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chr14:24,098,631-25,605,046

Best TWAS P=4.22e-10 · Best GWAS P=2.55e-10 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	KHNYN	0.30	0.14	lasso	2	0.14	7.1e-12	5.6	5.9	2.8e-09	0.18	0.11	0.89	TRUE
2	GTEx	Adipose Subcutaneous	CBLN3	0.65	0.39	lasso	23	0.37	6.1e-32	5.6	-5.5	5.0e-08	-0.18	0.10	0.90	FALSE
3	GTEx	Adipose Visceral Omentum	KHNYN	0.19	0.00	lasso	2	0.00	3.0e-01	5.4	5.2	2.5e-07	0.22	0.05	0.08	FALSE
4	GTEx	Artery Aorta	KHNYN	0.19	0.20	lasso	4	0.20	1.8e-11	4.9	5.5	5.0e-08	0.16	0.38	0.62	FALSE
5	GTEx	Artery Aorta	CBLN3	0.55	0.41	lasso	8	0.40	9.5e-24	5.6	-5.3	1.2e-07	-0.18	0.10	0.90	FALSE
6	GTEx	Artery Coronary	CBLN3	0.52	0.20	lasso	7	0.24	9.7e-09	5.6	-5.1	3.1e-07	-0.20	0.10	0.90	FALSE
7	GTEx	Artery Tibial	KHNYN	0.38	0.12	lasso	5	0.18	8.8e-14	5.4	5.7	1.3e-08	0.19	0.18	0.82	FALSE
8	GTEx	Breast Mammary Tissue (Female)	CBLN3	0.42	0.20	lasso	4	0.28	5.9e-09	5.6	-5.7	1.1e-08	-0.17	0.11	0.87	FALSE
9	GTEx	Cells Transformed fibroblasts	CBLN3	0.58	0.42	lasso	7	0.42	5.2e-34	5.6	-5.3	1.4e-07	-0.17	0.10	0.90	FALSE
10	GTEx	Esophagus Mucosa	CBLN3	0.50	0.25	lasso	7	0.25	1.7e-16	5.6	-5.2	1.8e-07	-0.17	0.10	0.90	FALSE
11	GTEx	Esophagus Muscularis	CBLN3	0.62	0.33	enet	23	0.36	1.8e-22	5.6	-5.4	5.9e-08	-0.21	0.10	0.90	FALSE
12	GTEx	Heart Atrial Appendage	ADCY4	0.28	0.14	lasso	4	0.10	2.1e-05	5.6	5.1	3.0e-07	0.36	0.09	0.79	FALSE
13	GTEx	Heart Atrial Appendage	CBLN3	0.58	0.40	lasso	5	0.38	2.3e-18	5.6	-5.5	4.9e-08	-0.17	0.11	0.89	FALSE
14	GTEx	Heart Left Ventricle	CBLN3	0.35	0.23	lasso	8	0.21	1.5e-11	5.6	-5.8	7.3e-09	-0.21	0.11	0.89	TRUE
15	GTEx	Lung	KHNYN	0.14	0.08	lasso	5	0.05	9.7e-05	5.4	5.7	1.2e-08	0.17	0.19	0.72	FALSE
16	GTEx	Muscle Skeletal	CBLN3	0.14	0.13	enet	7	0.13	4.8e-13	5.5	-5.9	3.6e-09	-0.19	0.11	0.89	FALSE
17	GTEx	Nerve Tibial	KHNYN	0.34	0.10	lasso	8	0.15	1.6e-10	5.4	5.7	9.9e-09	0.17	0.14	0.86	FALSE
18	GTEx	Ovary	CBLN3	0.62	0.38	lasso	19	0.39	1.2e-10	5.6	-5.7	1.6e-08	-0.17	0.10	0.90	FALSE
19	GTEx	Skin Not Sun Exposed Suprapubic	CBLN3	0.41	0.34	lasso	2	0.30	3.4e-17	5.6	-5.3	1.0e-07	-0.18	0.10	0.90	FALSE
20	GTEx	Thyroid	ADCY4	0.13	0.13	lasso	6	0.09	1.0e-07	4.4	5.3	1.4e-07	0.60	0.45	0.55	TRUE
21	GTEx	Whole Blood	KHNYN	0.17	0.15	lasso	1	0.14	2.1e-12	5.4	5.4	6.8e-08	0.14	0.26	0.74	FALSE
22	METSIM	Adipose	ADCY4	0.07	0.03	lasso	5	0.03	2.2e-05	5.7	6.2	4.2e-10	0.66	0.07	0.93	TRUE
23	METSIM	Adipose	CBLN3	0.34	0.30	enet	6	0.31	1.3e-47	5.6	-5.3	1.3e-07	-0.17	0.10	0.90	FALSE
24	METSIM	Adipose	KHNYN	0.04	0.04	lasso	1	0.03	2.2e-05	5.4	5.4	6.8e-08	0.14	0.20	0.63	FALSE
25	NTR	Blood	CBLN3	0.06	0.04	lasso	3	0.04	2.1e-13	5.6	-5.6	1.7e-08	-0.17	0.10	0.90	FALSE
26	YFS	Blood	KHNYN	0.36	0.20	enet	50	0.29	1.2e-96	4.9	5.7	9.4e-09	0.20	0.55	0.45	TRUE
27	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	CBLN3	0.34	0.15	lasso	5	0.14	2.4e-07	5.6	-5.5	2.9e-08	-0.24	0.01	0.99	FALSE
28	The Cancer Genome Atlas	Colon Adenocarcinoma	CBLN3	0.24	0.14	enet	8	0.13	4.0e-08	5.6	-5.7	1.2e-08	-0.19	0.01	0.99	FALSE
29	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CBLN3	0.18	0.14	lasso	3	0.14	1.2e-15	5.5	-5.3	1.2e-07	-0.18	0.01	0.99	FALSE
30	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CBLN3	0.33	0.33	enet	13	0.35	2.3e-40	5.6	-5.2	1.7e-07	-0.19	0.01	0.99	FALSE
31	The Cancer Genome Atlas	Brain Lower Grade Glioma	ADCY4	0.06	0.06	lasso	6	0.09	3.0e-10	5.6	6.1	1.2e-09	0.71	0.08	0.92	FALSE
32	The Cancer Genome Atlas	Lung Adenocarcinoma	ADCY4	0.07	0.09	lasso	3	0.08	4.4e-10	4.1	5.3	1.1e-07	0.61	0.81	0.19	TRUE
33	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	CBLN3	0.20	0.11	lasso	3	0.11	5.1e-08	5.6	-5.6	2.7e-08	-0.20	0.01	0.99	FALSE
34	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	CBLN3	0.37	0.35	lasso	4	0.34	4.4e-15	5.6	-5.4	6.3e-08	-0.18	0.01	0.99	FALSE
35	The Cancer Genome Atlas	Prostate Adenocarcinoma	CBLN3	0.38	0.30	lasso	9	0.30	2.7e-32	5.6	-5.5	4.7e-08	-0.19	0.01	0.99	FALSE
36	The Cancer Genome Atlas	Soft Tissue Sarcoma	CBLN3	0.22	0.18	lasso	3	0.17	2.2e-10	5.6	-5.5	3.0e-08	-0.18	0.01	0.99	FALSE
37	The Cancer Genome Atlas	Stomach Adenocarcinoma	CBLN3	0.30	0.26	lasso	1	0.24	1.4e-17	5.5	-5.5	3.4e-08	-0.18	0.01	0.99	FALSE
38	The Cancer Genome Atlas	Stomach Adenocarcinoma	LTB4R2	0.04	0.04	lasso	1	0.02	2.5e-02	5.3	-5.3	1.5e-07	-0.77	0.01	0.81	FALSE