TWAS hub - C10orf46

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Pheochromocytoma and Paraganglioma	0.226	0.0950	1.4e-03	0.041	0.030	-0.003	NA	0.042	9.6e-03	2.3e-02	4.3e-01	NA	8.6e-03
2	TCGA	Prostate Adenocarcinoma	0.194	0.0653	1.1e-09	0.033	0.074	0.076	NA	0.058	2.1e-04	3.5e-08	2.5e-08	NA	1.1e-06
3	TCGA	Thyroid Carcinoma	0.138	0.0470	1.4e-08	0.051	0.100	0.084	NA	0.075	9.4e-06	6.5e-10	1.4e-08	NA	9.0e-08

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Medication: Atorvastatin	5.8	7.2	9.7	-2.4	-2.4	-3.1
Diabetes (self-reported)	4.5	7.0	14.9	-3.9	-2.1	-1.3
Age when periods started (menarche)	3.8	9.2	16.0	1.4	3.1	4.0
Diabetes diagnosed by doctor	3.8	6.2	13.0	-3.6	-1.8	-1.6
Medication: Paracetamol	3.6	5.5	8.8	-3.0	-2.4	-1.4
Type 2 Diabetes (T2D) (2018)	3.4	6.3	13.5	-3.7	-1.9	-1.3
Medication: Lansoprazole	3.4	3.8	4.9	-2.0	-2.2	-1.6
Serious illness, injury or assault of a close relative in last 2 years	3.3	3.8	6.3	-0.6	-2.5	-2.2
Medication: Allopurinol	3.3	4.5	7.7	-2.2	-1.0	-2.8
Supplements: Fish oil (including cod liver oil)	3.0	3.9	4.8	2.2	1.5	2.2
Trunk fat-free mass	2.9	16.4	48.7	7.0	0.7	0.1
Trunk predicted mass	2.9	16.6	49.4	7.0	0.7	0.2
Leg pain on walking	2.9	3.7	6.2	-2.5	-2.1	-0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.7	3.3	5.1	-2.3	-1.0	-1.9
Diverticular disease/diverticulitis (self-reported)	2.6	3.1	5.0	-0.8	2.2	1.9
Medication for cholesterol, blood pressure or diabetes	2.6	4.3	5.7	2.4	1.6	2.2
Lupus	2.5	3.8	8.5	2.9	1.1	1.3
Ever used hormone-replacement therapy (HRT)	2.5	3.2	3.6	1.6	1.9	1.9
Supplements: Zinc	2.5	2.7	7.5	-2.7	-0.9	-0.2
Falls in the last year	2.5	3.3	3.9	-1.5	-2.0	-1.9
Medication: Paracetamol	2.5	4.2	5.0	-2.2	-2.2	-1.7
Age at first live birth	2.5	4.4	6.4	2.5	2.4	1.1
Alzheimer’s Disease (including proxy)	2.4	3.5	6.2	-0.0	-2.1	-2.5
Medication: Cholesterol lowering	2.4	3.7	6.7	-2.6	-1.8	-1.1
Gout (self-reported)	2.4	3.3	6.8	-1.6	-0.6	-2.6
Back pain experienced in last month	2.4	3.5	5.4	1.3	1.9	2.3
Arm fat-free mass (left)	2.4	12.0	34.6	5.9	1.2	-0.3
Medication: Metformin	2.3	3.2	6.6	-2.6	-1.2	-1.3
Arm fat-free mass (right)	2.3	12.0	34.1	5.8	1.4	0.0
Whole body fat-free mass	2.3	13.1	38.7	6.2	0.7	-0.4
Whole body water mass	2.3	13.2	38.7	6.2	0.8	-0.4
Arm predicted mass (left)	2.3	11.6	33.4	5.8	1.2	-0.1
Chronotype (morning person)	2.2	5.1	7.7	1.1	2.8	2.5
Medication: Blood pressure	2.2	3.8	7.0	-2.6	-0.7	-2.0
Average weekly red wine intake	2.2	3.2	6.5	2.5	1.3	1.2
Vascular/heart problems diagnosed by doctor	2.2	5.9	6.0	2.4	2.4	2.5
Bipolar Disorder or Schizophrenia	2.1	5.1	7.9	1.1	2.8	2.5
Birth weight of first child	2.1	3.8	7.9	2.8	1.4	1.3
Medication: Amlodipine	2.1	2.9	3.9	-1.8	-1.3	-2.0
Medication: Seretide 50 evohaler	2.1	2.4	4.0	1.4	1.1	2.0
Arm predicted mass (right)	2.1	10.6	30.8	5.5	0.9	-0.2
Age at last live birth	2.1	3.0	3.8	1.9	1.3	2.0
Lung FEV1/FVC ratio	2.0	10.3	16.3	1.5	3.5	4.0
High blood pressure	1.9	5.4	6.4	-2.4	-2.1	-2.5
Father’s age at death	1.9	2.5	4.3	2.1	-0.1	1.8
Noisy workplace	1.9	2.3	3.8	-0.5	1.9	1.7
Comparative body size at age 10	1.9	5.3	10.3	2.0	-1.2	-3.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.9	2.2	3.9	0.9	-1.4	-2.0
Medication: Gliclazide	1.9	2.1	2.8	-1.6	-1.0	-1.7
Basal metabolic rate	1.9	10.2	29.6	5.4	0.8	-0.7
Bipolar Disorder (2018)	1.8	2.9	4.5	0.9	2.1	1.8
Cardiovascular Disease	1.8	5.9	10.4	-3.2	-1.6	-2.1
Breast cancer (self-reported)	1.8	2.2	3.3	1.8	0.6	1.7
High cholesterol (Self-reported)	1.8	3.1	6.8	-2.6	-1.3	-1.0
Medication: Bendroflumethiazide	1.8	2.7	3.7	-1.9	-1.5	-1.5
Length of working week for main job	1.7	1.9	2.8	-1.7	-1.2	-1.1
Ovarian Cancer	1.6	2.1	5.7	2.4	0.6	0.5
Qualifications: CSEs or equivalent	1.6	2.1	5.3	-0.5	-0.9	-2.3
Standing height	1.6	15.5	43.3	6.6	1.1	1.4
Hypertension (Self-reported)	1.6	4.3	6.1	-2.5	-1.8	-1.9
Mouth/teeth dental problems: Mouth ulcers	1.6	2.5	5.9	1.3	2.4	-0.2
Leg fat-free mass (left)	1.5	7.7	21.9	4.7	0.7	-0.8
Hand grip strength (right)	1.5	4.2	8.7	2.9	0.9	1.7
Sitting height	1.5	10.9	30.4	5.5	0.5	1.5
High blood pressure (mother)	1.5	2.1	5.1	2.3	1.0	-0.2
Leg predicted mass (left)	1.5	7.7	21.9	4.7	0.7	-0.9
Medication: Ramipril	1.5	1.9	4.3	-2.1	-1.2	-0.5
Osteoarthritis (self-reported)	1.5	2.0	3.8	-1.9	-1.4	-0.5
Height	1.4	27.1	77.4	8.8	0.8	1.8
Hypothyroidism (self reported)	1.4	3.2	7.9	2.8	1.0	-0.8
Diabetes (mother)	1.4	1.8	4.3	-2.1	1.1	-0.0
Hypothyroidism/myxoedema (self-reported)	1.4	2.7	6.8	2.6	1.0	-0.5
Had major operations	1.4	1.7	2.9	-1.3	-0.8	-1.7
Leg fat-free mass (right)	1.4	7.6	20.8	4.6	0.0	-1.4
Leg predicted mass (right)	1.4	7.6	21.0	4.6	0.1	-1.4
Ever smoked	1.4	2.4	4.9	0.1	2.2	1.5
Systolic Blood Pressure	1.3	6.4	13.8	-3.7	-2.0	-1.2
Hearing difficulty/problems: Yes	1.3	2.0	4.5	0.5	-2.1	-1.1
Relative age voice broke	1.3	2.0	3.7	1.9	0.2	1.5
Mother’s age at death	1.3	1.6	4.2	2.0	-0.0	0.8
Medication: Lisinopril	1.3	1.6	4.7	-2.2	0.3	0.3
Bipolar Disorder (2011)	1.2	1.2	1.8	0.4	1.4	1.2
Waist Hip Ratio (WHR)	1.2	5.2	7.4	-2.7	-2.5	-1.3
Heart attack	1.2	1.6	2.6	-0.3	-1.4	-1.6
Birth weight	1.2	2.7	5.8	2.4	1.1	1.1
Illness, injury, bereavement, stress in last 2 years	1.2	1.5	3.7	0.5	0.7	1.9
Pain type(s) experienced in last month: Hip pain	1.2	1.5	3.6	-1.9	-0.2	-0.9
Illnesses of father: High blood pressure	1.2	1.5	4.0	-2.0	0.7	0.4
Heart attack/myocardial infarction (self-reported)	1.2	1.6	2.6	-0.5	-1.6	-1.4
Hand grip strength (left)	1.1	2.9	4.0	1.6	1.5	2.0
Diabetes (father)	1.1	1.4	1.5	-1.2	1.1	1.2
Townsend deprivation index at recruitment	1.1	1.5	2.0	-1.4	-1.2	-1.0
Impedance of arm (right)	1.1	5.2	15.4	-3.9	-0.4	-0.3
Arm fat percentage (right)	1.1	4.3	8.3	-2.2	-0.1	-2.9
Impedance of arm (left)	1.1	5.2	14.7	-3.8	0.5	0.7
Overall health rating	1.1	2.4	4.3	-2.1	-1.1	-1.4
Risk taking	1.1	1.6	3.0	1.2	-0.4	1.7
Ever depressed for a whole week	1.1	1.3	3.1	1.8	-0.9	-0.1
Impedance of whole body	1.1	5.4	15.0	-3.9	0.5	1.0
Schizophrenia (2018)	1.0	2.0	2.8	0.8	1.6	1.7
Primary Biliary Cirrhosis	1.0	1.4	2.5	1.6	-1.2	-0.6
Medication: Levothyroxine sodium	1.0	1.7	3.7	1.9	-0.0	-1.2
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.5	2.6	-0.8	1.6	1.1
Pulse rate	1.0	1.7	2.7	-1.6	-1.5	-0.4
Depression (self-reported)	1.0	1.2	2.8	-0.3	-0.9	-1.7
Body fat percentage	1.0	3.8	6.1	-2.3	0.4	-2.5
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	2.1	0.0	1.2	1.5
Qualifications: College or University degree	1.0	3.1	4.1	1.5	2.0	1.8
Number of full sisters	1.0	1.2	2.8	0.9	1.7	0.4
Illnesses of siblings: Diabetes	1.0	1.3	2.2	-1.5	-0.0	-1.3
Arm fat percentage (left)	1.0	4.0	6.3	-2.4	0.2	-2.5
Myopia	1.0	1.5	2.0	-0.8	-1.3	-1.4
Severe depression (siblings)	0.9	1.0	2.9	-0.1	1.7	-0.0
Impedance of leg (right)	0.9	4.6	7.3	-2.7	1.7	1.9
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.5	2.6	-1.6	-0.8	-1.0
Medication: Ventolin 100micrograms inhaler	0.9	1.2	2.9	1.7	0.8	-0.1
Shortness of breath walking on level ground	0.9	1.0	1.6	-1.2	-0.1	-1.3
Alcohol intake frequency.	0.9	2.1	2.8	-1.3	-1.3	-1.7
Commuting to job workplace: Walk	0.9	1.0	2.2	-0.5	-0.6	-1.5
Number of self-reported non-cancer illnesses	0.9	1.5	3.8	-1.9	0.1	-0.9
Supplements: Calcium	0.9	0.9	1.3	-1.0	-1.1	0.8
Pack years of smoking	0.9	1.4	2.4	0.1	-1.3	-1.6
Number of treatments/medications taken	0.8	1.4	2.0	-1.3	-0.7	-1.4
Systolic blood pressure, automated reading	0.8	2.5	3.6	-1.9	-1.6	-1.1
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	2.3	0.6	-0.3	1.5
Medication: Co-codamol	0.8	1.0	1.7	-0.8	-1.3	-0.8
Trunk fat percentage	0.8	3.3	4.8	-2.2	0.6	-2.2
Had menopause	0.8	1.0	1.6	0.2	1.3	1.2
Weight	0.8	3.8	8.0	2.8	0.8	-1.6
Forced expiratory volume in 1-second (FEV1)	0.8	2.8	6.7	2.6	1.2	0.4
Mouth/teeth dental problems: Bleeding gums	0.8	1.1	1.5	0.7	-1.1	-1.2
Mouth/teeth dental problems: Loose teeth	0.8	1.0	2.6	-1.6	-0.2	-0.6
Handedness (chirality/laterality): Left-handed	0.8	1.0	2.2	0.6	1.5	0.6
Hearing aid user	0.8	0.9	1.8	-0.7	-0.7	-1.4
Leg fat percentage (left)	0.8	2.9	5.4	-1.8	0.4	-2.3
Average weekly beer plus cider intake	0.8	1.1	2.1	0.4	-1.4	-1.1
Intelligence (Savage-Jansen 2018)	0.7	2.2	3.2	0.6	1.8	1.7
Alzheimer’s Disease (in mother)	0.7	0.8	1.3	0.2	-1.1	-1.1
Schizophrenia (2014)	0.7	1.6	2.2	0.6	1.5	1.5
Pack years adult smoking proportion	0.7	1.0	1.9	-0.1	-1.1	-1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	1.0	1.7	0.7	1.3	0.8
Supplements: Glucosamine	0.7	0.9	1.2	0.8	0.9	1.1
Impedance of leg (left)	0.7	3.6	9.1	-3.0	0.8	1.0
Happiness	0.7	0.9	2.6	1.6	-0.2	0.0
Mouth/teeth dental problems: Dentures	0.7	1.1	1.7	1.0	0.8	1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	2.8	0.0	-0.8	-1.7
Hair/balding pattern: Pattern 4	0.7	1.8	3.0	0.0	1.7	1.5
Ever highly irritable/argumentative for 2 days	0.7	0.8	1.2	-1.0	-1.1	-0.4
Leg fat percentage (right)	0.7	2.5	3.4	-1.8	1.0	-1.8
Pulse wave peak to peak time	0.7	0.8	2.2	1.5	0.6	0.0
Medication: Ibuprofen	0.7	0.8	2.3	0.2	1.5	0.4
Comparative height size at age 10	0.7	4.0	6.0	2.1	-1.2	-2.5
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	2.1	-1.5	0.4	-0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.9	1.2	-1.1	-0.9	-0.7
Ever had bowel cancer screening	0.7	0.8	1.8	-0.4	-1.3	0.6
Illnesses of father: None of the above (group 1)	0.7	0.9	2.5	1.6	-0.4	0.0
Guilty feelings	0.7	1.1	1.6	-1.3	1.1	-0.6
Ever had prostate specific antigen (PSA) test	0.7	0.8	2.1	-0.1	0.5	1.4
Major Depression (MDD)	0.6	0.7	1.4	0.9	-1.2	0.3
Breast Cancer	0.6	1.4	1.8	-1.3	-1.3	-0.9
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.4	-0.3	-0.7	-1.2
Frequency of depressed mood in last 2 weeks	0.6	0.9	1.4	0.2	1.1	1.2
Multivitamins +/- minerals	0.6	0.8	2.2	-0.0	1.5	0.4
Chronic bronchitis/emphysema (father)	0.6	0.7	1.8	-1.3	0.2	0.4
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	1.0	0.9	-0.5	1.0
Mouth/teeth dental problems	0.6	0.9	1.3	-1.1	-1.1	0.2
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.7	1.9	0.3	1.4	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.8	4.0	2.0	0.9	0.7
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.5	0.5	1.2	0.6
High blood pressure (siblings)	0.6	0.9	2.1	-0.7	1.5	-0.3
Number of full brothers	0.6	0.8	1.4	-1.2	-0.8	0.6
Wheeze or whistling in the chest in last year	0.6	1.0	1.5	-0.3	-1.2	-1.2
Neck or shoulder pain in last month	0.6	0.8	2.0	-1.4	-0.4	-0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.2	3.5	1.9	0.3	-0.3
Osteoporosis (self-reported)	0.6	0.7	1.4	-0.9	-0.3	1.2
Medication: Aspirin	0.6	0.7	1.0	-1.0	-1.0	-0.6
Financial situation satisfaction	0.6	0.8	1.8	-1.4	-0.7	-0.1
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.2	0.9	1.1	0.4
Medication: Blood pressure	0.6	1.1	3.0	-0.1	-1.7	-0.6
Fractured/broken bones in last 5 years	0.6	0.8	1.0	-1.0	-1.0	-0.6
Age started oral contraceptive pill	0.6	0.8	1.2	1.1	0.3	1.0
Diastolic blood pressure, automated reading	0.6	1.9	2.4	-1.4	-1.6	-1.2
Depression (Nagel 2018)	0.5	0.8	1.4	0.9	0.5	1.2
Alzheimer’s Disease (in father)	0.5	0.6	1.4	0.3	-0.5	-1.2
Coronary Artery Disease (CAD)	0.5	0.6	1.3	-1.1	0.4	0.4
HbA1C	0.5	0.6	1.0	0.9	0.3	-1.0
BMI	0.5	2.6	7.6	0.0	0.6	-2.8
Smoking Status	0.5	1.1	2.4	-0.4	-0.8	-1.6
Allergy or Eczema	0.5	1.4	1.6	-1.2	1.1	1.3
Average weekly spirits intake	0.5	0.6	1.5	-0.6	-1.2	0.3
Average weekly fortified wine intake	0.5	0.5	0.9	0.7	0.5	1.0
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	0.9	0.2	0.9	0.9
Number of incorrect matches in round	0.5	0.9	2.2	-1.5	-0.2	0.7
Past tobacco smoking	0.5	0.9	1.9	0.9	-1.4	-0.0
Forced vital capacity (FVC)	0.5	1.8	4.8	2.2	0.6	-0.3
Medication: Simvastatin	0.5	0.7	1.2	-1.1	-0.6	0.7
Illnesses of siblings	0.5	0.7	1.5	0.7	-1.2	0.2
Hip circumference	0.5	1.9	3.0	1.7	0.9	-1.4
Number of live births	0.5	0.6	1.3	-1.1	0.2	0.8
Qualifications: A levels/AS levels or equivalent	0.5	1.0	2.6	1.6	-0.5	-0.5
Medication for pain relief, constipation, heartburn	0.5	0.9	1.7	1.3	0.4	0.9
Migraine (self-reported)	0.5	0.6	1.1	-0.6	-1.1	-0.5
Medication: Omeprazole	0.5	0.6	1.3	0.6	1.1	-0.5
Heart disease (mother)	0.5	0.6	0.9	-0.9	-0.9	0.1
Leg fat mass (right)	0.5	1.8	5.0	-0.1	0.5	-2.2
Family relationship satisfaction	0.5	0.6	0.8	0.9	-0.8	-0.6
Commuting to job workplace: Car/motor vehicle	0.5	0.5	1.5	-0.4	0.1	-1.2
Supplements: Vitamin C	0.5	0.6	1.1	-0.7	1.0	0.5
Smoking status: Previous	0.5	0.8	1.8	-0.7	1.4	-0.4
Loneliness, isolation	0.5	0.6	1.4	-0.3	-1.2	-0.7
Friendships satisfaction	0.5	0.7	1.0	0.9	-0.5	-1.0
Qualifications: nursing, teaching	0.5	0.8	1.2	-0.9	-0.5	1.1
Mineral and other dietary supplements	0.5	0.6	1.5	-1.2	-0.1	-0.6
Average weekly champagne plus white wine intake	0.5	0.7	1.0	-0.5	-1.0	-0.8
Number of operations (self-reported)	0.5	0.7	0.8	-0.8	0.9	0.7
Irritability	0.5	0.8	1.2	-1.1	-0.7	-0.8
Cholesterol lowering medication	0.5	0.7	2.0	-1.4	-0.3	-0.3
Alcohol drinker status: Previous	0.5	0.6	1.7	-1.3	-0.2	-0.2
Leg fat mass (left)	0.5	2.0	5.9	0.0	0.2	-2.4
Crohns Disease (2017)	0.4	1.0	2.3	0.0	0.8	1.5
Irritable Bowel Disease (IBD)	0.4	0.8	1.7	0.5	0.7	1.3
Reaction Time	0.4	0.7	1.6	-0.6	0.6	-1.3
Body Mass Index (BMI) (2010)	0.4	0.5	1.4	-0.0	-0.0	-1.2
LDL Cholesterol	0.4	0.6	1.7	-1.3	-0.0	-0.4
Triglycerides	0.4	0.7	2.0	-1.4	0.2	0.2
Blood White Count	0.4	3.0	5.2	-1.5	-1.2	-2.3
Sensitivity / hurt feelings	0.4	0.7	1.7	0.3	-0.7	-1.3
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.0	0.6	-0.6	-1.0
Ever had hysterectomy (womb removed)	0.4	0.5	1.0	-1.0	-0.2	0.6
Vitamin and mineral supplements	0.4	0.6	1.1	0.5	-1.0	0.6
Maternal smoking around birth	0.4	0.5	0.9	-0.9	0.4	0.7
Taking other prescription medications	0.4	0.6	1.3	-0.2	-0.5	-1.1
Body mass index (BMI)	0.4	1.8	5.3	0.0	0.4	-2.3
Trunk fat mass	0.4	1.7	4.8	-0.5	0.4	-2.2
Hair/balding pattern: Pattern 2	0.4	0.5	0.9	-0.8	-0.9	-0.3
Had other major operations	0.4	0.5	0.7	-0.6	-0.8	-0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	2.2	0.1	0.6	-1.5
Arm fat mass (right)	0.4	1.8	5.3	0.1	0.3	-2.3
Breastfed as a baby	0.4	0.5	1.1	-0.7	-0.3	-1.0
Tense / ‘highly strung’	0.4	0.7	1.3	1.1	0.7	0.5
Loud music exposure frequency	0.4	0.4	1.3	-1.1	0.1	0.2
Headache pain in last month	0.4	0.8	1.7	-1.3	-0.8	-0.2
Worry too long after embarrassment	0.4	0.7	1.5	-0.9	0.1	-1.2
Mean time to correctly identify matches	0.4	0.8	2.2	-0.5	0.1	-1.5
Whole body fat mass	0.4	1.9	5.3	-0.3	0.5	-2.3
Pulse rate, automated reading	0.4	1.4	3.8	-0.6	-2.0	0.0
Medication: Aspirin	0.4	0.6	1.1	-1.0	-0.8	-0.2
Long-standing illness, disability or infirmity	0.4	0.6	1.6	-1.3	0.2	-0.3
Arm fat mass (left)	0.4	1.7	4.7	0.2	0.5	-2.2
Eye problems/disorders: Glaucoma	0.4	0.4	1.3	0.1	1.1	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.1	0.2	1.0	0.6
Heart disease (siblings)	0.4	0.5	1.3	0.5	1.1	0.3
Prostate Cancer	0.3	0.4	0.8	0.5	0.4	0.9
Crohns Disease (2012)	0.3	0.4	1.2	-0.2	1.1	0.4
Blood Red Count	0.3	3.0	7.1	-2.7	1.0	-1.0
Respiratory disease	0.3	0.8	1.1	-1.0	-0.9	-0.6
Lung FVC	0.3	1.3	2.9	-1.0	-0.3	-1.7
Hair Pigment	0.3	7.4	11.2	3.3	2.6	2.1
Tanning	0.3	3.7	4.7	-2.2	-1.7	-1.8
Relative age of first facial hair	0.3	0.6	0.7	0.8	0.9	0.7
Angina	0.3	0.3	0.9	0.2	-0.3	1.0
Current tobacco smoking	0.3	0.4	0.8	-0.2	-0.9	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	1.6	0.1	0.4	-1.3
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.7	-0.2	-0.4	-0.9
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.6	-1.3	-0.4	0.1
Waist circumference	0.3	1.3	3.7	0.1	-0.2	-1.9
Qualifications: None of the above	0.3	0.7	2.1	-1.4	-0.2	0.1
Allergy	0.3	0.7	1.4	1.2	0.8	0.3
Pain all over the body in last month	0.3	0.3	0.4	-0.3	-0.7	0.6
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	0.7	-0.6	0.8	-0.3
Neuroticism score	0.3	0.6	1.2	-0.7	-0.1	-1.1
Alcohol intake versus 10 years previously	0.3	0.4	0.6	0.6	-0.5	-0.8
Illnesses of mother	0.3	0.4	0.5	-0.6	0.5	0.7
Pulse wave Arterial Stiffness index	0.3	0.4	0.9	-1.0	-0.3	0.3
Exposure to tobacco smoke at home	0.3	0.3	0.5	-0.7	-0.5	-0.5
Peak expiratory flow (PEF)	0.3	0.7	2.1	1.4	0.1	0.1
Pulse wave reflection index	0.3	0.4	0.5	-0.6	0.7	0.4
Glaucoma (self-reported)	0.3	0.3	0.5	-0.3	0.7	-0.6
Forced vital capacity (FVC), Best measure	0.3	1.2	3.4	1.8	0.2	0.2
Exposure to tobacco smoke outside home	0.3	0.3	0.6	-0.6	0.8	-0.0
Angina (self-reported)	0.3	0.4	1.0	0.1	-0.3	1.0
Suffer from ‘nerves’	0.3	0.4	0.9	0.5	0.4	-1.0
Mood swings	0.3	0.5	1.1	-1.0	0.1	-0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.4	0.7	-0.5	-0.8	0.4
Medication for cholesterol	0.3	0.4	0.7	-0.3	0.8	0.7
Smoking status: Current	0.3	0.4	0.8	-0.2	-0.9	-0.6
Commuting to job workplace: Cycle	0.3	0.4	0.8	-0.9	0.5	0.4
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	0.6	0.1	0.8	-0.6
Ulcerative Colitis (UC)	0.2	0.4	0.6	0.7	0.3	0.8
Age at First Birth	0.2	0.3	0.7	0.8	0.3	0.5
Mean Putamen Volume	0.2	0.3	0.7	0.8	0.3	0.1
Ulcerative Colitis	0.2	0.2	0.4	0.6	0.5	-0.3
Blood Eosinophil Count	0.2	1.2	2.8	-1.7	-0.9	-0.1
Medication for hormone replacement therapy	0.2	0.2	0.5	0.1	-0.7	-0.1
Stomach or abdominal pain in last month	0.2	0.2	0.3	0.3	0.4	0.6
Alcohol usually taken with meals	0.2	0.3	0.7	-0.8	-0.3	0.4
Hearing difficulty/problems with background noise	0.2	0.4	0.5	0.5	-0.7	-0.6
Financial difficulties in last 2 years	0.2	0.2	0.3	-0.6	0.1	-0.6
Fluid intelligence score	0.2	0.4	1.1	0.0	-1.1	-0.3
Lung cancer (father)	0.2	0.3	0.6	0.8	-0.5	-0.2
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	0.6	0.8	-0.8	-0.0
Blood clot in the leg (DVT)	0.2	0.2	0.5	-0.1	0.7	0.4
Health satisfaction	0.2	0.2	0.6	-0.8	0.1	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	0.7	0.8	-0.2	-0.6
Basal cell carcinoma (self-reported)	0.2	0.2	0.6	0.0	0.1	-0.7
Neuroticism (Nagel 2018)	0.1	0.3	0.5	0.6	-0.1	-0.7
Schizophrenia vs Biploar Disorder	0.1	0.2	0.2	-0.4	-0.5	0.2
Worry (Nagel 2018)	0.1	0.2	0.4	0.5	0.6	0.2
Verbal and Numeric Reasoning (VNR)	0.1	0.3	0.6	0.8	-0.3	0.4
Fasting Glucose	0.1	0.1	0.1	-0.2	-0.2	-0.4
Neuroticism (2016)	0.1	0.1	0.3	0.0	0.5	-0.3
Rheumatoid Arthritis	0.1	0.1	0.3	0.5	-0.3	0.0
Blood Platelet Count	0.1	0.6	1.2	-1.1	0.6	-0.5
Heel T-Score	0.1	0.6	1.1	-0.1	-0.9	-1.0
Serious illness, injury or assault to yourself	0.1	0.1	0.1	0.3	0.4	-0.3
Medication: Atenolol	0.1	0.1	0.2	-0.2	0.0	0.5
Nervous feelings	0.1	0.3	0.5	0.5	0.7	0.3
Time employed in main current job	0.1	0.1	0.1	0.2	0.4	0.3
Worrier / anxious feelings	0.1	0.2	0.4	0.6	0.0	-0.6
Hair/balding pattern: Pattern 3	0.1	0.2	0.3	0.3	-0.2	-0.6
Asthma	0.1	0.1	0.4	0.3	-0.6	-0.1
Prospective memory result	0.1	0.1	0.3	0.6	0.2	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.2	0.2	0.1	-0.4
Eye problems/disorders: None of the above	0.1	0.1	0.2	-0.1	-0.3	0.5
Emphysema/chronic bronchitis	0.1	0.1	0.2	-0.1	-0.5	0.0
Chest pain or discomfort	0.1	0.1	0.2	0.0	0.4	0.5
Illnesses of father: Heart disease	0.1	0.2	0.4	0.1	0.1	-0.7
Asthma (self-reported)	0.1	0.1	0.2	0.3	-0.5	0.3
Miserableness	0.1	0.2	0.4	0.3	0.6	-0.5
Wears glasses or contact lenses	0.1	0.1	0.1	-0.3	0.2	0.1
Commuting to job workplace: Public transport	0.1	0.2	0.3	-0.1	0.4	0.5
Alcohol drinker status: Never	0.1	0.1	0.3	0.6	-0.1	0.1
Unable to work because of sickness or disability	0.1	0.2	0.4	-0.6	0.1	-0.3
Pain experienced in last month	0.1	0.1	0.2	0.5	0.0	0.4
Depressed Affect (Nagel 2018)	0.0	0.1	0.1	0.2	0.1	-0.3
HDL Cholesterol	0.0	0.1	0.1	0.3	0.3	-0.1
Neuroticism	0.0	0.1	0.3	0.2	0.2	-0.5
Fed-up feelings	0.0	0.0	0.1	0.0	0.0	-0.3
Number of children fathered	0.0	0.0	0.1	-0.0	0.4	-0.0
Knee pain experienced in last month	0.0	0.1	0.1	0.3	-0.2	-0.2
Eye problems/disorders: Cataract	0.0	0.0	0.1	-0.0	-0.3	-0.1
Ever taken oral contraceptive pill	0.0	0.0	0.1	-0.0	0.3	0.2

Hub : Genes

C10orf46

Models

Trait associations