Hub : Genes

GLB1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0600	0.0230	1.2e-03	0.019	0.025	0.031	0.025	0.028	2.1e-03	4.6e-04	9.1e-05	4.4e-04	1.9e-04
2	GTEx	Cells Transformed fibroblasts	0.1790	0.0540	2.5e-04	0.001	NA	0.050	NA	0.013	2.6e-01	NA	1.2e-04	NA	3.3e-02
3	GTEx	Muscle Skeletal	0.0913	0.0326	1.1e-03	0.021	NA	0.015	NA	0.019	3.3e-03	NA	1.1e-02	NA	4.9e-03
4	GTEx	Thyroid	0.3000	0.0650	6.6e-07	0.205	NA	0.210	NA	0.199	1.3e-15	NA	5.1e-16	NA	3.6e-15
5	METSIM	Adipose	0.0454	0.0201	7.1e-03	0.009	0.001	0.001	0.001	0.006	1.4e-02	2.1e-01	2.3e-01	2.0e-01	3.5e-02
6	ROSMAP	Brain Pre-frontal Cortex	0.2392	0.0535	7.4e-09	0.092	0.048	0.073	0.073	0.082	7.4e-12	6.9e-07	1.1e-09	1.1e-09	1.1e-10
7	YFS	Blood	0.0546	0.0185	5.3e-04	0.007	0.008	0.016	0.015	0.015	1.9e-03	8.3e-04	5.2e-06	9.7e-06	8.0e-06
8	TCGA	Breast Invasive Carcinoma	0.0448	0.0164	2.0e-08	0.031	0.038	0.046	NA	0.047	4.0e-07	2.1e-08	1.0e-09	NA	5.0e-10
9	TCGA	Head and Neck Squamous Cell Carcinoma	0.0547	0.0286	5.3e-04	0.031	0.030	0.006	NA	0.019	1.9e-04	2.3e-04	5.8e-02	NA	2.7e-03
10	TCGA	Brain Lower Grade Glioma	0.0329	0.0161	2.2e-03	0.004	0.016	0.003	NA	0.008	1.1e-01	4.9e-03	1.2e-01	NA	3.4e-02
11	TCGA	Pancreatic Adenocarcinoma	0.1110	0.0490	7.4e-04	0.051	0.088	0.092	NA	0.081	3.6e-03	1.6e-04	1.2e-04	NA	2.7e-04
12	TCGA	Stomach Adenocarcinoma	0.0590	0.0320	6.2e-03	0.020	0.031	0.013	NA	0.020	1.3e-02	2.4e-03	3.5e-02	NA	1.3e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Bipolar Disorder (2018)	0.4	0.7	2.3	0.2	0.3	-0.3	1.0	1.3	-0.8	-1.4	0.1	-0.0	0.4	0.8	1.5
Bipolar Disorder or Schizophrenia	0.3	0.8	3.4	-0.3	-0.0	-0.3	0.2	1.8	-1.1	-0.4	0.2	1.2	0.9	0.5	1.5
Depressed Affect (Nagel 2018)	0.2	0.5	1.6	0.0	0.2	1.3	0.5	0.6	0.8	0.6	1.1	-0.5	0.7	-0.0	0.4
Depression (Nagel 2018)	0.5	0.8	4.6	0.1	2.1	-0.1	0.6	1.1	-0.6	0.4	1.1	0.3	1.0	0.7	0.5
Intelligence (Savage-Jansen 2018)	0.5	1.6	6.8	-1.9	0.6	-2.6	-1.0	-1.5	-1.5	1.1	0.7	0.8	0.4	0.6	0.1
Neuroticism (Nagel 2018)	0.3	0.6	2.8	0.1	0.1	0.5	-0.1	0.6	0.5	1.6	1.7	-0.1	1.0	0.3	0.7
Schizophrenia (2018)	0.3	0.6	2.5	-0.5	-0.4	-0.1	-0.5	1.4	0.0	0.6	0.2	1.6	0.9	-0.0	0.7
Schizophrenia vs Biploar Disorder	1.6	2.1	6.9	-1.1	0.3	-0.8	-1.6	0.6	-2.6	1.4	0.3	2.5	2.0	0.6	0.2
Worry (Nagel 2018)	1.0	2.1	8.2	0.4	0.7	-1.4	-0.7	0.1	-0.8	2.9	2.5	0.8	1.9	1.4	1.2
Alzheimer’s Disease (in mother)	3.0	3.6	10.1	-1.0	-1.1	1.7	-0.1	-1.1	1.5	-0.8	-1.7	-2.9	-2.2	-2.7	-3.2
Alzheimer’s Disease (in father)	0.4	0.5	1.2	0.1	0.1	1.0	-1.1	-0.3	-0.8	1.0	0.5	0.7	0.9	0.5	-0.1
Alzheimer’s Disease (including proxy)	1.2	1.8	5.5	-1.1	0.0	1.4	-0.7	-1.6	0.6	0.6	-1.0	-1.9	-1.4	-1.6	-2.4
Crohns Disease (2017)	0.1	0.3	1.4	1.2	-0.9	0.0	0.4	-0.4	0.1	0.6	0.3	-0.5	-0.2	0.1	0.0
Irritable Bowel Disease (IBD)	1.4	3.3	8.9	0.0	-1.4	0.4	1.4	-1.2	2.4	-1.4	-1.7	-3.0	-2.5	-2.2	-1.9
Ulcerative Colitis (UC)	3.4	6.4	12.7	-1.4	-1.4	-0.1	0.9	-1.8	3.5	-2.4	-2.9	-3.6	-3.4	-3.1	-2.9
Major Depression (MDD)	0.2	0.2	0.7	0.6	-0.8	0.5	0.0	-0.2	0.5	-0.3	-0.5	-0.5	-0.0	0.1	0.2
Reaction Time	0.4	0.9	3.8	-0.9	0.8	0.3	-0.2	1.0	-1.9	-0.6	0.6	0.9	1.0	1.0	0.5
Verbal and Numeric Reasoning (VNR)	0.7	1.6	5.1	-1.0	0.5	-2.1	-1.6	-1.0	-0.8	2.3	0.7	1.6	0.8	0.5	-0.4
Breast Cancer	0.3	0.8	3.0	-0.9	-0.0	-0.1	0.8	-0.3	0.3	-1.7	-0.6	-1.0	-1.3	-0.8	-0.9
Ovarian Cancer	1.0	1.4	3.4	0.6	1.6	-0.4	1.3	0.9	-1.3	1.0	1.2	0.6	0.9	1.9	1.4
Prostate Cancer	0.5	0.7	2.0	0.5	1.1	-0.5	1.2	0.6	0.1	-0.2	0.9	0.7	0.7	1.0	1.4
Age at First Birth	0.5	0.7	5.4	0.2	-0.5	0.5	-2.3	-0.1	0.7	0.5	0.2	0.9	0.8	-0.7	-0.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.9	1.2	4.0	-0.4	-1.7	0.8	-0.6	-0.1	0.1	-2.0	-1.5	0.1	-0.8	-1.5	-1.3
Coronary Artery Disease (CAD)	1.9	2.3	9.4	2.0	3.1	0.3	2.1	1.1	-0.7	-0.3	1.8	0.2	0.6	1.4	1.6
Crohns Disease (2012)	0.5	0.9	3.1	1.8	0.3	0.5	1.4	0.5	0.0	-0.3	1.1	-0.1	0.6	1.2	1.3
Mean Putamen Volume	0.4	0.4	1.4	0.4	-0.2	-1.2	-1.2	0.2	0.7	0.3	0.1	0.9	0.3	0.2	0.5
Fasting Glucose	4.8	5.8	13.6	-0.9	-1.7	0.8	-0.6	-1.7	2.3	-2.8	-3.3	-2.6	-3.1	-3.7	-2.7
HbA1C	1.0	1.1	8.0	-0.7	0.6	0.1	0.8	0.2	0.2	-2.8	-0.7	-0.7	-1.1	-0.9	-0.8
HDL Cholesterol	0.2	0.3	1.4	-0.7	-0.0	-0.3	0.2	-0.5	0.1	-0.4	-1.2	-0.5	-0.7	-0.4	-0.3
LDL Cholesterol	0.8	1.2	3.5	1.0	1.8	1.1	-0.1	0.6	1.5	1.5	1.9	0.7	0.3	0.3	0.2
Lupus	0.4	0.6	1.9	-0.7	-0.8	-0.5	-0.6	-0.9	-0.3	-0.3	-1.4	-0.7	-1.0	-0.3	-0.8
Neuroticism (2016)	1.4	2.0	10.0	1.2	3.2	-0.5	0.9	0.7	0.0	0.7	1.5	0.6	1.0	2.1	1.5
Primary Biliary Cirrhosis	1.3	1.9	4.5	-0.7	-2.1	0.6	1.5	0.0	1.3	-0.9	-1.5	-2.0	-1.7	-1.5	-1.0
Rheumatoid Arthritis	0.6	0.8	1.7	-1.3	0.1	-0.3	0.3	-0.8	0.9	-0.7	-1.3	-0.9	-1.1	-0.9	-1.0
Schizophrenia (2014)	0.8	1.7	5.9	-0.4	-0.1	0.5	0.3	2.4	-1.8	0.0	0.6	2.1	1.8	0.9	1.3
Triglycerides	0.3	0.5	2.1	0.8	1.1	0.2	-0.3	0.3	0.6	0.7	1.4	0.3	0.6	0.4	-0.1
Type 2 Diabetes (T2D) (2012)	0.8	0.9	2.8	-0.9	-0.1	-1.3	1.6	0.1	0.0	-1.7	-0.8	-0.7	-1.3	-0.5	-0.0
Ulcerative Colitis	1.4	2.1	6.5	-0.2	0.2	0.7	1.8	0.7	2.2	-2.6	-1.0	-1.7	-1.5	-1.4	-0.8
Blood Eosinophil Count	1.2	9.3	31.6	0.1	-3.4	2.1	-5.6	3.5	-3.2	-0.7	-0.9	4.5	4.3	0.8	0.1
Blood Platelet Count	1.0	11.8	18.6	-3.8	-3.3	0.4	1.4	-2.8	4.1	-3.7	-3.5	-4.3	-4.2	-3.7	-3.7
Blood Red Count	0.0	0.4	1.0	-0.4	-0.4	-1.0	-0.4	-1.0	-0.6	0.4	-0.5	0.7	-0.2	-0.2	-0.8
Blood White Count	0.5	4.1	9.7	-1.2	-2.0	-0.7	-0.5	-2.2	3.1	-1.0	-2.3	-2.3	-2.8	-2.3	-1.9
Heel T-Score	0.7	5.4	25.2	-2.7	5.0	-2.1	3.0	-0.3	-2.7	-3.0	-0.7	0.3	-1.0	0.8	-0.8
BMI	0.2	1.0	5.0	0.4	-2.2	0.8	-1.4	-0.3	1.4	-0.1	0.4	1.2	0.4	-0.7	-0.1
Height	1.0	19.7	43.4	3.0	0.3	-0.2	-5.7	2.0	-3.5	6.2	4.3	6.0	6.6	4.5	4.8
Waist Hip Ratio (WHR)	0.5	2.3	10.8	1.5	-0.9	3.3	-0.1	1.8	2.2	-1.1	-0.3	-0.0	-0.3	-1.7	-0.9
Systolic Blood Pressure	1.1	5.7	12.1	-1.8	-1.3	0.1	0.4	-1.8	2.4	-2.9	-2.8	-2.3	-3.3	-3.5	-3.1
Smoking Status	1.2	2.8	7.3	-0.1	-2.0	0.7	-0.0	-0.9	2.7	-0.4	-0.3	-2.5	-1.6	-2.3	-2.4
Allergy or Eczema	2.8	7.5	22.6	1.9	-3.1	4.8	-3.0	4.4	-1.4	-2.4	-1.3	2.3	3.2	-0.6	0.1
Cardiovascular Disease	1.0	3.4	7.2	-2.0	-2.7	-1.3	-2.1	-2.5	1.5	0.3	-1.2	-0.8	-1.7	-2.1	-2.5
Hypothyroidism (self reported)	0.1	0.1	0.5	0.1	0.3	0.4	0.2	-0.1	-0.2	-0.7	0.2	0.5	-0.3	-0.0	-0.6
Respiratory disease	3.7	8.3	31.0	-1.2	-5.6	2.1	-3.7	-0.7	2.0	-1.9	-3.4	-0.4	-0.3	-3.9	-3.6
Type 2 Diabetes (T2D) (2018)	0.9	1.8	4.5	-0.9	-0.7	-0.7	-2.1	-2.0	1.5	0.4	-0.4	-0.8	-1.3	-1.7	-1.9
Lung FEV1/FVC ratio	0.2	0.9	3.5	0.2	-1.0	-1.3	-0.3	-0.9	-0.3	1.9	1.4	-0.6	0.1	1.1	0.7
Lung FVC	1.3	6.8	26.3	3.5	-1.5	0.5	-2.1	0.7	0.5	5.1	2.7	1.4	3.0	1.9	3.6
Neuroticism	0.1	0.3	1.3	-0.7	-0.4	-0.3	-0.2	-0.7	0.1	0.4	0.3	-1.1	-0.1	-0.5	-0.6
Chronotype (morning person)	0.3	0.7	2.8	0.7	-1.7	0.8	0.2	0.1	1.1	1.1	0.3	-1.3	-0.4	-0.4	-0.5
Hair Pigment	0.0	0.5	3.6	-0.4	0.0	-1.9	-1.0	-0.7	0.0	0.6	-0.2	0.3	-0.1	0.6	0.1
Tanning	0.1	1.0	2.7	0.5	-1.5	0.8	1.0	0.1	1.6	-1.3	-0.8	-0.9	-1.2	-0.7	-0.8
Hand grip strength (left)	1.1	2.9	8.0	0.9	1.6	1.4	0.1	1.9	-2.4	0.5	1.6	1.8	2.8	1.9	1.7
Number of treatments/medications taken	1.8	3.2	9.6	-0.8	-3.1	-0.2	-0.7	-1.0	1.8	-1.4	-1.5	-2.0	-1.7	-2.7	-2.2
Average weekly spirits intake	0.6	0.7	2.9	0.6	0.9	1.7	-1.0	1.1	-0.4	-0.9	-0.5	0.6	0.5	-0.2	-0.2
Sensitivity / hurt feelings	0.4	0.7	3.3	0.2	-1.2	0.1	1.3	-0.5	0.1	-0.6	0.1	-1.8	-0.5	-0.1	-0.6
Frequency of depressed mood in last 2 weeks	0.6	0.8	2.9	0.0	1.7	-0.6	1.0	0.3	-1.3	0.7	1.1	0.2	0.6	1.0	0.5
Hearing difficulty/problems: Yes	1.8	2.7	7.9	-0.9	-0.4	0.1	-0.7	-2.1	0.9	-1.4	-1.1	-2.8	-1.8	-2.2	-2.6
Relative age of first facial hair	0.2	0.4	1.8	-0.2	-0.8	-0.3	-0.3	-0.9	0.3	-0.2	-1.3	-0.3	-0.7	-0.3	-0.8
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.8	-0.5	-0.5	0.7	-0.8	0.1	-0.3	-1.3	-0.9	-0.4	-0.3	-1.0	-0.7
Ever used hormone-replacement therapy (HRT)	1.5	1.9	6.1	0.4	-0.6	1.1	2.0	0.1	1.5	-1.0	-0.8	-2.5	-1.8	-1.3	-1.3
Ever had hysterectomy (womb removed)	0.7	0.8	4.7	-0.6	0.3	-2.2	1.7	-0.6	-0.8	0.4	-0.1	-0.3	-0.4	0.6	0.3
Systolic blood pressure, automated reading	0.4	1.1	3.2	0.4	0.4	1.8	1.3	0.8	1.3	-1.5	-1.0	0.2	-0.7	-1.1	-0.7
Eye problems/disorders: Diabetes related eye disease	1.7	1.8	8.9	0.7	-0.2	0.2	-3.0	-0.2	-0.1	2.2	0.9	1.6	1.5	1.1	0.8
Angina	0.3	0.3	1.4	0.4	-0.5	-0.2	0.9	0.2	0.1	-1.2	0.2	-0.9	-0.4	-0.2	0.4
Medication for hormone replacement therapy	0.8	0.9	4.0	1.3	1.6	0.5	2.0	0.5	-0.4	-0.3	0.6	-0.9	-0.1	0.6	0.1
Vitamin and mineral supplements	0.3	0.5	3.7	0.9	0.2	0.2	-0.4	-0.2	0.6	1.9	0.3	0.5	0.4	0.3	0.0
Supplements: Zinc	0.5	0.5	2.8	-0.9	-0.5	0.3	-1.7	-0.3	0.0	0.1	0.4	0.7	0.8	-0.3	-0.5
Medication: Co-codamol	0.3	0.3	1.5	-0.2	0.1	1.2	-0.0	0.4	-0.4	1.1	-0.4	0.4	0.2	-0.2	-0.3
Medication: Metformin	0.2	0.3	1.5	0.5	0.3	0.6	-0.7	-0.3	0.6	1.2	0.5	-0.4	-0.1	-0.3	-0.4
Diabetes (father)	0.8	1.0	5.1	-0.2	-0.5	-0.5	0.2	-0.9	0.9	-0.8	-2.3	-0.5	-1.5	-0.7	-0.6
Diabetes (mother)	0.7	0.8	4.5	-1.2	0.7	-2.1	-1.3	-1.0	-0.5	0.2	-0.3	-0.0	-0.5	0.1	-0.3
Severe depression (siblings)	1.1	1.3	2.6	1.5	-0.5	1.6	-0.3	1.6	-0.1	0.9	0.9	1.3	1.5	0.8	1.2
Pack years adult smoking proportion	0.8	1.2	5.2	0.4	0.5	1.2	1.7	1.2	1.2	-2.3	-0.5	-0.3	-0.3	-0.2	0.6
Impedance of leg (right)	1.3	6.1	35.8	-1.3	1.1	0.6	0.7	0.2	-1.1	-6.0	-3.1	-2.3	-2.5	-2.2	-2.7
Leg fat-free mass (left)	2.3	12.3	29.4	3.0	-0.3	0.7	-3.4	1.8	-1.4	5.4	3.7	5.1	4.9	3.3	4.2
Trunk fat percentage	0.3	1.4	8.2	-0.1	-0.8	-0.2	-2.9	-0.9	0.5	0.7	-0.5	2.3	0.5	-0.4	-0.4
Hand grip strength (right)	0.9	2.4	7.8	1.8	0.6	2.8	-0.8	1.6	-1.3	0.7	1.0	1.6	2.5	1.2	1.0
Townsend deprivation index at recruitment	1.4	2.0	5.4	-1.1	-0.7	-0.7	0.7	-1.5	1.2	-0.7	-1.0	-1.5	-2.3	-1.8	-2.3
Current tobacco smoking	0.2	0.3	1.0	0.3	-0.6	0.8	0.2	0.2	0.7	-0.7	0.0	-1.0	-0.5	-0.6	-0.4
Average weekly fortified wine intake	0.5	0.6	2.8	-0.1	1.7	0.3	1.1	0.7	-1.0	-0.6	0.3	0.2	0.7	0.5	0.7
Maternal smoking around birth	0.1	0.1	1.0	-0.1	0.2	-0.5	0.2	-0.3	-0.0	1.0	-0.2	0.2	-0.2	0.4	-0.1
Fed-up feelings	0.3	0.6	1.9	0.5	-0.3	0.5	-0.1	0.6	-0.6	0.8	1.4	0.8	1.2	0.7	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.8	0.1	1.4	0.1	0.4	0.3	-0.1	0.4	1.3	0.2	0.7	0.4	0.0
Relative age voice broke	2.6	4.0	7.6	-1.9	-1.5	-0.6	0.2	-2.1	2.7	-1.5	-2.0	-2.4	-2.5	-2.3	-2.8
Taking other prescription medications	1.0	1.6	4.1	-0.1	-2.0	1.7	-0.2	0.5	1.5	-1.2	-0.7	-1.2	-0.7	-1.9	-1.4
Age when periods started (menarche)	0.5	1.1	7.7	0.3	0.5	0.0	0.5	-0.2	0.9	-2.8	-1.1	-0.8	-1.2	-1.1	-0.0
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.3	0.3	0.0	-0.4	0.0	-0.2	0.5	0.5	0.6	0.3	0.2	0.1	0.0
Heel bone mineral density (BMD) T-score, automated (left)	1.6	3.5	19.1	0.5	4.4	-0.1	3.5	1.2	-1.9	-1.3	0.3	0.3	-0.0	1.4	1.3
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	1.6	-0.6	-0.9	-0.1	0.6	-0.2	1.3	-0.4	-0.4	-0.4	-0.9	-1.0	-0.9
Qualifications: CSEs or equivalent	0.4	0.5	1.3	0.7	-0.6	1.0	-0.4	0.8	-1.1	-0.5	0.6	0.3	1.0	0.6	0.3
Serious illness, injury or assault to yourself	0.2	0.3	1.1	0.6	0.6	-0.1	-1.0	-0.9	0.1	0.4	0.4	-0.0	0.3	0.1	-0.1
High blood pressure	1.0	2.7	5.4	-0.9	-1.9	-1.1	0.6	-2.0	1.5	-1.4	-1.5	-1.9	-2.3	-2.0	-1.7
Hayfever, allergic rhinitis or eczema	2.2	4.8	13.6	0.6	-3.1	3.7	-2.5	3.2	-1.4	-2.3	-1.4	1.2	2.2	-1.1	-0.3
Multivitamins +/- minerals	1.7	2.2	5.9	-1.0	-1.3	-0.1	1.4	-1.1	0.9	-2.3	-1.0	-2.4	-2.0	-1.5	-0.8
Stomach or abdominal pain in last month	0.9	1.1	6.1	-0.9	2.5	-1.2	0.7	0.3	-1.7	-0.5	0.4	0.0	0.2	1.1	0.6
Supplements: Glucosamine	0.4	0.5	1.9	-1.4	0.1	-0.5	-0.3	-0.7	0.1	-0.8	-0.9	-0.1	-0.9	-0.5	-0.5
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	5.8	-1.2	-1.3	-0.1	0.3	-0.5	1.1	-2.4	-0.8	-0.5	-1.2	-1.2	-1.0
Medication: Atenolol	0.4	0.5	3.6	1.9	0.7	0.5	-0.7	0.2	0.6	0.5	0.5	0.5	0.1	-0.0	-0.1
Medication: Levothyroxine sodium	0.5	0.8	2.5	-0.0	-1.1	0.4	1.4	-0.3	0.7	-1.6	-0.6	-0.5	-1.4	-0.9	-0.4
Sitting height	2.3	16.5	34.3	1.7	0.5	-0.7	-4.4	2.6	-4.7	4.9	3.4	5.7	5.9	4.3	5.0
Chronic bronchitis/emphysema (father)	1.3	1.5	6.5	-0.9	-0.4	-0.5	-0.1	-1.6	2.5	1.6	-0.7	-0.9	-1.3	-1.0	-1.2
High blood pressure (mother)	0.3	0.4	1.5	-1.2	-1.0	-0.7	-0.2	-0.2	-0.4	-0.0	-0.6	0.7	0.0	-0.3	-0.1
Body mass index (BMI)	0.1	0.4	1.3	0.1	-1.0	-0.0	-0.8	-0.8	1.1	0.5	0.3	1.0	0.2	-0.4	-0.1
Impedance of leg (left)	1.3	6.5	33.8	-1.7	1.0	0.3	0.8	-0.1	-1.0	-5.8	-3.3	-2.3	-2.8	-2.5	-2.9
Leg predicted mass (left)	2.3	12.1	29.5	2.9	-0.4	0.6	-3.5	1.7	-1.4	5.4	3.7	5.1	4.8	3.2	4.1
Trunk fat mass	0.6	2.4	10.8	0.7	-0.7	0.1	-3.1	0.1	-0.3	1.4	0.7	3.3	1.9	0.6	0.9
Waist circumference	0.8	3.0	9.5	1.9	-0.0	1.0	-1.6	1.3	-0.2	1.3	2.1	3.1	2.4	1.2	2.0
Number of incorrect matches in round	0.4	0.7	2.0	0.5	1.4	-0.2	0.2	0.3	0.7	1.1	0.7	0.3	0.5	1.0	1.4
Past tobacco smoking	0.5	0.8	2.6	-0.9	0.8	-1.5	0.4	-0.4	-1.2	0.1	-0.3	1.0	0.2	1.0	1.6
Alcohol usually taken with meals	0.5	0.7	2.0	0.4	0.9	1.0	0.9	1.1	-1.3	-1.4	0.5	-0.4	0.5	0.4	0.7
Nervous feelings	1.7	3.1	7.5	0.7	1.4	-1.6	-0.4	0.3	-2.4	2.4	2.7	1.7	1.9	2.0	1.5
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.8	0.0	0.6	-0.4	-0.0	0.6	-0.9	0.1	0.6	0.5	0.8	0.6	0.4
Hearing difficulty/problems with background noise	2.4	3.8	11.6	-0.8	-0.7	0.7	0.3	-0.9	1.6	-3.4	-2.1	-2.4	-2.1	-2.8	-2.5
Hair/balding pattern: Pattern 2	0.5	0.7	2.0	0.5	0.6	0.6	1.3	1.4	-0.7	-0.8	0.3	0.5	0.6	0.7	1.0
Had menopause	0.6	0.7	1.8	-0.5	-0.2	-1.2	0.0	-0.7	0.6	-0.0	-0.9	-1.1	-1.4	-1.0	-1.2
Had other major operations	1.8	2.2	6.7	-2.1	1.1	-2.6	-1.3	-0.8	-2.1	1.2	0.2	1.4	0.9	1.2	1.2
Forced vital capacity (FVC)	2.4	9.4	20.1	3.7	-0.8	1.8	-3.0	2.4	-1.6	3.7	2.5	3.6	4.2	2.5	4.5
Heel bone mineral density (BMD) T-score, automated (right)	1.6	3.6	17.6	1.1	4.2	0.3	4.1	1.3	-1.5	-1.2	0.3	-0.1	-0.3	1.0	1.0
Ever unenthusiastic/disinterested for a whole week	1.0	1.2	5.8	0.2	-0.6	-0.1	-2.0	-0.6	0.5	2.4	0.8	1.3	1.0	-0.5	-0.1
Qualifications: None of the above	0.7	1.6	4.3	-0.1	-0.5	1.4	-0.9	-1.5	1.9	-0.7	-0.8	-0.5	-1.1	-1.7	-2.1
Financial difficulties in last 2 years	2.5	3.4	11.1	0.2	-1.5	0.9	0.2	-0.9	3.3	-1.0	-2.0	-2.4	-2.3	-2.4	-2.0
Mouth/teeth dental problems	1.1	1.6	3.4	-0.0	0.3	-0.9	0.6	1.8	-1.8	0.7	1.4	1.2	1.5	1.8	1.5
Heart attack	0.2	0.3	1.4	1.0	0.4	0.0	0.2	-0.1	1.2	0.4	0.4	0.2	0.1	0.1	0.3
Allergy	2.5	5.8	16.2	0.0	4.0	-3.6	2.7	-2.9	1.2	3.2	2.5	-1.1	-1.8	1.7	0.9
Pain all over the body in last month	0.6	0.7	1.8	-0.9	1.0	-0.9	-0.4	-0.6	-0.4	1.3	0.8	0.8	0.8	0.7	0.6
Diabetes (self-reported)	0.3	0.5	2.1	-0.2	0.6	-0.6	-1.1	-1.5	0.6	0.8	0.3	-0.1	-0.6	-0.4	-0.7
Hayfever/allergic rhinitis (self-reported)	1.2	1.6	4.7	-0.3	-2.2	1.1	-0.9	0.4	0.4	-1.4	-1.9	-0.4	-0.3	-1.8	-1.6
Medication: Ramipril	0.5	0.7	2.5	0.4	0.1	0.1	1.6	-0.6	1.0	0.2	0.3	-1.5	-0.8	-0.5	-0.8
Medication: Simvastatin	4.0	5.8	12.0	-1.8	-1.7	0.5	0.4	-1.6	3.0	-2.0	-2.3	-3.0	-3.2	-3.4	-3.5
Fluid intelligence score	0.7	1.4	5.1	-0.9	0.7	-1.8	-0.7	-0.3	-1.5	2.3	0.4	1.5	1.2	1.0	0.3
Illnesses of siblings	1.7	2.4	6.4	0.5	2.5	0.6	1.7	1.5	-0.9	1.3	1.6	1.3	1.6	1.8	2.0
Neuroticism score	0.2	0.5	1.8	-0.2	0.2	-1.0	0.6	-0.1	-0.8	0.8	1.3	-0.4	0.5	0.9	0.6
Weight	1.0	4.8	15.4	1.6	-0.4	0.4	-2.8	1.0	-1.0	2.5	2.1	3.9	3.2	1.7	2.4
Impedance of arm (right)	0.3	1.4	7.2	-0.2	1.3	-0.4	-2.7	0.6	-1.2	0.5	-0.9	2.0	0.7	0.5	0.0
Arm fat percentage (right)	0.2	0.9	3.8	0.1	-0.8	0.1	-1.9	-0.6	0.9	0.5	-0.3	1.9	0.4	-0.5	-0.3
Trunk fat-free mass	1.7	9.5	20.9	3.2	0.2	0.9	-1.8	2.6	-2.0	3.4	3.6	4.0	4.6	3.1	4.2
Hip circumference	1.2	5.2	16.7	1.7	1.2	-0.1	-2.3	1.0	-1.6	2.2	2.2	4.1	3.1	2.3	2.8
Time employed in main current job	0.7	0.8	2.3	0.4	0.8	-1.2	0.3	-0.1	-1.4	1.2	0.9	0.3	0.5	1.5	0.8
Alcohol intake versus 10 years previously	0.3	0.4	1.1	0.4	0.2	-0.3	0.2	-0.1	-0.5	1.0	1.0	0.7	0.6	0.8	0.7
Father’s age at death	0.6	0.8	1.8	1.4	1.0	1.2	1.1	1.1	-0.0	0.6	0.8	0.1	0.7	0.5	1.3
Worrier / anxious feelings	0.2	0.5	2.9	0.1	-0.5	-0.7	1.7	-0.2	0.6	0.2	-0.1	-1.0	-0.6	0.1	-0.2
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.4	-1.1	0.3	-1.2	0.0	-1.0	-0.2	0.6	-0.3	-0.5	-0.6	0.3	-0.8
Falls in the last year	0.4	0.5	1.4	-0.8	-1.2	-0.2	0.3	0.0	-0.3	-1.2	-1.2	-0.1	-0.6	-0.7	-0.1
Hair/balding pattern: Pattern 3	0.4	0.6	3.0	0.5	1.7	1.1	1.0	0.2	0.2	0.3	0.5	-0.4	0.2	0.7	1.1
Number of live births	0.6	0.8	2.0	-0.2	-1.0	-1.1	0.8	-0.9	1.1	1.1	-0.5	-1.4	-1.1	-0.2	-0.7
Forced expiratory volume in 1-second (FEV1)	2.1	7.1	15.1	3.2	-1.6	1.7	-2.4	1.7	-1.3	3.8	2.4	2.6	3.5	2.1	3.9
Pulse rate	0.2	0.4	1.7	-0.4	0.4	-0.4	1.3	-0.1	-0.9	-0.2	-0.3	-1.1	-0.0	0.3	-0.2
Happiness	1.0	1.2	4.9	0.0	-2.2	0.5	-0.1	-0.2	0.7	0.3	-1.0	-1.6	-0.9	-1.5	-1.5
Noisy workplace	0.5	0.6	2.0	1.4	0.9	1.3	0.6	-0.2	0.5	0.1	1.3	-0.5	-0.0	0.2	0.4
Qualifications: A levels/AS levels or equivalent	0.3	0.7	3.7	0.3	1.9	-0.9	1.1	-0.2	-0.6	0.5	-0.2	-0.7	-0.7	0.4	1.0
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.4	3.3	-0.2	-0.8	1.1	0.4	-0.2	1.3	-1.8	-1.4	-1.4	-1.3	-1.8	-1.0
Mouth/teeth dental problems: Dentures	1.8	3.0	8.5	-0.6	-1.2	1.8	-0.2	-1.0	2.9	-1.2	-2.0	-1.8	-1.8	-2.6	-1.8
Asthma	1.5	2.9	10.2	-0.4	-3.2	2.3	-1.6	0.9	0.3	-1.9	-2.4	0.2	0.7	-1.9	-1.6
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	4.2	-0.9	-2.0	-0.3	-1.0	-1.2	0.6	0.5	-0.1	-1.1	-0.6	-0.9	-1.1
Medication: Cholesterol lowering	1.2	1.8	5.4	0.0	-1.0	-0.2	-0.3	-1.6	1.7	-0.2	-0.6	-2.3	-1.9	-1.5	-1.9
Depression (self-reported)	1.0	1.2	4.7	-1.2	0.6	-0.8	0.5	-0.7	0.9	-2.2	-0.4	-1.1	-1.2	-1.5	-0.7
Medication: Lansoprazole	3.3	3.8	9.8	-0.1	-3.1	1.7	0.9	0.3	1.4	-2.6	-2.4	-1.7	-1.6	-2.8	-1.9
Prospective memory result	0.6	0.7	3.2	1.8	-1.0	0.8	0.3	0.5	1.2	0.5	0.9	0.7	0.5	0.5	0.5
Lung cancer (father)	0.9	1.1	5.6	0.5	-0.3	-0.8	0.7	-0.8	2.4	-0.2	-0.6	-1.0	-1.5	-1.2	-0.6
Illnesses of mother	0.2	0.2	0.7	0.3	0.3	0.7	-0.2	0.1	-0.4	0.0	0.3	0.4	0.8	0.9	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	2.3	7.3	17.3	3.5	-1.1	1.0	-2.6	1.5	-1.3	3.7	2.3	3.0	3.4	2.5	4.2
Pulse wave Arterial Stiffness index	1.1	1.2	5.1	-1.5	0.7	-1.8	0.3	-1.8	-0.1	2.3	0.4	0.0	-0.6	0.2	-0.2
Impedance of arm (left)	0.4	1.7	8.6	-0.8	0.7	-0.7	-2.9	0.4	-1.6	0.8	-0.9	2.1	0.9	0.5	-0.0
Arm fat mass (right)	0.3	1.3	6.0	0.7	-1.0	0.2	-2.0	-0.1	0.5	1.2	0.5	2.5	1.2	0.1	0.6
Trunk predicted mass	1.6	9.2	20.3	3.2	0.1	1.0	-1.7	2.6	-2.0	3.3	3.6	3.9	4.5	3.0	4.2
Standing height	2.0	19.9	42.8	3.1	1.0	0.8	-4.7	3.7	-4.7	4.5	4.0	6.5	6.5	4.4	5.4
Length of working week for main job	1.7	1.9	6.0	-1.1	-1.4	0.8	-2.0	-0.5	0.7	-2.5	-1.3	-0.7	-1.1	-1.6	-1.5
Exposure to tobacco smoke at home	1.2	1.4	4.7	-2.2	-1.7	-1.3	-0.1	-0.3	0.0	-1.7	-1.1	-1.0	-0.9	-0.8	-0.3
Breastfed as a baby	0.4	0.5	1.4	-0.6	-0.1	0.1	-0.8	-0.9	0.9	-0.5	-0.7	-0.5	-0.7	-0.9	-1.2
Tense / ‘highly strung’	0.4	0.7	3.1	-0.1	1.8	-1.0	0.2	-0.2	-0.8	0.4	0.8	0.1	0.5	1.0	1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	1.1	-0.9	-0.9	-0.6	0.5	-0.3	0.7	-0.3	-0.2	-0.7	-0.8	-1.0	-0.0
Hair/balding pattern: Pattern 4	0.2	0.6	2.5	-0.9	-0.4	-1.6	-0.1	-0.2	-1.5	0.3	-0.1	0.7	0.1	0.9	0.0
Birth weight of first child	0.3	0.6	2.6	0.9	-1.6	0.5	0.0	-0.1	1.2	1.2	0.1	-0.8	0.1	0.2	-0.0
Peak expiratory flow (PEF)	1.1	2.7	9.6	1.5	-1.7	0.4	-2.2	0.2	-0.6	3.1	1.4	1.3	1.7	0.8	2.1
Pulse wave reflection index	1.3	1.6	5.1	-1.3	-0.2	-2.3	-0.3	-2.0	0.6	0.8	-1.2	-0.5	-1.9	-0.9	-1.3
Ever highly irritable/argumentative for 2 days	0.7	0.9	5.3	-1.0	-0.6	0.3	-2.3	-0.4	1.0	-0.0	-0.4	0.1	0.2	-1.0	-1.2
Loud music exposure frequency	0.6	0.6	2.7	0.2	-1.2	0.6	-1.1	-0.6	1.6	-0.2	0.1	0.1	-0.2	-0.8	-0.7
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.7	-0.4	-0.0	-0.7	0.8	0.1	-0.1	-0.1	-0.4	-0.4	-0.3	-0.0	0.3
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	2.6	0.7	1.6	0.6	1.1	-0.7	-0.5	-1.0	0.3	-1.2	-0.5	-0.0	-0.3
Blood clot in the leg (DVT)	1.5	1.9	9.8	-1.9	-3.1	-0.8	-1.3	-1.0	0.4	-0.3	-1.8	-0.4	-0.9	-1.1	-0.9
Medication: Paracetamol	0.3	0.5	1.5	-0.4	-0.4	0.8	0.1	-0.4	0.9	-0.3	-1.2	-0.5	-0.6	-1.2	-0.8
Headache pain in last month	0.5	0.9	2.7	-1.5	0.3	0.2	1.6	-0.3	-0.3	-0.8	-0.0	-1.5	-1.2	-0.8	-0.8
Medication for cholesterol, blood pressure or diabetes	1.9	3.1	6.7	1.1	1.3	1.9	0.7	2.6	-1.6	0.2	0.8	2.4	2.4	1.8	2.3
Glaucoma (self-reported)	0.6	0.7	2.3	0.3	1.1	-0.0	1.5	0.5	-0.9	-0.5	1.4	0.4	0.7	1.2	0.4
Gout (self-reported)	0.3	0.4	1.2	0.7	0.1	1.0	0.7	1.1	-0.0	-0.4	0.0	0.4	0.7	0.4	0.3
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	2.5	-1.0	-0.5	-0.7	0.7	-0.5	-0.6	-1.6	-0.3	-0.3	-0.9	-0.3	-0.8
Medication: Amlodipine	0.8	1.2	2.7	-0.9	0.3	-0.1	0.9	-1.6	0.9	-0.3	-0.4	-1.6	-1.4	-1.0	-1.6
Medication: Ventolin 100micrograms inhaler	1.2	1.6	5.7	-0.1	-2.4	2.2	-1.0	1.0	0.3	-1.6	-1.2	-0.1	0.4	-1.2	-0.9
Birth weight	0.9	1.9	4.8	-0.6	-2.2	-1.1	-0.6	-2.0	1.6	1.0	0.4	-1.9	-0.9	-1.3	-1.3
Chronic bronchitis/emphysema (mother)	1.0	1.2	7.4	-0.2	1.1	-0.3	1.2	0.3	-0.5	-2.7	-1.7	-0.5	-0.9	-0.4	-0.3
High blood pressure (siblings)	1.7	2.5	5.9	-1.3	-2.4	-1.5	-1.3	-2.0	0.5	-0.7	-1.4	-1.3	-1.7	-1.8	-2.0
Forced vital capacity (FVC), Best measure	3.0	10.9	22.4	4.0	-0.6	1.4	-3.3	2.2	-2.0	4.0	2.9	3.9	4.5	3.1	4.7
Body fat percentage	0.3	1.1	4.4	-0.4	-0.9	0.0	-2.1	-1.0	0.8	-0.6	-1.0	1.4	-0.2	-1.1	-1.0
Leg fat percentage (right)	0.7	2.5	10.9	-0.9	-0.6	0.2	-0.2	-0.9	1.3	-3.3	-1.9	-0.6	-1.7	-2.1	-2.0
Arm fat-free mass (right)	1.0	5.1	11.5	2.4	-0.7	1.0	-1.7	1.7	-1.4	2.4	2.8	2.9	3.4	2.0	3.0
Exposure to tobacco smoke outside home	0.2	0.3	0.9	0.5	0.9	0.8	-0.2	-0.3	0.5	-0.5	0.4	-0.9	-0.2	-0.4	-0.1
Comparative body size at age 10	0.8	2.3	4.8	2.2	1.6	1.7	1.4	1.2	1.7	-0.3	2.1	1.5	1.2	0.8	1.3
Number of full brothers	0.4	0.5	2.3	0.2	0.1	1.5	0.5	0.7	0.2	-1.0	-0.8	-0.5	-0.6	-0.6	-0.3
Worry too long after embarrassment	0.5	0.8	2.9	-1.0	-0.9	-0.5	0.5	-0.9	0.5	-1.2	-0.3	-1.7	-1.2	-0.8	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	3.1	-0.5	-0.3	-1.7	0.4	-0.4	-0.0	0.3	0.6	-0.5	-0.5	-0.2	0.8
Wheeze or whistling in the chest in last year	1.4	2.6	7.7	-0.5	-2.8	1.1	-1.6	0.4	1.0	-2.2	-2.5	-0.1	-0.3	-2.1	-1.5
Number of children fathered	2.7	3.1	6.8	-1.9	-2.2	0.3	-0.9	-0.8	1.7	-1.7	-1.8	-1.6	-1.5	-2.6	-2.5
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	3.2	-0.6	0.8	-1.5	1.5	-0.2	-1.8	0.3	0.5	-1.0	0.1	0.7	0.2
Age at first live birth	5.7	10.1	16.9	3.5	3.7	2.0	0.4	3.2	-2.5	1.9	2.7	3.6	4.1	4.0	4.1
Pulse wave peak to peak time	1.2	1.4	4.7	1.6	-0.6	1.8	-0.6	2.2	-0.3	-1.8	0.0	0.6	1.1	0.3	0.7
Health satisfaction	0.1	0.1	0.4	-0.1	0.3	0.4	-0.6	-0.3	-0.2	0.2	0.3	-0.1	0.0	-0.4	-0.4
Shortness of breath walking on level ground	1.3	1.6	5.0	-0.0	-1.7	0.6	-0.8	-0.7	2.2	-1.0	-1.0	-0.9	-1.4	-1.8	-1.3
Qualifications: College or University degree	0.8	2.4	5.7	0.5	1.6	-0.1	0.3	1.6	-2.0	0.7	1.4	1.9	1.9	1.9	2.4
Eye problems/disorders: None of the above	0.3	0.4	2.2	0.2	0.9	-0.2	0.2	-0.1	-0.5	1.5	0.6	0.4	0.4	0.6	0.4
Mouth/teeth dental problems: Loose teeth	1.3	1.5	2.9	-0.2	-0.6	1.1	-0.9	-1.2	1.7	-1.5	-0.8	-1.5	-1.2	-1.6	-1.5
Emphysema/chronic bronchitis	1.3	1.4	5.9	-1.0	-0.9	-1.4	-2.4	-1.6	0.4	-0.6	-0.9	-0.1	-0.5	-0.9	-1.6
Medication for pain relief, constipation, heartburn	0.2	0.4	2.0	-0.2	1.4	-0.4	0.2	0.1	-0.4	-0.7	0.1	0.6	0.3	0.8	0.4
Neck or shoulder pain in last month	1.4	2.0	7.3	-0.3	-0.8	0.7	0.2	-0.7	1.7	-0.6	-0.5	-2.7	-1.7	-2.3	-1.9
Medication: Blood pressure	1.1	1.9	4.5	-0.8	-0.4	-1.7	0.4	-1.9	0.7	-1.1	-0.7	-2.0	-2.1	-1.4	-1.7
Angina (self-reported)	0.2	0.2	0.8	0.4	-0.4	-0.3	0.7	0.2	0.1	-0.9	0.3	-0.8	-0.4	-0.2	0.4
Migraine (self-reported)	0.9	1.2	3.8	-1.9	-0.5	-1.7	1.5	-0.8	0.0	-0.3	-0.9	-1.1	-1.1	-0.8	-0.5
Medication: Ibuprofen	0.8	1.0	3.9	-0.9	-1.9	-0.6	-2.0	-0.9	-0.3	1.0	0.3	-0.1	0.4	-0.3	-0.9
Medication: Allopurinol	0.4	0.6	2.0	0.7	0.1	0.9	1.3	1.2	0.5	-1.4	0.1	0.2	0.3	0.1	0.0
Medication: Omeprazole	3.4	4.1	8.8	1.8	1.4	1.1	-0.3	1.4	-3.0	0.6	2.5	2.1	2.7	2.6	2.6
Medication: Seretide 50 evohaler	0.5	0.6	3.0	0.5	0.2	1.2	0.3	1.4	-0.2	-1.7	-0.4	-0.2	0.4	-0.4	-0.3
Mean time to correctly identify matches	0.2	0.4	1.6	-1.0	0.2	-0.5	-0.7	0.2	-1.3	-0.5	0.6	0.5	0.5	0.7	0.3
Heart disease (mother)	0.3	0.4	3.2	0.9	-1.8	-0.1	-0.3	0.4	0.1	0.3	-0.3	-0.2	-0.2	-0.2	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	4.3	5.2	18.3	-1.1	-1.4	0.9	1.6	-0.7	1.8	-4.3	-2.8	-2.7	-2.7	-2.5	-2.2
Whole body fat mass	0.4	1.6	7.6	0.7	-0.9	0.3	-2.6	0.0	0.0	0.8	0.4	2.8	1.4	0.2	0.6
Leg fat mass (right)	0.2	0.6	2.3	0.5	-0.8	0.6	-1.5	0.0	0.5	-0.7	0.1	1.5	0.6	-0.5	-0.1
Arm predicted mass (right)	0.9	4.6	9.9	2.3	-1.0	0.9	-1.8	1.4	-1.0	2.5	2.6	2.8	3.1	1.7	2.9
Pulse rate, automated reading	0.5	1.7	5.4	-0.5	-0.0	0.5	-0.0	-1.5	1.6	-0.9	-0.8	-1.8	-1.4	-1.6	-2.3
Alcohol intake frequency.	0.4	0.8	3.1	-1.4	-0.8	0.2	-1.8	-0.7	-0.7	-1.1	-0.9	0.6	-0.0	-0.4	-0.9
Comparative height size at age 10	1.8	10.0	23.8	2.8	1.0	1.5	-2.8	3.1	-3.0	2.7	2.6	4.8	4.9	2.9	3.6
Number of full sisters	4.2	5.1	11.2	-3.1	-3.2	-2.1	-1.1	-3.4	-0.1	-0.3	-1.6	-2.2	-2.3	-1.6	-3.1
Suffer from ‘nerves’	1.0	1.5	5.5	-0.7	0.8	-2.4	-1.8	-1.1	-0.5	2.0	1.6	0.2	0.6	0.4	0.5
Overall health rating	0.1	0.3	0.9	-0.0	-0.9	-0.4	0.3	-0.2	0.2	0.6	-0.5	-0.7	-0.6	-0.3	-0.4
Chest pain or discomfort	0.6	0.9	4.2	0.0	-1.1	-0.1	-1.1	1.0	0.2	-2.0	-1.1	0.7	0.0	-1.1	0.2
Had major operations	1.2	1.4	11.0	0.5	0.7	0.1	-3.3	-0.7	0.3	1.1	-0.3	1.7	0.6	-0.0	0.3
Age at last live birth	2.9	4.2	7.7	2.1	2.8	0.8	0.6	2.2	-1.9	2.0	1.6	2.0	2.4	2.6	2.5
Family relationship satisfaction	1.4	1.7	4.2	-1.6	-2.1	-0.7	-1.1	-1.1	0.3	0.5	-2.0	-0.9	-0.9	-1.5	-1.7
Leg pain on walking	0.4	0.6	2.3	-0.3	-1.5	0.2	-0.3	0.1	0.1	-0.6	-1.2	-0.4	-1.0	-1.0	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	1.9	0.5	0.5	0.6	1.0	1.4	-0.4	0.7	0.1	-0.1	0.6	0.4	0.4
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.9	1.1	1.2	0.4	0.6	1.0	-0.7	-0.2	0.3	0.4	0.8	0.9	1.4
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	3.2	-1.2	-1.8	-0.8	-1.5	-1.5	0.5	0.4	-0.9	-0.3	-0.6	-0.4	-1.0
Medication: Aspirin	2.6	3.4	8.8	-0.3	-2.6	0.6	0.2	-0.7	1.4	-1.6	-1.8	-2.2	-2.4	-3.0	-2.4
Supplements: Vitamin C	0.9	1.1	3.6	-0.9	-0.9	0.2	-0.9	-0.2	-0.6	-1.9	-1.6	-0.6	-0.8	-1.5	-1.1
Knee pain experienced in last month	0.8	1.3	4.9	-1.1	-2.2	-0.3	0.4	-0.1	0.7	-0.4	-2.1	-0.2	-1.3	-1.3	-0.7
Hypertension (Self-reported)	1.4	3.8	6.5	-1.6	-2.2	-1.2	0.3	-2.4	1.5	-1.2	-1.6	-2.3	-2.6	-2.4	-2.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.8	4.1	-0.3	-1.0	1.2	0.2	0.5	0.1	-2.0	-0.6	-0.9	-0.3	-0.9	-0.5
Illnesses of father: Heart disease	0.7	0.9	3.7	1.2	-0.8	1.9	-0.7	0.9	0.1	-1.6	-0.3	0.2	-0.1	-0.9	-0.1
Illnesses of siblings: Diabetes	1.5	1.8	6.0	-2.0	-2.5	-1.5	-0.9	-1.3	0.1	-0.3	-1.0	-1.0	-1.3	-0.5	-1.7
Smoking status: Previous	0.4	0.7	2.5	0.8	-0.9	0.9	-0.5	-0.0	0.9	0.1	0.1	-0.8	-0.3	-1.1	-1.6
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.5	4.6	-0.4	-0.9	0.6	-0.9	1.6	-2.1	-0.6	0.4	1.4	1.6	1.1	1.5
Whole body fat-free mass	1.7	9.7	20.0	3.0	-0.3	0.7	-2.4	2.1	-1.6	4.1	3.5	4.3	4.5	3.0	4.1
Leg fat-free mass (right)	2.4	12.6	33.2	2.9	-0.5	0.5	-3.2	1.7	-1.4	5.8	3.7	5.2	4.9	3.3	4.3
Arm fat percentage (left)	0.3	1.1	4.9	-0.1	-1.3	0.0	-2.2	-0.6	0.9	0.6	-0.3	2.1	0.5	-0.6	-0.3
Average weekly red wine intake	4.5	6.7	13.6	2.2	2.6	0.6	2.4	2.9	-2.9	0.6	2.3	2.4	2.9	3.5	3.7
Handedness (chirality/laterality): Left-handed	1.2	1.4	3.1	-1.4	-0.9	-0.1	-0.7	-1.3	-0.5	-1.8	-1.4	-0.8	-1.2	-1.2	-1.7
Mood swings	0.5	1.0	2.0	1.1	-0.3	1.4	0.7	1.3	-0.4	0.1	1.4	0.7	1.2	0.9	1.3
Loneliness, isolation	0.5	0.7	2.7	-1.6	-0.9	-1.1	-0.8	-0.6	-0.3	-0.3	-1.0	-0.1	-0.3	-0.6	-0.6
Long-standing illness, disability or infirmity	0.5	0.7	3.1	-1.5	0.3	-0.8	-1.8	-0.7	-0.5	0.7	-0.8	0.1	0.2	-0.7	-0.5
Ever had bowel cancer screening	0.7	0.9	3.8	-0.8	-0.7	-1.9	0.5	-1.3	0.0	0.5	-0.4	-1.4	-0.7	0.1	-0.4
Diabetes diagnosed by doctor	0.5	0.8	3.3	0.1	0.2	-0.7	-1.4	-1.8	0.8	0.9	0.1	-0.4	-0.7	-0.8	-1.1
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	3.5	1.1	0.7	0.2	1.4	0.9	-0.2	1.9	1.0	-1.3	0.2	0.6	0.3
Friendships satisfaction	0.4	0.5	3.2	1.1	0.3	0.5	-0.3	0.5	-0.2	1.8	-0.2	0.5	0.8	0.5	-0.1
Qualifications: nursing, teaching	0.5	0.8	2.2	-0.4	-0.8	-1.3	-0.4	-0.3	0.7	-0.9	-1.5	-1.2	-1.1	-1.0	-0.2
Commuting to job workplace: Walk	1.4	1.5	3.7	-0.7	-1.4	-1.2	-1.3	-1.7	1.2	0.5	-1.0	-0.9	-1.2	-1.3	-1.9
Eye problems/disorders: Cataract	1.1	1.3	3.4	-1.6	-1.5	-0.9	-0.0	-0.5	0.5	-1.1	-1.9	-0.2	-1.0	-1.6	-1.1
Mouth/teeth dental problems: Mouth ulcers	1.0	1.5	5.9	0.7	0.1	-0.4	-2.1	-0.6	-1.0	1.6	0.7	2.4	1.2	0.6	0.8
Medication for cholesterol	0.2	0.2	0.6	0.2	-0.8	0.7	-0.6	0.4	-0.6	-0.5	-0.3	0.4	0.5	0.1	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.7	2.0	4.0	1.7	1.6	2.0	0.2	1.9	-0.2	0.6	1.8	1.7	1.9	0.9	1.0
Back pain experienced in last month	0.2	0.3	0.9	0.7	0.1	0.7	0.9	0.9	-0.4	-0.4	-0.1	-0.7	-0.3	-0.0	0.0
Mineral and other dietary supplements	0.3	0.4	1.1	0.9	1.1	0.5	0.6	0.5	-0.3	0.8	0.6	0.5	0.8	0.7	0.4
Breast cancer (self-reported)	1.0	1.2	2.5	0.1	1.4	-0.5	-0.6	0.9	-1.6	1.2	0.8	1.4	1.5	1.3	0.9
Asthma (self-reported)	1.7	3.3	12.0	-0.3	-3.5	2.3	-1.6	0.8	0.5	-2.2	-2.5	-0.1	0.6	-2.1	-1.8
Osteoporosis (self-reported)	0.8	1.0	2.4	-0.8	0.5	-0.5	-0.9	0.9	-1.6	-0.4	0.8	1.3	1.4	0.5	1.3
Osteoarthritis (self-reported)	5.1	6.6	13.2	-2.5	-1.6	-1.3	0.7	-2.1	2.0	-2.6	-3.6	-3.0	-3.5	-3.3	-2.9
Medication: Aspirin	2.3	3.0	8.2	-0.2	-2.3	0.8	0.2	-0.7	1.1	-1.5	-1.7	-2.2	-2.1	-2.9	-2.3
Medication: Gliclazide	0.5	0.6	1.7	1.1	0.8	1.0	-1.3	0.6	-0.3	0.0	0.1	1.0	0.9	0.4	0.4
Illnesses of father: None of the above (group 1)	0.2	0.3	1.2	0.3	0.7	-0.1	1.1	0.9	0.5	-0.7	-0.2	-0.2	-0.0	-0.1	0.2
Smoking status: Current	0.3	0.4	1.5	0.4	-0.7	0.8	0.3	0.1	1.0	-0.6	0.0	-1.2	-0.7	-0.6	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.3	5.0	12.3	3.2	0.3	1.5	-0.5	1.5	-0.4	3.3	2.6	1.5	2.5	2.3	3.5
Whole body water mass	1.8	10.1	20.7	3.2	-0.1	0.8	-2.3	2.2	-1.7	4.2	3.7	4.3	4.6	3.1	4.2
Leg predicted mass (right)	2.4	12.7	33.6	2.9	-0.5	0.5	-3.2	1.7	-1.5	5.8	3.8	5.2	4.9	3.3	4.3
Arm fat mass (left)	0.4	1.6	6.8	0.6	-1.2	0.2	-2.4	-0.2	0.4	1.3	0.6	2.6	1.4	0.1	0.6
Number of self-reported non-cancer illnesses	3.8	6.6	12.7	-2.2	-3.6	-1.1	-1.0	-2.7	2.1	-1.4	-2.4	-2.9	-2.7	-3.5	-3.4
Average weekly champagne plus white wine intake	1.7	2.3	7.8	-2.1	-1.1	-1.6	1.1	-1.6	-0.5	-1.1	-1.4	-2.8	-1.9	-0.6	-0.8
Miserableness	0.2	0.4	1.5	0.0	0.9	1.2	0.7	0.4	0.2	-0.5	1.0	-0.4	0.4	0.1	0.2
Guilty feelings	0.3	0.4	0.9	-0.5	0.2	-0.6	-0.9	0.7	-0.6	0.3	0.9	0.6	1.0	0.6	0.1
Wears glasses or contact lenses	0.5	0.6	1.9	-0.2	-0.4	0.7	-0.1	-0.3	1.3	-0.6	-0.9	-0.2	-1.1	-1.4	-0.5
Ever taken oral contraceptive pill	0.4	0.4	3.0	0.1	-0.2	-0.1	0.4	-0.1	-0.4	-1.7	-0.1	-0.8	-0.3	-0.0	0.9
Hearing aid user	3.8	4.3	10.6	-1.3	-3.3	-0.1	-1.7	-1.5	2.5	-0.6	-2.3	-1.8	-1.5	-2.7	-3.1
Mother’s age at death	0.6	0.8	3.7	0.0	1.5	0.2	-1.2	0.0	0.1	1.9	1.1	0.7	0.5	-0.1	-0.0
Financial situation satisfaction	1.3	1.6	4.1	-0.8	-0.6	0.0	-1.2	-1.0	2.0	0.8	-1.2	-0.9	-1.3	-2.0	-1.7
Tinnitus: Yes, now most or all of the time	0.7	0.8	2.9	0.4	-0.3	1.7	-0.9	0.9	-0.9	-1.5	0.4	-0.2	1.0	-0.1	-0.2
Commuting to job workplace: Public transport	0.5	0.6	2.3	-1.2	-1.5	-0.9	-1.1	-0.0	-0.7	-0.3	-0.4	0.1	0.2	-0.4	-0.3
Eye problems/disorders: Glaucoma	0.8	0.9	2.9	1.2	0.8	-0.1	1.0	0.6	-0.5	1.1	1.7	0.7	0.9	1.3	0.6
Medication: Blood pressure	0.8	1.4	3.1	-1.2	-1.4	-1.7	-0.9	-1.7	1.2	0.4	-0.7	-0.5	-1.4	-1.2	-1.1
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.8	-0.6	-1.3	-0.3	-0.2	1.0	-1.0	-1.1	-0.4	0.6	0.5	0.4	0.6
Supplements: Fish oil (including cod liver oil)	0.3	0.3	1.0	-0.6	-0.0	0.2	0.4	0.1	0.2	-1.0	-0.2	-0.9	-0.7	-0.8	-0.6
High cholesterol (Self-reported)	1.9	3.4	9.7	-1.2	-0.7	-0.7	0.0	-1.7	1.4	-1.8	-1.3	-3.1	-2.9	-2.3	-2.4
Medication: Bendroflumethiazide	3.7	5.7	13.1	-0.9	-2.2	-0.8	-0.7	-2.9	3.6	-0.6	-2.1	-2.7	-2.8	-3.2	-3.2
Medication: Paracetamol	0.1	0.2	0.6	-0.3	-0.5	0.2	-0.6	-0.1	0.2	0.1	-0.7	0.0	0.2	-0.7	-0.5
Medication: Lisinopril	0.2	0.2	0.7	-0.6	-0.3	-0.3	-0.1	-0.1	-0.1	-0.4	0.3	-0.8	-0.8	-0.4	-0.5
Medication: Atorvastatin	0.1	0.2	0.4	0.6	0.4	-0.5	-0.4	-0.4	-0.6	0.5	0.6	0.1	0.1	0.3	-0.0
Illnesses of father: High blood pressure	0.3	0.4	2.8	-0.0	0.1	0.1	-0.7	-0.1	-1.7	-0.0	0.4	0.5	0.4	0.6	0.5
Alcohol drinker status: Never	0.5	0.6	2.5	-1.6	-0.0	0.2	-1.4	-0.2	-0.8	-0.3	-0.2	0.9	0.8	0.1	0.1
Ever smoked	0.4	0.7	3.0	1.1	0.1	1.7	-0.4	1.2	0.3	-0.3	0.5	-0.1	0.4	-0.6	-1.0
Basal metabolic rate	1.6	8.7	18.8	2.8	-0.3	0.9	-2.6	1.9	-1.4	3.8	3.3	4.3	4.3	2.7	3.7
Leg fat percentage (left)	0.8	2.7	10.1	-1.1	-0.8	-0.0	-0.0	-1.1	1.3	-3.2	-1.9	-0.6	-1.9	-2.3	-2.1
Arm fat-free mass (left)	0.9	4.5	9.2	2.6	-0.4	1.0	-1.4	1.5	-0.8	2.3	2.6	2.8	3.0	1.8	2.9
Number of operations (self-reported)	1.1	1.7	4.7	-0.6	0.1	-1.4	-2.2	0.3	-1.9	0.1	-0.4	2.0	1.2	1.0	1.6
Average weekly beer plus cider intake	1.7	2.5	6.8	-1.2	-2.6	-0.2	-1.6	-0.8	2.0	0.1	-2.4	-0.5	-1.0	-1.9	-2.1
Irritability	0.2	0.4	1.6	0.4	-0.6	1.3	-0.7	0.8	-0.7	-0.1	0.5	0.4	0.7	0.1	0.5
Risk taking	1.6	2.3	5.2	-2.3	-1.2	-0.8	-1.5	-2.2	0.4	-1.6	-1.5	-1.0	-1.2	-1.7	-1.6
Ever had prostate specific antigen (PSA) test	1.8	2.1	5.0	1.0	1.4	0.5	-0.9	0.6	-1.6	2.2	1.3	1.4	1.8	1.8	1.5
Fractured/broken bones in last 5 years	0.7	0.9	2.2	-1.5	1.3	-1.2	0.8	-0.9	0.2	-0.6	-0.1	-0.6	-1.1	-1.1	-0.4
Age started oral contraceptive pill	0.1	0.2	0.5	-0.2	0.1	-0.7	0.6	-0.2	-0.0	-0.5	0.4	-0.3	-0.5	0.3	-0.5
Diastolic blood pressure, automated reading	0.4	1.1	4.6	1.0	-0.4	2.2	1.0	0.8	1.7	-1.1	-0.9	0.5	-0.6	-0.9	-0.2
Ever depressed for a whole week	1.2	1.5	5.5	0.1	-1.3	-0.2	-2.3	-1.5	1.8	2.0	-0.0	0.3	-0.3	-1.1	-0.6
Unable to work because of sickness or disability	0.9	1.2	2.5	-1.1	-1.4	0.2	-0.1	-1.1	0.8	-0.5	-1.3	-1.1	-1.4	-1.6	-1.3
Commuting to job workplace: Cycle	1.1	1.3	4.8	1.2	0.4	2.2	0.1	1.5	-0.8	0.9	1.2	1.0	1.4	0.8	0.8
Myopia	1.0	1.4	4.2	2.0	1.6	0.3	0.8	1.6	0.1	1.0	0.7	0.6	0.7	0.9	2.0
Vascular/heart problems diagnosed by doctor	1.2	3.3	6.4	0.9	2.2	1.3	-0.4	2.4	-1.9	1.1	1.4	2.1	2.5	2.1	2.0
Cholesterol lowering medication	1.1	1.6	3.5	-1.5	0.1	-0.4	1.3	-0.2	0.9	-1.6	-1.2	-1.5	-1.9	-1.5	-1.5
Medication: Omeprazole (e.g. Zanprol)	4.9	6.0	11.3	2.1	1.9	1.5	0.1	2.4	-3.0	0.8	2.8	3.0	3.4	2.7	3.3
Pain experienced in last month	0.4	0.6	2.2	0.8	0.1	0.6	-0.0	-0.6	1.5	-1.4	-0.7	-0.3	-0.5	-0.8	-0.8
Supplements: Calcium	1.4	1.5	3.8	-1.8	-1.1	0.8	-1.9	0.7	-1.1	-1.7	-1.5	0.7	0.5	-1.0	-0.7
Basal cell carcinoma (self-reported)	0.7	0.8	5.4	0.4	1.2	0.9	0.5	-0.4	0.6	2.3	0.7	-0.5	0.3	0.5	-0.1
Heart attack/myocardial infarction (self-reported)	0.2	0.2	1.1	0.9	0.3	-0.2	-0.0	-0.4	1.0	0.4	0.3	0.1	0.0	-0.0	0.1
Deep venous thrombosis (DVT) (self-reported)	1.6	2.1	9.6	-2.0	-3.1	-1.1	-1.6	-1.0	0.1	-0.3	-1.8	-0.0	-0.8	-1.1	-1.0
Heart disease (siblings)	2.3	2.8	6.3	-0.1	-1.4	1.6	-1.0	-0.4	1.7	-2.4	-2.0	-1.3	-1.7	-2.5	-2.0
Alcohol drinker status: Previous	1.1	1.2	5.4	-0.2	-1.5	1.2	-0.6	0.8	-1.2	-2.3	-1.4	0.2	-0.2	-0.6	-0.3
Pack years of smoking	0.6	0.9	4.9	0.3	0.3	0.8	1.3	0.8	1.5	-2.2	-0.5	-0.5	-0.5	-0.4	0.3
Impedance of whole body	0.3	1.8	5.6	-1.4	0.8	-0.4	-1.5	-0.1	-1.1	-2.2	-2.4	0.1	-1.0	-1.1	-1.6
Leg fat mass (left)	0.1	0.5	2.3	0.3	-0.8	0.5	-1.5	-0.1	0.5	-0.5	0.1	1.5	0.5	-0.6	-0.1
Arm predicted mass (left)	0.8	4.2	8.8	2.6	-0.5	1.3	-1.3	1.6	-0.6	2.2	2.4	2.7	3.0	1.6	2.8