Best TWAS P=1.13e-10 · Best GWAS P=1.51e-59 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Visceral Omentum | LEMD3 | 0.14 | 0.05 | lasso | 8 | 0.05 | 1.1e-03 | -5.3 | -6.2 | 6.1e-10 | 0.12 | 0.36 | 0.25 | FALSE |
| 2 | GTEx | Brain Nucleus accumbens basal ganglia | TMBIM4 | 0.27 | 0.23 | enet | 16 | 0.11 | 8.3e-04 | 4.5 | 5.3 | 1.1e-07 | -0.05 | 0.55 | 0.03 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | LEMD3 | 0.09 | 0.10 | lasso | 3 | 0.09 | 4.4e-07 | -5.2 | -5.3 | 1.4e-07 | 0.11 | 0.97 | 0.00 | FALSE |
| 4 | GTEx | Esophagus Muscularis | LEMD3 | 0.09 | 0.09 | enet | 7 | 0.09 | 4.3e-06 | -5.7 | -5.7 | 1.3e-08 | 0.12 | 0.98 | 0.01 | FALSE |
| 5 | GTEx | Heart Atrial Appendage | LEMD3 | 0.12 | 0.03 | enet | 12 | 0.06 | 7.5e-04 | -5.3 | -6.5 | 1.1e-10 | 0.12 | 0.02 | 0.94 | TRUE |
| 6 | GTEx | Heart Atrial Appendage | RBMS1P1 | 0.17 | 0.03 | lasso | 11 | 0.04 | 7.3e-03 | 8.6 | -6.2 | 5.1e-10 | -0.41 | 0.06 | 0.41 | TRUE |
| 7 | GTEx | Nerve Tibial | LEMD3 | 0.12 | 0.14 | enet | 13 | 0.16 | 2.0e-11 | -5.2 | -6.2 | 5.9e-10 | 0.12 | 0.99 | 0.01 | FALSE |
| 8 | GTEx | Skin Sun Exposed Lower leg | TMBIM4 | 0.16 | 0.13 | lasso | 5 | 0.13 | 9.8e-11 | 4.8 | 5.2 | 1.6e-07 | -0.06 | 1.00 | 0.00 | TRUE |
| 9 | GTEx | Testis | LEMD3 | 0.15 | 0.15 | lasso | 7 | 0.16 | 1.9e-07 | -5.2 | -5.5 | 5.0e-08 | 0.14 | 0.23 | 0.69 | FALSE |
| 10 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | LEMD3 | 0.02 | 0.02 | blup | 36 | 0.02 | 5.9e-03 | -6.1 | -5.8 | 5.4e-09 | 0.13 | 0.01 | 0.79 | FALSE |
| 11 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | LLPH | 0.04 | 0.01 | blup | 74 | 0.01 | 8.3e-03 | 4.3 | 5.3 | 1.4e-07 | -0.07 | 0.08 | 0.40 | TRUE |
| 12 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | TMBIM4 | 0.21 | 0.28 | enet | 22 | 0.28 | 1.3e-31 | 4.5 | -5.4 | 5.6e-08 | 0.04 | 1.00 | 0.00 | FALSE |
| 13 | The Cancer Genome Atlas | Brain Lower Grade Glioma | LLPH | 0.16 | 0.20 | lasso | 7 | 0.20 | 1.8e-22 | 4.5 | 5.2 | 1.5e-07 | -0.05 | 1.00 | 0.00 | TRUE |
| 14 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | LLPH | 0.19 | 0.11 | blup | 74 | 0.12 | 9.2e-06 | 4.8 | 5.2 | 2.5e-07 | -0.04 | 0.60 | 0.27 | FALSE |
| 15 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | LLPH | 0.25 | 0.24 | enet | 9 | 0.25 | 2.3e-10 | 4.8 | 5.7 | 9.4e-09 | -0.05 | 0.69 | 0.31 | FALSE |
| 16 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | TMBIM4 | 0.09 | 0.05 | lasso | 2 | 0.06 | 4.6e-03 | 4.5 | -6.2 | 6.7e-10 | 0.06 | 0.02 | 0.51 | FALSE |
| 17 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | LLPH | 0.12 | 0.12 | enet | 13 | 0.09 | 1.7e-03 | 4.5 | 5.2 | 2.2e-07 | -0.05 | 0.10 | 0.28 | FALSE |