Best TWAS P=5.94e-21 · Best GWAS P=2.63e-20 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | MAX | 0.15 | 0.16 | lasso | 2 | 0.16 | 1.2e-18 | -7.8 | 7.7 | 1.1e-14 | -0.80 | 0.98 | 0.02 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | RAB15 | 0.64 | 0.08 | enet | 41 | 0.33 | 1.3e-25 | -3.7 | -5.2 | 2.4e-07 | 0.45 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Esophagus Muscularis | RAB15 | 0.35 | 0.06 | enet | 23 | 0.17 | 1.2e-10 | -3.7 | -6.0 | 1.7e-09 | 0.50 | 1.00 | 0.00 | FALSE |
| 4 | GTEx | Muscle Skeletal | FNTB | 0.05 | 0.02 | lasso | 6 | 0.01 | 5.8e-02 | -7.7 | 7.8 | 6.4e-15 | -0.75 | 0.12 | 0.75 | FALSE |
| 5 | GTEx | Pituitary | RAB15 | 0.32 | 0.03 | enet | 16 | 0.10 | 1.9e-03 | -7.4 | -6.6 | 5.3e-11 | 0.70 | 0.05 | 0.82 | FALSE |
| 6 | METSIM | Adipose | RAB15 | 0.10 | 0.04 | enet | 22 | 0.08 | 3.8e-12 | -5.8 | -6.5 | 8.6e-11 | 0.51 | 1.00 | 0.00 | FALSE |
| 7 | YFS | Blood | MAX | 0.04 | 0.02 | lasso | 4 | 0.02 | 2.8e-06 | -9.2 | 9.4 | 5.9e-21 | -0.99 | 0.00 | 1.00 | TRUE |
| 8 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | FNTB | 0.10 | 0.03 | blup | 107 | 0.07 | 7.9e-07 | -2.5 | 5.3 | 9.3e-08 | -0.46 | 0.68 | 0.21 | FALSE |
| 9 | The Cancer Genome Atlas | Breast Invasive Carcinoma | FNTB | 0.02 | 0.03 | enet | 8 | 0.03 | 2.0e-07 | -5.1 | 5.2 | 2.2e-07 | -0.54 | 0.94 | 0.04 | FALSE |
| 10 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RAB15 | 0.02 | 0.01 | blup | 49 | 0.02 | 6.7e-05 | -4.7 | -7.1 | 1.3e-12 | 0.56 | 0.09 | 0.84 | FALSE |
| 11 | The Cancer Genome Atlas | Esophageal Carcinoma | FNTB | 0.09 | 0.05 | lasso | 3 | 0.04 | 2.6e-02 | -6.1 | 5.5 | 4.5e-08 | -0.47 | 0.05 | 0.29 | FALSE |
| 12 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | RAB15 | 0.03 | 0.00 | blup | 49 | 0.01 | 1.8e-02 | -7.6 | -6.2 | 7.5e-10 | 0.57 | 0.01 | 0.93 | FALSE |
| 13 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | RAB15 | 0.14 | 0.07 | enet | 15 | 0.09 | 5.5e-10 | -7.6 | -6.7 | 1.6e-11 | 0.55 | 0.00 | 1.00 | FALSE |
| 14 | The Cancer Genome Atlas | Brain Lower Grade Glioma | RAB15 | 0.04 | 0.05 | blup | 49 | 0.06 | 2.5e-07 | -4.7 | -5.8 | 5.3e-09 | 0.53 | 0.35 | 0.63 | FALSE |
| 15 | The Cancer Genome Atlas | Lung Adenocarcinoma | RAB15 | 0.04 | 0.01 | enet | 5 | 0.03 | 1.9e-04 | -6.6 | -5.4 | 6.8e-08 | 0.56 | 0.04 | 0.80 | FALSE |
| 16 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | RAB15 | 0.11 | 0.01 | enet | 12 | 0.06 | 1.1e-04 | -5.3 | -7.1 | 1.2e-12 | 0.50 | 0.02 | 0.89 | FALSE |
| 17 | The Cancer Genome Atlas | Prostate Adenocarcinoma | RAB15 | 0.04 | 0.00 | blup | 49 | 0.01 | 6.9e-02 | -7.6 | -7.3 | 2.2e-13 | 0.57 | 0.00 | 0.96 | FALSE |
| 18 | The Cancer Genome Atlas | Thyroid Carcinoma | FNTB | 0.14 | 0.06 | enet | 18 | 0.14 | 1.4e-13 | -2.4 | 6.8 | 1.4e-11 | -0.64 | 0.30 | 0.70 | FALSE |