TWAS hub - FAM45A

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.1044	0.0469	4.0e-03	0.074	NA	0.047	NA	0.058	2.0e-06	NA	1.3e-04	NA	2.3e-05
2	GTEx	Breast Mammary Tissue	0.1300	0.0560	7.5e-03	0.014	NA	0.014	NA	0.027	6.2e-02	NA	5.9e-02	NA	1.6e-02
3	GTEx	Breast Mammary Tissue (Male)	0.1121	0.0865	1.3e-01	-0.005	NA	-0.008	NA	0.002	4.2e-01	NA	5.6e-01	NA	2.8e-01
4	GTEx	Breast Mammary Tissue (Female)	0.1155	0.0808	1.1e-01	0.025	NA	-0.009	NA	-0.002	6.1e-02	NA	8.3e-01	NA	3.7e-01
5	GTEx	Esophagus Gastroesophageal Junction	0.2350	0.0810	2.3e-03	0.128	NA	0.094	NA	0.072	2.3e-05	NA	2.7e-04	NA	1.4e-03
6	GTEx	Esophagus Muscularis	0.0960	0.0400	7.1e-03	0.097	NA	0.097	NA	0.088	1.7e-06	NA	1.8e-06	NA	5.2e-06
7	ROSMAP	Brain Pre-frontal Cortex	0.2168	0.0339	0.0e+00	0.263	0.219	0.249	0.247	0.261	1.1e-33	1.1e-27	9.4e-32	1.9e-31	2.2e-33
8	YFS	Blood	0.0573	0.0173	3.6e-07	0.018	0.023	0.033	0.032	0.028	1.3e-06	3.1e-08	4.0e-11	6.7e-11	1.6e-09
9	TCGA	Kidney Renal Clear Cell Carcinoma	0.0332	0.0258	7.9e-03	0.018	0.011	0.001	NA	0.015	3.8e-03	1.8e-02	2.3e-01	NA	7.2e-03
10	TCGA	Thyroid Carcinoma	0.0360	0.0200	9.2e-04	0.001	0.017	0.014	NA	0.013	2.6e-01	7.5e-03	1.5e-02	NA	1.8e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Eye problems/disorders: Glaucoma	5.4	6.4	13.8	-2.2	-3.7	-1.7	-3.3	-2.8	-2.5	3.3	-0.5	2.3	1.2
Health satisfaction	5.2	6.8	11.9	-3.3	-3.2	-1.3	-2.8	-1.7	-3.4	2.7	-1.9	2.4	2.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	5.0	6.0	13.5	-2.1	-3.7	-2.9	-2.2	-2.1	-2.0	2.6	0.0	2.6	2.5
Glaucoma (self-reported)	4.6	5.4	11.0	-2.2	-3.3	-1.5	-2.8	-2.5	-2.3	2.8	-0.8	2.3	1.6
Age started oral contraceptive pill	4.6	5.8	10.4	3.2	2.9	-0.1	2.8	1.4	3.0	-2.9	-0.1	-2.6	-2.3
Supplements: Fish oil (including cod liver oil)	4.4	5.7	8.1	2.8	2.4	0.5	2.8	0.8	2.8	-2.8	2.2	-2.7	-2.6
Current tobacco smoking	4.3	7.0	10.3	-2.6	-2.9	-0.1	-2.7	-2.8	-3.1	2.7	-2.6	2.5	3.2
Smoking status: Current	4.2	6.6	10.7	-2.4	-2.7	-0.0	-2.7	-2.4	-3.0	2.7	-2.8	2.2	3.3
Mineral and other dietary supplements	4.1	5.6	9.4	-2.7	-2.6	-0.9	-2.8	-1.4	-2.6	2.8	-1.7	2.0	3.1
Mother’s age at death	3.6	4.6	8.4	2.2	1.8	-1.9	2.3	1.0	2.9	-2.7	1.7	-1.6	-2.4
Risk taking	3.6	5.3	9.0	-2.8	-2.8	-0.7	-2.6	-1.2	-3.0	2.5	-2.3	1.4	2.5
Breast Cancer	3.4	8.1	14.8	3.2	2.8	-1.4	3.4	-0.0	3.4	-3.6	2.8	-3.8	-1.5
Financial situation satisfaction	3.4	4.3	8.0	-2.5	-1.8	-0.4	-1.7	-0.7	-2.6	2.0	-2.8	1.8	2.8
Rheumatoid Arthritis	3.3	4.6	7.8	2.7	2.0	-1.1	2.4	0.6	2.8	-2.5	1.7	-2.8	-1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.3	7.0	14.8	3.0	2.7	-0.4	3.6	1.1	3.6	-3.8	1.9	-2.3	-1.9
Pulse wave peak to peak time	3.2	3.8	6.2	2.1	2.5	1.9	1.9	2.0	1.9	-1.8	0.9	-1.9	-2.1
Pulse wave Arterial Stiffness index	3.0	3.5	5.7	-2.1	-2.4	-1.6	-2.0	-1.5	-2.0	1.8	-1.1	2.0	1.9
Nervous feelings	2.9	5.3	8.0	2.5	2.7	1.1	2.8	-0.3	2.4	-2.7	1.8	-2.8	-2.5
Chest pain or discomfort	2.9	4.1	7.3	-2.3	-2.5	-0.9	-2.4	-2.0	-2.7	2.4	-1.0	1.2	2.0
Smoking Status	2.8	6.7	11.9	-2.6	-2.9	-1.3	-2.5	-3.4	-3.0	2.5	-1.4	1.8	3.5
Tinnitus: Yes, but not now, but have in the past	2.8	3.0	9.1	-2.0	-1.9	-1.4	-1.3	-1.0	-2.0	1.6	-0.7	1.4	3.0
Type 2 Diabetes (T2D) (2012)	2.7	3.1	6.1	-1.5	-2.5	-1.8	-2.0	-1.2	-1.4	2.3	-0.9	2.1	0.9
Ever smoked	2.7	4.8	8.4	-2.3	-1.8	-0.2	-2.1	-1.8	-2.9	2.1	-2.4	2.2	2.9
Heart attack	2.6	3.3	6.6	-1.6	-2.1	-0.3	-2.2	-1.0	-1.7	2.6	-1.8	2.1	1.8
Back pain experienced in last month	2.6	3.8	8.2	-2.9	-2.1	-0.2	-2.2	-1.0	-2.8	2.4	-1.2	0.8	1.9
Diverticular disease/diverticulitis (self-reported)	2.5	3.0	7.1	2.7	1.8	0.4	1.0	1.4	2.5	-1.5	1.4	-2.1	-0.9
Handedness (chirality/laterality): Left-handed	2.5	3.0	6.8	-1.9	-1.4	0.6	-2.0	-1.5	-2.0	2.0	-0.3	2.6	1.8
Number of children fathered	2.4	2.7	6.6	1.3	1.9	-1.3	2.0	1.1	1.4	-1.7	-0.2	-2.6	-1.9
Tinnitus: Yes, now most or all of the time	2.4	2.8	5.2	-1.9	-1.9	-1.0	-1.4	-1.9	-1.9	1.4	-0.7	1.6	2.3
Heart attack/myocardial infarction (self-reported)	2.4	3.0	5.9	-1.5	-2.0	-0.3	-2.1	-0.8	-1.6	2.4	-1.8	2.0	1.8
Major Depression (MDD)	2.3	2.8	6.1	-1.6	-1.9	-0.7	-1.7	-1.5	-1.6	1.5	-0.0	2.2	2.5
Medication: Cholesterol lowering	2.3	3.5	8.4	-2.3	-1.9	-0.7	-2.2	-0.5	-2.0	1.9	-1.5	1.6	2.9
Number of full sisters	2.3	2.8	6.4	-2.1	-1.4	0.9	-1.6	-1.0	-2.5	1.5	-2.3	1.9	0.4
Leg pain on walking	2.3	2.8	6.8	-2.6	-1.2	0.4	-1.6	-1.2	-2.4	1.6	-1.4	1.6	1.7
Supplements: Vitamin C	2.3	2.7	6.1	1.9	1.8	-0.1	1.8	-0.2	1.9	-2.1	2.5	-1.5	-0.3
Vitamin and mineral supplements	2.2	3.0	9.5	-2.3	-1.4	-0.9	-1.3	-0.7	-2.4	1.6	-3.1	0.7	1.3
Ever had stillbirth, spontaneous miscarriage or termination	2.2	2.4	4.5	-1.6	-1.4	-0.7	-1.7	-0.8	-2.0	1.4	-1.3	2.1	1.8
Alcohol drinker status: Previous	2.2	2.5	4.3	-1.8	-1.9	-1.1	-1.7	-0.5	-1.8	2.1	-1.6	1.9	0.1
Hand grip strength (right)	2.1	5.6	26.7	0.8	2.5	3.8	1.6	5.2	0.7	-1.3	0.5	-0.7	-1.7
Birth weight of first child	2.1	3.8	6.3	2.2	2.2	0.8	2.1	2.5	2.0	-1.8	-0.8	-2.0	-2.3
HbA1C	2.0	2.2	5.4	-1.0	-1.7	-1.1	-2.0	-2.3	-1.1	1.9	1.1	0.9	0.9
Pack years adult smoking proportion	2.0	3.1	7.6	-2.8	-1.8	-0.0	-1.6	-1.1	-2.5	1.9	-0.5	2.2	0.8
Townsend deprivation index at recruitment	2.0	2.9	6.5	-1.8	-1.4	0.3	-2.0	-0.6	-1.7	1.8	-0.8	2.5	2.4
Serious illness, injury or assault of a close relative in last 2 years	2.0	2.3	8.3	-1.9	-1.6	-1.0	-1.3	-0.8	-1.7	1.2	-0.9	0.3	2.9
Unable to work because of sickness or disability	2.0	2.6	6.6	-1.8	-1.6	1.0	-1.7	-0.7	-1.4	1.5	0.4	2.6	2.1
Body Mass Index (BMI) (2010)	1.9	2.6	6.0	1.7	2.4	1.7	1.7	1.1	1.5	-1.8	1.2	-1.3	-1.1
Medication: Atenolol	1.9	2.3	6.1	-1.0	-2.1	-0.3	-2.5	-0.9	-1.1	2.4	-0.2	1.8	0.7
Ever highly irritable/argumentative for 2 days	1.9	2.3	4.3	-1.9	-1.1	0.3	-2.0	-1.5	-2.1	1.6	-0.4	0.8	1.9
Medication: Aspirin	1.9	2.5	4.8	-1.5	-2.2	-2.0	-1.7	-0.9	-1.6	1.8	-0.0	1.3	1.6
Medication: Aspirin	1.9	2.5	4.4	-1.6	-2.1	-1.3	-1.9	-0.6	-1.7	1.9	-0.1	1.4	1.9
Medication: Blood pressure	1.9	3.7	8.6	-2.0	-2.9	-2.4	-2.0	-1.5	-2.0	2.1	0.4	1.0	1.5
Hearing difficulty/problems with background noise	1.8	2.8	8.3	-1.7	-2.5	-2.9	-1.4	-0.5	-1.4	1.6	1.4	1.0	1.1
Loud music exposure frequency	1.8	2.0	3.4	-1.1	-1.7	-1.3	-1.8	-1.3	-1.2	1.6	0.0	1.1	1.8
Mouth/teeth dental problems: Bleeding gums	1.8	2.3	5.6	1.0	2.4	1.5	2.1	1.5	1.0	-1.9	0.3	-1.6	0.0
Illness, injury, bereavement, stress in last 2 years	1.8	2.2	10.9	0.6	1.6	3.3	0.3	2.7	0.4	-0.2	-0.5	0.2	-0.3
Friendships satisfaction	1.8	2.3	6.5	-1.0	-1.1	0.8	-1.4	-1.2	-1.3	1.6	-1.4	2.5	1.9
Average weekly beer plus cider intake	1.8	2.6	5.1	-1.6	-1.6	-0.1	-1.7	-2.3	-1.6	1.5	-0.5	1.8	2.0
Hand grip strength (left)	1.7	4.5	16.2	1.2	2.6	2.9	2.0	4.0	1.0	-1.5	0.4	-1.0	-1.8
Serious illness, injury or assault to yourself	1.7	2.1	6.8	-0.6	-1.9	-2.5	-1.1	-2.6	-0.7	1.1	-0.2	0.8	0.4
Stomach or abdominal pain in last month	1.7	2.2	5.1	-1.6	-1.9	-1.7	-1.4	-2.3	-1.4	1.1	0.3	1.1	1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	1.7	2.6	8.9	1.2	-0.3	-3.0	0.9	-1.7	1.5	-1.1	1.9	-1.7	-1.3
Medication for cholesterol, blood pressure or diabetes	1.7	2.8	7.3	2.1	1.5	0.4	1.9	0.6	1.8	-1.8	0.4	-1.8	-2.7
Birth weight	1.7	3.6	7.5	1.3	2.7	1.3	1.6	1.7	1.6	-2.1	-0.8	-2.3	-2.6
Overall health rating	1.7	3.6	7.9	-1.9	-2.8	-2.0	-2.2	-2.2	-1.7	1.9	0.5	1.1	1.8
Had major operations	1.7	2.0	3.8	-1.2	-1.2	0.7	-1.9	0.6	-1.4	2.0	-1.1	1.7	1.8
Ever depressed for a whole week	1.7	2.1	4.3	-1.4	-2.0	-2.1	-1.6	-1.4	-1.4	1.2	-0.6	0.9	1.2
Other serious medical condition/disability diagnosed by doctor	1.6	2.0	4.2	-1.0	-2.1	0.3	-1.9	-0.8	-1.3	1.8	0.2	1.4	2.0
Pain all over the body in last month	1.6	1.7	4.6	-1.4	-2.1	-0.4	-1.7	-1.2	-1.4	1.8	-0.6	0.9	0.3
Hair/balding pattern: Pattern 3	1.6	2.4	4.1	1.7	1.4	-1.9	1.7	0.7	1.9	-2.0	0.8	-1.8	-0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.6	1.9	10.2	1.0	0.8	2.2	0.5	3.2	1.1	-0.7	0.8	-0.2	-0.2
Miserableness	1.6	2.8	9.1	-0.9	-2.1	-1.8	-1.6	-3.0	-1.1	1.4	1.1	0.9	1.7
Alcohol drinker status: Never	1.6	1.9	7.4	-0.4	-1.9	-1.8	-1.2	-1.2	0.4	0.9	2.7	0.8	0.8
Fractured/broken bones in last 5 years	1.6	2.1	4.7	-1.0	-1.8	-1.7	-1.3	-1.8	-0.9	1.1	-0.5	2.2	1.4
Coronary Artery Disease (CAD)	1.5	1.8	3.4	-1.1	-1.7	-1.1	-1.4	-0.9	-1.0	1.5	-1.3	1.8	1.3
Frequency of depressed mood in last 2 weeks	1.5	2.1	4.7	-1.1	-1.7	0.2	-1.7	-2.2	-1.5	1.8	-1.5	0.7	1.3
Relative age voice broke	1.5	2.3	3.3	1.5	1.5	0.5	1.7	1.8	1.8	-1.7	1.4	-1.5	-1.4
Forced expiratory volume in 1-second (FEV1)	1.5	5.2	10.3	1.9	2.4	1.1	3.0	3.2	2.0	-2.8	1.3	-1.8	-2.3
Lung cancer (father)	1.5	1.8	3.2	1.5	1.8	0.4	1.6	0.9	1.7	-1.5	1.2	-1.4	-0.1
Pack years of smoking	1.5	2.2	5.8	-2.4	-1.5	-0.1	-1.3	-0.6	-2.1	1.6	-0.9	1.9	0.4
Alcohol usually taken with meals	1.4	2.3	4.5	1.2	2.1	0.7	1.8	1.2	1.3	-1.6	0.7	-2.1	-1.7
Medication: Simvastatin	1.4	2.0	5.0	-1.3	-2.2	-1.5	-1.8	0.1	-0.9	1.4	0.3	1.7	1.5
Number of live births	1.4	2.0	4.3	-1.9	-1.4	0.7	-1.3	-0.8	-2.1	1.7	-2.0	1.0	0.3
Medication: Blood pressure	1.4	2.5	6.0	-1.8	-1.2	-0.1	-1.7	-0.8	-1.6	1.8	-0.5	2.5	2.2
Depression (Nagel 2018)	1.3	2.0	3.3	-1.2	-1.4	0.2	-1.7	-1.3	-1.7	1.8	-1.8	0.4	1.5
HDL Cholesterol	1.3	2.2	4.6	-1.3	-1.9	0.6	-1.8	-1.9	-1.5	2.2	0.5	1.3	1.0
Lupus	1.3	2.0	6.2	-1.2	-2.0	-2.0	-1.0	-0.0	-1.4	1.1	0.1	0.2	2.5
Medication: Co-codamol	1.3	1.5	3.2	-1.4	-1.2	-0.2	-1.6	-1.1	-1.3	1.8	-0.2	1.6	-0.3
Frequency of tiredness / lethargy in last 2 weeks	1.3	2.2	3.8	-1.7	-1.8	-0.2	-1.6	-1.5	-1.8	1.9	1.1	0.4	1.4
Irritability	1.3	2.2	9.5	-0.1	-0.9	-2.8	-0.3	-3.1	-0.1	0.1	1.7	-0.7	-0.5
Bipolar Disorder or Schizophrenia	1.2	2.8	4.9	-1.8	-2.2	-1.5	-2.1	-1.6	-2.1	2.1	-0.9	1.1	-0.2
Neuroticism (2016)	1.2	1.7	6.9	-1.1	-1.1	-1.0	-0.8	-2.6	-0.6	0.3	1.6	0.5	1.5
Schizophrenia (2014)	1.2	2.7	5.4	-1.6	-2.3	-1.8	-2.0	-1.6	-2.1	2.0	-0.3	1.0	0.2
Cardiovascular Disease	1.2	4.1	7.4	-2.3	-2.4	-0.5	-2.6	-0.7	-2.1	2.3	0.4	2.2	2.7
Fed-up feelings	1.2	2.1	6.8	-0.4	-1.9	-2.6	-1.2	-2.2	-0.6	0.9	1.0	1.1	1.2
Supplements: Glucosamine	1.2	1.5	3.1	1.5	1.8	1.1	1.3	0.7	0.9	-1.3	-0.6	-1.2	-1.4
Sitting height	1.2	8.2	45.2	1.4	3.0	4.0	1.9	6.7	1.1	-1.4	-0.6	-0.7	-1.6
Forced expiratory volume in 1-second (FEV1), Best measure	1.2	3.8	8.2	1.3	2.1	1.0	2.7	2.9	1.6	-2.5	1.7	-1.1	-1.6
Pulse wave reflection index	1.2	1.5	4.3	-1.3	-1.2	-0.2	-0.9	-2.1	-0.9	0.9	0.6	0.8	2.1
Shortness of breath walking on level ground	1.2	1.5	2.9	-1.6	-1.3	-0.4	-1.7	-1.1	-1.7	1.3	-0.3	1.1	0.5
Hypertension (Self-reported)	1.2	3.4	5.6	-2.2	-2.1	-0.7	-2.0	-0.2	-2.2	2.3	-0.8	1.9	2.4
Medication for cholesterol	1.2	1.8	6.7	0.4	2.1	2.6	1.3	1.2	0.2	-1.2	-1.2	-0.4	0.5
Average weekly champagne plus white wine intake	1.2	1.7	4.5	1.7	0.9	-1.2	1.1	0.7	1.8	-0.9	0.5	-2.1	-1.0
Cholesterol lowering medication	1.2	1.8	6.2	-0.9	-2.3	-2.5	-1.1	-1.1	-0.7	1.0	0.9	1.2	0.4
Depressed Affect (Nagel 2018)	1.1	2.3	7.9	-0.8	-1.6	-2.5	-0.8	-2.8	-0.8	0.6	0.5	0.4	1.8
Neuroticism (Nagel 2018)	1.1	2.5	15.5	-0.5	-1.2	-2.3	-0.2	-3.9	-0.4	0.1	1.4	-0.5	0.4
Alzheimer’s Disease (including proxy)	1.1	1.6	3.0	-1.6	-1.1	1.5	-1.7	-0.0	-1.7	1.5	-1.2	1.0	-0.1
Crohns Disease (2012)	1.1	1.7	5.1	-1.3	-1.5	-0.8	-1.2	-1.2	-1.2	1.5	-0.4	1.0	2.3
Blood Platelet Count	1.1	12.7	24.1	3.6	4.8	3.6	4.3	1.8	3.4	-4.1	0.0	-4.9	-1.6
Number of treatments/medications taken	1.1	1.9	8.1	0.9	0.2	-2.2	0.9	0.4	1.2	-1.0	2.9	-1.3	-0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.5	2.7	-1.1	-1.0	0.4	-1.5	-1.4	-1.6	1.6	-1.5	0.4	0.8
Forced vital capacity (FVC)	1.1	4.4	8.8	1.8	2.3	1.9	2.8	3.0	1.6	-2.5	0.8	-1.2	-2.2
Financial difficulties in last 2 years	1.1	1.5	2.7	-1.6	-1.1	-1.4	-0.6	-1.4	-1.6	0.9	-1.5	-0.0	1.0
Forced vital capacity (FVC), Best measure	1.1	4.1	9.3	1.3	2.3	2.6	2.4	3.1	1.5	-2.3	1.3	-0.3	-1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.4	3.9	-0.6	-1.9	-0.6	-1.6	-1.3	-0.9	2.0	-0.2	-0.1	0.9
Medication: Omeprazole	1.1	1.4	3.8	-1.9	-1.4	-1.0	-1.0	-0.2	-1.8	1.2	-0.3	0.1	1.1
Long-standing illness, disability or infirmity	1.1	1.7	6.7	-1.0	-1.8	-1.2	-1.0	-1.1	-0.9	0.9	0.7	0.8	2.6
High cholesterol (Self-reported)	1.1	2.0	4.0	-2.0	-1.5	-0.2	-1.8	-0.2	-1.8	1.3	-0.0	1.6	1.7
Medication: Lisinopril	1.1	1.4	3.2	-0.9	-1.5	-1.5	-0.8	-1.8	-0.9	0.7	-0.5	1.6	0.9
Schizophrenia (2018)	1.0	2.1	4.3	-1.5	-1.9	-0.7	-1.7	-1.6	-2.1	1.9	-0.9	0.8	0.4
Age at First Birth	1.0	1.4	2.9	1.6	1.5	0.8	1.7	0.3	1.3	-1.6	-0.3	-0.9	-0.6
Bipolar Disorder (2011)	1.0	0.9	3.4	-0.6	-1.5	-1.8	-1.0	-0.3	-0.4	1.0	1.0	0.0	0.0
Fasting Glucose	1.0	1.2	3.3	-0.2	-1.5	-0.3	-1.6	-0.5	-0.1	1.8	-1.1	1.2	0.9
Relative age of first facial hair	1.0	2.0	4.9	1.1	1.2	-0.1	1.8	0.3	1.4	-1.5	1.9	-2.2	-1.0
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	2.1	-1.4	-1.0	0.4	-1.3	0.2	-1.2	1.1	0.5	1.5	0.7
High blood pressure	1.0	2.9	4.4	-2.0	-1.9	-1.1	-1.8	-0.1	-2.0	2.1	-0.3	1.9	2.0
Medication: Ramipril	1.0	1.2	2.2	-1.1	-1.1	-0.0	-1.2	0.2	-1.4	1.5	-1.4	0.4	1.4
Neuroticism score	1.0	2.0	8.9	-0.4	-1.1	-2.3	-0.4	-3.0	-0.3	0.2	2.0	-0.6	0.1
Trunk fat-free mass	1.0	6.0	36.0	0.6	2.7	3.2	1.7	6.0	0.3	-1.1	-0.3	-1.4	-0.3
Trunk predicted mass	1.0	5.9	36.2	0.6	2.7	3.1	1.6	6.0	0.3	-1.1	-0.2	-1.3	-0.3
Hair/balding pattern: Pattern 4	1.0	2.5	5.1	-1.6	-1.6	1.0	-1.4	-1.3	-1.9	1.6	-1.1	2.3	1.3
Chronic bronchitis/emphysema (mother)	1.0	1.2	3.8	1.3	1.2	1.9	0.8	0.7	1.1	-0.7	1.3	-0.9	-0.3
Number of full brothers	1.0	1.2	2.5	1.0	1.1	-0.6	1.6	1.6	0.7	-1.3	-1.0	-1.1	-0.5
Neck or shoulder pain in last month	1.0	1.5	3.2	-1.7	-1.4	0.2	-1.4	-1.1	-1.8	1.3	-0.1	0.6	1.1
Whole body fat-free mass	1.0	5.7	35.8	0.6	2.5	3.1	1.5	6.0	0.2	-0.9	-0.5	-1.4	-0.0
Leg fat-free mass (right)	1.0	5.4	36.2	0.7	2.1	2.9	1.3	6.0	0.3	-0.9	-0.7	-1.2	0.1
Leg predicted mass (right)	1.0	5.6	37.1	0.7	2.2	3.0	1.4	6.1	0.3	-0.9	-0.7	-1.1	0.2
Vascular/heart problems diagnosed by doctor	1.0	2.7	5.0	1.9	1.7	0.5	1.8	0.4	1.9	-2.0	0.6	-1.7	-2.2
Basal cell carcinoma (self-reported)	1.0	1.2	2.6	-0.8	-0.5	1.6	-1.4	-0.4	-0.7	1.0	0.0	1.5	1.6
Height	0.9	17.8	127.7	0.4	3.2	4.5	1.5	11.3	0.0	-0.9	-1.0	0.0	-3.9
Average weekly spirits intake	0.9	1.1	6.4	0.6	-1.0	-2.5	0.1	-1.3	0.9	-0.2	0.4	0.6	-0.2
Hearing difficulty/problems: Yes	0.9	1.4	4.2	-1.4	-1.7	-2.0	-0.8	-0.6	-1.3	1.0	-0.2	0.1	1.2
Ever used hormone-replacement therapy (HRT)	0.9	1.2	6.5	0.1	-1.1	-2.5	-0.4	-1.6	0.3	0.2	0.3	0.7	-0.6
Medication: Metformin	0.9	1.2	3.1	-1.4	-1.2	0.4	-1.2	-0.6	-1.0	1.2	-0.9	0.7	1.8
Severe depression (siblings)	0.9	1.0	4.3	-0.4	-0.4	-2.1	0.2	-1.4	-0.6	-0.2	1.7	-0.6	0.0
Impedance of leg (right)	0.9	4.1	15.6	-1.1	-2.3	-3.0	-1.7	-4.0	-0.9	1.6	0.8	1.5	-1.0
Leg fat-free mass (left)	0.9	4.8	31.9	0.5	2.0	2.8	1.1	5.6	0.0	-0.7	-0.6	-1.2	0.3
Bilateral oophorectomy (both ovaries removed)	0.9	1.1	5.6	0.5	0.1	-1.0	0.6	-0.1	0.8	-0.8	2.4	-0.8	-1.2
Leg predicted mass (left)	0.9	4.9	32.4	0.6	2.1	2.8	1.2	5.7	0.1	-0.8	-0.5	-1.3	0.3
Past tobacco smoking	0.9	1.7	5.2	1.2	0.8	0.2	1.0	1.4	1.6	-1.2	1.5	-0.8	-2.3
Standing height	0.9	9.2	62.7	0.4	2.5	3.7	1.4	7.9	0.1	-0.8	-0.9	-0.1	-2.5
Age at first live birth	0.9	1.7	7.3	0.3	1.0	2.7	0.1	2.4	-0.0	0.0	-0.6	0.2	1.4
Mouth/teeth dental problems: Loose teeth	0.9	1.0	4.4	-0.6	0.2	2.1	-0.8	0.5	-0.5	0.4	-1.2	1.1	1.3
Medication for pain relief, constipation, heartburn	0.9	1.5	5.2	1.6	1.4	1.1	0.8	0.2	1.3	-0.9	-0.1	0.7	-2.3
Heart disease (mother)	0.9	1.1	2.7	-0.8	-0.9	0.4	-1.6	0.5	-1.1	1.2	-0.5	1.1	1.5
Age at last live birth	0.9	1.2	5.2	-0.1	1.0	1.5	0.5	2.3	-0.4	-0.1	-1.6	-0.1	1.0
Illnesses of siblings: Diabetes	0.9	1.1	5.2	0.5	0.9	0.6	1.3	-0.6	0.5	-0.3	-1.0	-2.3	-0.4
Whole body water mass	0.9	5.4	34.3	0.5	2.3	3.1	1.4	5.9	0.1	-0.8	-0.5	-1.3	0.0
Basal metabolic rate	0.9	4.8	31.2	0.6	2.2	2.5	1.4	5.6	0.2	-0.9	-0.2	-1.5	-0.1
Alzheimer’s Disease (in father)	0.8	0.9	2.1	-0.8	-0.7	1.4	-1.2	1.0	-0.9	1.2	-0.4	0.6	0.4
Blood White Count	0.8	6.0	15.2	3.9	3.1	1.6	2.7	1.3	3.4	-2.9	0.6	-1.7	-0.5
Age when periods started (menarche)	0.8	2.0	4.6	1.1	0.7	-1.3	1.8	-1.7	1.3	-2.1	-1.3	-1.1	-1.4
Impedance of leg (left)	0.8	3.9	14.4	-0.7	-2.2	-3.5	-1.3	-3.8	-0.3	1.1	0.8	1.3	-1.2
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.3	7.6	-0.4	-1.4	-0.0	-0.9	-2.8	-0.7	1.1	0.6	-0.4	-0.5
Had other major operations	0.8	0.9	2.7	-0.5	-1.0	0.7	-1.4	1.6	-0.8	0.9	0.0	1.2	0.3
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	4.4	-0.3	-0.8	-2.1	-0.2	-1.6	-0.5	-0.1	0.1	-0.6	1.3
Diabetes (self-reported)	0.8	1.3	2.5	-1.6	-1.3	-0.5	-1.1	-0.2	-1.1	1.0	-1.5	0.6	1.6
Time employed in main current job	0.8	0.9	2.5	0.7	0.9	0.8	0.9	1.2	1.0	-0.8	1.6	-0.9	-0.3
Noisy workplace	0.8	1.0	3.6	-0.8	-0.4	0.1	-0.4	-1.9	-1.3	0.1	-0.8	0.0	1.9
Headache pain in last month	0.8	1.4	4.3	-2.1	-1.3	-0.0	-0.8	0.7	-1.6	0.7	-0.9	0.4	1.8
Emphysema/chronic bronchitis	0.8	0.9	2.8	-0.9	-1.1	-0.5	-0.8	0.0	-1.0	1.1	-0.6	0.5	1.7
Comparative height size at age 10	0.8	4.4	29.9	-0.5	1.1	2.7	-0.1	5.5	-0.8	0.7	-1.2	0.6	-1.6
Illnesses of father: Heart disease	0.8	1.1	2.5	-0.8	-1.0	0.0	-1.6	0.9	-0.8	1.5	-0.2	1.2	1.1
Guilty feelings	0.8	1.2	6.2	-0.2	-0.2	-1.4	-0.3	-2.5	-0.3	0.3	1.2	-1.1	-1.1
Hearing aid user	0.8	0.9	3.3	-1.3	-0.9	-1.0	-0.5	1.8	-0.9	0.5	-0.3	0.7	0.2
Medication: Bendroflumethiazide	0.8	1.2	7.9	0.0	-1.0	-2.8	-0.4	-1.3	-0.3	0.5	1.1	0.1	0.2
Number of operations (self-reported)	0.8	1.2	3.3	-0.6	-1.3	-0.1	-1.8	0.6	-0.8	1.3	0.1	1.1	1.5
Arm predicted mass (left)	0.8	3.8	22.2	0.7	2.3	1.8	1.5	4.7	0.4	-1.1	0.1	-1.8	-0.3
Chronotype (morning person)	0.7	1.5	4.0	1.0	1.5	1.2	0.7	2.0	1.0	-1.2	-0.3	-0.8	-1.6
Average weekly fortified wine intake	0.7	0.8	1.9	0.2	0.5	-0.7	1.3	0.6	0.6	-0.8	0.8	-1.3	-1.4
Worrier / anxious feelings	0.7	1.2	2.9	-1.4	-1.1	-0.1	-1.3	-1.7	-1.6	1.2	-0.0	0.5	0.7
Happiness	0.7	0.9	4.4	-0.8	-0.4	-1.5	0.0	-0.7	-0.8	-0.1	-0.3	-0.2	2.1
Medication: Lansoprazole	0.7	0.8	4.6	0.6	-0.3	-0.8	0.3	0.3	1.1	-0.4	2.1	-0.7	0.5
Length of working week for main job	0.7	0.8	3.2	0.4	0.7	1.7	-0.4	1.8	0.1	-0.0	0.8	0.1	-0.6
Exposure to tobacco smoke at home	0.7	0.8	2.5	-0.3	0.4	-1.1	0.9	-1.6	-0.1	-0.3	-0.2	-1.2	-1.1
Exposure to tobacco smoke outside home	0.7	1.0	2.0	-1.1	-0.8	-0.1	-1.1	-0.8	-1.1	1.4	0.9	1.2	0.6
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	2.4	-1.0	-0.8	0.8	-1.6	0.3	-1.6	1.0	-0.7	0.5	1.4
Pain type(s) experienced in last month: Hip pain	0.7	0.8	2.0	-1.4	-1.1	-1.0	-0.4	-0.7	-1.0	0.7	1.3	0.1	0.5
Arm fat-free mass (left)	0.7	3.4	21.0	0.5	2.0	1.8	1.3	4.6	0.2	-0.8	0.1	-1.6	0.0
Bipolar Disorder (2018)	0.6	1.0	2.5	-1.0	-1.2	-1.6	-1.2	0.0	-0.8	1.1	-0.3	0.9	-0.8
Allergy or Eczema	0.6	1.5	7.9	-0.2	0.6	2.8	-0.6	0.3	-0.6	0.4	-1.6	1.7	0.1
Type 2 Diabetes (T2D) (2018)	0.6	1.1	5.1	-1.1	-0.9	-0.3	-0.7	-1.0	-0.8	0.7	-0.8	0.6	2.3
Neuroticism	0.6	1.5	4.6	-0.6	-1.1	-2.0	-0.6	-2.1	-0.5	0.4	1.7	-0.7	0.3
Sensitivity / hurt feelings	0.6	1.0	3.8	0.6	0.5	-0.7	0.7	-2.0	0.4	-0.8	1.1	-1.5	-0.2
Systolic blood pressure, automated reading	0.6	1.8	4.1	0.8	0.9	-0.4	2.0	1.6	1.4	-1.8	0.7	-1.4	-1.3
Falls in the last year	0.6	0.9	2.1	-0.7	-1.5	-0.6	-1.1	-1.1	-0.7	1.0	0.6	0.6	1.0
Mouth/teeth dental problems: Dentures	0.6	1.0	5.6	-0.2	-0.4	-2.4	0.5	-0.9	-0.4	-0.4	-1.0	-1.0	-0.8
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	2.7	-0.4	-0.9	-0.3	-0.6	-1.6	-0.6	0.9	0.7	-0.6	1.3
Depression (self-reported)	0.6	0.7	2.3	0.7	0.1	-1.2	0.5	-1.5	1.0	-0.7	0.5	-0.6	-0.7
Peak expiratory flow (PEF)	0.6	1.3	5.7	0.0	1.3	0.8	1.3	2.4	0.3	-1.0	0.6	-0.9	-0.9
Medication: Paracetamol	0.6	1.0	2.8	-1.7	-0.9	-0.1	-0.6	-1.0	-1.2	0.4	-0.9	-0.6	1.6
Comparative body size at age 10	0.6	1.7	4.2	1.7	0.8	-0.6	1.1	1.0	2.0	-1.8	1.6	-1.0	0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	2.6	0.1	-0.8	-0.4	-1.2	-0.7	-0.3	1.2	0.5	0.4	1.6
Arm predicted mass (right)	0.6	2.9	19.5	0.2	1.7	1.4	1.3	4.4	0.0	-0.7	-0.0	-1.5	0.4
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	4.4	-0.0	0.0	-0.9	-0.3	-2.1	-0.6	-0.3	1.0	0.0	0.4
Knee pain experienced in last month	0.6	0.9	1.9	0.3	1.3	0.8	1.3	0.6	0.4	-1.0	0.9	-1.4	-0.3
Mood swings	0.6	1.1	5.0	-0.0	-0.3	-2.2	0.1	-1.8	0.1	-0.6	1.5	-0.2	0.5
Diabetes diagnosed by doctor	0.6	1.0	3.8	-1.2	-0.9	-0.1	-0.9	-0.0	-0.9	0.9	-1.1	0.6	1.9
Worry (Nagel 2018)	0.5	1.1	5.4	-0.1	-0.0	-0.6	0.6	-2.3	0.4	-0.8	1.6	-1.1	-0.8
Alzheimer’s Disease (in mother)	0.5	0.5	1.2	-1.1	-0.6	-0.0	-0.9	-0.3	-0.9	0.8	-0.5	0.5	-0.8
BMI	0.5	2.8	8.2	1.6	2.3	1.2	2.0	0.9	1.5	-1.9	0.4	-2.9	-0.1
High blood pressure (mother)	0.5	0.6	1.9	-1.1	-1.0	-1.4	0.1	-1.1	-0.3	-0.0	0.4	-0.1	0.9
Weight	0.5	2.7	17.8	0.5	1.8	1.0	1.2	4.2	0.2	-0.7	0.1	-1.6	-0.1
Hip circumference	0.5	2.0	9.2	1.0	1.7	1.7	1.2	3.0	0.4	-0.6	-0.5	-1.3	-0.1
Father’s age at death	0.5	0.7	1.9	-0.4	-0.3	-0.8	-0.5	-1.4	-0.2	-0.5	-1.2	0.7	-1.3
Breastfed as a baby	0.5	0.7	2.3	-0.5	-0.7	-0.3	-1.1	-0.4	-0.8	1.1	-1.5	0.1	0.3
Arm fat-free mass (right)	0.5	2.8	19.6	0.1	1.6	1.3	1.2	4.4	-0.1	-0.7	-0.2	-1.4	0.5
Wheeze or whistling in the chest in last year	0.5	0.9	1.9	-1.4	-1.1	-0.6	-1.1	-0.9	-1.4	1.0	-0.6	-0.0	0.1
Alcohol intake frequency.	0.5	1.2	3.0	-1.1	-1.6	-1.7	-1.1	-0.1	-0.7	1.1	0.7	1.3	-0.2
Suffer from ‘nerves’	0.5	0.8	3.7	0.1	-0.2	-1.0	0.2	-1.4	0.4	-0.4	0.9	-0.6	-1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.5	1.5	-1.2	-0.3	1.2	-0.6	-0.0	-0.9	0.6	-0.8	0.6	-0.1
Osteoporosis (self-reported)	0.5	0.6	1.7	0.8	0.9	-0.1	0.9	0.3	0.6	-1.3	0.6	-0.6	-0.8
Number of self-reported non-cancer illnesses	0.5	0.8	3.5	-0.4	-1.3	-1.4	-0.6	0.3	-0.5	0.5	0.4	0.2	1.9
Pain experienced in last month	0.5	0.8	3.1	1.8	0.5	-0.6	0.8	0.1	1.6	-0.9	0.4	-0.2	-0.3
Crohns Disease (2017)	0.4	0.9	3.6	-1.0	-0.6	-1.3	0.0	0.5	-0.8	0.4	-0.8	-0.8	1.9
Ulcerative Colitis (UC)	0.4	0.7	2.6	-0.5	-1.0	0.2	-0.6	-0.2	-0.5	0.7	-0.4	1.2	1.6
Verbal and Numeric Reasoning (VNR)	0.4	1.0	4.0	-0.0	-1.0	-2.0	-0.4	0.1	0.4	-0.3	2.0	0.3	0.3
Prostate Cancer	0.4	0.6	1.7	1.0	0.8	1.3	0.4	0.2	0.8	-0.7	0.6	0.5	-0.5
Heel T-Score	0.4	3.2	7.7	1.9	0.8	-2.5	1.8	-0.3	2.0	-1.9	1.5	-2.8	0.2
Waist Hip Ratio (WHR)	0.4	1.9	3.9	-1.5	-1.3	-2.0	-1.4	-0.3	-1.0	1.4	-1.6	1.7	-0.8
Hypothyroidism (self reported)	0.4	1.0	4.2	0.2	-0.3	2.0	-0.6	1.4	-0.2	0.6	-0.5	-0.1	1.7
Diabetes (father)	0.4	0.4	1.6	-0.5	-0.4	1.2	-0.8	0.8	-0.6	0.6	-0.2	0.5	-0.4
Taking other prescription medications	0.4	0.7	2.7	-1.0	-1.1	-0.8	-0.6	-0.3	-0.6	0.7	0.2	-0.2	1.6
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	2.4	0.1	0.6	-0.1	0.6	1.6	0.6	-1.0	1.3	-1.3	0.4
Qualifications: CSEs or equivalent	0.4	0.6	3.6	0.6	0.1	0.8	0.6	0.2	0.5	-0.6	1.9	-0.2	-0.3
Hayfever, allergic rhinitis or eczema	0.4	0.8	3.3	0.1	0.6	1.8	-0.1	0.7	-0.2	-0.2	-1.5	1.2	-0.5
Chronic bronchitis/emphysema (father)	0.4	0.4	1.2	-0.4	-0.8	-1.1	-0.7	-0.8	-0.8	0.5	-0.2	0.4	0.1
Number of incorrect matches in round	0.4	0.6	1.3	1.1	1.2	0.8	0.9	-0.4	0.8	-0.8	0.2	-0.5	-0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.8	3.7	0.1	0.9	0.3	0.7	1.9	0.4	-0.7	0.4	-1.5	-0.0
Fluid intelligence score	0.4	0.7	3.7	0.2	-0.2	-1.9	0.1	-0.0	0.6	-0.6	1.3	-0.5	-1.0
Illnesses of siblings	0.4	0.5	1.6	1.0	0.3	-0.0	0.1	1.1	1.0	-0.6	-0.5	-0.1	-1.3
Pulse rate	0.4	0.7	2.2	0.2	0.4	-0.8	0.7	1.5	0.2	-1.1	-0.8	-0.9	-1.1
Qualifications: A levels/AS levels or equivalent	0.4	0.9	7.5	-0.1	-0.2	-0.2	-0.3	-0.8	0.4	-0.2	2.7	-0.1	-0.2
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.9	-0.8	-0.2	0.0	-0.4	1.4	-0.4	0.4	1.3	0.5	0.3
High blood pressure (siblings)	0.4	0.6	1.4	-1.1	-0.8	-0.3	-0.1	-1.1	-1.0	0.6	0.4	0.4	1.2
Leg fat percentage (right)	0.4	1.6	6.5	-0.5	-0.8	-2.6	-0.4	-1.7	-0.5	0.7	0.8	-0.9	1.7
Qualifications: College or University degree	0.4	1.4	5.4	1.0	1.2	1.0	0.5	2.3	1.4	-1.0	1.0	-0.7	-0.6
Eye problems/disorders: None of the above	0.4	0.5	2.0	0.8	0.3	-0.4	0.9	0.4	0.7	-0.4	-1.4	-0.4	0.5
Medication: Ibuprofen	0.4	0.4	1.4	0.2	0.1	-0.4	0.3	-1.2	0.0	-0.0	0.9	-0.9	1.0
Family relationship satisfaction	0.4	0.5	2.9	0.2	-0.3	-0.4	-0.4	-1.7	-0.1	0.3	-0.9	0.9	-0.0
Average weekly red wine intake	0.4	0.5	2.0	0.5	0.9	0.2	0.9	1.4	0.4	-0.7	0.8	-0.1	-0.5
Ever had bowel cancer screening	0.4	0.5	1.8	-0.2	-0.6	-0.9	-0.0	-0.6	-0.0	-0.3	-1.3	-1.1	0.2
Commuting to job workplace: Walk	0.4	0.4	2.1	0.5	0.3	1.4	0.2	-0.6	0.6	-0.6	-0.7	-0.2	-0.0
Osteoarthritis (self-reported)	0.4	0.5	1.4	-0.1	-0.9	-1.2	-0.1	-1.1	-0.2	0.5	-0.4	-0.2	-1.0
Medication: Gliclazide	0.4	0.5	1.1	-0.4	-1.0	0.1	-0.8	-0.4	-0.7	0.5	-0.7	-0.5	1.0
Illnesses of father: None of the above (group 1)	0.4	0.5	1.6	0.2	0.8	-0.4	1.0	-1.3	0.5	-0.7	0.1	-0.9	0.1
Wears glasses or contact lenses	0.4	0.5	2.0	-0.8	-0.3	-1.4	0.1	-1.0	-0.4	-0.1	0.1	-0.3	1.0
Medication: Paracetamol	0.4	0.6	2.0	-1.2	-0.4	0.2	-0.3	-0.4	-0.9	0.1	-0.5	-1.0	1.4
Leg fat percentage (left)	0.4	1.6	9.2	-0.3	-0.7	-3.0	-0.1	-1.4	-0.1	0.3	0.9	-1.0	1.5
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.6	0.7	0.6	1.3	-0.1	0.5	0.2	-0.0	-0.8	-0.2	-1.2
Schizophrenia vs Biploar Disorder	0.3	0.4	1.7	-0.5	-0.0	0.6	0.3	-0.1	-0.5	-0.2	-1.3	-0.5	-0.8
Irritable Bowel Disease (IBD)	0.3	0.8	4.7	-0.7	-0.8	-0.4	-0.3	0.3	-0.7	0.5	-0.7	0.2	2.2
LDL Cholesterol	0.3	0.5	1.5	-0.9	-0.3	0.2	-0.8	-1.2	-0.7	0.8	-0.8	0.7	0.3
Primary Biliary Cirrhosis	0.3	0.4	1.5	-0.1	-0.2	1.2	-1.2	0.5	-0.2	0.7	-0.3	-0.1	0.5
Ulcerative Colitis	0.3	0.5	3.5	0.3	-0.0	0.6	-0.1	-0.5	-0.0	0.1	-0.4	0.6	1.9
Lung FEV1/FVC ratio	0.3	1.5	9.1	-0.5	-0.6	-3.0	0.4	-0.6	0.0	-0.8	0.7	-1.9	0.6
Medication for hormone replacement therapy	0.3	0.4	2.1	0.2	-0.2	-0.7	-0.6	-0.8	0.2	0.4	-0.3	0.0	-1.4
Diabetes (mother)	0.3	0.3	1.3	0.2	-0.2	-1.1	0.7	-0.2	0.4	0.1	0.6	-0.3	-0.9
Maternal smoking around birth	0.3	0.4	2.4	0.8	-0.7	-1.6	0.1	0.2	0.6	-0.4	-0.1	-0.4	0.4
Multivitamins +/- minerals	0.3	0.3	1.3	0.3	-0.2	1.1	-0.1	0.6	0.4	0.2	0.7	0.2	-0.8
Hair/balding pattern: Pattern 2	0.3	0.4	1.0	-0.7	-0.2	1.0	-0.8	0.6	-0.5	0.7	0.6	0.8	0.5
Qualifications: None of the above	0.3	0.6	2.5	-0.1	-0.4	-1.6	0.5	0.1	-0.2	-0.0	-1.3	-1.0	-0.7
Tense / ‘highly strung’	0.3	0.4	1.5	0.2	0.3	0.3	0.3	-1.2	0.2	-0.5	0.7	-1.1	-0.6
Angina (self-reported)	0.3	0.4	1.8	-0.2	-0.1	0.7	-0.7	-0.0	-0.3	0.7	-1.3	1.1	0.3
Migraine (self-reported)	0.3	0.4	1.2	-1.0	-0.4	-0.8	-0.1	0.7	-0.7	-0.1	-0.1	-1.1	-0.1
Pulse rate, automated reading	0.3	0.9	5.0	-0.5	0.2	-1.0	0.1	2.2	-0.4	-0.2	-1.4	-1.0	-0.1
Commuting to job workplace: Car/motor vehicle	0.3	0.4	1.3	-0.3	0.2	0.1	-0.2	1.1	-0.9	0.7	-0.4	0.2	-1.0
Smoking status: Previous	0.3	0.5	2.2	-0.5	-0.1	-0.7	-0.1	-1.0	-0.6	0.4	0.2	-0.1	1.5
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.7	3.9	-0.0	-0.2	0.3	-0.5	2.0	-0.3	0.5	1.0	1.2	0.2
Loneliness, isolation	0.3	0.4	2.4	-0.6	-0.8	-0.2	-0.4	-1.6	-0.4	0.3	0.2	0.5	0.4
Breast cancer (self-reported)	0.3	0.3	0.7	0.7	0.2	-0.1	0.7	0.5	0.7	-0.8	-0.4	-0.2	-0.8
Asthma (self-reported)	0.3	0.5	1.9	0.5	0.0	-1.1	0.4	0.8	0.8	-0.4	1.4	-0.5	-0.2
Ever taken oral contraceptive pill	0.3	0.4	1.9	-0.3	-0.4	-1.4	-0.1	-0.2	-0.3	0.2	0.4	0.3	1.1
Commuting to job workplace: Public transport	0.3	0.3	1.2	0.8	0.4	0.5	-0.1	0.2	1.1	-0.5	0.5	-0.1	-0.3
Diastolic blood pressure, automated reading	0.3	1.0	3.0	0.7	0.9	1.0	1.2	1.7	0.9	-1.2	0.0	-1.1	0.2
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	1.2	-0.9	-0.7	-1.1	-0.1	0.3	-0.6	0.4	0.4	-0.8	0.7
Heart disease (siblings)	0.3	0.4	1.7	-0.4	-0.4	-0.3	-0.4	-1.3	-0.7	0.7	0.0	0.5	-0.3
Impedance of whole body	0.3	1.6	3.4	-0.4	-1.5	-1.7	-1.1	-1.7	-0.2	0.9	0.1	1.4	-1.9
Reaction Time	0.2	0.4	2.3	0.3	0.4	1.5	-0.2	-0.3	0.5	-0.2	1.0	0.1	-0.1
Ovarian Cancer	0.2	0.3	0.9	-0.2	-0.4	-0.2	-0.7	0.6	-0.4	0.6	-0.4	0.2	1.0
Mean Putamen Volume	0.2	0.2	1.0	0.6	0.0	-0.6	-0.1	0.1	0.5	-0.2	1.0	0.2	0.2
Triglycerides	0.2	0.3	2.3	-0.3	-0.5	-1.5	0.1	-0.5	-0.1	-0.2	-0.1	0.1	0.7
Lung FVC	0.2	0.8	2.2	0.6	0.5	0.4	1.1	-1.5	0.3	-1.3	1.3	-0.7	-0.5
Ever had hysterectomy (womb removed)	0.2	0.2	0.9	-0.4	-0.9	-0.4	-0.4	-0.5	-0.3	0.3	0.5	0.3	0.5
Angina	0.2	0.3	1.3	-0.1	0.0	0.3	-0.5	-0.5	-0.2	0.5	-1.1	0.8	0.3
Medication: Levothyroxine sodium	0.2	0.3	0.9	0.6	0.1	0.9	0.3	0.2	0.7	-0.4	-0.3	-0.1	1.0
Body mass index (BMI)	0.2	0.7	2.7	0.4	0.7	-0.6	0.7	0.8	0.2	-0.4	0.5	-1.6	1.1
Trunk fat mass	0.2	0.8	5.2	0.2	0.7	-0.6	0.5	2.3	0.0	-0.2	-0.0	-1.4	0.3
Waist circumference	0.2	0.7	4.7	-0.0	0.8	0.5	0.3	2.2	-0.2	0.1	-0.9	-0.9	0.3
Had menopause	0.2	0.2	1.4	0.6	0.2	-0.0	0.0	-1.2	0.5	-0.4	-0.1	-0.0	0.5
Mouth/teeth dental problems	0.2	0.3	0.8	0.3	-0.5	-0.0	-0.5	-0.5	0.5	0.8	0.9	0.4	0.2
Allergy	0.2	0.4	1.7	-0.2	-0.7	-1.3	-0.2	-0.9	-0.1	0.3	0.8	-0.5	0.5
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	1.6	0.0	0.7	0.6	-0.1	0.4	-0.3	-0.1	-0.7	0.4	-1.2
Impedance of arm (right)	0.2	1.0	3.5	-0.1	-0.8	0.4	-1.2	-0.4	-0.3	0.9	-0.6	1.7	-1.9
Alcohol intake versus 10 years previously	0.2	0.4	0.7	0.1	0.6	-0.7	0.8	0.5	0.0	-0.9	0.7	-0.6	-0.6
Asthma	0.2	0.4	1.5	0.3	0.1	-1.0	0.5	0.7	0.7	-0.4	1.2	-0.5	-0.4
Prospective memory result	0.2	0.2	0.7	0.6	0.5	-0.4	0.3	-0.5	0.4	0.0	-0.8	0.4	0.4
Illnesses of mother	0.2	0.3	1.2	-0.2	-0.4	0.3	-0.3	-0.5	-0.5	0.2	-1.1	0.6	0.4
Impedance of arm (left)	0.2	0.9	3.2	-0.4	-0.9	-0.1	-1.2	-0.3	-0.6	0.9	-0.4	1.8	-1.5
Arm fat mass (right)	0.2	0.6	2.7	0.2	0.8	-0.5	0.6	1.6	-0.0	-0.4	0.2	-1.2	0.9
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	3.3	0.1	0.2	0.1	-0.1	-0.2	0.3	-0.4	1.8	-0.0	-0.5
Blood clot in the leg (DVT)	0.2	0.2	0.7	-0.3	0.7	0.6	-0.1	-0.5	-0.8	0.1	-0.7	0.0	0.3
Gout (self-reported)	0.2	0.3	0.6	0.6	0.7	0.6	0.3	0.5	0.7	-0.8	0.4	0.2	0.1
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	2.2	0.1	-0.1	1.2	-0.0	0.6	0.1	0.3	-0.6	0.3	1.5
Medication: Amlodipine	0.2	0.3	0.9	-0.3	-0.4	-0.5	-0.6	-0.9	-0.3	0.7	0.4	-0.4	0.0
Worry too long after embarrassment	0.2	0.3	1.3	0.1	-0.3	-0.5	0.0	-0.7	0.2	0.1	1.2	0.0	-0.6
Medication: Allopurinol	0.2	0.2	1.0	-0.3	-0.8	-1.0	-0.5	0.1	-0.3	0.1	0.5	0.3	0.3
Medication: Seretide 50 evohaler	0.2	0.3	1.1	-0.1	-0.6	-0.2	-0.4	-0.6	0.1	0.3	1.0	0.0	0.7
Mean time to correctly identify matches	0.2	0.4	2.5	-0.1	-0.1	1.6	-0.8	-0.5	-0.1	0.3	0.3	0.5	0.4
Leg fat mass (right)	0.2	0.7	2.5	-0.4	0.1	-1.3	0.1	0.5	-0.6	0.3	-0.0	-1.3	1.6
Qualifications: nursing, teaching	0.2	0.3	0.7	0.2	-0.8	-0.8	0.2	0.7	0.5	-0.2	0.7	0.3	0.5
Medication: Atorvastatin	0.2	0.3	1.9	-0.4	-0.3	-1.4	0.0	-0.6	-0.1	-0.0	0.4	0.1	-0.2
Illnesses of father: High blood pressure	0.2	0.3	1.6	0.0	-0.1	-0.1	0.3	0.7	0.3	-0.6	1.3	0.2	-0.0
Commuting to job workplace: Cycle	0.2	0.2	1.2	-0.1	-0.1	1.1	-0.1	0.1	0.0	0.2	-0.3	-0.2	-0.8
Myopia	0.2	0.2	1.0	0.2	0.6	-0.2	0.8	-0.3	0.2	-1.0	0.2	-0.0	0.3
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.8	-0.3	0.7	0.8	0.0	-0.4	-0.9	0.0	-0.7	0.2	0.5
Leg fat mass (left)	0.2	0.7	2.2	-0.1	0.1	-1.5	0.3	0.8	-0.2	-0.0	0.0	-1.4	1.3
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.8	-0.2	-0.6	-0.9	-0.5	0.6	-0.1	0.3	0.6	0.1	-0.3
Systolic Blood Pressure	0.1	0.5	1.3	-0.1	0.2	-0.4	1.1	1.1	0.7	-0.8	1.1	-0.2	-0.2
Respiratory disease	0.1	0.3	1.7	-0.6	-0.4	-0.3	-0.2	0.3	-0.5	0.4	-0.0	-0.2	1.3
Tanning	0.1	1.0	5.2	-0.2	-1.0	-2.3	-0.2	-1.4	0.1	-0.1	0.3	-1.0	-0.6
Supplements: Zinc	0.1	0.1	0.4	-0.1	0.1	0.5	0.2	0.6	0.2	-0.6	0.2	0.3	0.2
Trunk fat percentage	0.1	0.4	2.4	0.1	0.0	-1.5	0.0	0.8	-0.1	0.1	-0.1	-1.1	0.3
Arm fat percentage (right)	0.1	0.4	2.1	-0.5	-0.2	-1.1	-0.2	0.1	-0.6	0.3	0.1	-0.5	1.5
Body fat percentage	0.1	0.5	3.4	-0.2	-0.2	-1.8	-0.1	0.0	-0.3	0.3	0.1	-1.0	0.9
Whole body fat mass	0.1	0.6	2.8	0.1	0.5	-0.8	0.4	1.7	-0.1	-0.1	0.1	-1.3	0.7
Arm fat percentage (left)	0.1	0.5	2.3	-0.5	-0.3	-1.4	-0.3	0.0	-0.6	0.4	0.2	-0.5	1.5
Eye problems/disorders: Cataract	0.1	0.1	0.4	-0.4	0.2	0.3	-0.0	0.2	-0.3	-0.1	0.6	0.7	-0.4
Arm fat mass (left)	0.1	0.6	2.8	-0.2	0.5	-0.5	0.3	1.7	-0.4	-0.1	0.1	-1.0	1.0
Blood Eosinophil Count	0.0	0.2	0.7	0.1	0.8	0.8	0.2	0.7	0.1	-0.3	-0.3	-0.3	-0.0
Blood Red Count	0.0	0.2	0.7	-0.5	-0.2	0.3	-0.5	-0.0	-0.6	0.5	-0.7	0.1	-0.8
Hair Pigment	0.0	0.6	1.7	0.5	-0.9	-1.2	0.1	-0.7	0.5	0.3	0.9	-0.2	1.3
Supplements: Calcium	0.0	0.1	0.3	0.0	-0.1	0.1	0.0	-0.5	-0.1	-0.1	0.1	-0.1	-0.5

Hub : Genes

FAM45A

Models

Trait associations