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chr4:55,517,005-57,110,821

Best TWAS P=3.24e-14 · Best GWAS P=1.92e-13 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	TMEM165	0.22	0.20	enet	47	0.26	1.7e-31	6.36	-5.5	3.3e-08	-0.84	0.21	0.79	FALSE
2	GTEx	Adipose Subcutaneous	TMEM165	0.09	0.01	lasso	3	0.03	1.6e-03	7.30	-6.8	9.7e-12	-0.98	0.01	0.98	FALSE
3	GTEx	Adipose Visceral Omentum	TMEM165	0.14	0.04	enet	20	0.06	3.3e-04	-0.42	-5.6	2.4e-08	-0.59	0.04	0.72	FALSE
4	GTEx	Adipose Visceral Omentum	SRD5A3-AS1	0.18	0.04	lasso	4	0.11	2.5e-06	6.47	6.1	1.2e-09	0.67	0.03	0.91	FALSE
5	GTEx	Artery Aorta	CLOCK	0.13	0.05	enet	32	0.08	3.2e-05	6.36	5.3	1.4e-07	0.70	0.05	0.92	FALSE
6	GTEx	Artery Tibial	SRD5A3	0.41	0.09	enet	63	0.23	8.5e-18	6.39	5.5	3.5e-08	0.45	0.03	0.97	FALSE
7	GTEx	Artery Tibial	SRD5A3-AS1	0.19	0.05	enet	26	0.10	2.4e-08	7.29	6.1	1.0e-09	0.78	0.01	0.99	FALSE
8	GTEx	Brain Cortex	TMEM165	0.31	0.08	lasso	6	0.04	2.2e-02	6.47	-6.2	7.2e-10	-0.85	0.04	0.70	FALSE
9	GTEx	Breast Mammary Tissue	TMEM165	0.10	0.12	lasso	5	0.12	6.4e-07	6.47	-6.5	9.2e-11	-0.89	0.02	0.97	FALSE
10	GTEx	Breast Mammary Tissue (Male)	TMEM165	0.18	0.11	lasso	10	0.11	1.4e-03	6.47	-6.5	9.6e-11	-0.87	0.03	0.82	FALSE
11	GTEx	Breast Mammary Tissue (Female)	TMEM165	0.09	0.07	lasso	2	0.05	1.3e-02	6.37	-6.7	1.6e-11	-0.87	0.06	0.57	FALSE
12	GTEx	Cells EBV-transformed lymphocytes	SRD5A3	0.19	0.06	enet	21	0.13	5.9e-05	6.47	5.4	5.3e-08	0.81	0.02	0.94	FALSE
13	GTEx	Cells EBV-transformed lymphocytes	SRD5A3-AS1	0.21	0.09	lasso	3	0.20	4.3e-07	6.47	5.8	8.5e-09	0.82	0.03	0.95	FALSE
14	GTEx	Cells Transformed fibroblasts	SRD5A3	0.39	0.22	enet	51	0.36	2.9e-28	6.39	5.8	5.4e-09	0.68	0.13	0.87	FALSE
15	GTEx	Cells Transformed fibroblasts	SRD5A3-AS1	0.36	0.19	enet	52	0.30	1.2e-22	6.39	5.8	5.4e-09	0.69	0.04	0.96	FALSE
16	GTEx	Colon Sigmoid	SRD5A3	0.34	0.18	enet	30	0.31	1.5e-11	6.39	5.2	1.6e-07	0.63	0.01	0.98	FALSE
17	GTEx	Colon Sigmoid	SRD5A3-AS1	0.16	0.14	enet	18	0.13	2.9e-05	7.30	5.8	5.3e-09	0.82	0.01	0.97	FALSE
18	GTEx	Esophagus Gastroesophageal Junction	SRD5A3-AS1	0.19	0.12	lasso	3	0.14	9.3e-06	2.68	5.2	1.9e-07	0.74	0.03	0.88	FALSE
19	GTEx	Esophagus Mucosa	SRD5A3	0.20	0.12	enet	24	0.18	2.5e-12	6.39	5.8	5.0e-09	0.74	0.04	0.96	FALSE
20	GTEx	Esophagus Mucosa	CLOCK	0.12	0.11	enet	22	0.09	9.3e-07	6.38	5.5	5.1e-08	0.82	0.02	0.98	FALSE
21	GTEx	Esophagus Mucosa	SRD5A3-AS1	0.18	0.12	enet	26	0.17	1.1e-11	6.39	6.0	1.6e-09	0.74	0.03	0.97	FALSE
22	GTEx	Esophagus Muscularis	SRD5A3	0.34	0.08	enet	30	0.25	1.6e-15	7.29	5.8	6.2e-09	0.60	0.02	0.98	FALSE
23	GTEx	Esophagus Muscularis	SRD5A3-AS1	0.15	0.04	enet	28	0.12	1.8e-07	6.83	6.1	1.3e-09	0.60	0.02	0.94	FALSE
24	GTEx	Liver	SRD5A3	0.16	0.00	lasso	18	0.09	1.4e-03	6.38	6.2	7.7e-10	0.73	0.04	0.70	FALSE
25	GTEx	Lung	SRD5A3	0.35	0.13	enet	32	0.27	1.1e-20	7.29	5.6	2.7e-08	0.63	0.01	0.99	FALSE
26	GTEx	Lung	TMEM165	0.09	0.01	lasso	6	0.01	3.4e-02	6.36	-6.2	4.7e-10	-0.88	0.02	0.91	FALSE
27	GTEx	Lung	SRD5A3-AS1	0.19	0.07	enet	26	0.14	8.6e-11	6.47	6.4	1.6e-10	0.68	0.02	0.98	FALSE
28	GTEx	Muscle Skeletal	SRD5A3-AS1	0.20	0.13	enet	25	0.20	1.4e-19	6.39	5.9	3.0e-09	0.73	0.06	0.94	FALSE
29	GTEx	Nerve Tibial	TMEM165	0.18	0.22	enet	29	0.27	1.6e-19	6.37	-6.3	2.8e-10	-0.87	0.02	0.98	FALSE
30	GTEx	Pancreas	SRD5A3	0.34	0.14	lasso	4	0.25	6.9e-11	5.62	5.9	2.9e-09	0.69	0.15	0.83	FALSE
31	GTEx	Pancreas	SRD5A3-AS1	0.16	0.08	lasso	4	0.15	7.0e-07	6.83	6.2	6.6e-10	0.69	0.06	0.88	FALSE
32	GTEx	Prostate	SRD5A3	0.39	0.04	enet	27	0.28	9.6e-08	6.39	5.2	1.9e-07	0.63	0.05	0.88	FALSE
33	GTEx	Skin Not Sun Exposed Suprapubic	CLOCK	0.08	0.08	lasso	5	0.05	1.4e-03	7.35	7.3	1.9e-13	1.00	0.01	0.97	FALSE
34	GTEx	Small Intestine Terminal Ileum	SRD5A3	0.38	0.28	lasso	4	0.25	2.2e-06	6.47	6.1	9.2e-10	0.85	0.05	0.77	FALSE
35	GTEx	Small Intestine Terminal Ileum	SRD5A3-AS1	0.40	0.32	lasso	3	0.28	4.5e-07	6.47	6.3	3.6e-10	0.86	0.06	0.80	FALSE
36	GTEx	Spleen	TMEM165	0.17	0.13	enet	10	0.11	7.7e-04	6.47	-7.1	1.2e-12	-0.95	0.02	0.82	FALSE
37	GTEx	Stomach	SRD5A3	0.13	0.08	enet	17	0.09	3.0e-05	2.68	5.5	3.9e-08	0.73	0.10	0.88	FALSE
38	GTEx	Stomach	SRD5A3-AS1	0.16	0.11	lasso	11	0.12	1.8e-06	6.38	6.1	9.7e-10	0.85	0.12	0.86	FALSE
39	GTEx	Thyroid	SRD5A3	0.45	0.06	enet	53	0.28	8.5e-22	6.39	5.3	1.4e-07	0.57	0.12	0.88	FALSE
40	GTEx	Thyroid	TMEM165	0.10	0.03	lasso	5	0.03	1.9e-03	6.36	-6.2	6.7e-10	-0.81	0.02	0.97	FALSE
41	GTEx	Thyroid	SRD5A3-AS1	0.32	0.14	enet	56	0.21	1.1e-15	6.37	5.8	7.9e-09	0.67	0.03	0.97	FALSE
42	GTEx	Whole Blood	SRD5A3	0.37	0.19	enet	57	0.30	1.3e-27	6.39	5.9	4.4e-09	0.67	0.12	0.88	FALSE
43	GTEx	Whole Blood	SRD5A3-AS1	0.33	0.17	lasso	9	0.21	4.1e-19	6.38	6.6	4.3e-11	0.84	0.12	0.88	FALSE
44	METSIM	Adipose	TMEM165	0.07	0.07	enet	12	0.07	1.1e-10	7.30	-7.3	3.4e-13	-0.99	0.01	0.99	FALSE
45	NTR	Blood	CLOCK	0.02	0.01	lasso	2	0.01	5.4e-05	6.47	6.8	7.3e-12	0.92	0.02	0.98	FALSE
46	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	SRD5A3	0.18	0.08	blup	44	0.09	1.0e-07	7.30	7.1	1.4e-12	0.86	0.00	1.00	FALSE
47	The Cancer Genome Atlas	Breast Invasive Carcinoma	TMEM165	0.02	0.04	lasso	3	0.03	1.0e-07	7.30	-7.0	2.6e-12	-0.99	0.00	1.00	FALSE
48	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	SRD5A3	0.09	0.08	lasso	4	0.09	2.7e-05	6.39	6.6	4.0e-11	0.78	0.03	0.52	FALSE
49	The Cancer Genome Atlas	Colon Adenocarcinoma	TMEM165	0.06	0.07	enet	11	0.06	2.1e-04	7.30	-7.5	4.3e-14	-0.98	0.01	0.98	FALSE
50	The Cancer Genome Atlas	Glioblastoma Multiforme	SRD5A3	0.22	0.14	blup	44	0.12	1.9e-04	6.47	6.6	3.7e-11	0.85	0.00	0.97	FALSE
51	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SRD5A3	0.04	0.03	blup	44	0.03	1.1e-04	7.30	7.3	2.3e-13	0.88	0.00	0.99	FALSE
52	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CLOCK	0.02	0.02	enet	5	0.02	1.9e-03	6.37	7.1	1.5e-12	0.83	0.03	0.82	FALSE
53	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SRD5A3	0.21	0.14	lasso	4	0.14	2.6e-15	6.39	6.2	4.5e-10	0.87	0.33	0.67	FALSE
54	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TMEM165	0.08	0.06	lasso	3	0.09	1.5e-10	7.34	-7.5	6.8e-14	-0.91	0.00	1.00	FALSE
55	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SRD5A3	0.24	0.08	enet	16	0.12	2.8e-07	-5.15	6.3	2.8e-10	0.77	0.01	0.99	FALSE
56	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	TMEM165	0.06	0.02	blup	55	0.03	6.2e-03	-5.15	-6.5	8.1e-11	-0.74	0.02	0.41	FALSE
57	The Cancer Genome Atlas	Brain Lower Grade Glioma	SRD5A3	0.14	0.07	blup	44	0.08	3.4e-09	6.38	5.6	1.9e-08	0.68	0.29	0.70	FALSE
58	The Cancer Genome Atlas	Brain Lower Grade Glioma	TMEM165	0.19	0.16	lasso	4	0.17	2.1e-18	7.32	-7.5	6.1e-14	-0.99	0.00	1.00	FALSE
59	The Cancer Genome Atlas	Lung Adenocarcinoma	SRD5A3	0.04	0.03	lasso	4	0.02	1.0e-03	6.39	6.3	2.7e-10	0.90	0.01	0.98	FALSE
60	The Cancer Genome Atlas	Lung Adenocarcinoma	TMEM165	0.03	0.01	blup	55	0.02	1.4e-03	7.34	-6.5	8.3e-11	-0.89	0.01	0.96	FALSE
61	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SRD5A3	0.03	0.03	enet	4	0.05	3.1e-06	-2.79	5.3	9.0e-08	0.83	0.02	0.95	FALSE
62	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	SRD5A3	0.12	0.07	lasso	2	0.06	4.2e-05	6.39	6.4	1.4e-10	0.87	0.01	0.91	FALSE
63	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	SRD5A3	0.26	0.12	lasso	6	0.10	7.0e-05	6.39	6.7	2.8e-11	0.83	0.02	0.94	FALSE
64	The Cancer Genome Atlas	Prostate Adenocarcinoma	TMEM165	0.05	0.06	enet	5	0.05	4.3e-06	7.34	-7.6	3.2e-14	-0.95	0.00	1.00	TRUE
65	The Cancer Genome Atlas	Rectum Adenocarcinoma	TMEM165	0.40	0.05	enet	19	0.12	9.4e-04	-1.70	-5.2	1.8e-07	-0.52	0.01	0.33	FALSE
66	The Cancer Genome Atlas	Skin Cutaneous Melanoma	SRD5A3	0.17	0.05	blup	44	0.09	1.8e-03	-5.15	5.5	4.3e-08	0.55	0.01	0.30	FALSE
67	The Cancer Genome Atlas	Stomach Adenocarcinoma	CLOCK	0.08	0.07	enet	9	0.06	4.5e-05	6.20	5.7	1.4e-08	0.81	0.20	0.63	FALSE
68	The Cancer Genome Atlas	Thyroid Carcinoma	TMEM165	0.12	0.08	enet	12	0.08	2.1e-08	7.32	-7.2	6.6e-13	-0.94	0.00	1.00	FALSE