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chr12:69,045,442-70,671,423

Best TWAS P=3.72e-20 · Best GWAS P=2.99e-23 conditioned to 0.0225

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	LYZ	0.15	0.08	lasso	3	0.09	5.4e-08	-5.5	-5.7	1.6e-08	-0.06	1.00	0.00	FALSE
2	GTEx	Adipose Subcutaneous	YEATS4	0.32	0.28	enet	17	0.30	1.0e-24	5.5	-6.1	1.4e-09	-0.06	1.00	0.00	FALSE
3	GTEx	Adipose Subcutaneous	RP11-1143G9.4	0.12	0.04	lasso	4	0.04	5.0e-04	-5.5	-5.5	3.2e-08	-0.03	0.81	0.01	FALSE
4	GTEx	Adipose Visceral Omentum	LYZ	0.17	0.12	enet	12	0.12	5.2e-07	5.2	-5.5	4.1e-08	-0.11	0.98	0.00	FALSE
5	GTEx	Adipose Visceral Omentum	YEATS4	0.32	0.30	lasso	3	0.29	2.7e-15	5.5	-5.5	3.1e-08	-0.10	1.00	0.00	FALSE
6	GTEx	Adipose Visceral Omentum	RP11-1143G9.4	0.16	0.13	enet	10	0.13	2.3e-07	5.2	-5.7	1.2e-08	-0.15	0.99	0.00	FALSE
7	GTEx	Adrenal Gland	LYZ	0.24	0.22	enet	14	0.23	6.9e-09	5.1	-5.7	1.0e-08	-0.17	0.97	0.00	FALSE
8	GTEx	Adrenal Gland	RP11-1143G9.4	0.18	0.15	enet	11	0.17	8.5e-07	5.5	-5.4	6.1e-08	-0.15	0.88	0.01	FALSE
9	GTEx	Brain Cortex	YEATS4	0.22	0.11	enet	18	0.09	1.8e-03	6.4	-6.8	1.2e-11	-0.08	0.36	0.05	TRUE
10	GTEx	Brain Hypothalamus	YEATS4	0.21	0.00	enet	21	0.03	6.1e-02	-1.6	-5.2	1.9e-07	-0.23	0.08	0.06	FALSE
11	GTEx	Brain Nucleus accumbens basal ganglia	YEATS4	0.29	0.25	enet	8	0.17	2.6e-05	5.5	-5.4	5.7e-08	-0.07	0.42	0.03	FALSE
12	GTEx	Breast Mammary Tissue	YEATS4	0.44	0.30	lasso	9	0.29	2.9e-15	5.5	-5.1	3.0e-07	-0.08	1.00	0.00	FALSE
13	GTEx	Breast Mammary Tissue (Male)	YEATS4	0.25	0.20	lasso	6	0.13	6.1e-04	5.2	-5.2	2.5e-07	-0.17	0.10	0.27	FALSE
14	GTEx	Cells EBV-transformed lymphocytes	YEATS4	0.47	0.43	lasso	6	0.43	1.8e-15	5.2	5.1	3.0e-07	0.17	1.00	0.00	FALSE
15	GTEx	Colon Sigmoid	YEATS4	0.20	0.26	lasso	2	0.25	2.2e-09	5.5	-5.5	3.1e-08	-0.11	0.95	0.00	FALSE
16	GTEx	Colon Transverse	YEATS4	0.17	0.06	enet	11	0.10	1.2e-05	5.7	-5.4	6.1e-08	0.01	0.67	0.02	FALSE
17	GTEx	Heart Atrial Appendage	LYZ	0.20	0.20	enet	17	0.16	1.7e-07	5.7	-6.4	1.2e-10	-0.11	0.98	0.00	FALSE
18	GTEx	Heart Atrial Appendage	YEATS4	0.28	0.19	lasso	4	0.20	3.7e-09	5.5	-5.3	1.1e-07	-0.05	0.95	0.00	FALSE
19	GTEx	Heart Atrial Appendage	RP11-1143G9.4	0.14	0.08	enet	12	0.00	3.9e-01	5.7	-6.1	1.2e-09	-0.09	0.67	0.02	FALSE
20	GTEx	Heart Left Ventricle	YEATS4	0.21	0.18	enet	9	0.11	1.8e-06	-5.5	-5.8	6.1e-09	-0.08	1.00	0.00	FALSE
21	GTEx	Lung	LYZ	0.30	0.25	enet	22	0.27	1.1e-20	5.2	-5.5	3.3e-08	-0.15	1.00	0.00	FALSE
22	GTEx	Lung	YEATS4	0.13	0.18	lasso	6	0.16	1.1e-12	5.5	-5.8	9.1e-09	-0.11	1.00	0.00	FALSE
23	GTEx	Lung	RP11-1143G9.4	0.30	0.24	enet	23	0.27	1.5e-20	5.5	-5.2	2.1e-07	-0.15	1.00	0.00	FALSE
24	GTEx	Muscle Skeletal	YEATS4	0.24	0.25	lasso	6	0.24	8.3e-24	5.5	-5.6	2.8e-08	-0.10	1.00	0.00	FALSE
25	GTEx	Ovary	YEATS4	0.28	0.21	lasso	3	0.14	2.9e-04	5.5	-5.5	4.5e-08	-0.08	0.13	0.05	FALSE
26	GTEx	Skin Not Sun Exposed Suprapubic	YEATS4	0.36	0.37	lasso	3	0.37	3.9e-21	5.5	-5.5	4.8e-08	-0.09	1.00	0.00	FALSE
27	GTEx	Skin Sun Exposed Lower leg	LYZ	0.09	0.10	enet	13	0.10	8.0e-09	5.5	-6.8	1.5e-11	-0.17	1.00	0.00	FALSE
28	GTEx	Skin Sun Exposed Lower leg	YEATS4	0.30	0.32	enet	19	0.31	6.6e-26	5.5	-5.7	1.4e-08	-0.14	1.00	0.00	FALSE
29	GTEx	Skin Sun Exposed Lower leg	RP11-1143G9.4	0.08	0.07	lasso	5	0.07	2.1e-06	5.5	-6.1	1.1e-09	-0.11	0.99	0.00	FALSE
30	GTEx	Spleen	LYZ	0.30	0.14	enet	25	0.09	2.5e-03	5.2	-6.3	2.4e-10	-0.13	0.36	0.04	FALSE
31	GTEx	Spleen	RP11-1143G9.4	0.29	0.09	lasso	11	0.09	2.9e-03	5.2	-6.5	7.2e-11	-0.15	0.32	0.04	FALSE
32	GTEx	Stomach	YEATS4	0.19	0.16	lasso	8	0.12	2.7e-06	5.5	-5.5	3.0e-08	-0.02	0.85	0.02	FALSE
33	GTEx	Thyroid	LYZ	0.09	0.01	enet	12	0.03	1.9e-03	5.7	-6.3	2.4e-10	-0.04	0.70	0.01	FALSE
34	GTEx	Thyroid	YEATS4	0.32	0.37	lasso	4	0.37	1.0e-29	5.5	-5.5	3.9e-08	-0.08	1.00	0.00	FALSE
35	GTEx	Thyroid	FRS2	0.30	0.16	lasso	6	0.17	8.8e-13	9.9	9.2	3.7e-20	0.93	0.00	1.00	TRUE
36	GTEx	Thyroid	RP11-1143G9.4	0.08	0.04	enet	9	0.02	6.8e-03	5.7	-6.5	7.8e-11	-0.07	0.79	0.01	FALSE
37	GTEx	Vagina	YEATS4	0.45	0.13	lasso	6	0.18	8.2e-05	5.5	-5.2	1.5e-07	-0.14	0.19	0.09	FALSE
38	GTEx	Whole Blood	LYZ	0.18	0.12	enet	17	0.13	6.0e-12	-5.5	-6.2	7.7e-10	-0.11	1.00	0.00	FALSE
39	GTEx	Whole Blood	RP11-1143G9.4	0.15	0.08	enet	18	0.08	1.2e-07	-5.5	-6.1	1.3e-09	-0.10	1.00	0.00	FALSE
40	METSIM	Adipose	LYZ	0.06	0.06	enet	9	0.07	2.5e-10	6.2	-6.1	1.1e-09	-0.17	1.00	0.00	FALSE
41	METSIM	Adipose	YEATS4	0.24	0.29	lasso	2	0.28	8.4e-42	5.5	-5.5	3.1e-08	-0.10	1.00	0.00	FALSE
42	NTR	Blood	LYZ	0.19	0.22	lasso	6	0.26	2.6e-83	5.5	-5.9	3.7e-09	-0.07	1.00	0.00	FALSE
43	YFS	Blood	LYZ	0.57	0.68	enet	49	0.73	0.0e+00	5.7	-5.9	3.6e-09	-0.11	1.00	0.00	FALSE
44	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	LYZ	0.06	0.03	blup	42	0.05	6.9e-05	5.6	-6.4	1.5e-10	-0.09	0.04	0.96	FALSE
45	The Cancer Genome Atlas	Breast Invasive Carcinoma	LYZ	0.08	0.12	enet	7	0.14	1.4e-27	-5.5	-6.2	6.0e-10	-0.10	0.00	1.00	FALSE
46	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	YEATS4	0.11	0.02	blup	74	0.03	9.0e-03	5.2	5.3	1.1e-07	0.18	0.09	0.03	FALSE
47	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CPSF6	0.05	0.03	lasso	4	0.03	3.0e-04	-6.1	6.3	3.7e-10	0.12	0.03	0.96	FALSE
48	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	LYZ	0.08	0.10	enet	9	0.12	1.4e-13	6.4	-5.9	2.9e-09	-0.09	0.00	1.00	FALSE
49	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	LYZ	0.13	0.16	enet	8	0.17	2.6e-18	-5.5	-6.2	7.9e-10	-0.13	0.07	0.93	FALSE
50	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	YEATS4	0.26	0.18	enet	17	0.29	4.9e-33	5.7	-5.3	1.3e-07	0.04	1.00	0.00	FALSE
51	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	LYZ	0.17	0.22	lasso	7	0.25	1.6e-14	-5.5	-5.8	8.8e-09	-0.08	0.09	0.91	FALSE
52	The Cancer Genome Atlas	Brain Lower Grade Glioma	LYZ	0.06	0.06	enet	6	0.06	7.5e-08	-5.5	-5.9	4.5e-09	-0.13	0.10	0.90	FALSE
53	The Cancer Genome Atlas	Lung Adenocarcinoma	LYZ	0.12	0.10	lasso	2	0.10	9.5e-12	5.6	-5.2	2.1e-07	-0.12	0.23	0.77	FALSE
54	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	LYZ	0.10	0.08	enet	8	0.10	2.4e-11	6.4	-6.3	3.0e-10	-0.13	0.00	1.00	FALSE
55	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	LYZ	0.19	0.16	enet	10	0.18	4.5e-12	5.2	-5.5	4.7e-08	-0.15	0.06	0.94	FALSE
56	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	LYZ	0.29	0.14	lasso	6	0.26	6.8e-11	6.4	-6.2	4.0e-10	-0.14	0.00	1.00	FALSE
57	The Cancer Genome Atlas	Prostate Adenocarcinoma	LYZ	0.09	0.12	enet	9	0.14	3.9e-14	5.7	-5.8	7.4e-09	-0.14	0.14	0.86	FALSE
58	The Cancer Genome Atlas	Soft Tissue Sarcoma	LYZ	0.06	0.02	blup	43	0.03	7.4e-03	-5.5	-5.8	5.7e-09	-0.07	0.01	0.80	FALSE
59	The Cancer Genome Atlas	Stomach Adenocarcinoma	LYZ	0.07	0.07	enet	6	0.08	4.1e-06	5.7	-5.7	9.6e-09	-0.10	0.10	0.83	FALSE
60	The Cancer Genome Atlas	Testicular Germ Cell Tumors	LYZ	0.17	0.17	lasso	4	0.19	2.2e-07	5.7	-6.1	9.4e-10	-0.08	0.01	0.99	FALSE
61	The Cancer Genome Atlas	Thyroid Carcinoma	LYZ	0.05	0.05	lasso	2	0.05	2.1e-05	6.4	-6.3	2.2e-10	-0.11	0.00	1.00	FALSE
62	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	LYZ	0.16	0.12	enet	13	0.13	2.3e-04	5.5	-5.4	6.0e-08	-0.13	0.02	0.93	FALSE