Best TWAS P=2.86e-08 · Best GWAS P=1.87e-07 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Nerve Tibial | HELLS | 0.12 | 0.12 | enet | 17 | 0.10 | 1.6e-07 | 5.2 | 5.5 | 3.6e-08 | 0.91 | 0.03 | 0.97 | FALSE |
| 2 | GTEx | Ovary | HELLS | 0.15 | 0.04 | lasso | 5 | 0.09 | 3.1e-03 | 5.1 | 5.3 | 8.8e-08 | 0.83 | 0.04 | 0.80 | FALSE |
| 3 | METSIM | Adipose | HELLS | 0.03 | 0.04 | lasso | 3 | 0.03 | 9.3e-05 | 5.2 | 5.2 | 2.1e-07 | 0.91 | 0.03 | 0.97 | FALSE |
| 4 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | TBC1D12 | 0.04 | 0.01 | blup | 63 | 0.03 | 8.3e-03 | 5.1 | -5.5 | 2.9e-08 | -0.95 | 0.02 | 0.73 | TRUE |
| 5 | The Cancer Genome Atlas | Prostate Adenocarcinoma | TBC1D12 | 0.04 | 0.04 | blup | 63 | 0.03 | 3.9e-04 | 5.1 | 5.1 | 3.1e-07 | 0.89 | 0.02 | 0.95 | FALSE |