Best TWAS P=3.48e-08 · Best GWAS P=3.14e-09 conditioned to 0.00193
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | WDR19 | 0.05 | 0.01 | lasso | 5 | 0.00 | 1.3e-01 | -5.0 | 5.3 | 1.1e-07 | 0.04 | 0.15 | 0.70 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | SMIM14 | 0.12 | 0.13 | enet | 13 | 0.11 | 2.5e-08 | 3.5 | -5.3 | 1.2e-07 | -0.02 | 0.96 | 0.02 | TRUE |
| 3 | GTEx | Lung | SMIM14 | 0.06 | 0.00 | enet | 5 | 0.00 | 3.7e-01 | -3.6 | -5.2 | 1.8e-07 | -0.09 | 0.06 | 0.50 | FALSE |
| 4 | GTEx | Testis | WDR19 | 0.28 | 0.29 | lasso | 5 | 0.27 | 1.6e-12 | -5.0 | 5.5 | 4.8e-08 | 0.05 | 0.33 | 0.67 | FALSE |
| 5 | METSIM | Adipose | WDR19 | 0.04 | 0.01 | enet | 20 | 0.02 | 7.7e-04 | -4.9 | 5.5 | 3.5e-08 | 0.00 | 0.18 | 0.74 | TRUE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | WDR19 | 0.02 | 0.02 | enet | 9 | 0.02 | 2.8e-03 | 5.2 | 5.4 | 7.8e-08 | 0.04 | 0.06 | 0.85 | FALSE |
| 7 | The Cancer Genome Atlas | Colon Adenocarcinoma | FLJ13197 | 0.12 | 0.00 | blup | 85 | 0.05 | 9.1e-04 | 2.3 | 5.5 | 4.3e-08 | -0.69 | 0.01 | 0.91 | TRUE |
| 8 | The Cancer Genome Atlas | Lung Adenocarcinoma | FLJ13197 | 0.11 | 0.07 | blup | 85 | 0.08 | 7.0e-10 | 2.3 | 5.3 | 8.9e-08 | -0.64 | 0.18 | 0.82 | FALSE |
| 9 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | WDR19 | 0.08 | 0.00 | blup | 61 | 0.03 | 1.9e-02 | -5.0 | 5.3 | 8.6e-08 | 0.05 | 0.03 | 0.45 | FALSE |
| 10 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | WDR19 | 0.09 | 0.01 | blup | 61 | 0.03 | 4.1e-02 | -5.0 | 5.2 | 1.5e-07 | 0.05 | 0.02 | 0.40 | FALSE |
| 11 | The Cancer Genome Atlas | Thyroid Carcinoma | WDR19 | 0.02 | 0.00 | blup | 61 | 0.01 | 2.8e-02 | -4.7 | 5.4 | 6.0e-08 | 0.04 | 0.05 | 0.57 | FALSE |