Best TWAS P=1.87e-11 · Best GWAS P=1.58e-10 conditioned to 0.00373
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | INPP5F | 0.13 | 0.01 | lasso | 5 | 0.01 | 4.0e-02 | -4.3 | 5.5 | 4.2e-08 | 0.38 | 0.06 | 0.61 | FALSE |
| 2 | GTEx | Esophagus Gastroesophageal Junction | FAM45A | 0.24 | 0.13 | enet | 51 | 0.09 | 2.7e-04 | 6.4 | 6.7 | 1.9e-11 | 0.61 | 0.01 | 0.94 | TRUE |
| 3 | ROSMAP | Brain Pre-frontal Cortex | CACUL1 | 0.12 | 0.08 | lasso | 4 | 0.06 | 1.2e-08 | -5.4 | 5.3 | 1.4e-07 | 0.01 | 0.00 | 1.00 | FALSE |
| 4 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | C10orf46 | 0.23 | 0.04 | lasso | 4 | 0.04 | 8.6e-03 | -5.4 | 5.5 | 3.5e-08 | 0.00 | 0.00 | 0.82 | TRUE |