[Hub]/) : Traits : Sitting height :

chr4:55,517,005-57,110,821

Best TWAS P=3.24e-14 · Best GWAS P=1.92e-13 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex TMEM165 0.22 0.20 enet 47 0.26 1.7e-31 6.36 -5.5 3.3e-08 -0.84 0.21 0.79 FALSE
2 GTEx Adipose Subcutaneous TMEM165 0.09 0.01 lasso 3 0.03 1.6e-03 7.30 -6.8 9.7e-12 -0.98 0.01 0.98 FALSE
3 GTEx Adipose Visceral Omentum TMEM165 0.14 0.04 enet 20 0.06 3.3e-04 -0.42 -5.6 2.4e-08 -0.59 0.04 0.72 FALSE
4 GTEx Adipose Visceral Omentum SRD5A3-AS1 0.18 0.04 lasso 4 0.11 2.5e-06 6.47 6.1 1.2e-09 0.67 0.03 0.91 FALSE
5 GTEx Artery Aorta CLOCK 0.13 0.05 enet 32 0.08 3.2e-05 6.36 5.3 1.4e-07 0.70 0.05 0.92 FALSE
6 GTEx Artery Tibial SRD5A3 0.41 0.09 enet 63 0.23 8.5e-18 6.39 5.5 3.5e-08 0.45 0.03 0.97 FALSE
7 GTEx Artery Tibial SRD5A3-AS1 0.19 0.05 enet 26 0.10 2.4e-08 7.29 6.1 1.0e-09 0.78 0.01 0.99 FALSE
8 GTEx Brain Cortex TMEM165 0.31 0.08 lasso 6 0.04 2.2e-02 6.47 -6.2 7.2e-10 -0.85 0.04 0.70 FALSE
9 GTEx Breast Mammary Tissue TMEM165 0.10 0.12 lasso 5 0.12 6.4e-07 6.47 -6.5 9.2e-11 -0.89 0.02 0.97 FALSE
10 GTEx Breast Mammary Tissue (Male) TMEM165 0.18 0.11 lasso 10 0.11 1.4e-03 6.47 -6.5 9.6e-11 -0.87 0.03 0.82 FALSE
11 GTEx Breast Mammary Tissue (Female) TMEM165 0.09 0.07 lasso 2 0.05 1.3e-02 6.37 -6.7 1.6e-11 -0.87 0.06 0.57 FALSE
12 GTEx Cells EBV-transformed lymphocytes SRD5A3 0.19 0.06 enet 21 0.13 5.9e-05 6.47 5.4 5.3e-08 0.81 0.02 0.94 FALSE
13 GTEx Cells EBV-transformed lymphocytes SRD5A3-AS1 0.21 0.09 lasso 3 0.20 4.3e-07 6.47 5.8 8.5e-09 0.82 0.03 0.95 FALSE
14 GTEx Cells Transformed fibroblasts SRD5A3 0.39 0.22 enet 51 0.36 2.9e-28 6.39 5.8 5.4e-09 0.68 0.13 0.87 FALSE
15 GTEx Cells Transformed fibroblasts SRD5A3-AS1 0.36 0.19 enet 52 0.30 1.2e-22 6.39 5.8 5.4e-09 0.69 0.04 0.96 FALSE
16 GTEx Colon Sigmoid SRD5A3 0.34 0.18 enet 30 0.31 1.5e-11 6.39 5.2 1.6e-07 0.63 0.01 0.98 FALSE
17 GTEx Colon Sigmoid SRD5A3-AS1 0.16 0.14 enet 18 0.13 2.9e-05 7.30 5.8 5.3e-09 0.82 0.01 0.97 FALSE
18 GTEx Esophagus Gastroesophageal Junction SRD5A3-AS1 0.19 0.12 lasso 3 0.14 9.3e-06 2.68 5.2 1.9e-07 0.74 0.03 0.88 FALSE
19 GTEx Esophagus Mucosa SRD5A3 0.20 0.12 enet 24 0.18 2.5e-12 6.39 5.8 5.0e-09 0.74 0.04 0.96 FALSE
20 GTEx Esophagus Mucosa CLOCK 0.12 0.11 enet 22 0.09 9.3e-07 6.38 5.5 5.1e-08 0.82 0.02 0.98 FALSE
21 GTEx Esophagus Mucosa SRD5A3-AS1 0.18 0.12 enet 26 0.17 1.1e-11 6.39 6.0 1.6e-09 0.74 0.03 0.97 FALSE
22 GTEx Esophagus Muscularis SRD5A3 0.34 0.08 enet 30 0.25 1.6e-15 7.29 5.8 6.2e-09 0.60 0.02 0.98 FALSE
23 GTEx Esophagus Muscularis SRD5A3-AS1 0.15 0.04 enet 28 0.12 1.8e-07 6.83 6.1 1.3e-09 0.60 0.02 0.94 FALSE
24 GTEx Liver SRD5A3 0.16 0.00 lasso 18 0.09 1.4e-03 6.38 6.2 7.7e-10 0.73 0.04 0.70 FALSE
25 GTEx Lung SRD5A3 0.35 0.13 enet 32 0.27 1.1e-20 7.29 5.6 2.7e-08 0.63 0.01 0.99 FALSE
26 GTEx Lung TMEM165 0.09 0.01 lasso 6 0.01 3.4e-02 6.36 -6.2 4.7e-10 -0.88 0.02 0.91 FALSE
27 GTEx Lung SRD5A3-AS1 0.19 0.07 enet 26 0.14 8.6e-11 6.47 6.4 1.6e-10 0.68 0.02 0.98 FALSE
28 GTEx Muscle Skeletal SRD5A3-AS1 0.20 0.13 enet 25 0.20 1.4e-19 6.39 5.9 3.0e-09 0.73 0.06 0.94 FALSE
29 GTEx Nerve Tibial TMEM165 0.18 0.22 enet 29 0.27 1.6e-19 6.37 -6.3 2.8e-10 -0.87 0.02 0.98 FALSE
30 GTEx Pancreas SRD5A3 0.34 0.14 lasso 4 0.25 6.9e-11 5.62 5.9 2.9e-09 0.69 0.15 0.83 FALSE
31 GTEx Pancreas SRD5A3-AS1 0.16 0.08 lasso 4 0.15 7.0e-07 6.83 6.2 6.6e-10 0.69 0.06 0.88 FALSE
32 GTEx Prostate SRD5A3 0.39 0.04 enet 27 0.28 9.6e-08 6.39 5.2 1.9e-07 0.63 0.05 0.88 FALSE
33 GTEx Skin Not Sun Exposed Suprapubic CLOCK 0.08 0.08 lasso 5 0.05 1.4e-03 7.35 7.3 1.9e-13 1.00 0.01 0.97 FALSE
34 GTEx Small Intestine Terminal Ileum SRD5A3 0.38 0.28 lasso 4 0.25 2.2e-06 6.47 6.1 9.2e-10 0.85 0.05 0.77 FALSE
35 GTEx Small Intestine Terminal Ileum SRD5A3-AS1 0.40 0.32 lasso 3 0.28 4.5e-07 6.47 6.3 3.6e-10 0.86 0.06 0.80 FALSE
36 GTEx Spleen TMEM165 0.17 0.13 enet 10 0.11 7.7e-04 6.47 -7.1 1.2e-12 -0.95 0.02 0.82 FALSE
37 GTEx Stomach SRD5A3 0.13 0.08 enet 17 0.09 3.0e-05 2.68 5.5 3.9e-08 0.73 0.10 0.88 FALSE
38 GTEx Stomach SRD5A3-AS1 0.16 0.11 lasso 11 0.12 1.8e-06 6.38 6.1 9.7e-10 0.85 0.12 0.86 FALSE
39 GTEx Thyroid SRD5A3 0.45 0.06 enet 53 0.28 8.5e-22 6.39 5.3 1.4e-07 0.57 0.12 0.88 FALSE
40 GTEx Thyroid TMEM165 0.10 0.03 lasso 5 0.03 1.9e-03 6.36 -6.2 6.7e-10 -0.81 0.02 0.97 FALSE
41 GTEx Thyroid SRD5A3-AS1 0.32 0.14 enet 56 0.21 1.1e-15 6.37 5.8 7.9e-09 0.67 0.03 0.97 FALSE
42 GTEx Whole Blood SRD5A3 0.37 0.19 enet 57 0.30 1.3e-27 6.39 5.9 4.4e-09 0.67 0.12 0.88 FALSE
43 GTEx Whole Blood SRD5A3-AS1 0.33 0.17 lasso 9 0.21 4.1e-19 6.38 6.6 4.3e-11 0.84 0.12 0.88 FALSE
44 METSIM Adipose TMEM165 0.07 0.07 enet 12 0.07 1.1e-10 7.30 -7.3 3.4e-13 -0.99 0.01 0.99 FALSE
45 NTR Blood CLOCK 0.02 0.01 lasso 2 0.01 5.4e-05 6.47 6.8 7.3e-12 0.92 0.02 0.98 FALSE
46 The Cancer Genome Atlas Bladder Urothelial Carcinoma SRD5A3 0.18 0.08 blup 44 0.09 1.0e-07 7.30 7.1 1.4e-12 0.86 0.00 1.00 FALSE
47 The Cancer Genome Atlas Breast Invasive Carcinoma TMEM165 0.02 0.04 lasso 3 0.03 1.0e-07 7.30 -7.0 2.6e-12 -0.99 0.00 1.00 FALSE
48 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma SRD5A3 0.09 0.08 lasso 4 0.09 2.7e-05 6.39 6.6 4.0e-11 0.78 0.03 0.52 FALSE
49 The Cancer Genome Atlas Colon Adenocarcinoma TMEM165 0.06 0.07 enet 11 0.06 2.1e-04 7.30 -7.5 4.3e-14 -0.98 0.01 0.98 FALSE
50 The Cancer Genome Atlas Glioblastoma Multiforme SRD5A3 0.22 0.14 blup 44 0.12 1.9e-04 6.47 6.6 3.7e-11 0.85 0.00 0.97 FALSE
51 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma SRD5A3 0.04 0.03 blup 44 0.03 1.1e-04 7.30 7.3 2.3e-13 0.88 0.00 0.99 FALSE
52 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma CLOCK 0.02 0.02 enet 5 0.02 1.9e-03 6.37 7.1 1.5e-12 0.83 0.03 0.82 FALSE
53 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma SRD5A3 0.21 0.14 lasso 4 0.14 2.6e-15 6.39 6.2 4.5e-10 0.87 0.33 0.67 FALSE
54 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma TMEM165 0.08 0.06 lasso 3 0.09 1.5e-10 7.34 -7.5 6.8e-14 -0.91 0.00 1.00 FALSE
55 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma SRD5A3 0.24 0.08 enet 16 0.12 2.8e-07 -5.15 6.3 2.8e-10 0.77 0.01 0.99 FALSE
56 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma TMEM165 0.06 0.02 blup 55 0.03 6.2e-03 -5.15 -6.5 8.1e-11 -0.74 0.02 0.41 FALSE
57 The Cancer Genome Atlas Brain Lower Grade Glioma SRD5A3 0.14 0.07 blup 44 0.08 3.4e-09 6.38 5.6 1.9e-08 0.68 0.29 0.70 FALSE
58 The Cancer Genome Atlas Brain Lower Grade Glioma TMEM165 0.19 0.16 lasso 4 0.17 2.1e-18 7.32 -7.5 6.1e-14 -0.99 0.00 1.00 FALSE
59 The Cancer Genome Atlas Lung Adenocarcinoma SRD5A3 0.04 0.03 lasso 4 0.02 1.0e-03 6.39 6.3 2.7e-10 0.90 0.01 0.98 FALSE
60 The Cancer Genome Atlas Lung Adenocarcinoma TMEM165 0.03 0.01 blup 55 0.02 1.4e-03 7.34 -6.5 8.3e-11 -0.89 0.01 0.96 FALSE
61 The Cancer Genome Atlas Lung Squamous Cell Carcinoma SRD5A3 0.03 0.03 enet 4 0.05 3.1e-06 -2.79 5.3 9.0e-08 0.83 0.02 0.95 FALSE
62 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma SRD5A3 0.12 0.07 lasso 2 0.06 4.2e-05 6.39 6.4 1.4e-10 0.87 0.01 0.91 FALSE
63 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma SRD5A3 0.26 0.12 lasso 6 0.10 7.0e-05 6.39 6.7 2.8e-11 0.83 0.02 0.94 FALSE
64 The Cancer Genome Atlas Prostate Adenocarcinoma TMEM165 0.05 0.06 enet 5 0.05 4.3e-06 7.34 -7.6 3.2e-14 -0.95 0.00 1.00 TRUE
65 The Cancer Genome Atlas Rectum Adenocarcinoma TMEM165 0.40 0.05 enet 19 0.12 9.4e-04 -1.70 -5.2 1.8e-07 -0.52 0.01 0.33 FALSE
66 The Cancer Genome Atlas Skin Cutaneous Melanoma SRD5A3 0.17 0.05 blup 44 0.09 1.8e-03 -5.15 5.5 4.3e-08 0.55 0.01 0.30 FALSE
67 The Cancer Genome Atlas Stomach Adenocarcinoma CLOCK 0.08 0.07 enet 9 0.06 4.5e-05 6.20 5.7 1.4e-08 0.81 0.20 0.63 FALSE
68 The Cancer Genome Atlas Thyroid Carcinoma TMEM165 0.12 0.08 enet 12 0.08 2.1e-08 7.32 -7.2 6.6e-13 -0.94 0.00 1.00 FALSE