6.0	2.6e-09	0.90	0.01	0.99	FALSE
46	ROSMAP	Brain Pre-frontal Cortex	DLG5	0.19	0.17	bslmm	592	0.20	1.5e-24	-6.6	-6.5	1.1e-10	0.91	0.02	0.98	FALSE
47	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	DLG5	0.12	0.01	blup	116	0.03	1.2e-02	-6.4	-6.0	2.2e-09	0.83	0.02	0.66	FALSE
48	The Cancer Genome Atlas	Colon Adenocarcinoma	DLG5	0.08	0.03	blup	116	0.06	2.1e-04	4.0	-6.1	1.1e-09	0.79	0.06	0.92	FALSE
49	The Cancer Genome Atlas	Prostate Adenocarcinoma	DLG5	0.10	0.05	blup	116	0.05	2.1e-06	-6.8	-5.4	7.1e-08	0.84	0.01	0.99	FALSE
50	The Cancer Genome Atlas	Thyroid Carcinoma	DLG5	0.13	0.08	enet	10	0.10	1.2e-09	-6.3	-6.0	2.0e-09	0.85	0.04	0.96	FALSE