Hub : Genes

TBC1D12

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 TCGA Cervical Squamous Cell Carcinoma 0.0430 0.0290 0.00700 0.012 0.034 0.015 NA 0.005 7.9e-02 0.00830 0.0560 NA 0.1800
2 TCGA Prostate Adenocarcinoma 0.0351 0.0224 0.00046 0.039 0.030 0.022 NA 0.025 5.9e-05 0.00039 0.0022 NA 0.0011

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 1.3 2.1 2.2 1.4 -1.5
Bipolar Disorder or Schizophrenia 3.5 8.5 10.2 2.6 -3.2
Depressed Affect (Nagel 2018) 2.4 5.1 6.0 2.4 -2.0
Depression (Nagel 2018) 2.1 3.2 3.7 1.9 -1.6
Intelligence (Savage-Jansen 2018) 0.0 0.0 0.0 -0.0 -0.2
Neuroticism (Nagel 2018) 0.9 2.2 2.8 1.7 -1.3
Schizophrenia (2018) 3.2 6.6 8.4 2.2 -2.9
Schizophrenia vs Biploar Disorder 0.3 0.4 0.5 0.5 -0.7
Worry (Nagel 2018) 0.6 1.2 1.5 1.2 -0.9
Alzheimer’s Disease (in mother) 2.1 2.5 2.5 -1.6 1.6
Alzheimer’s Disease (in father) 0.5 0.5 0.6 -0.7 0.8
Alzheimer’s Disease (including proxy) 1.9 2.8 2.9 -1.7 1.6
Crohns Disease (2017) 2.0 4.4 4.8 -2.2 2.0
Irritable Bowel Disease (IBD) 1.4 3.4 3.4 -1.8 1.9
Ulcerative Colitis (UC) 0.7 1.2 1.4 -1.0 1.2
Major Depression (MDD) 0.1 0.1 0.3 -0.2 0.5
Reaction Time 0.0 0.0 0.0 -0.2 0.1
Verbal and Numeric Reasoning (VNR) 0.1 0.1 0.2 -0.1 -0.5
Breast Cancer 0.0 0.1 0.1 0.3 -0.1
Ovarian Cancer 1.7 2.2 2.5 1.4 -1.6
Prostate Cancer 1.7 2.4 2.6 -1.5 1.6
Age at First Birth 0.1 0.1 0.2 0.4 -0.1
Bipolar Disorder (2011) 0.2 0.2 0.4 -0.6 0.3
Body Mass Index (BMI) (2010) 0.3 0.4 0.7 -0.4 0.8
Coronary Artery Disease (CAD) 3.7 4.4 4.5 -2.1 2.1
Crohns Disease (2012) 1.8 2.9 3.6 -1.9 1.5
Mean Putamen Volume 0.1 0.1 0.1 0.3 -0.3
Fasting Glucose 0.8 1.0 1.2 -1.1 0.9
HbA1C 1.6 1.7 2.0 -1.4 1.2
HDL Cholesterol 1.0 1.7 1.9 -1.4 1.2
LDL Cholesterol 1.7 2.7 2.8 -1.7 1.6
Lupus 0.5 0.8 1.1 -0.7 1.1
Neuroticism (2016) 0.4 0.5 0.8 0.9 -0.5
Primary Biliary Cirrhosis 0.3 0.4 0.5 0.6 -0.7
Rheumatoid Arthritis 0.4 0.5 0.6 -0.8 0.6
Schizophrenia (2014) 2.0 4.3 5.5 1.8 -2.3
Triglycerides 0.3 0.5 0.6 -0.7 0.8
Type 2 Diabetes (T2D) (2012) 0.9 1.1 1.4 0.8 -1.2
Ulcerative Colitis 0.0 0.0 0.0 -0.2 0.0
Blood Eosinophil Count 0.1 0.9 1.0 1.0 -0.9
Blood Platelet Count 3.1 36.5 37.1 6.1 -6.0
Blood Red Count 5.9 56.7 59.4 7.7 -7.3
Blood White Count 13.7 101.4 110.2 9.6 -10.5
Heel T-Score 0.5 4.4 4.7 -2.0 2.2
BMI 0.0 0.2 0.3 0.6 -0.3
Height 1.1 21.7 23.4 -4.8 4.5
Waist Hip Ratio (WHR) 2.0 8.8 9.5 3.1 -2.9
Systolic Blood Pressure 14.8 74.1 84.3 8.0 -9.2
Smoking Status 0.4 0.8 1.1 -1.0 0.8
Allergy or Eczema 0.1 0.2 0.3 -0.5 0.4
Cardiovascular Disease 6.2 20.6 25.5 4.0 -5.0
Hypothyroidism (self reported) 1.9 4.3 4.4 -2.0 2.1
Respiratory disease 0.3 0.6 1.2 -0.3 1.1
Type 2 Diabetes (T2D) (2018) 0.0 0.0 0.0 0.1 -0.2
Lung FEV1/FVC ratio 3.4 17.3 21.8 -4.7 3.6
Lung FVC 0.0 0.2 0.3 0.4 -0.5
Neuroticism 1.5 3.5 3.9 2.0 -1.8
Chronotype (morning person) 0.0 0.1 0.1 0.2 -0.3
Hair Pigment 0.0 0.6 0.6 0.8 -0.8
Tanning 0.3 3.4 4.0 -2.0 1.6
Hand grip strength (left) 2.5 6.5 7.7 -2.3 2.8
Number of treatments/medications taken 1.3 2.3 2.7 1.4 -1.6
Average weekly spirits intake 0.0 0.0 0.0 -0.1 0.2
Sensitivity / hurt feelings 1.9 3.3 3.8 -1.7 1.9
Frequency of depressed mood in last 2 weeks 2.5 3.5 3.9 2.0 -1.8
Hearing difficulty/problems: Yes 0.4 0.6 0.9 0.5 -0.9
Relative age of first facial hair 0.6 1.2 1.3 -1.1 1.1
Other serious medical condition/disability diagnosed by doctor 0.3 0.4 0.5 0.7 -0.4
Ever used hormone-replacement therapy (HRT) 0.2 0.3 0.4 0.6 -0.5
Ever had hysterectomy (womb removed) 1.7 1.9 2.5 1.6 -1.2
Systolic blood pressure, automated reading 8.6 25.1 28.4 4.7 -5.3
Eye problems/disorders: Diabetes related eye disease 0.1 0.1 0.1 0.1 -0.4
Angina 0.0 0.0 0.0 -0.2 0.2
Medication for hormone replacement therapy 0.0 0.0 0.0 -0.1 -0.1
Vitamin and mineral supplements 0.5 0.7 0.7 0.8 -0.8
Supplements: Zinc 0.1 0.1 0.1 0.3 0.2
Medication: Co-codamol 0.0 0.0 0.0 0.0 0.1
Medication: Metformin 0.9 1.3 1.6 1.3 -1.0
Diabetes (father) 0.5 0.6 1.0 0.5 -1.0
Diabetes (mother) 0.9 1.2 1.3 -1.1 1.1
Severe depression (siblings) 4.1 4.6 5.2 2.0 -2.3
Pack years adult smoking proportion 3.7 5.7 5.8 2.3 -2.4
Impedance of leg (right) 10.4 50.2 58.1 6.5 -7.6
Leg fat-free mass (left) 3.7 19.6 21.4 -4.2 4.6
Trunk fat percentage 5.0 19.9 22.0 4.2 -4.7
Hand grip strength (right) 1.9 5.0 6.0 -2.0 2.4
Townsend deprivation index at recruitment 3.5 4.9 5.7 2.0 -2.4
Current tobacco smoking 0.0 0.0 0.1 -0.3 0.1
Average weekly fortified wine intake 0.0 0.0 0.0 -0.1 -0.0
Maternal smoking around birth 0.2 0.3 0.3 0.5 -0.5
Fed-up feelings 0.4 0.8 1.1 1.0 -0.7
Frequency of unenthusiasm / disinterest in last 2 weeks 2.7 3.6 4.0 1.8 -2.0
Relative age voice broke 0.0 0.0 0.0 -0.1 -0.2
Taking other prescription medications 0.9 1.4 1.4 1.2 -1.2
Age when periods started (menarche) 1.9 4.5 4.9 -2.2 2.0
Bilateral oophorectomy (both ovaries removed) 2.6 3.1 3.5 -1.6 1.9
Heel bone mineral density (BMD) T-score, automated (left) 0.7 1.5 1.7 -1.3 1.1
Tinnitus: Yes, but not now, but have in the past 0.9 1.0 1.3 1.1 -0.9
Qualifications: CSEs or equivalent 0.1 0.1 0.2 -0.1 0.4
Serious illness, injury or assault to yourself 0.6 0.7 0.8 0.8 -0.9
High blood pressure 6.0 16.7 21.2 3.5 -4.6
Hayfever, allergic rhinitis or eczema 0.0 0.0 0.0 0.0 -0.2
Multivitamins +/- minerals 0.8 1.0 1.1 -1.0 1.0
Stomach or abdominal pain in last month 2.2 2.8 2.9 1.7 -1.6
Supplements: Glucosamine 1.3 1.7 1.7 -1.3 1.3
Diverticular disease/diverticulitis (self-reported) 0.3 0.3 0.4 -0.4 0.7
Medication: Atenolol 9.8 12.2 12.8 3.4 -3.6
Medication: Levothyroxine sodium 3.6 6.1 6.9 -2.3 2.6
Sitting height 4.0 28.5 30.8 -5.5 5.1
Chronic bronchitis/emphysema (father) 0.1 0.1 0.2 -0.3 0.4
High blood pressure (mother) 6.1 8.5 9.6 2.7 -3.1
Body mass index (BMI) 0.1 0.3 0.5 0.7 -0.4
Impedance of leg (left) 10.6 51.5 59.1 6.6 -7.7
Leg predicted mass (left) 3.6 19.3 21.1 -4.2 4.6
Trunk fat mass 1.8 7.5 8.4 2.6 -2.9
Waist circumference 1.7 6.4 7.3 2.7 -2.3
Number of incorrect matches in round 0.0 0.0 0.0 0.1 -0.0
Past tobacco smoking 0.1 0.2 0.3 0.5 -0.2
Alcohol usually taken with meals 0.0 0.0 0.1 0.2 -0.3
Nervous feelings 0.1 0.2 0.4 0.6 -0.2
Frequency of tenseness / restlessness in last 2 weeks 5.0 7.7 7.8 2.8 -2.8
Hearing difficulty/problems with background noise 1.5 2.3 3.2 1.2 -1.8
Hair/balding pattern: Pattern 2 2.0 2.5 3.3 1.8 -1.3
Had menopause 0.0 0.0 0.0 0.2 -0.1
Had other major operations 0.0 0.0 0.0 -0.1 0.2
Forced vital capacity (FVC) 0.6 2.3 2.7 -1.6 1.4
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.2 1.7 -1.3 0.9
Ever unenthusiastic/disinterested for a whole week 1.0 1.2 1.2 1.1 -1.1
Qualifications: None of the above 0.4 0.9 1.0 -0.9 1.0
Financial difficulties in last 2 years 0.6 0.8 1.2 0.6 -1.1
Mouth/teeth dental problems 0.1 0.1 0.3 0.2 -0.5
Heart attack 1.0 1.3 1.4 -1.1 1.2
Allergy 0.1 0.1 0.2 0.3 -0.4
Pain all over the body in last month 0.7 0.7 0.8 -0.8 0.9
Diabetes (self-reported) 0.9 1.4 1.8 1.0 -1.3
Hayfever/allergic rhinitis (self-reported) 0.1 0.1 0.1 -0.1 0.4
Medication: Ramipril 0.9 1.2 1.5 0.9 -1.2
Medication: Simvastatin 0.6 0.9 0.9 0.9 -1.0
Fluid intelligence score 0.0 0.0 0.0 -0.2 -0.2
Illnesses of siblings 0.1 0.2 0.3 0.5 -0.2
Neuroticism score 0.9 1.9 2.2 1.5 -1.2
Weight 0.1 0.5 0.6 -0.6 0.8
Impedance of arm (right) 6.2 28.8 34.4 4.8 -5.9
Arm fat percentage (right) 2.2 8.8 9.3 2.9 -3.1
Trunk fat-free mass 5.2 29.9 33.1 -5.2 5.8
Hip circumference 0.7 3.1 3.1 1.7 -1.8
Time employed in main current job 0.0 0.0 0.0 0.1 -0.1
Alcohol intake versus 10 years previously 0.1 0.1 0.2 -0.2 0.5
Father’s age at death 0.0 0.0 0.0 0.2 0.1
Worrier / anxious feelings 0.4 0.8 0.9 1.0 -0.8
Frequency of tiredness / lethargy in last 2 weeks 2.7 4.3 4.4 2.1 -2.1
Falls in the last year 2.6 3.5 4.1 1.7 -2.0
Hair/balding pattern: Pattern 3 0.1 0.2 0.2 -0.4 0.4
Number of live births 0.0 0.0 0.0 0.2 -0.1
Forced expiratory volume in 1-second (FEV1) 1.7 5.6 7.1 -2.7 2.0
Pulse rate 1.6 2.7 3.3 -1.5 1.8
Happiness 3.8 4.6 4.7 2.2 -2.1
Noisy workplace 2.5 3.1 3.4 -1.7 1.9
Qualifications: A levels/AS levels or equivalent 0.2 0.5 0.8 -0.9 0.4
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.3 0.3 -0.6 0.5
Mouth/teeth dental problems: Dentures 0.7 1.2 1.4 -1.0 1.2
Asthma 0.1 0.2 0.4 0.2 0.6
Medication: Ibuprofen (e.g. Nurofen) 0.1 0.1 0.1 -0.4 0.2
Medication: Cholesterol lowering 0.2 0.3 0.4 -0.7 0.4
Depression (self-reported) 0.7 0.8 0.8 0.9 -0.9
Medication: Lansoprazole 0.8 0.9 1.1 -0.8 1.0
Prospective memory result 3.3 4.1 4.8 -2.2 1.8
Lung cancer (father) 0.2 0.3 0.3 -0.5 0.5
Illnesses of mother 3.2 4.0 4.9 -1.8 2.2
Forced expiratory volume in 1-second (FEV1), Best measure 1.4 4.5 6.1 -2.5 1.7
Pulse wave Arterial Stiffness index 0.8 1.0 1.3 -1.1 0.8
Impedance of arm (left) 6.1 28.0 33.5 4.8 -5.8
Arm fat mass (right) 0.3 1.3 1.4 1.2 -1.1
Trunk predicted mass 5.0 28.7 31.9 -5.0 5.7
Standing height 1.1 10.6 11.6 -3.4 3.1
Length of working week for main job 1.9 2.1 2.4 -1.3 1.5
Exposure to tobacco smoke at home 1.6 1.8 1.9 1.3 -1.4
Breastfed as a baby 0.2 0.2 0.2 -0.5 0.5
Tense / ‘highly strung’ 2.3 3.8 4.1 2.0 -1.9
Seen doctor (GP) for nerves, anxiety, tension or depression 1.0 1.5 1.8 1.1 -1.3
Hair/balding pattern: Pattern 4 3.1 7.4 7.5 -2.7 2.7
Birth weight of first child 13.0 23.6 25.6 -5.1 4.7
Peak expiratory flow (PEF) 3.8 8.8 10.0 -3.2 2.8
Pulse wave reflection index 2.1 2.5 3.1 1.4 -1.8
Ever highly irritable/argumentative for 2 days 0.3 0.4 0.4 0.7 -0.6
Loud music exposure frequency 0.1 0.1 0.2 -0.5 0.3
Qualifications: O levels/GCSEs or equivalent 0.1 0.1 0.2 -0.4 0.1
Mouth/teeth dental problems: Bleeding gums 0.6 0.8 0.8 -0.9 0.8
Blood clot in the leg (DVT) 3.2 4.1 4.7 -2.2 1.9
Medication: Paracetamol 2.4 4.0 4.8 1.8 -2.2
Headache pain in last month 8.3 14.3 14.6 3.7 -3.8
Medication for cholesterol, blood pressure or diabetes 0.5 0.9 1.6 -0.5 1.3
Glaucoma (self-reported) 0.0 0.0 0.0 0.1 0.2
Gout (self-reported) 0.3 0.4 0.5 0.5 -0.7
Hypothyroidism/myxoedema (self-reported) 1.7 3.4 3.6 -1.8 1.9
Medication: Amlodipine 7.5 10.5 13.0 2.8 -3.6
Medication: Ventolin 100micrograms inhaler 0.1 0.2 0.2 0.5 -0.3
Birth weight 6.5 14.1 14.6 -3.7 3.8
Chronic bronchitis/emphysema (mother) 0.1 0.1 0.2 -0.1 0.5
High blood pressure (siblings) 0.2 0.3 0.5 0.2 -0.7
Forced vital capacity (FVC), Best measure 0.2 0.9 1.3 -1.2 0.7
Body fat percentage 5.8 23.1 25.2 4.6 -5.0
Leg fat percentage (right) 7.6 27.5 29.5 5.0 -5.4
Arm fat-free mass (right) 3.5 18.1 20.6 -4.0 4.5
Exposure to tobacco smoke outside home 0.1 0.1 0.1 0.3 -0.4
Comparative body size at age 10 0.9 2.5 3.0 -1.4 1.7
Number of full brothers 0.4 0.5 0.6 0.6 -0.7
Worry too long after embarrassment 1.0 1.7 1.7 1.3 -1.3
Seen a psychiatrist for nerves, anxiety, tension or depression 2.7 3.6 3.8 1.8 -1.9
Wheeze or whistling in the chest in last year 0.1 0.2 0.5 -0.1 0.7
Number of children fathered 0.0 0.0 0.0 0.2 -0.0
Reason for reducing amount of alcohol drunk: Health precaution 0.0 0.0 0.0 -0.1 0.1
Age at first live birth 0.9 1.7 1.7 1.3 -1.3
Pulse wave peak to peak time 0.4 0.5 0.6 0.8 -0.5
Health satisfaction 0.3 0.4 0.5 0.7 -0.6
Shortness of breath walking on level ground 0.1 0.1 0.2 0.5 -0.1
Qualifications: College or University degree 1.7 5.4 5.9 2.2 -2.4
Eye problems/disorders: None of the above 1.7 2.0 2.2 -1.3 1.5
Mouth/teeth dental problems: Loose teeth 0.4 0.5 0.6 0.6 -0.8
Emphysema/chronic bronchitis 0.9 1.0 1.4 1.2 -0.8
Medication for pain relief, constipation, heartburn 2.4 4.1 5.0 -1.8 2.2
Neck or shoulder pain in last month 0.1 0.1 0.1 -0.3 0.3
Medication: Blood pressure 2.2 3.9 5.7 1.5 -2.4
Angina (self-reported) 0.0 0.0 0.0 -0.2 0.0
Migraine (self-reported) 3.9 4.8 5.8 2.0 -2.4
Medication: Ibuprofen 0.1 0.1 0.1 -0.4 0.4
Medication: Allopurinol 0.1 0.2 0.3 -0.5 0.2
Medication: Omeprazole 0.5 0.6 0.6 -0.7 0.8
Medication: Seretide 50 evohaler 0.2 0.2 0.3 -0.3 0.6
Mean time to correctly identify matches 0.0 0.0 0.0 -0.1 -0.1
Heart disease (mother) 4.0 4.8 5.4 2.1 -2.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.2 0.3 0.5 -0.5
Whole body fat mass 1.5 6.1 6.7 2.4 -2.6
Leg fat mass (right) 1.9 7.5 7.9 2.7 -2.8
Arm predicted mass (right) 3.5 17.7 20.0 -3.9 4.5
Pulse rate, automated reading 2.0 6.3 6.7 -2.4 2.6
Alcohol intake frequency. 0.1 0.2 0.3 0.6 -0.3
Comparative height size at age 10 0.7 3.8 4.2 -2.0 1.9
Number of full sisters 0.3 0.4 0.6 0.8 -0.5
Suffer from ‘nerves’ 0.6 1.0 1.3 1.1 -0.8
Overall health rating 1.3 2.9 3.4 1.8 -1.5
Chest pain or discomfort 0.8 1.2 1.8 1.4 -0.7
Had major operations 0.8 0.9 1.3 -0.7 1.2
Age at last live birth 0.3 0.5 0.6 0.8 -0.6
Family relationship satisfaction 1.6 2.0 2.1 1.4 -1.4
Leg pain on walking 1.7 2.1 2.3 -1.5 1.4
Qualifications: NVQ or HND or HNC or equivalent 0.0 0.0 0.1 0.3 -0.0
Commuting to job workplace: Car/motor vehicle 0.5 0.6 0.7 -0.7 0.8
Illness, injury, bereavement, stress in last 2 years 0.5 0.6 0.9 0.9 -0.6
Medication: Aspirin 0.0 0.1 0.1 0.2 -0.3
Supplements: Vitamin C 1.7 2.0 2.7 -1.2 1.6
Knee pain experienced in last month 0.7 1.0 1.6 -1.3 0.7
Hypertension (Self-reported) 6.2 17.1 21.4 3.6 -4.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 3.9 4.5 4.6 2.1 -2.1
Illnesses of father: Heart disease 2.6 3.7 4.2 -2.0 1.8
Illnesses of siblings: Diabetes 0.8 1.0 1.2 1.1 -0.9
Smoking status: Previous 0.0 0.0 0.0 -0.1 0.1
Forced expiratory volume in 1-second (FEV1), predicted 0.9 1.8 1.9 -1.4 1.3
Whole body fat-free mass 5.1 29.1 32.1 -5.1 5.7
Leg fat-free mass (right) 4.5 24.1 26.5 -4.7 5.2
Arm fat percentage (left) 2.7 10.9 11.4 3.2 -3.4
Average weekly red wine intake 0.1 0.2 0.3 -0.5 0.3
Handedness (chirality/laterality): Left-handed 0.3 0.4 0.5 0.5 -0.7
Mood swings 1.3 2.4 2.6 1.6 -1.5
Loneliness, isolation 1.4 1.9 2.0 1.4 -1.4
Long-standing illness, disability or infirmity 2.5 3.8 3.9 1.9 -2.0
Ever had bowel cancer screening 0.0 0.1 0.1 -0.2 0.3
Diabetes diagnosed by doctor 0.8 1.2 1.4 1.0 -1.2
Ever had stillbirth, spontaneous miscarriage or termination 0.0 0.0 0.0 -0.1 -0.1
Friendships satisfaction 3.4 4.2 4.6 2.0 -2.1
Qualifications: nursing, teaching 0.3 0.5 0.6 -0.7 0.6
Commuting to job workplace: Walk 2.0 2.2 2.7 1.3 -1.6
Eye problems/disorders: Cataract 1.4 1.6 1.8 1.2 -1.3
Mouth/teeth dental problems: Mouth ulcers 0.2 0.4 0.7 0.8 -0.3
Medication for cholesterol 1.8 2.7 2.8 -1.6 1.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.8 1.0 1.1 1.1 -0.9
Back pain experienced in last month 2.4 3.6 3.6 1.9 -1.9
Mineral and other dietary supplements 0.0 0.0 0.0 -0.2 -0.1
Breast cancer (self-reported) 0.2 0.2 0.3 -0.5 0.5
Asthma (self-reported) 0.1 0.2 0.5 0.1 0.7
Osteoporosis (self-reported) 7.9 9.8 10.9 3.3 -2.9
Osteoarthritis (self-reported) 0.1 0.1 0.1 0.1 -0.4
Medication: Aspirin 0.0 0.0 0.0 0.1 -0.1
Medication: Gliclazide 0.8 0.9 1.0 1.0 -0.9
Illnesses of father: None of the above (group 1) 0.3 0.4 0.7 0.8 -0.2
Smoking status: Current 0.0 0.0 0.0 -0.2 -0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.4 0.8 -0.9 0.3
Whole body water mass 4.9 28.1 31.4 -5.0 5.6
Leg predicted mass (right) 4.6 24.6 27.0 -4.7 5.2
Arm fat mass (left) 0.4 1.8 1.9 1.4 -1.3
Number of self-reported non-cancer illnesses 6.9 11.9 12.5 3.4 -3.5
Average weekly champagne plus white wine intake 0.5 0.7 1.1 -1.0 0.7
Miserableness 2.2 3.7 3.9 2.0 -1.9
Guilty feelings 1.0 1.5 1.7 1.2 -1.3
Wears glasses or contact lenses 0.2 0.3 0.3 0.5 -0.5
Ever taken oral contraceptive pill 0.4 0.5 0.6 -0.8 0.6
Hearing aid user 0.7 0.7 0.8 -0.8 0.9
Mother’s age at death 1.0 1.2 1.3 -1.1 1.1
Financial situation satisfaction 2.3 2.8 3.5 1.5 -1.9
Tinnitus: Yes, now most or all of the time 0.1 0.1 0.1 -0.3 0.4
Commuting to job workplace: Public transport 0.2 0.3 0.4 0.6 -0.3
Eye problems/disorders: Glaucoma 0.7 0.9 1.1 -0.8 1.1
Medication: Blood pressure 3.6 6.8 7.2 2.5 -2.7
Pain type(s) experienced in last month: Hip pain 0.6 0.7 0.9 -0.8 0.9
Supplements: Fish oil (including cod liver oil) 0.1 0.1 0.1 -0.4 0.4
High cholesterol (Self-reported) 0.6 1.1 1.2 1.0 -1.1
Medication: Bendroflumethiazide 1.1 1.6 2.1 1.1 -1.5
Medication: Paracetamol 1.2 1.9 2.5 1.2 -1.6
Medication: Lisinopril 0.1 0.1 0.2 -0.4 0.3
Medication: Atorvastatin 0.1 0.1 0.1 -0.4 0.2
Illnesses of father: High blood pressure 0.0 0.0 0.1 -0.0 -0.2
Alcohol drinker status: Never 1.8 2.2 2.6 1.6 -1.4
Ever smoked 0.5 0.9 1.3 -1.2 0.7
Basal metabolic rate 3.1 17.4 19.4 -3.9 4.4
Leg fat percentage (left) 6.9 24.9 26.6 4.8 -5.2
Arm fat-free mass (left) 2.7 13.8 15.9 -3.4 4.0
Number of operations (self-reported) 0.5 0.8 1.1 -0.7 1.1
Average weekly beer plus cider intake 0.1 0.1 0.2 0.4 -0.2
Irritability 1.6 2.7 2.7 1.6 -1.6
Risk taking 0.3 0.5 0.6 0.8 -0.6
Ever had prostate specific antigen (PSA) test 0.9 1.1 1.3 -1.1 0.9
Fractured/broken bones in last 5 years 0.0 0.0 0.0 -0.0 0.1
Age started oral contraceptive pill 1.5 1.9 2.2 -1.5 1.3
Diastolic blood pressure, automated reading 3.9 12.0 15.4 2.9 -3.9
Ever depressed for a whole week 1.4 1.7 1.9 1.4 -1.2
Unable to work because of sickness or disability 0.0 0.0 0.0 -0.0 -0.2
Commuting to job workplace: Cycle 0.8 1.0 1.0 1.0 -1.0
Myopia 0.4 0.6 0.7 -0.8 0.8
Vascular/heart problems diagnosed by doctor 4.3 11.6 15.0 -2.9 3.9
Cholesterol lowering medication 0.0 0.0 0.0 0.2 0.1
Medication: Omeprazole (e.g. Zanprol) 0.2 0.2 0.3 -0.4 0.5
Pain experienced in last month 0.6 1.0 1.3 -0.8 1.1
Supplements: Calcium 7.2 8.0 8.4 2.9 -2.7
Basal cell carcinoma (self-reported) 2.8 3.3 3.8 1.7 -2.0
Heart attack/myocardial infarction (self-reported) 0.7 0.9 1.0 -0.9 1.0
Deep venous thrombosis (DVT) (self-reported) 2.4 3.1 3.6 -1.9 1.6
Heart disease (siblings) 1.0 1.2 1.3 -1.1 1.0
Alcohol drinker status: Previous 0.6 0.6 0.8 -0.7 0.9
Pack years of smoking 4.9 7.2 7.6 2.6 -2.8
Impedance of whole body 8.7 44.2 52.4 6.0 -7.2
Leg fat mass (left) 1.5 5.7 6.0 2.3 -2.5
Arm predicted mass (left) 3.3 16.8 19.2 -3.8 4.4