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chr4:17,104,059-18,507,692

Best TWAS P=9.27e-17 · Best GWAS P=5.43e-18 conditioned to 0.000202

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
14	GTEx	Spleen	DCAF16	0.35	0.02	lasso	5	0.11	8.5e-04	6.5	8.3	9.3e-17	0.74	0.02	0.80	TRUE
20	The Cancer Genome Atlas	Brain Lower Grade Glioma	DCAF16	0.09	0.02	lasso	3	0.04	5.2e-05	6.6	8.2	2.1e-16	0.72	0.00	0.99	FALSE
16	GTEx	Thyroid	DCAF16	0.11	0.02	lasso	5	0.03	2.3e-03	6.5	8.1	4.3e-16	0.79	0.03	0.95	FALSE
23	The Cancer Genome Atlas	Thyroid Carcinoma	DCAF16	0.07	0.04	blup	31	0.07	4.9e-07	6.5	7.9	2.7e-15	0.68	0.01	0.99	FALSE
3	GTEx	Artery Aorta	DCAF16	0.10	0.01	enet	6	0.02	4.7e-02	-6.0	7.9	3.5e-15	0.61	0.11	0.54	FALSE
6	GTEx	Breast Mammary Tissue (Male)	DCAF16	0.24	0.03	enet	18	-0.01	4.4e-01	-6.5	7.7	1.3e-14	0.50	0.07	0.35	FALSE
15	GTEx	Stomach	DCAF16	0.21	0.04	lasso	6	0.02	5.6e-02	6.5	7.7	1.5e-14	0.91	0.02	0.92	FALSE
5	GTEx	Breast Mammary Tissue	DCAF16	0.12	0.08	lasso	4	0.10	6.4e-06	6.3	7.3	2.2e-13	0.71	0.14	0.66	FALSE
4	GTEx	Artery Tibial	DCAF16	0.16	0.16	lasso	5	0.13	1.5e-10	6.6	7.3	3.2e-13	0.84	0.05	0.95	FALSE
10	GTEx	Nerve Tibial	DCAF16	0.16	0.14	lasso	3	0.14	2.8e-10	6.5	7.0	2.5e-12	0.78	0.97	0.03	FALSE
22	The Cancer Genome Atlas	Prostate Adenocarcinoma	DCAF16	0.04	0.04	blup	31	0.04	2.2e-05	6.5	7.0	3.4e-12	0.73	0.01	0.98	FALSE
13	GTEx	Skin Sun Exposed Lower leg	DCAF16	0.14	0.12	enet	14	0.12	5.4e-10	6.3	6.9	3.8e-12	0.80	0.42	0.58	FALSE
8	GTEx	Esophagus Mucosa	DCAF16	0.10	0.02	lasso	4	0.02	8.3e-03	6.3	6.7	1.7e-11	0.77	0.03	0.84	FALSE
12	GTEx	Skin Not Sun Exposed Suprapubic	DCAF16	0.16	0.08	lasso	5	0.12	4.4e-07	6.5	6.6	3.5e-11	0.75	0.27	0.60	FALSE
18	YFS	Blood	DCAF16	0.02	0.02	lasso	1	0.01	1.1e-04	6.6	6.6	5.2e-11	0.83	0.07	0.92	FALSE
9	GTEx	Esophagus Muscularis	DCAF16	0.16	0.14	lasso	3	0.14	9.3e-09	6.5	6.5	8.8e-11	0.79	0.82	0.17	FALSE
7	GTEx	Breast Mammary Tissue (Female)	DCAF16	0.16	0.13	lasso	2	0.06	7.8e-03	6.5	6.4	1.4e-10	0.78	0.06	0.15	FALSE
17	ROSMAP	Brain Pre-frontal Cortex	DCAF16	0.04	0.02	bslmm	379	0.01	3.9e-02	-6.5	6.3	3.4e-10	0.29	0.29	0.02	FALSE
11	GTEx	Pituitary	DCAF16	0.27	0.20	enet	15	0.19	1.3e-05	6.5	6.2	5.5e-10	0.61	0.07	0.30	FALSE
19	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	NCAPG	0.14	0.07	lasso	3	0.07	5.2e-08	-6.5	-6.2	6.4e-10	-0.18	0.01	0.99	FALSE
1	GTEx	Adipose Subcutaneous	DCAF16	0.21	0.15	lasso	3	0.17	5.1e-14	6.5	6.1	7.8e-10	0.72	1.00	0.00	FALSE
2	GTEx	Adipose Visceral Omentum	DCAF16	0.19	0.06	enet	10	0.11	3.9e-06	6.5	5.9	4.1e-09	0.59	0.16	0.69	FALSE
21	The Cancer Genome Atlas	Brain Lower Grade Glioma	NCAPG	0.02	0.03	lasso	1	0.02	9.0e-04	-5.7	-5.7	1.2e-08	-0.24	0.02	0.59	FALSE