Best TWAS P=7.54e-16 · Best GWAS P=3.96e-23 conditioned to 6.28e-24
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | GNPTAB | 0.08 | 0.02 | enet | 13 | 0.03 | 8.2e-04 | 3.2 | -5.2 | 2.1e-07 | -0.01 | 0.20 | 0.03 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | DRAM1 | 0.12 | 0.01 | lasso | 3 | 0.00 | 3.5e-01 | -3.1 | 5.2 | 1.6e-07 | 0.01 | 0.05 | 0.05 | FALSE |
| 3 | GTEx | Esophagus Gastroesophageal Junction | CHPT1 | 0.17 | 0.16 | enet | 24 | 0.15 | 5.7e-06 | 4.9 | -5.2 | 1.7e-07 | 0.02 | 0.38 | 0.03 | FALSE |
| 4 | GTEx | Lung | CCDC53 | 0.12 | 0.10 | lasso | 3 | 0.11 | 6.8e-09 | 4.6 | -5.4 | 8.5e-08 | -0.08 | 1.00 | 0.00 | TRUE |
| 5 | GTEx | Prostate | DRAM1 | 0.57 | 0.08 | lasso | 20 | 0.00 | 2.7e-01 | 1.8 | 5.4 | 5.9e-08 | 0.00 | 0.06 | 0.05 | FALSE |
| 6 | METSIM | Adipose | DRAM1 | 0.12 | 0.03 | enet | 24 | 0.08 | 1.1e-12 | 4.7 | 6.4 | 1.2e-10 | -0.05 | 1.00 | 0.00 | FALSE |
| 7 | YFS | Blood | DRAM1 | 0.33 | 0.13 | enet | 101 | 0.19 | 1.6e-58 | 6.5 | 8.1 | 7.5e-16 | -0.04 | 1.00 | 0.00 | TRUE |
| 8 | YFS | Blood | GNPTAB | 0.03 | 0.02 | lasso | 2 | 0.02 | 2.5e-06 | 4.1 | -5.7 | 1.2e-08 | 0.07 | 0.82 | 0.00 | FALSE |