Best TWAS P=3.79e-14 · Best GWAS P=1.9e-44 conditioned to NaN
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adrenal Gland | U91328.19 | 0.28 | 0.12 | lasso | 10 | 0.14 | 1.3e-05 | -5.5 | 6.9 | 4.7e-12 | -0.30 | 0.95 | 0.00 | FALSE |
2 | GTEx | Artery Aorta | U91328.19 | 0.32 | 0.24 | lasso | 7 | 0.25 | 8.3e-14 | -5.2 | 5.7 | 1.6e-08 | -0.32 | 1.00 | 0.00 | FALSE |
3 | GTEx | Brain Caudate basal ganglia | U91328.19 | 0.23 | 0.16 | lasso | 10 | 0.16 | 3.1e-05 | -7.0 | 5.6 | 1.9e-08 | -0.23 | 0.73 | 0.02 | FALSE |
4 | GTEx | Brain Cerebellar Hemisphere | U91328.19 | 0.47 | 0.33 | enet | 44 | 0.26 | 2.8e-07 | -5.5 | 6.5 | 8.2e-11 | -0.34 | 0.98 | 0.00 | FALSE |
5 | GTEx | Brain Cerebellum | U91328.19 | 0.13 | 0.15 | lasso | 2 | 0.09 | 1.1e-03 | -6.4 | 6.2 | 7.9e-10 | -0.31 | 0.35 | 0.06 | TRUE |
6 | GTEx | Esophagus Gastroesophageal Junction | U91328.20 | 0.16 | 0.13 | enet | 16 | 0.13 | 2.0e-05 | -3.7 | 7.3 | 2.0e-13 | -0.31 | 0.45 | 0.03 | FALSE |
7 | GTEx | Esophagus Gastroesophageal Junction | U91328.19 | 0.28 | 0.07 | lasso | 7 | 0.21 | 4.3e-08 | -3.7 | 5.2 | 2.1e-07 | -0.32 | 0.71 | 0.02 | FALSE |
8 | GTEx | Esophagus Muscularis | TRIM38 | 0.06 | 0.04 | lasso | 4 | 0.02 | 1.7e-02 | -5.2 | 6.0 | 2.3e-09 | -0.31 | 0.53 | 0.04 | TRUE |
9 | GTEx | Esophagus Muscularis | U91328.19 | 0.36 | 0.30 | lasso | 10 | 0.30 | 1.7e-18 | -5.2 | 5.6 | 2.1e-08 | -0.30 | 1.00 | 0.00 | TRUE |
10 | GTEx | Lung | U91328.19 | 0.20 | 0.22 | enet | 15 | 0.24 | 2.9e-18 | -5.0 | 5.2 | 1.6e-07 | -0.31 | 1.00 | 0.00 | FALSE |
11 | GTEx | Ovary | U91328.19 | 0.37 | 0.17 | enet | 18 | 0.34 | 4.7e-09 | -3.7 | 7.6 | 3.8e-14 | -0.37 | 0.75 | 0.02 | TRUE |
12 | METSIM | Adipose | U91328.20 | 0.07 | 0.04 | bslmm | 658 | 0.04 | 8.9e-07 | -5.2 | 7.2 | 7.3e-13 | -0.46 | 0.93 | 0.03 | TRUE |
13 | YFS | Blood | TRIM38 | 0.37 | 0.31 | bslmm | 672 | 0.34 | 3.8e-115 | -6.5 | -6.3 | 2.6e-10 | 0.15 | 1.00 | 0.00 | TRUE |