Hub : Traits :

Birth weight

519 significantly associated models · 140 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 66585659 68090386 1 1 1.5e-07 1.6e-07 1.0e+00 100 WDR78
2 1 154282146 156572984 4 2 2.8e-14 3.6e-14 1.0e+00 100 ADAM15 RIT1
3 1 160851894 162347618 1 1 9.8e-08 2.8e-05 3.5e-01 95 FCGR2B
4 1 204982713 206329620 3 1 1.5e-08 2.0e-07 2.0e-02 80 NUCKS1
5 2 8850817 10394558 5 1 1.1e-16 1.4e-18 3.2e-04 83 IAH1
6 2 37230728 37791321 1 1 2.3e-07 4.6e-07 1.3e-02 76 PRKD3
7 2 160095086 161610478 1 1 2.2e-07 1.8e-06 8.6e-02 87 PLA2R1
8 3 52242902 53860103 2 1 1.4e-09 4.1e-08 6.4e-01 99 RFT1
9 3 122306920 123860565 2 1 1.6e-18 3.3e-24 2.5e-11 57 RP11-797D24.4
10 3 141326602 142864702 1 1 1.0e-07 3.2e-07 3.1e-01 96 XRN1
11 3 155695485 157118526 2 1 3.5e-46 7.1e-46 1.0e+00 100 TIPARP
12 3 182655858 184099956 1 1 1.3e-09 1.6e-08 9.2e-01 100 KLHL24
13 4 17104059 18507692 2 1 9.3e-17 5.4e-18 2.0e-04 82 DCAF16
14 4 145203531 146706624 1 1 6.2e-14 4.5e-16 1.0e-04 77 ANAPC10
15 5 67264583 67845698 1 1 1.2e-07 9.1e-08 1.0e+00 100 PIK3R1
16 6 34747603 36158878 2 2 9.6e-10 1.1e-12 5.2e-05 68 C6orf126 TEAD3
17 6 87358929 88769878 1 1 4.6e-08 3.7e-07 2.1e-01 94 C6orf163
18 6 108612536 110710018 5 2 1.7e-15 1.2e-15 1.0e+00 100 RP11-425D10.10 SESN1
19 6 129638583 131163098 2 1 1.1e-07 3.2e-08 5.2e-02 88 RP11-73O6.3
20 6 141924760 143456607 1 1 3.9e-10 1.3e-11 1.0e+00 100 GPR126
21 7 2032803 3581391 2 1 1.5e-13 1.1e-13 1.3e-01 96 GNA12
22 7 22946782 24382726 3 2 2.5e-11 9.1e-20 2.2e-07 68 CCDC126 TRA2A
23 7 45255940 46658015 1 1 7.1e-09 4.5e-10 2.0e-03 75 IGFBP3
24 7 72674074 73803303 2 1 8.6e-10 2.7e-09 3.1e-02 87 BCL7B
25 7 106110799 107893695 2 1 2.1e-07 1.7e-06 3.6e-01 96 COG5
26 7 126593467 128425768 1 1 1.4e-10 3.6e-10 2.1e-01 96 SND1
27 8 40811597 42450441 1 1 7.7e-09 1.5e-09 1.0e+00 100 ANK1
28 9 97520168 98975128 1 1 2.5e-13 8.3e-17 1.0e+00 100 PTCH1
29 9 122817066 124681858 7 1 1.9e-09 3.4e-09 1.0e+00 100 RAB14
30 9 124913308 126563910 2 1 2.5e-12 2.0e-12 2.0e-01 97 RABGAP1
31 9 138525778 139943112 1 1 2.3e-08 1.9e-12 1.8e-05 63 GPSM1
32 10 70251287 71665054 2 1 9.8e-16 6.1e-18 1.4e-03 86 HKDC1
33 10 93657148 95151622 3 1 9.5e-12 8.3e-13 1.4e-02 88 EIF2S2P3
34 10 101602004 103018321 1 1 2.3e-07 9.8e-06 3.2e-01 95 HIF1AN
35 10 103807817 106042502 9 2 5.3e-14 2.8e-15 1.5e-01 97 C10orf26 CNNM2
36 10 115555541 116053000 1 1 1.1e-09 7.8e-15 2.4e-07 56 ADRB1
37 10 123438113 124889817 1 1 1.0e-09 2.9e-09 1.0e+00 100 PLEKHA1
38 11 1242690 2640824 4 3 2.6e-10 1.4e-12 1.2e-01 95 C11orf21 IGF2 TNNT3
39 11 32208950 32707915 1 1 2.5e-07 1.6e-08 2.1e-02 83 WIT1
40 11 64501991 66011280 2 1 4.4e-08 1.7e-07 1.7e-02 79 LTBP3
41 11 68781070 70179848 1 1 2.9e-07 2.9e-07 1.0e+00 100 ORAOV1
42 11 101284459 102802722 2 1 2.1e-08 4.1e-09 1.0e+00 100 RP11-864G5.3
43 11 111051115 112491227 5 1 4.7e-08 4.4e-08 1.5e-02 80 HSPB2
44 12 25789333 27681980 1 1 5.1e-10 5.5e-12 2.9e-03 81 ITPR2
45 12 65930145 67328072 1 1 3.8e-08 1.0e-36 3.9e-30 19 RBMS1P1
46 12 111102574 113517494 9 2 1.7e-10 4.8e-21 4.5e-06 76 ADAM1A HECTD4
47 15 49216723 50623952 1 1 1.5e-07 1.0e-07 2.4e-01 95 DTWD1
48 15 90712555 92135418 2 1 6.0e-10 3.2e-08 8.5e-01 100 FES
49 16 1605051 3015262 1 1 2.0e-07 7.4e-05 2.1e-01 90 RNPS1
50 16 66947363 67446037 1 1 2.0e-07 1.3e-06 5.5e-01 98 FBXL8
51 16 67651879 69084178 1 1 2.8e-07 5.7e-06 1.4e-01 90 PRMT7
52 16 86743421 88216892 1 1 2.3e-07 1.2e-06 9.1e-01 100 ZCCHC14
53 17 1517914 2918626 1 1 1.9e-07 1.7e-07 9.6e-02 90 SRR
54 17 6397773 8057572 14 1 2.9e-31 2.8e-27 3.6e-01 99 C17orf81
55 17 25295032 26338912 2 1 1.4e-10 2.1e-11 6.1e-03 83 RP11-173M1.8
56 19 54004939 55427510 2 2 2.1e-09 1.9e-07 1.0e-01 90 CTD-3093M3.1 RPS9
57 20 30591354 32140287 2 1 1.2e-15 3.1e-15 3.6e-03 86 COMMD7
58 20 56567724 57961572 1 1 1.4e-07 4.2e-07 4.1e-01 97 STX16-NPEPL1
59 20 62337406 62836520 1 1 4.8e-09 6.6e-07 1.3e-01 91 UCKL1AS
60 22 28792887 30261219 1 1 4.2e-09 8.7e-09 1.0e+00 100 KREMEN1
61 22 46185873 46688208 1 1 2.7e-07 1.6e-07 2.8e-03 67 LOC100271722

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Bipolar Disorder or Schizophrenia 1.61 3 2 4.4 0.00 1.0e+00 CNNM2 FES PRMT7
Depressed Affect (Nagel 2018) 1.14 1 0 0.0 0.00 1.0e+00 PTCH1
Intelligence (Savage-Jansen 2018) 1.33 3 2 4.4 0.00 1.0e+00 DCAF16 PLEKHA1 SND1
Neuroticism (Nagel 2018) 1.26 3 1 2.2 0.00 1.0e+00 CNNM2 PTCH1 RP11-73O6.3
Schizophrenia (2018) 1.55 3 2 4.4 0.00 1.0e+00 C10orf26 CNNM2 FES
Schizophrenia vs Biploar Disorder 1.29 1 0 0.0 0.00 1.0e+00 CNNM2
Worry (Nagel 2018) 1.42 3 1 2.2 0.00 1.0e+00 CNNM2 PTCH1 WDR78
Alzheimer’s Disease (including proxy) 1.13 1 0 0.0 0.00 1.0e+00 PLEKHA1
Crohns Disease (2017) 1.73 4 1 2.2 0.56 4.4e-01 GPSM1 RFT1 RIT1 RPS9
Irritable Bowel Disease (IBD) 1.84 5 1 2.2 0.30 6.3e-01 EIF2S2P3 GNA12 GPSM1 RIT1 TEAD3
Ulcerative Colitis (UC) 1.81 2 1 2.2 0.00 1.0e+00 GNA12 GPSM1
Major Depression (MDD) 1.83 2 0 0.0 0.00 1.0e+00 CNNM2 FES
Reaction Time 1.84 2 1 2.2 0.00 1.0e+00 C17orf81 HECTD4
Verbal and Numeric Reasoning (VNR) 1.27 2 1 2.2 0.00 1.0e+00 DCAF16 SND1
Breast Cancer 1.79 6 1 2.2 -0.42 4.1e-01 C17orf81 FES LTBP3 PIK3R1 RIT1 RP11-73O6.3
Ovarian Cancer 1.34 1 0 0.0 0.00 1.0e+00 PRMT7
Prostate Cancer 2.10 2 0 0.0 0.00 1.0e+00 ADAM15 TNNT3
Body Mass Index (BMI) (2010) 1.43 1 0 0.0 0.00 1.0e+00 CNNM2
Coronary Artery Disease (CAD) 2.32 3 0 0.0 0.00 1.0e+00 CNNM2 DCAF16 HECTD4
Crohns Disease (2012) 1.30 1 0 0.0 0.00 1.0e+00 RIT1
HbA1C 1.62 1 0 0.0 0.00 1.0e+00 ADAM1A
HDL Cholesterol 2.11 5 3 6.7 0.18 7.7e-01 ADRB1 BCL7B FBXL8 PRMT7 RFT1
LDL Cholesterol 1.35 1 1 2.2 0.00 1.0e+00 HECTD4
Lupus 1.03 1 0 0.0 0.00 1.0e+00 HECTD4
Primary Biliary Cirrhosis 1.34 1 0 0.0 0.00 1.0e+00 HECTD4
Rheumatoid Arthritis 1.22 1 0 0.0 0.00 1.0e+00 FCGR2B
Schizophrenia (2014) 1.72 3 2 4.4 0.00 1.0e+00 CNNM2 FES PRMT7
Triglycerides 3.55 1 1 2.2 0.00 1.0e+00 BCL7B
Type 2 Diabetes (T2D) (2012) 3.17 3 1 2.2 0.00 1.0e+00 ANK1 EIF2S2P3 PLEKHA1
Ulcerative Colitis 1.65 2 0 0.0 0.00 1.0e+00 GNA12 GPSM1
Blood Eosinophil Count 4.47 19 9 20.0 -0.41 7.7e-02 ADAM15 ADAM1A C17orf81 C6orf126 C6orf163 COMMD7 EIF2S2P3 FBXL8 GNA12 GPSM1 HECTD4 HSPB2 LTBP3 PIK3R1 RFT1 RP11-73O6.3 SESN1 TEAD3 XRN1
Blood Platelet Count 2.78 17 11 24.4 -0.43 8.6e-02 ADAM15 ADAM1A BCL7B COMMD7 DCAF16 FCGR2B GNA12 HECTD4 LTBP3 ORAOV1 RAB14 RP11-864G5.3 SND1 STX16-NPEPL1 TIPARP TNNT3 WIT1
Blood Red Count 1.84 18 11 24.4 -0.38 1.2e-01 ADAM15 ADAM1A CNNM2 EIF2S2P3 FCGR2B GNA12 GPR126 HECTD4 IGF2 ITPR2 PIK3R1 PRMT7 RP11-425D10.10 RP11-73O6.3 SESN1 STX16-NPEPL1 TEAD3 TIPARP
Blood White Count 3.14 23 15 33.3 -0.54 7.3e-03 ADAM1A BCL7B C6orf163 CCDC126 CNNM2 DCAF16 FCGR2B FES GNA12 GPSM1 HECTD4 HKDC1 ORAOV1 PLA2R1 PTCH1 RAB14 RFT1 RNPS1 RP11-73O6.3 RP11-864G5.3 TIPARP TRA2A WDR78
Heel T-Score 3.01 18 13 28.9 -0.12 6.4e-01 ANAPC10 C17orf81 CNNM2 DCAF16 FBXL8 GNA12 GPR126 IGFBP3 KREMEN1 LOC100271722 RABGAP1 RFT1 RNPS1 RP11-173M1.8 RP11-73O6.3 SRR TIPARP XRN1
BMI 1.28 12 6 13.3 0.59 4.5e-02 ADAM15 C17orf81 CNNM2 DCAF16 GPR126 HECTD4 KLHL24 LTBP3 ORAOV1 RIT1 RP11-73O6.3 SRR
Height 6.06 41 34 75.6 0.74 3.3e-08 ADAM15 ADRB1 ANAPC10 BCL7B C6orf126 CCDC126 COMMD7 DCAF16 FBXL8 FES GNA12 GPR126 GPSM1 HECTD4 HIF1AN HSPB2 IAH1 IGFBP3 KLHL24 KREMEN1 NUCKS1 PIK3R1 PLEKHA1 PTCH1 RABGAP1 RBMS1P1 RFT1 RNPS1 RP11-173M1.8 RP11-425D10.10 RP11-73O6.3 RP11-797D24.4 RP11-864G5.3 RPS9 SESN1 SRR TEAD3 TRA2A WDR78 XRN1 ZCCHC14
Waist Hip Ratio (WHR) 3.31 15 11 24.4 -0.20 4.7e-01 ADAM15 ADAM1A ANAPC10 BCL7B C6orf126 EIF2S2P3 HSPB2 IAH1 IGFBP3 ORAOV1 PLA2R1 RFT1 RP11-73O6.3 TIPARP WIT1
Systolic Blood Pressure 4.36 18 16 35.6 -0.40 1.0e-01 ADAM1A ADRB1 C10orf26 C17orf81 CNNM2 DCAF16 FES GPR126 HECTD4 HSPB2 PLEKHA1 PRKD3 RABGAP1 SND1 SRR TNNT3 UCKL1AS WIT1
Smoking Status 1.23 3 1 2.2 0.00 1.0e+00 ADAM1A FES SRR
Allergy or Eczema 2.09 10 3 6.7 -0.13 7.1e-01 ADAM15 ADAM1A FES GNA12 HECTD4 HSPB2 RIT1 SESN1 SRR WDR78
Cardiovascular Disease 3.31 13 9 20.0 -0.46 1.1e-01 ADAM1A ADRB1 C17orf81 CNNM2 COG5 DCAF16 FES HECTD4 HSPB2 KREMEN1 NUCKS1 TNNT3 UCKL1AS
Hypothyroidism (self reported) 3.66 6 4 8.9 -0.33 5.2e-01 ADAM1A C6orf163 HECTD4 PLEKHA1 PRMT7 SESN1
Respiratory disease 1.70 2 1 2.2 0.00 1.0e+00 EIF2S2P3 HSPB2
Type 2 Diabetes (T2D) (2018) 3.12 4 2 4.4 -0.46 5.4e-01 ADAM1A ANK1 EIF2S2P3 GPSM1
Lung FEV1/FVC ratio 4.78 12 7 15.6 -0.30 3.5e-01 ADAM15 DTWD1 FBXL8 FCGR2B GNA12 GPR126 NUCKS1 PLA2R1 PRMT7 PTCH1 RP11-173M1.8 SESN1
Lung FVC 1.79 13 6 13.3 0.16 6.0e-01 ANAPC10 C17orf81 C6orf126 C6orf163 CCDC126 DCAF16 GPSM1 HECTD4 HKDC1 NUCKS1 PTCH1 TEAD3 TIPARP
Neuroticism 1.24 2 2 4.4 0.00 1.0e+00 CNNM2 PTCH1
Chronotype (morning person) 0.94 3 1 2.2 0.00 1.0e+00 C10orf26 GPSM1 HECTD4
Hair Pigment 0.24 6 6 13.3 -0.12 8.2e-01 C11orf21 FES HECTD4 NUCKS1 RIT1 RP11-73O6.3
Tanning 0.33 4 1 2.2 -0.93 6.7e-02 ADAM15 DTWD1 HECTD4 IGFBP3
Hand grip strength (left) 2.49 7 3 6.7 0.90 5.1e-03 DCAF16 FES NUCKS1 RFT1 RP11-73O6.3 SND1 TRA2A
Number of treatments/medications taken 1.95 4 0 0.0 -1.00 4.8e-03 ADAM1A DCAF16 HECTD4 NUCKS1
Sensitivity / hurt feelings 1.34 2 1 2.2 0.00 1.0e+00 FES PTCH1
Hearing difficulty/problems: Yes 1.13 1 0 0.0 0.00 1.0e+00 C17orf81
Systolic blood pressure, automated reading 3.20 11 6 13.3 -0.36 2.8e-01 ADRB1 C10orf26 C17orf81 CNNM2 DCAF16 FES HECTD4 HSPB2 PRKD3 SRR TNNT3
Angina 1.59 1 1 2.2 0.00 1.0e+00 FES
Medication: Metformin 2.11 1 1 2.2 0.00 1.0e+00 EIF2S2P3
Diabetes (father) 2.30 1 1 2.2 0.00 1.0e+00 EIF2S2P3
Diabetes (mother) 1.90 3 0 0.0 0.00 1.0e+00 ANK1 EIF2S2P3 RP11-797D24.4
Pack years adult smoking proportion 1.05 1 0 0.0 0.00 1.0e+00 RFT1
Impedance of leg (right) 2.46 12 9 20.0 -0.85 5.2e-04 ADAM15 C6orf163 CNNM2 FES GPR126 IGFBP3 LTBP3 ORAOV1 PTCH1 RIT1 RP11-73O6.3 SRR
Leg fat-free mass (left) 4.63 27 20 44.4 0.94 3.3e-13 ADAM15 ANAPC10 C6orf163 CCDC126 CNNM2 COMMD7 DCAF16 FES GNA12 GPR126 HECTD4 HIF1AN IGFBP3 KLHL24 LTBP3 NUCKS1 ORAOV1 PIK3R1 PLEKHA1 PTCH1 RBMS1P1 RFT1 RNPS1 RP11-425D10.10 RP11-73O6.3 TRA2A XRN1
Trunk fat percentage 1.33 7 3 6.7 0.44 3.2e-01 C6orf126 GNA12 GPR126 KLHL24 PLEKHA1 SRR TEAD3
Hand grip strength (right) 2.62 8 4 8.9 0.73 4.2e-02 DCAF16 IGFBP3 NUCKS1 PTCH1 RFT1 RP11-73O6.3 TRA2A UCKL1AS
Fed-up feelings 1.24 2 0 0.0 0.00 1.0e+00 C17orf81 HECTD4
Relative age voice broke 1.00 1 0 0.0 0.00 1.0e+00 ADAM1A
Taking other prescription medications 1.55 2 0 0.0 0.00 1.0e+00 ADAM1A HECTD4
Age when periods started (menarche) 1.12 2 1 2.2 0.00 1.0e+00 RFT1 TIPARP
Heel bone mineral density (BMD) T-score, automated (left) 1.74 3 3 6.7 0.00 1.0e+00 FBXL8 KREMEN1 TIPARP
High blood pressure 3.55 14 8 17.8 -0.49 7.9e-02 ADAM1A ADRB1 C17orf81 CNNM2 DCAF16 FES HECTD4 HSPB2 KREMEN1 NUCKS1 SRR TNNT3 UCKL1AS WIT1
Hayfever, allergic rhinitis or eczema 1.96 5 1 2.2 -0.36 5.5e-01 ADAM15 ADAM1A HSPB2 RAB14 WDR78
Medication: Atenolol 2.51 2 2 4.4 0.00 1.0e+00 FES HECTD4
Medication: Levothyroxine sodium 2.94 3 2 4.4 0.00 1.0e+00 ADAM1A HECTD4 PLEKHA1
Sitting height 6.96 29 23 51.1 0.67 7.4e-05 ADAM15 ADRB1 ANAPC10 C6orf163 CCDC126 COMMD7 DCAF16 FBXL8 GNA12 GPR126 GPSM1 HIF1AN IGFBP3 ITPR2 KREMEN1 NUCKS1 PIK3R1 PTCH1 RBMS1P1 RFT1 RP11-425D10.10 RP11-73O6.3 RP11-797D24.4 TEAD3 TIPARP TRA2A WDR78 XRN1 ZCCHC14
High blood pressure (mother) 2.33 3 2 4.4 0.00 1.0e+00 ADRB1 CNNM2 FES
Body mass index (BMI) 1.27 9 3 6.7 0.43 2.5e-01 ADAM15 CNNM2 DCAF16 KLHL24 LTBP3 ORAOV1 RFT1 RP11-73O6.3 SRR
Impedance of leg (left) 2.45 12 9 20.0 -0.83 8.3e-04 ADAM15 C6orf163 CNNM2 FES GPR126 IGFBP3 LTBP3 ORAOV1 PTCH1 RIT1 RP11-73O6.3 SRR
Leg predicted mass (left) 4.60 26 20 44.4 0.94 6.9e-13 ADAM15 ANAPC10 C6orf163 CCDC126 CNNM2 COMMD7 DCAF16 FES GNA12 GPR126 HECTD4 HIF1AN IGFBP3 KLHL24 LTBP3 NUCKS1 ORAOV1 PIK3R1 PLEKHA1 PTCH1 RBMS1P1 RFT1 RNPS1 RP11-425D10.10 RP11-73O6.3 TRA2A
Trunk fat mass 1.83 9 6 13.3 0.99 4.3e-07 ANAPC10 CNNM2 GNA12 GPR126 KLHL24 PLEKHA1 RNPS1 RP11-73O6.3 SRR
Waist circumference 1.52 6 2 4.4 0.84 3.5e-02 ADAM15 C17orf81 GNA12 PLEKHA1 RNPS1 TIPARP
Number of incorrect matches in round 1.00 1 0 0.0 0.00 1.0e+00 PLEKHA1
Past tobacco smoking 1.22 2 0 0.0 0.00 1.0e+00 ADAM1A SRR
Nervous feelings 1.30 1 1 2.2 0.00 1.0e+00 CNNM2
Frequency of tenseness / restlessness in last 2 weeks 1.18 1 0 0.0 0.00 1.0e+00 CNNM2
Hearing difficulty/problems with background noise 1.19 1 0 0.0 0.00 1.0e+00 NUCKS1
Forced vital capacity (FVC) 4.16 13 9 20.0 0.97 7.4e-08 ANAPC10 C6orf126 CCDC126 DCAF16 GNA12 GPR126 IGFBP3 PTCH1 RFT1 RP11-425D10.10 RP11-73O6.3 TEAD3 TRA2A
Heel bone mineral density (BMD) T-score, automated (right) 1.87 3 3 6.7 0.00 1.0e+00 FBXL8 KREMEN1 TIPARP
Heart attack 1.80 1 1 2.2 0.00 1.0e+00 FES
Allergy 1.87 6 1 2.2 -0.28 5.9e-01 ADAM1A FES GNA12 HSPB2 SESN1 WDR78
Diabetes (self-reported) 2.56 3 2 4.4 0.00 1.0e+00 ANK1 EIF2S2P3 GPSM1
Medication: Ramipril 1.82 2 0 0.0 0.00 1.0e+00 ADAM1A FES
Medication: Simvastatin 1.83 2 1 2.2 0.00 1.0e+00 DCAF16 FES
Fluid intelligence score 1.21 1 0 0.0 0.00 1.0e+00 DCAF16
Illnesses of siblings 1.84 3 0 0.0 0.00 1.0e+00 ADAM1A FES HECTD4
Neuroticism score 0.99 1 1 2.2 0.00 1.0e+00 PTCH1
Weight 3.18 19 12 26.7 0.95 5.4e-10 ADAM15 ANAPC10 CCDC126 CNNM2 DCAF16 GNA12 GPR126 HECTD4 HIF1AN KLHL24 LTBP3 ORAOV1 PIK3R1 PLEKHA1 PTCH1 RBMS1P1 RNPS1 RP11-73O6.3 TRA2A
Impedance of arm (right) 1.92 10 5 11.1 0.09 8.0e-01 ADAM15 GPR126 IGFBP3 KREMEN1 LTBP3 RP11-73O6.3 RP11-864G5.3 TIPARP UCKL1AS WIT1
Arm fat percentage (right) 1.42 8 4 8.9 -0.46 2.5e-01 CNNM2 DCAF16 KLHL24 LTBP3 ORAOV1 RABGAP1 SRR TEAD3
Trunk fat-free mass 5.49 29 20 44.4 0.91 5.9e-12 ADAM15 ANAPC10 BCL7B C6orf126 C6orf163 CCDC126 CNNM2 COMMD7 DCAF16 GNA12 GPR126 GPSM1 HECTD4 HIF1AN IAH1 IGFBP3 NUCKS1 ORAOV1 PIK3R1 PLEKHA1 PTCH1 RBMS1P1 RFT1 RNPS1 RP11-425D10.10 RP11-73O6.3 TEAD3 TRA2A WDR78
Hip circumference 2.79 14 10 22.2 0.94 5.0e-07 ADAM15 ANAPC10 BCL7B C17orf81 CNNM2 GNA12 GPR126 HECTD4 KLHL24 ORAOV1 PLEKHA1 PTCH1 RNPS1 RP11-73O6.3
Father's age at death 1.53 2 1 2.2 0.00 1.0e+00 FES HECTD4
Worrier / anxious feelings 1.33 3 1 2.2 0.00 1.0e+00 CNNM2 PTCH1 SND1
Forced expiratory volume in 1-second (FEV1) 3.04 11 6 13.3 0.97 1.6e-06 ANAPC10 C6orf126 CCDC126 DCAF16 IGFBP3 PTCH1 RFT1 RP11-425D10.10 RP11-73O6.3 TEAD3 TRA2A
Qualifications: A levels/AS levels or equivalent 0.88 1 0 0.0 0.00 1.0e+00 DCAF16
Asthma 1.70 2 0 0.0 0.00 1.0e+00 EIF2S2P3 HSPB2
Medication: Ibuprofen (e.g. Nurofen) 1.30 1 0 0.0 0.00 1.0e+00 HECTD4
Medication: Cholesterol lowering 1.74 2 1 2.2 0.00 1.0e+00 DCAF16 FES
Illnesses of mother 1.86 1 1 2.2 0.00 1.0e+00 FES
Forced expiratory volume in 1-second (FEV1), Best measure 3.09 10 6 13.3 0.97 4.0e-06 ANAPC10 C6orf126 CCDC126 DCAF16 IGFBP3 PLA2R1 RFT1 RP11-73O6.3 TEAD3 TRA2A
Pulse wave Arterial Stiffness index 1.91 1 1 2.2 0.00 1.0e+00 ADAM1A
Impedance of arm (left) 1.86 12 3 6.7 0.06 8.5e-01 ADAM15 GNA12 GPR126 HECTD4 KREMEN1 LTBP3 ORAOV1 RP11-73O6.3 RP11-864G5.3 TIPARP UCKL1AS WIT1
Arm fat mass (right) 1.59 10 4 8.9 1.00 2.6e-10 ADAM15 CNNM2 GNA12 KLHL24 LTBP3 ORAOV1 PLEKHA1 RNPS1 RP11-73O6.3 SRR
Trunk predicted mass 5.51 29 21 46.7 0.91 5.8e-12 ADAM15 ANAPC10 BCL7B C6orf126 C6orf163 CCDC126 CNNM2 COMMD7 DCAF16 GNA12 GPR126 GPSM1 HECTD4 HIF1AN IAH1 IGFBP3 NUCKS1 ORAOV1 PIK3R1 PLEKHA1 PTCH1 RBMS1P1 RFT1 RNPS1 RP11-425D10.10 RP11-73O6.3 TEAD3 TRA2A WDR78
Standing height 5.96 30 27 60.0 0.80 1.0e-07 ADAM15 ADRB1 ANAPC10 C6orf126 CCDC126 COMMD7 DCAF16 GNA12 GPR126 GPSM1 HECTD4 HIF1AN IAH1 IGFBP3 NUCKS1 PIK3R1 PLEKHA1 PTCH1 RABGAP1 RBMS1P1 RFT1 RNPS1 RP11-425D10.10 RP11-73O6.3 RP11-797D24.4 TEAD3 TRA2A WDR78 XRN1 ZCCHC14
Tense / 'highly strung' 1.37 1 0 0.0 0.00 1.0e+00 CNNM2
Hair/balding pattern: Pattern 4 1.15 1 1 2.2 0.00 1.0e+00 SRR
Birth weight of first child 6.91 23 9 20.0 0.93 6.7e-11 ADAM15 ADAM1A ANAPC10 C10orf26 C17orf81 C6orf126 DCAF16 FES HECTD4 HKDC1 IAH1 IGFBP3 ITPR2 PIK3R1 PLEKHA1 RP11-797D24.4 RP11-864G5.3 RPS9 SESN1 SND1 TEAD3 TIPARP WIT1
Peak expiratory flow (PEF) 2.08 4 3 6.7 0.99 1.5e-02 ANAPC10 DCAF16 NUCKS1 RP11-425D10.10
Qualifications: O levels/GCSEs or equivalent 0.98 1 0 0.0 0.00 1.0e+00 NUCKS1
Mouth/teeth dental problems: Bleeding gums 1.11 1 0 0.0 0.00 1.0e+00 SND1
Medication for cholesterol, blood pressure or diabetes 2.57 3 2 4.4 0.00 1.0e+00 DCAF16 FES HSPB2
Gout (self-reported) 1.38 2 0 0.0 0.00 1.0e+00 ADAM15 HECTD4
Hypothyroidism/myxoedema (self-reported) 3.13 6 2 4.4 -0.31 5.5e-01 ADAM1A C6orf163 HECTD4 PLEKHA1 PRMT7 SESN1
Medication: Amlodipine 1.79 2 1 2.2 0.00 1.0e+00 FES TNNT3
High blood pressure (siblings) 1.95 2 1 2.2 0.00 1.0e+00 FES HECTD4
Forced vital capacity (FVC), Best measure 4.13 13 10 22.2 0.97 5.5e-08 ANAPC10 C11orf21 C6orf126 CCDC126 DCAF16 GNA12 GPR126 IGFBP3 PTCH1 RFT1 RP11-73O6.3 TEAD3 TRA2A
Body fat percentage 1.21 5 1 2.2 -0.58 3.0e-01 C6orf126 DCAF16 KLHL24 SRR TEAD3
Leg fat percentage (right) 1.26 4 2 4.4 -0.64 3.6e-01 DCAF16 IGFBP3 LTBP3 TEAD3
Arm fat-free mass (right) 4.79 28 18 40.0 0.89 2.7e-10 ADAM15 ANAPC10 BCL7B C11orf21 CCDC126 CNNM2 COMMD7 DCAF16 GNA12 GPR126 GPSM1 HECTD4 IAH1 IGFBP3 LTBP3 NUCKS1 ORAOV1 PIK3R1 PLEKHA1 PTCH1 RBMS1P1 RFT1 RNPS1 RP11-425D10.10 RP11-73O6.3 RP11-864G5.3 TEAD3 TRA2A
Comparative body size at age 10 2.01 8 3 6.7 0.96 1.5e-04 HKDC1 KLHL24 LTBP3 ORAOV1 PLA2R1 RIT1 SRR WDR78
Seen a psychiatrist for nerves, anxiety, tension or depression 1.44 1 0 0.0 0.00 1.0e+00 ADRB1
Wheeze or whistling in the chest in last year 1.69 2 1 2.2 0.00 1.0e+00 HSPB2 XRN1
Age at first live birth 1.20 1 0 0.0 0.00 1.0e+00 DCAF16
Pulse wave peak to peak time 1.77 1 1 2.2 0.00 1.0e+00 ADAM1A
Qualifications: College or University degree 1.11 4 2 4.4 -0.01 9.9e-01 C6orf163 DCAF16 RP11-864G5.3 SND1
Medication: Blood pressure 3.04 9 2 4.4 -0.42 2.6e-01 ADAM1A ADRB1 C17orf81 DCAF16 FES HECTD4 HSPB2 TNNT3 WIT1
Angina (self-reported) 1.58 1 1 2.2 0.00 1.0e+00 FES
Medication: Allopurinol 1.24 1 0 0.0 0.00 1.0e+00 ADAM15
Medication: Seretide 50 evohaler 1.42 1 0 0.0 0.00 1.0e+00 PRMT7
Mean time to correctly identify matches 2.02 3 2 4.4 0.00 1.0e+00 C17orf81 HECTD4 RP11-73O6.3
Whole body fat mass 1.65 11 3 6.7 0.98 1.1e-07 ADAM15 ANAPC10 CNNM2 GNA12 GPR126 KLHL24 LTBP3 PLEKHA1 RNPS1 RP11-73O6.3 SRR
Leg fat mass (right) 1.35 7 2 4.4 0.99 1.5e-05 ADAM15 CNNM2 GNA12 HECTD4 KLHL24 LTBP3 RP11-73O6.3
Arm predicted mass (right) 4.82 27 18 40.0 0.90 2.8e-10 ADAM15 ANAPC10 BCL7B C11orf21 CCDC126 CNNM2 DCAF16 GNA12 GPR126 GPSM1 HECTD4 IAH1 IGFBP3 LTBP3 NUCKS1 ORAOV1 PIK3R1 PLEKHA1 PTCH1 RBMS1P1 RFT1 RNPS1 RP11-425D10.10 RP11-73O6.3 RP11-864G5.3 TEAD3 TRA2A
Pulse rate, automated reading 1.25 2 1 2.2 0.00 1.0e+00 RFT1 RP11-864G5.3
Comparative height size at age 10 5.22 26 19 42.2 0.90 2.2e-10 ADAM15 ANAPC10 C6orf126 CCDC126 COMMD7 DCAF16 GNA12 GPR126 GPSM1 HECTD4 HKDC1 IAH1 IGFBP3 KLHL24 NUCKS1 PIK3R1 PLEKHA1 PTCH1 RBMS1P1 RFT1 RNPS1 RP11-425D10.10 RP11-73O6.3 TEAD3 TRA2A WDR78
Overall health rating 1.07 1 0 0.0 0.00 1.0e+00 TRA2A
Age at last live birth 1.21 1 0 0.0 0.00 1.0e+00 EIF2S2P3
Family relationship satisfaction 1.32 1 0 0.0 0.00 1.0e+00 RP11-73O6.3
Medication: Aspirin 1.95 1 1 2.2 0.00 1.0e+00 FES
Hypertension (Self-reported) 3.48 14 7 15.6 -0.49 7.6e-02 ADAM1A ADRB1 C17orf81 CNNM2 DCAF16 FES HECTD4 HSPB2 KREMEN1 NUCKS1 SRR TNNT3 UCKL1AS WIT1
Illnesses of father: Heart disease 1.71 1 1 2.2 0.00 1.0e+00 FES
Illnesses of siblings: Diabetes 1.77 1 0 0.0 0.00 1.0e+00 EIF2S2P3
Smoking status: Previous 1.08 1 0 0.0 0.00 1.0e+00 HECTD4
Forced expiratory volume in 1-second (FEV1), predicted 4.47 11 6 13.3 0.96 1.7e-06 ANAPC10 COMMD7 DCAF16 GNA12 GPR126 GPSM1 PTCH1 RFT1 RP11-73O6.3 TEAD3 TRA2A
Whole body fat-free mass 5.22 30 22 48.9 0.91 4.0e-12 ADAM15 ANAPC10 BCL7B C6orf163 CCDC126 CNNM2 COMMD7 DCAF16 GNA12 GPR126 GPSM1 HECTD4 HIF1AN IAH1 IGFBP3 KLHL24 LTBP3 NUCKS1 ORAOV1 PIK3R1 PLEKHA1 PTCH1 RBMS1P1 RFT1 RNPS1 RP11-425D10.10 RP11-73O6.3 TEAD3 TRA2A WDR78
Leg fat-free mass (right) 4.71 29 19 42.2 0.93 1.7e-13 ADAM15 ANAPC10 BCL7B C6orf163 CCDC126 CNNM2 COMMD7 DCAF16 FES GNA12 GPR126 GPSM1 HECTD4 HIF1AN IAH1 IGFBP3 KLHL24 LTBP3 NUCKS1 ORAOV1 PIK3R1 PLEKHA1 PTCH1 RBMS1P1 RFT1 RNPS1 RP11-425D10.10 RP11-73O6.3 TRA2A
Arm fat percentage (left) 1.37 7 4 8.9 0.07 8.8e-01 CNNM2 DCAF16 KLHL24 LTBP3 PLEKHA1 SRR TEAD3
Diabetes diagnosed by doctor 2.66 3 2 4.4 0.00 1.0e+00 ANK1 EIF2S2P3 GPSM1
Mouth/teeth dental problems: Mouth ulcers 1.00 2 0 0.0 0.00 1.0e+00 DTWD1 STX16-NPEPL1
Medication for cholesterol 2.30 2 0 0.0 0.00 1.0e+00 FES HECTD4
Asthma (self-reported) 1.65 2 0 0.0 0.00 1.0e+00 EIF2S2P3 HSPB2
Osteoarthritis (self-reported) 1.18 1 0 0.0 0.00 1.0e+00 NUCKS1
Medication: Aspirin 2.04 1 1 2.2 0.00 1.0e+00 FES
Illnesses of father: None of the above (group 1) 2.07 1 1 2.2 0.00 1.0e+00 FES
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.43 1 0 0.0 0.00 1.0e+00 GPR126
Whole body water mass 5.20 29 22 48.9 0.93 1.8e-13 ADAM15 ANAPC10 BCL7B C6orf163 CCDC126 CNNM2 COMMD7 DCAF16 GNA12 GPR126 GPSM1 HECTD4 HIF1AN IAH1 IGFBP3 KLHL24 LTBP3 NUCKS1 ORAOV1 PIK3R1 PLEKHA1 PTCH1 RBMS1P1 RFT1 RNPS1 RP11-425D10.10 RP11-73O6.3 TEAD3 TRA2A
Leg predicted mass (right) 4.72 29 18 40.0 0.93 1.7e-13 ADAM15 ANAPC10 BCL7B C6orf163 CCDC126 CNNM2 COMMD7 DCAF16 FES GNA12 GPR126 GPSM1 HECTD4 HIF1AN IAH1 IGFBP3 KLHL24 LTBP3 NUCKS1 ORAOV1 PIK3R1 PLEKHA1 PTCH1 RBMS1P1 RFT1 RNPS1 RP11-425D10.10 RP11-73O6.3 TRA2A
Arm fat mass (left) 1.56 10 4 8.9 1.00 2.5e-10 ADAM15 CNNM2 GNA12 KLHL24 LTBP3 ORAOV1 PLEKHA1 RNPS1 RP11-73O6.3 SRR
Number of self-reported non-cancer illnesses 1.48 1 0 0.0 0.00 1.0e+00 HECTD4
Guilty feelings 1.10 1 0 0.0 0.00 1.0e+00 PTCH1
Medication: Blood pressure 2.98 7 5 11.1 -0.68 9.6e-02 ADRB1 CNNM2 FES HECTD4 HSPB2 TNNT3 UCKL1AS
High cholesterol (Self-reported) 1.25 1 0 0.0 0.00 1.0e+00 DCAF16
Medication: Bendroflumethiazide 1.94 3 1 2.2 0.00 1.0e+00 ADRB1 FES TNNT3
Illnesses of father: High blood pressure 1.88 1 1 2.2 0.00 1.0e+00 FES
Ever smoked 1.15 1 0 0.0 0.00 1.0e+00 SRR
Basal metabolic rate 4.81 29 19 42.2 0.93 2.2e-13 ADAM15 ANAPC10 BCL7B C6orf163 CCDC126 CNNM2 COMMD7 DCAF16 GNA12 GPR126 GPSM1 HECTD4 HIF1AN IAH1 IGFBP3 KLHL24 LTBP3 NUCKS1 ORAOV1 PIK3R1 PLEKHA1 PTCH1 RBMS1P1 RFT1 RNPS1 RP11-425D10.10 RP11-73O6.3 TEAD3 TRA2A
Leg fat percentage (left) 1.23 3 2 4.4 0.00 1.0e+00 DCAF16 LTBP3 TEAD3
Arm fat-free mass (left) 4.64 28 17 37.8 0.89 1.9e-10 ADAM15 ANAPC10 C11orf21 CCDC126 CNNM2 COMMD7 DCAF16 GNA12 GPR126 GPSM1 HECTD4 HIF1AN IAH1 IGFBP3 LTBP3 NUCKS1 ORAOV1 PIK3R1 PLEKHA1 PTCH1 RBMS1P1 RFT1 RNPS1 RP11-425D10.10 RP11-73O6.3 RP11-864G5.3 TEAD3 TRA2A
Number of operations (self-reported) 1.37 1 0 0.0 0.00 1.0e+00 CCDC126
Irritability 1.29 1 0 0.0 0.00 1.0e+00 RP11-73O6.3
Fractured/broken bones in last 5 years 1.23 1 0 0.0 0.00 1.0e+00 PLEKHA1
Diastolic blood pressure, automated reading 2.79 8 7 15.6 -0.27 5.2e-01 ADAM1A ADRB1 C17orf81 CNNM2 DCAF16 FES HECTD4 SRR
Vascular/heart problems diagnosed by doctor 3.66 13 8 17.8 0.68 1.0e-02 ADAM1A ADRB1 CNNM2 DCAF16 FES HECTD4 HSPB2 KREMEN1 NUCKS1 SRR TEAD3 TNNT3 UCKL1AS
Cholesterol lowering medication 1.37 1 0 0.0 0.00 1.0e+00 DCAF16
Pain experienced in last month 0.95 1 0 0.0 0.00 1.0e+00 HECTD4
Heart attack/myocardial infarction (self-reported) 1.85 1 1 2.2 0.00 1.0e+00 FES
Heart disease (siblings) 1.34 1 0 0.0 0.00 1.0e+00 FES
Impedance of whole body 2.11 12 7 15.6 -0.60 4.1e-02 ADAM15 ADAM1A C6orf163 CNNM2 GPR126 IGFBP3 KREMEN1 LTBP3 ORAOV1 PTCH1 RP11-73O6.3 WIT1
Leg fat mass (left) 1.38 7 2 4.4 0.99 1.7e-05 ADAM15 CNNM2 GNA12 HECTD4 KLHL24 LTBP3 RP11-73O6.3
Arm predicted mass (left) 4.60 27 16 35.6 0.89 4.6e-10 ADAM15 ANAPC10 CCDC126 CNNM2 COMMD7 DCAF16 GNA12 GPR126 GPSM1 HECTD4 HIF1AN IAH1 IGFBP3 LTBP3 NUCKS1 ORAOV1 PIK3R1 PLEKHA1 PTCH1 RBMS1P1 RFT1 RNPS1 RP11-425D10.10 RP11-73O6.3 RP11-864G5.3 TEAD3 TRA2A

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 15 0.43 2.2
GTEx Adipose Visceral Omentum 7 0.34 2.2
GTEx Adrenal Gland 7 0.48 2.3
GTEx Artery Aorta 14 0.47 2.2
GTEx Artery Coronary 7 0.59 2.4
GTEx Artery Tibial 11 0.29 2.3
GTEx Brain Caudate basal ganglia 4 0.43 2.2
GTEx Brain Cerebellar Hemisphere 4 0.27 2.2
GTEx Brain Cerebellum 3 0.15 2.2
GTEx Brain Cortex 3 0.29 2.1
GTEx Brain Frontal Cortex BA9 4 0.43 2.2
GTEx Brain Hippocampus 4 0.76 2.2
GTEx Brain Hypothalamus 1 0.17 2.0
GTEx Brain Nucleus accumbens basal ganglia 2 0.23 2.2
GTEx Brain Putamen basal ganglia 3 0.48 2.2
GTEx Breast Mammary Tissue 7 0.35 2.2
GTEx Breast Mammary Tissue (Male) 5 0.42 2.2
GTEx Breast Mammary Tissue (Female) 3 0.18 2.0
GTEx Cells EBV-transformed lymphocytes 3 0.21 2.2
GTEx Cells Transformed fibroblasts 15 0.36 2.1
GTEx Colon Sigmoid 6 0.41 2.4
GTEx Colon Transverse 8 0.39 2.2
GTEx Esophagus Gastroesophageal Junction 5 0.35 2.3
GTEx Esophagus Mucosa 9 0.27 2.2
GTEx Esophagus Muscularis 12 0.37 2.2
GTEx Heart Atrial Appendage 4 0.25 2.2
GTEx Heart Left Ventricle 4 0.26 2.2
GTEx Liver 4 0.56 2.3
GTEx Lung 6 0.21 2.2
GTEx Muscle Skeletal 10 0.35 2.3
GTEx Nerve Tibial 14 0.32 2.2
GTEx Ovary 3 0.33 2.1
GTEx Pancreas 5 0.31 2.2
GTEx Pituitary 3 0.27 2.3
GTEx Prostate 6 0.72 2.3
GTEx Skin Not Sun Exposed Suprapubic 7 0.28 2.3
GTEx Skin Sun Exposed Lower leg 16 0.44 2.3
GTEx Small Intestine Terminal Ileum 3 0.65 2.3
GTEx Spleen 10 0.71 2.3
GTEx Stomach 7 0.48 2.3
GTEx Testis 13 0.41 2.3
GTEx Thyroid 12 0.30 2.2
GTEx Uterus 1 0.18 2.1
GTEx Vagina 4 0.63 2.1
GTEx Whole Blood 5 0.25 2.3
METSIM Adipose 16 0.35 2.1
NTR Blood 13 0.54 2.3
ROSMAP Brain Pre-frontal Cortex 17 0.39 2.2
YFS Blood 15 0.32 2.1
CommonMind Brain Pre-frontal Cortex 15 0.28 2.1
The Cancer Genome Atlas Bladder Urothelial Carcinoma 4 0.24 2.2
The Cancer Genome Atlas Breast Invasive Carcinoma 10 0.23 2.2
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 3 0.27 2.2
The Cancer Genome Atlas Colon Adenocarcinoma 6 0.29 2.2
The Cancer Genome Atlas Esophageal Carcinoma 2 0.29 2.2
The Cancer Genome Atlas Glioblastoma Multiforme 5 0.49 2.1
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 7 0.26 2.2
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 12 0.29 2.0
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 4 0.20 2.1
The Cancer Genome Atlas Brain Lower Grade Glioma 18 0.42 2.2
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 3 0.27 2.3
The Cancer Genome Atlas Lung Adenocarcinoma 8 0.27 2.1
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 6 0.24 2.1
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 2 0.13 2.0
The Cancer Genome Atlas Pancreatic Adenocarcinoma 5 0.30 2.2
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 6 0.45 2.1
The Cancer Genome Atlas Prostate Adenocarcinoma 12 0.26 2.1
The Cancer Genome Atlas Rectum Adenocarcinoma 2 0.29 2.3
The Cancer Genome Atlas Soft Tissue Sarcoma 2 0.19 2.0
The Cancer Genome Atlas Skin Cutaneous Melanoma 2 0.37 2.1
The Cancer Genome Atlas Stomach Adenocarcinoma 5 0.30 2.2
The Cancer Genome Atlas Testicular Germ Cell Tumors 4 0.31 2.2
The Cancer Genome Atlas Thyroid Carcinoma 15 0.29 2.1
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 1 0.20 2.2