[Hub]/) : Traits : Sitting height :

chr14:24,098,631-25,605,046

Best TWAS P=4.22e-10 · Best GWAS P=2.55e-10 conditioned to NaN

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous KHNYN 0.30 0.14 lasso 2 0.14 7.1e-12 5.6 5.9 2.8e-09 0.18 0.11 0.89 TRUE
2 GTEx Adipose Subcutaneous CBLN3 0.65 0.39 lasso 23 0.37 6.1e-32 5.6 -5.5 5.0e-08 -0.18 0.10 0.90 FALSE
3 GTEx Adipose Visceral Omentum KHNYN 0.19 0.00 lasso 2 0.00 3.0e-01 5.4 5.2 2.5e-07 0.22 0.05 0.08 FALSE
4 GTEx Artery Aorta KHNYN 0.19 0.20 lasso 4 0.20 1.8e-11 4.9 5.5 5.0e-08 0.16 0.38 0.62 FALSE
5 GTEx Artery Aorta CBLN3 0.55 0.41 lasso 8 0.40 9.5e-24 5.6 -5.3 1.2e-07 -0.18 0.10 0.90 FALSE
6 GTEx Artery Coronary CBLN3 0.52 0.20 lasso 7 0.24 9.7e-09 5.6 -5.1 3.1e-07 -0.20 0.10 0.90 FALSE
7 GTEx Artery Tibial KHNYN 0.38 0.12 lasso 5 0.18 8.8e-14 5.4 5.7 1.3e-08 0.19 0.18 0.82 FALSE
8 GTEx Breast Mammary Tissue (Female) CBLN3 0.42 0.20 lasso 4 0.28 5.9e-09 5.6 -5.7 1.1e-08 -0.17 0.11 0.87 FALSE
9 GTEx Cells Transformed fibroblasts CBLN3 0.58 0.42 lasso 7 0.42 5.2e-34 5.6 -5.3 1.4e-07 -0.17 0.10 0.90 FALSE
10 GTEx Esophagus Mucosa CBLN3 0.50 0.25 lasso 7 0.25 1.7e-16 5.6 -5.2 1.8e-07 -0.17 0.10 0.90 FALSE
11 GTEx Esophagus Muscularis CBLN3 0.62 0.33 enet 23 0.36 1.8e-22 5.6 -5.4 5.9e-08 -0.21 0.10 0.90 FALSE
12 GTEx Heart Atrial Appendage ADCY4 0.28 0.14 lasso 4 0.10 2.1e-05 5.6 5.1 3.0e-07 0.36 0.09 0.79 FALSE
13 GTEx Heart Atrial Appendage CBLN3 0.58 0.40 lasso 5 0.38 2.3e-18 5.6 -5.5 4.9e-08 -0.17 0.11 0.89 FALSE
14 GTEx Heart Left Ventricle CBLN3 0.35 0.23 lasso 8 0.21 1.5e-11 5.6 -5.8 7.3e-09 -0.21 0.11 0.89 TRUE
15 GTEx Lung KHNYN 0.14 0.08 lasso 5 0.05 9.7e-05 5.4 5.7 1.2e-08 0.17 0.19 0.72 FALSE
16 GTEx Muscle Skeletal CBLN3 0.14 0.13 enet 7 0.13 4.8e-13 5.5 -5.9 3.6e-09 -0.19 0.11 0.89 FALSE
17 GTEx Nerve Tibial KHNYN 0.34 0.10 lasso 8 0.15 1.6e-10 5.4 5.7 9.9e-09 0.17 0.14 0.86 FALSE
18 GTEx Ovary CBLN3 0.62 0.38 lasso 19 0.39 1.2e-10 5.6 -5.7 1.6e-08 -0.17 0.10 0.90 FALSE
19 GTEx Skin Not Sun Exposed Suprapubic CBLN3 0.41 0.34 lasso 2 0.30 3.4e-17 5.6 -5.3 1.0e-07 -0.18 0.10 0.90 FALSE
20 GTEx Thyroid ADCY4 0.13 0.13 lasso 6 0.09 1.0e-07 4.4 5.3 1.4e-07 0.60 0.45 0.55 TRUE
21 GTEx Whole Blood KHNYN 0.17 0.15 lasso 1 0.14 2.1e-12 5.4 5.4 6.8e-08 0.14 0.26 0.74 FALSE
22 METSIM Adipose ADCY4 0.07 0.03 lasso 5 0.03 2.2e-05 5.7 6.2 4.2e-10 0.66 0.07 0.93 TRUE
23 METSIM Adipose CBLN3 0.34 0.30 enet 6 0.31 1.3e-47 5.6 -5.3 1.3e-07 -0.17 0.10 0.90 FALSE
24 METSIM Adipose KHNYN 0.04 0.04 lasso 1 0.03 2.2e-05 5.4 5.4 6.8e-08 0.14 0.20 0.63 FALSE
25 NTR Blood CBLN3 0.06 0.04 lasso 3 0.04 2.1e-13 5.6 -5.6 1.7e-08 -0.17 0.10 0.90 FALSE
26 YFS Blood KHNYN 0.36 0.20 enet 50 0.29 1.2e-96 4.9 5.7 9.4e-09 0.20 0.55 0.45 TRUE
27 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma CBLN3 0.34 0.15 lasso 5 0.14 2.4e-07 5.6 -5.5 2.9e-08 -0.24 0.01 0.99 FALSE
28 The Cancer Genome Atlas Colon Adenocarcinoma CBLN3 0.24 0.14 enet 8 0.13 4.0e-08 5.6 -5.7 1.2e-08 -0.19 0.01 0.99 FALSE
29 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma CBLN3 0.18 0.14 lasso 3 0.14 1.2e-15 5.5 -5.3 1.2e-07 -0.18 0.01 0.99 FALSE
30 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma CBLN3 0.33 0.33 enet 13 0.35 2.3e-40 5.6 -5.2 1.7e-07 -0.19 0.01 0.99 FALSE
31 The Cancer Genome Atlas Brain Lower Grade Glioma ADCY4 0.06 0.06 lasso 6 0.09 3.0e-10 5.6 6.1 1.2e-09 0.71 0.08 0.92 FALSE
32 The Cancer Genome Atlas Lung Adenocarcinoma ADCY4 0.07 0.09 lasso 3 0.08 4.4e-10 4.1 5.3 1.1e-07 0.61 0.81 0.19 TRUE
33 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma CBLN3 0.20 0.11 lasso 3 0.11 5.1e-08 5.6 -5.6 2.7e-08 -0.20 0.01 0.99 FALSE
34 The Cancer Genome Atlas Pancreatic Adenocarcinoma CBLN3 0.37 0.35 lasso 4 0.34 4.4e-15 5.6 -5.4 6.3e-08 -0.18 0.01 0.99 FALSE
35 The Cancer Genome Atlas Prostate Adenocarcinoma CBLN3 0.38 0.30 lasso 9 0.30 2.7e-32 5.6 -5.5 4.7e-08 -0.19 0.01 0.99 FALSE
36 The Cancer Genome Atlas Soft Tissue Sarcoma CBLN3 0.22 0.18 lasso 3 0.17 2.2e-10 5.6 -5.5 3.0e-08 -0.18 0.01 0.99 FALSE
37 The Cancer Genome Atlas Stomach Adenocarcinoma CBLN3 0.30 0.26 lasso 1 0.24 1.4e-17 5.5 -5.5 3.4e-08 -0.18 0.01 0.99 FALSE
38 The Cancer Genome Atlas Stomach Adenocarcinoma LTB4R2 0.04 0.04 lasso 1 0.02 2.5e-02 5.3 -5.3 1.5e-07 -0.77 0.01 0.81 FALSE