Best TWAS P=8.04e-14 · Best GWAS P=3.39e-13 conditioned to 0.0116
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Testis | CRTAP | 0.16 | 0.04 | lasso | 4 | 0.11 | 1.7e-05 | -3.5 | -5.3 | 1.1e-07 | 0.47 | 0.06 | 0.89 | FALSE |
| 2 | GTEx | Thyroid | CRTAP | 0.23 | 0.10 | enet | 26 | 0.16 | 1.9e-12 | -4.9 | -7.5 | 8.0e-14 | 0.75 | 0.01 | 0.99 | TRUE |
| 3 | GTEx | Thyroid | RP11-627J17.1 | 0.29 | 0.08 | enet | 22 | 0.11 | 5.0e-09 | -5.3 | -6.7 | 2.3e-11 | 0.56 | 0.90 | 0.08 | FALSE |
| 4 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CRTAP | 0.02 | 0.01 | blup | 55 | 0.01 | 1.4e-03 | -6.6 | -7.1 | 1.7e-12 | 0.78 | 0.03 | 0.56 | FALSE |
| 5 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | GLB1 | 0.05 | 0.03 | blup | 83 | 0.03 | 2.3e-04 | -5.5 | 5.7 | 1.3e-08 | -0.39 | 0.19 | 0.42 | FALSE |
| 6 | The Cancer Genome Atlas | Brain Lower Grade Glioma | GLB1 | 0.03 | 0.00 | blup | 84 | 0.02 | 4.9e-03 | -4.1 | 5.9 | 4.7e-09 | -0.20 | 0.09 | 0.08 | FALSE |
| 7 | The Cancer Genome Atlas | Thyroid Carcinoma | CRTAP | 0.07 | 0.03 | blup | 55 | 0.04 | 4.3e-05 | -7.3 | -7.3 | 3.0e-13 | 0.82 | 0.00 | 1.00 | FALSE |