Hub : Traits :

Birth weight

519 significantly associated models · 140 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	1	66585659	68090386	1	1	1.5e-07	1.6e-07	1.0e+00	100	WDR78
2	1	154282146	156572984	4	2	2.8e-14	3.6e-14	1.0e+00	100	ADAM15 RIT1
3	1	160851894	162347618	1	1	9.8e-08	2.8e-05	3.5e-01	95	FCGR2B
4	1	204982713	206329620	3	1	1.5e-08	2.0e-07	2.0e-02	80	NUCKS1
5	2	8850817	10394558	5	1	1.1e-16	1.4e-18	3.2e-04	83	IAH1
6	2	37230728	37791321	1	1	2.3e-07	4.6e-07	1.3e-02	76	PRKD3
7	2	160095086	161610478	1	1	2.2e-07	1.8e-06	8.6e-02	87	PLA2R1
8	3	52242902	53860103	2	1	1.4e-09	4.1e-08	6.4e-01	99	RFT1
9	3	122306920	123860565	2	1	1.6e-18	3.3e-24	2.5e-11	57	RP11-797D24.4
10	3	141326602	142864702	1	1	1.0e-07	3.2e-07	3.1e-01	96	XRN1
11	3	155695485	157118526	2	1	3.5e-46	7.1e-46	1.0e+00	100	TIPARP
12	3	182655858	184099956	1	1	1.3e-09	1.6e-08	9.2e-01	100	KLHL24
13	4	17104059	18507692	2	1	9.3e-17	5.4e-18	2.0e-04	82	DCAF16
14	4	145203531	146706624	1	1	6.2e-14	4.5e-16	1.0e-04	77	ANAPC10
15	5	67264583	67845698	1	1	1.2e-07	9.1e-08	1.0e+00	100	PIK3R1
16	6	34747603	36158878	2	2	9.6e-10	1.1e-12	5.2e-05	68	C6orf126 TEAD3
17	6	87358929	88769878	1	1	4.6e-08	3.7e-07	2.1e-01	94	C6orf163
18	6	108612536	110710018	5	2	1.7e-15	1.2e-15	1.0e+00	100	RP11-425D10.10 SESN1
19	6	129638583	131163098	2	1	1.1e-07	3.2e-08	5.2e-02	88	RP11-73O6.3
20	6	141924760	143456607	1	1	3.9e-10	1.3e-11	1.0e+00	100	GPR126
21	7	2032803	3581391	2	1	1.5e-13	1.1e-13	1.3e-01	96	GNA12
22	7	22946782	24382726	3	2	2.5e-11	9.1e-20	2.2e-07	68	CCDC126 TRA2A
23	7	45255940	46658015	1	1	7.1e-09	4.5e-10	2.0e-03	75	IGFBP3
24	7	72674074	73803303	2	1	8.6e-10	2.7e-09	3.1e-02	87	BCL7B
25	7	106110799	107893695	2	1	2.1e-07	1.7e-06	3.6e-01	96	COG5
26	7	126593467	128425768	1	1	1.4e-10	3.6e-10	2.1e-01	96	SND1
27	8	40811597	42450441	1	1	7.7e-09	1.5e-09	1.0e+00	100	ANK1
28	9	97520168	98975128	1	1	2.5e-13	8.3e-17	1.0e+00	100	PTCH1
29	9	122817066	124681858	7	1	1.9e-09	3.4e-09	1.0e+00	100	RAB14
30	9	124913308	126563910	2	1	2.5e-12	2.0e-12	2.0e-01	97	RABGAP1
31	9	138525778	139943112	1	1	2.3e-08	1.9e-12	1.8e-05	63	GPSM1
32	10	70251287	71665054	2	1	9.8e-16	6.1e-18	1.4e-03	86	HKDC1
33	10	93657148	95151622	3	1	9.5e-12	8.3e-13	1.4e-02	88	EIF2S2P3
34	10	101602004	103018321	1	1	2.3e-07	9.8e-06	3.2e-01	95	HIF1AN
35	10	103807817	106042502	9	2	5.3e-14	2.8e-15	1.5e-01	97	C10orf26 CNNM2
36	10	115555541	116053000	1	1	1.1e-09	7.8e-15	2.4e-07	56	ADRB1
37	10	123438113	124889817	1	1	1.0e-09	2.9e-09	1.0e+00	100	PLEKHA1
38	11	1242690	2640824	4	3	2.6e-10	1.4e-12	1.2e-01	95	C11orf21 IGF2 TNNT3
39	11	32208950	32707915	1	1	2.5e-07	1.6e-08	2.1e-02	83	WIT1
40	11	64501991	66011280	2	1	4.4e-08	1.7e-07	1.7e-02	79	LTBP3
41	11	68781070	70179848	1	1	2.9e-07	2.9e-07	1.0e+00	100	ORAOV1
42	11	101284459	102802722	2	1	2.1e-08	4.1e-09	1.0e+00	100	RP11-864G5.3
43	11	111051115	112491227	5	1	4.7e-08	4.4e-08	1.5e-02	80	HSPB2
44	12	25789333	27681980	1	1	5.1e-10	5.5e-12	2.9e-03	81	ITPR2
45	12	65930145	67328072	1	1	3.8e-08	1.0e-36	3.9e-30	19	RBMS1P1
46	12	111102574	113517494	9	2	1.7e-10	4.8e-21	4.5e-06	76	ADAM1A HECTD4
47	15	49216723	50623952	1	1	1.5e-07	1.0e-07	2.4e-01	95	DTWD1
48	15	90712555	92135418	2	1	6.0e-10	3.2e-08	8.5e-01	100	FES
49	16	1605051	3015262	1	1	2.0e-07	7.4e-05	2.1e-01	90	RNPS1
50	16	66947363	67446037	1	1	2.0e-07	1.3e-06	5.5e-01	98	FBXL8
51	16	67651879	69084178	1	1	2.8e-07	5.7e-06	1.4e-01	90	PRMT7
52	16	86743421	88216892	1	1	2.3e-07	1.2e-06	9.1e-01	100	ZCCHC14
53	17	1517914	2918626	1	1	1.9e-07	1.7e-07	9.6e-02	90	SRR
54	17	6397773	8057572	14	1	2.9e-31	2.8e-27	3.6e-01	99	C17orf81
55	17	25295032	26338912	2	1	1.4e-10	2.1e-11	6.1e-03	83	RP11-173M1.8
56	19	54004939	55427510	2	2	2.1e-09	1.9e-07	1.0e-01	90	CTD-3093M3.1 RPS9
57	20	30591354	32140287	2	1	1.2e-15	3.1e-15	3.6e-03	86	COMMD7
58	20	56567724	57961572	1	1	1.4e-07	4.2e-07	4.1e-01	97	STX16-NPEPL1
59	20	62337406	62836520	1	1	4.8e-09	6.6e-07	1.3e-01	91	UCKL1AS
60	22	28792887	30261219	1	1	4.2e-09	8.7e-09	1.0e+00	100	KREMEN1
61	22	46185873	46688208	1	1	2.7e-07	1.6e-07	2.8e-03	67	LOC100271722

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr	corr P	genes
Bipolar Disorder or Schizophrenia	1.61	3	2	4.4	0.00	1.0e+00	CNNM2 FES PRMT7
Depressed Affect (Nagel 2018)	1.14	1	0	0.0	0.00	1.0e+00	PTCH1
Intelligence (Savage-Jansen 2018)	1.33	3	2	4.4	0.00	1.0e+00	DCAF16 PLEKHA1 SND1
Neuroticism (Nagel 2018)	1.26	3	1	2.2	0.00	1.0e+00	CNNM2 PTCH1 RP11-73O6.3
Schizophrenia (2018)	1.55	3	2	4.4	0.00	1.0e+00	C10orf26 CNNM2 FES
Schizophrenia vs Biploar Disorder	1.29	1	0	0.0	0.00	1.0e+00	CNNM2
Worry (Nagel 2018)	1.42	3	1	2.2	0.00	1.0e+00	CNNM2 PTCH1 WDR78
Alzheimer’s Disease (including proxy)	1.13	1	0	0.0	0.00	1.0e+00	PLEKHA1
Crohns Disease (2017)	1.73	4	1	2.2	0.56	4.4e-01	GPSM1 RFT1 RIT1 RPS9
Irritable Bowel Disease (IBD)	1.84	5	1	2.2	0.30	6.3e-01	EIF2S2P3 GNA12 GPSM1 RIT1 TEAD3
Ulcerative Colitis (UC)	1.81	2	1	2.2	0.00	1.0e+00	GNA12 GPSM1
Major Depression (MDD)	1.83	2	0	0.0	0.00	1.0e+00	CNNM2 FES
Reaction Time	1.84	2	1	2.2	0.00	1.0e+00	C17orf81 HECTD4
Verbal and Numeric Reasoning (VNR)	1.27	2	1	2.2	0.00	1.0e+00	DCAF16 SND1
Breast Cancer	1.79	6	1	2.2	-0.42	4.1e-01	C17orf81 FES LTBP3 PIK3R1 RIT1 RP11-73O6.3
Ovarian Cancer	1.34	1	0	0.0	0.00	1.0e+00	PRMT7
Prostate Cancer	2.10	2	0	0.0	0.00	1.0e+00	ADAM15 TNNT3
Body Mass Index (BMI) (2010)	1.43	1	0	0.0	0.00	1.0e+00	CNNM2
Coronary Artery Disease (CAD)	2.32	3	0	0.0	0.00	1.0e+00	CNNM2 DCAF16 HECTD4
Crohns Disease (2012)	1.30	1	0	0.0	0.00	1.0e+00	RIT1
HbA1C	1.62	1	0	0.0	0.00	1.0e+00	ADAM1A
HDL Cholesterol	2.11	5	3	6.7	0.18	7.7e-01	ADRB1 BCL7B FBXL8 PRMT7 RFT1
LDL Cholesterol	1.35	1	1	2.2	0.00	1.0e+00	HECTD4
Lupus	1.03	1	0	0.0	0.00	1.0e+00	HECTD4
Primary Biliary Cirrhosis	1.34	1	0	0.0	0.00	1.0e+00	HECTD4
Rheumatoid Arthritis	1.22	1	0	0.0	0.00	1.0e+00	FCGR2B
Schizophrenia (2014)	1.72	3	2	4.4	0.00	1.0e+00	CNNM2 FES PRMT7
Triglycerides	3.55	1	1	2.2	0.00	1.0e+00	BCL7B
Type 2 Diabetes (T2D) (2012)	3.17	3	1	2.2	0.00	1.0e+00	ANK1 EIF2S2P3 PLEKHA1
Ulcerative Colitis	1.65	2	0	0.0	0.00	1.0e+00	GNA12 GPSM1
Blood Eosinophil Count	4.47	19	9	20.0	-0.41	7.7e-02	ADAM15 ADAM1A C17orf81 C6orf126 C6orf163 COMMD7 EIF2S2P3 FBXL8 GNA12 GPSM1 HECTD4 HSPB2 LTBP3 PIK3R1 RFT1 RP11-73O6.3 SESN1 TEAD3 XRN1
Blood Platelet Count	2.78	17	11	24.4	-0.43	8.6e-02	ADAM15 ADAM1A BCL7B COMMD7 DCAF16 FCGR2B GNA12 HECTD4 LTBP3 ORAOV1 RAB14 RP11-864G5.3 SND1 STX16-NPEPL1 TIPARP TNNT3 WIT1
Blood Red Count	1.84	18	11	24.4	-0.38	1.2e-01	ADAM15 ADAM1A CNNM2 EIF2S2P3 FCGR2B GNA12 GPR126 HECTD4 IGF2 ITPR2 PIK3R1 PRMT7 RP11-425D10.10 RP11-73O6.3 SESN1 STX16-NPEPL1 TEAD3 TIPARP
Blood White Count	3.14	23	15	33.3	-0.54	7.3e-03	ADAM1A BCL7B C6orf163 CCDC126 CNNM2 DCAF16 FCGR2B FES GNA12 GPSM1 HECTD4 HKDC1 ORAOV1 PLA2R1 PTCH1 RAB14 RFT1 RNPS1 RP11-73O6.3 RP11-864G5.3 TIPARP TRA2A WDR78
Heel T-Score	3.01	18	13	28.9	-0.12	6.4e-01	ANAPC10 C17orf81 CNNM2 DCAF16 FBXL8 GNA12 GPR126 IGFBP3 KREMEN1 LOC100271722 RABGAP1 RFT1 RNPS1 RP11-173M1.8 RP11-73O6.3 SRR TIPARP XRN1
BMI	1.28	12	6	13.3	0.59	4.5e-02	ADAM15 C17orf81 CNNM2 DCAF16 GPR126 HECTD4 KLHL24 LTBP3 ORAOV1 RIT1 RP11-73O6.3 SRR
Height	6.06	41	34	75.6	0.74	3.3e-08	ADAM15 ADRB1 ANAPC10 BCL7B C6orf126 CCDC126 COMMD7 DCAF16 FBXL8 FES GNA12 GPR126 GPSM1 HECTD4 HIF1AN HSPB2 IAH1 IGFBP3 KLHL24 KREMEN1 NUCKS1 PIK3R1 PLEKHA1 PTCH1 RABGAP1 RBMS1P1 RFT1 RNPS1 RP11-173M1.8 RP11-425D10.10 RP11-73O6.3 RP11-797D24.4 RP11-864G5.3 RPS9 SESN1 SRR TEAD3 TRA2A WDR78 XRN1 ZCCHC14
Waist Hip Ratio (WHR)	3.31	15	11	24.4	-0.20	4.7e-01	ADAM15 ADAM1A ANAPC10 BCL7B C6orf126 EIF2S2P3 HSPB2 IAH1 IGFBP3 ORAOV1 PLA2R1 RFT1 RP11-73O6.3 TIPARP WIT1
Systolic Blood Pressure	4.36	18	16	35.6	-0.40	1.0e-01	ADAM1A ADRB1 C10orf26 C17orf81 CNNM2 DCAF16 FES GPR126 HECTD4 HSPB2 PLEKHA1 PRKD3 RABGAP1 SND1 SRR TNNT3 UCKL1AS WIT1
Smoking Status	1.23	3	1	2.2	0.00	1.0e+00	ADAM1A FES SRR
Allergy or Eczema	2.09	10	3	6.7	-0.13	7.1e-01	ADAM15 ADAM1A FES GNA12 HECTD4 HSPB2 RIT1 SESN1 SRR WDR78
Cardiovascular Disease	3.31	13	9	20.0	-0.46	1.1e-01	ADAM1A ADRB1 C17orf81 CNNM2 COG5 DCAF16 FES HECTD4 HSPB2 KREMEN1 NUCKS1 TNNT3 UCKL1AS
Hypothyroidism (self reported)	3.66	6	4	8.9	-0.33	5.2e-01	ADAM1A C6orf163 HECTD4 PLEKHA1 PRMT7 SESN1
Respiratory disease	1.70	2	1	2.2	0.00	1.0e+00	EIF2S2P3 HSPB2
Type 2 Diabetes (T2D) (2018)	3.12	4	2	4.4	-0.46	5.4e-01	ADAM1A ANK1 EIF2S2P3 GPSM1
Lung FEV1/FVC ratio	4.78	12	7	15.6	-0.30	3.5e-01	ADAM15 DTWD1 FBXL8 FCGR2B GNA12 GPR126 NUCKS1 PLA2R1 PRMT7 PTCH1 RP11-173M1.8 SESN1
Lung FVC	1.79	13	6	13.3	0.16	6.0e-01	ANAPC10 C17orf81 C6orf126 C6orf163 CCDC126 DCAF16 GPSM1 HECTD4 HKDC1 NUCKS1 PTCH1 TEAD3 TIPARP
Neuroticism	1.24	2	2	4.4	0.00	1.0e+00	CNNM2 PTCH1
Chronotype (morning person)	0.94	3	1	2.2	0.00	1.0e+00	C10orf26 GPSM1 HECTD4
Hair Pigment	0.24	6	6	13.3	-0.12	8.2e-01	C11orf21 FES HECTD4 NUCKS1 RIT1 RP11-73O6.3
Tanning	0.33	4	1	2.2	-0.93	6.7e-02	ADAM15 DTWD1 HECTD4 IGFBP3
Hand grip strength (left)	2.49	7	3	6.7	0.90	5.1e-03	DCAF16 FES NUCKS1 RFT1 RP11-73O6.3 SND1 TRA2A
Number of treatments/medications taken	1.95	4	0	0.0	-1.00	4.8e-03	ADAM1A DCAF16 HECTD4 NUCKS1
Sensitivity / hurt feelings	1.34	2	1	2.2	0.00	1.0e+00	FES PTCH1
Hearing difficulty/problems: Yes	1.13	1	0	0.0	0.00	1.0e+00	C17orf81
Systolic blood pressure, automated reading	3.20	11	6	13.3	-0.36	2.8e-01	ADRB1 C10orf26 C17orf81 CNNM2 DCAF16 FES HECTD4 HSPB2 PRKD3 SRR TNNT3
Angina	1.59	1	1	2.2	0.00	1.0e+00	FES
Medication: Metformin	2.11	1	1	2.2	0.00	1.0e+00	EIF2S2P3
Diabetes (father)	2.30	1	1	2.2	0.00	1.0e+00	EIF2S2P3
Diabetes (mother)	1.90	3	0	0.0	0.00	1.0e+00	ANK1 EIF2S2P3 RP11-797D24.4
Pack years adult smoking proportion	1.05	1	0	0.0	0.00	1.0e+00	RFT1
Impedance of leg (right)	2.46	12	9	20.0	-0.85	5.2e-04	ADAM15 C6orf163 CNNM2 FES GPR126 IGFBP3 LTBP3 ORAOV1 PTCH1 RIT1 RP11-73O6.3 SRR
Leg fat-free mass (left)	4.63	27	20	44.4	0.94	3.3e-13	ADAM15 ANAPC10 C6orf163 CCDC126 CNNM2 COMMD7 DCAF16 FES GNA12 GPR126 HECTD4 HIF1AN IGFBP3 KLHL24 LTBP3 NUCKS1 ORAOV1 PIK3R1 PLEKHA1 PTCH1 RBMS1P1 RFT1 RNPS1 RP11-425D10.10 RP11-73O6.3 TRA2A XRN1
Trunk fat percentage	1.33	7	3	6.7	0.44	3.2e-01	C6orf126 GNA12 GPR126 KLHL24 PLEKHA1 SRR TEAD3
Hand grip strength (right)	2.62	8	4	8.9	0.73	4.2e-02	DCAF16 IGFBP3 NUCKS1 PTCH1 RFT1 RP11-73O6.3 TRA2A UCKL1AS
Fed-up feelings	1.24	2	0	0.0	0.00	1.0e+00	C17orf81 HECTD4
Relative age voice broke	1.00	1	0	0.0	0.00	1.0e+00	ADAM1A
Taking other prescription medications	1.55	2	0	0.0	0.00	1.0e+00	ADAM1A HECTD4
Age when periods started (menarche)	1.12	2	1	2.2	0.00	1.0e+00	RFT1 TIPARP
Heel bone mineral density (BMD) T-score, automated (left)	1.74	3	3	6.7	0.00	1.0e+00	FBXL8 KREMEN1 TIPARP
High blood pressure	3.55	14	8	17.8	-0.49	7.9e-02	ADAM1A ADRB1 C17orf81 CNNM2 DCAF16 FES HECTD4 HSPB2 KREMEN1 NUCKS1 SRR TNNT3 UCKL1AS WIT1
Hayfever, allergic rhinitis or eczema	1.96	5	1	2.2	-0.36	5.5e-01	ADAM15 ADAM1A HSPB2 RAB14 WDR78
Medication: Atenolol	2.51	2	2	4.4	0.00	1.0e+00	FES HECTD4
Medication: Levothyroxine sodium	2.94	3	2	4.4	0.00	1.0e+00	ADAM1A HECTD4 PLEKHA1
Sitting height	6.96	29	23	51.1	0.67	7.4e-05	ADAM15 ADRB1 ANAPC10 C6orf163 CCDC126 COMMD7 DCAF16 FBXL8 GNA12 GPR126 GPSM1 HIF1AN IGFBP3 ITPR2 KREMEN1 NUCKS1 PIK3R1 PTCH1 RBMS1P1 RFT1 RP11-425D10.10 RP11-73O6.3 RP11-797D24.4 TEAD3 TIPARP TRA2A WDR78 XRN1 ZCCHC14
High blood pressure (mother)	2.33	3	2	4.4	0.00	1.0e+00	ADRB1 CNNM2 FES
Body mass index (BMI)	1.27	9	3	6.7	0.43	2.5e-01	ADAM15 CNNM2 DCAF16 KLHL24 LTBP3 ORAOV1 RFT1 RP11-73O6.3 SRR
Impedance of leg (left)	2.45	12	9	20.0	-0.83	8.3e-04	ADAM15 C6orf163 CNNM2 FES GPR126 IGFBP3 LTBP3 ORAOV1 PTCH1 RIT1 RP11-73O6.3 SRR
Leg predicted mass (left)	4.60	26	20	44.4	0.94	6.9e-13	ADAM15 ANAPC10 C6orf163 CCDC126 CNNM2 COMMD7 DCAF16 FES GNA12 GPR126 HECTD4 HIF1AN IGFBP3 KLHL24 LTBP3 NUCKS1 ORAOV1 PIK3R1 PLEKHA1 PTCH1 RBMS1P1 RFT1 RNPS1 RP11-425D10.10 RP11-73O6.3 TRA2A
Trunk fat mass	1.83	9	6	13.3	0.99	4.3e-07	ANAPC10 CNNM2 GNA12 GPR126 KLHL24 PLEKHA1 RNPS1 RP11-73O6.3 SRR
Waist circumference	1.52	6	2	4.4	0.84	3.5e-02	ADAM15 C17orf81 GNA12 PLEKHA1 RNPS1 TIPARP
Number of incorrect matches in round	1.00	1	0	0.0	0.00	1.0e+00	PLEKHA1
Past tobacco smoking	1.22	2	0	0.0	0.00	1.0e+00	ADAM1A SRR
Nervous feelings	1.30	1	1	2.2	0.00	1.0e+00	CNNM2
Frequency of tenseness / restlessness in last 2 weeks	1.18	1	0	0.0	0.00	1.0e+00	CNNM2
Hearing difficulty/problems with background noise	1.19	1	0	0.0	0.00	1.0e+00	NUCKS1
Forced vital capacity (FVC)	4.16	13	9	20.0	0.97	7.4e-08	ANAPC10 C6orf126 CCDC126 DCAF16 GNA12 GPR126 IGFBP3 PTCH1 RFT1 RP11-425D10.10 RP11-73O6.3 TEAD3 TRA2A
Heel bone mineral density (BMD) T-score, automated (right)	1.87	3	3	6.7	0.00	1.0e+00	FBXL8 KREMEN1 TIPARP
Heart attack	1.80	1	1	2.2	0.00	1.0e+00	FES
Allergy	1.87	6	1	2.2	-0.28	5.9e-01	ADAM1A FES GNA12 HSPB2 SESN1 WDR78
Diabetes (self-reported)	2.56	3	2	4.4	0.00	1.0e+00	ANK1 EIF2S2P3 GPSM1
Medication: Ramipril	1.82	2	0	0.0	0.00	1.0e+00	ADAM1A FES
Medication: Simvastatin	1.83	2	1	2.2	0.00	1.0e+00	DCAF16 FES
Fluid intelligence score	1.21	1	0	0.0	0.00	1.0e+00	DCAF16
Illnesses of siblings	1.84	3	0	0.0	0.00	1.0e+00	ADAM1A FES HECTD4
Neuroticism score	0.99	1	1	2.2	0.00	1.0e+00	PTCH1
Weight	3.18	19	12	26.7	0.95	5.4e-10	ADAM15 ANAPC10 CCDC126 CNNM2 DCAF16 GNA12 GPR126 HECTD4 HIF1AN KLHL24 LTBP3 ORAOV1 PIK3R1 PLEKHA1 PTCH1 RBMS1P1 RNPS1 RP11-73O6.3 TRA2A
Impedance of arm (right)	1.92	10	5	11.1	0.09	8.0e-01	ADAM15 GPR126 IGFBP3 KREMEN1 LTBP3 RP11-73O6.3 RP11-864G5.3 TIPARP UCKL1AS WIT1
Arm fat percentage (right)	1.42	8	4	8.9	-0.46	2.5e-01	CNNM2 DCAF16 KLHL24 LTBP3 ORAOV1 RABGAP1 SRR TEAD3
Trunk fat-free mass	5.49	29	20	44.4	0.91	5.9e-12	ADAM15 ANAPC10 BCL7B C6orf126 C6orf163 CCDC126 CNNM2 COMMD7 DCAF16 GNA12 GPR126 GPSM1 HECTD4 HIF1AN IAH1 IGFBP3 NUCKS1 ORAOV1 PIK3R1 PLEKHA1 PTCH1 RBMS1P1 RFT1 RNPS1 RP11-425D10.10 RP11-73O6.3 TEAD3 TRA2A WDR78
Hip circumference	2.79	14	10	22.2	0.94	5.0e-07	ADAM15 ANAPC10 BCL7B C17orf81 CNNM2 GNA12 GPR126 HECTD4 KLHL24 ORAOV1 PLEKHA1 PTCH1 RNPS1 RP11-73O6.3
Father's age at death	1.53	2	1	2.2	0.00	1.0e+00	FES HECTD4
Worrier / anxious feelings	1.33	3	1	2.2	0.00	1.0e+00	CNNM2 PTCH1 SND1
Forced expiratory volume in 1-second (FEV1)	3.04	11	6	13.3	0.97	1.6e-06	ANAPC10 C6orf126 CCDC126 DCAF16 IGFBP3 PTCH1 RFT1 RP11-425D10.10 RP11-73O6.3 TEAD3 TRA2A
Qualifications: A levels/AS levels or equivalent	0.88	1	0	0.0	0.00	1.0e+00	DCAF16
Asthma	1.70	2	0	0.0	0.00	1.0e+00	EIF2S2P3 HSPB2
Medication: Ibuprofen (e.g. Nurofen)	1.30	1	0	0.0	0.00	1.0e+00	HECTD4
Medication: Cholesterol lowering	1.74	2	1	2.2	0.00	1.0e+00	DCAF16 FES
Illnesses of mother	1.86	1	1	2.2	0.00	1.0e+00	FES
Forced expiratory volume in 1-second (FEV1), Best measure	3.09	10	6	13.3	0.97	4.0e-06	ANAPC10 C6orf126 CCDC126 DCAF16 IGFBP3 PLA2R1 RFT1 RP11-73O6.3 TEAD3 TRA2A
Pulse wave Arterial Stiffness index	1.91	1	1	2.2	0.00	1.0e+00	ADAM1A
Impedance of arm (left)	1.86	12	3	6.7	0.06	8.5e-01	ADAM15 GNA12 GPR126 HECTD4 KREMEN1 LTBP3 ORAOV1 RP11-73O6.3 RP11-864G5.3 TIPARP UCKL1AS WIT1
Arm fat mass (right)	1.59	10	4	8.9	1.00	2.6e-10	ADAM15 CNNM2 GNA12 KLHL24 LTBP3 ORAOV1 PLEKHA1 RNPS1 RP11-73O6.3 SRR
Trunk predicted mass	5.51	29	21	46.7	0.91	5.8e-12	ADAM15 ANAPC10 BCL7B C6orf126 C6orf163 CCDC126 CNNM2 COMMD7 DCAF16 GNA12 GPR126 GPSM1 HECTD4 HIF1AN IAH1 IGFBP3 NUCKS1 ORAOV1 PIK3R1 PLEKHA1 PTCH1 RBMS1P1 RFT1 RNPS1 RP11-425D10.10 RP11-73O6.3 TEAD3 TRA2A WDR78
Standing height	5.96	30	27	60.0	0.80	1.0e-07	ADAM15 ADRB1 ANAPC10 C6orf126 CCDC126 COMMD7 DCAF16 GNA12 GPR126 GPSM1 HECTD4 HIF1AN IAH1 IGFBP3 NUCKS1 PIK3R1 PLEKHA1 PTCH1 RABGAP1 RBMS1P1 RFT1 RNPS1 RP11-425D10.10 RP11-73O6.3 RP11-797D24.4 TEAD3 TRA2A WDR78 XRN1 ZCCHC14
Tense / 'highly strung'	1.37	1	0	0.0	0.00	1.0e+00	CNNM2
Hair/balding pattern: Pattern 4	1.15	1	1	2.2	0.00	1.0e+00	SRR
Birth weight of first child	6.91	23	9	20.0	0.93	6.7e-11	ADAM15 ADAM1A ANAPC10 C10orf26 C17orf81 C6orf126 DCAF16 FES HECTD4 HKDC1 IAH1 IGFBP3 ITPR2 PIK3R1 PLEKHA1 RP11-797D24.4 RP11-864G5.3 RPS9 SESN1 SND1 TEAD3 TIPARP WIT1
Peak expiratory flow (PEF)	2.08	4	3	6.7	0.99	1.5e-02	ANAPC10 DCAF16 NUCKS1 RP11-425D10.10
Qualifications: O levels/GCSEs or equivalent	0.98	1	0	0.0	0.00	1.0e+00	NUCKS1
Mouth/teeth dental problems: Bleeding gums	1.11	1	0	0.0	0.00	1.0e+00	SND1
Medication for cholesterol, blood pressure or diabetes	2.57	3	2	4.4	0.00	1.0e+00	DCAF16 FES HSPB2
Gout (self-reported)	1.38	2	0	0.0	0.00	1.0e+00	ADAM15 HECTD4
Hypothyroidism/myxoedema (self-reported)	3.13	6	2	4.4	-0.31	5.5e-01	ADAM1A C6orf163 HECTD4 PLEKHA1 PRMT7 SESN1
Medication: Amlodipine	1.79	2	1	2.2	0.00	1.0e+00	FES TNNT3
High blood pressure (siblings)	1.95	2	1	2.2	0.00	1.0e+00	FES HECTD4
Forced vital capacity (FVC), Best measure	4.13	13	10	22.2	0.97	5.5e-08	ANAPC10 C11orf21 C6orf126 CCDC126 DCAF16 GNA12 GPR126 IGFBP3 PTCH1 RFT1 RP11-73O6.3 TEAD3 TRA2A
Body fat percentage	1.21	5	1	2.2	-0.58	3.0e-01	C6orf126 DCAF16 KLHL24 SRR TEAD3
Leg fat percentage (right)	1.26	4	2	4.4	-0.64	3.6e-01	DCAF16 IGFBP3 LTBP3 TEAD3
Arm fat-free mass (right)	4.79	28	18	40.0	0.89	2.7e-10	ADAM15 ANAPC10 BCL7B C11orf21 CCDC126 CNNM2 COMMD7 DCAF16 GNA12 GPR126 GPSM1 HECTD4 IAH1 IGFBP3 LTBP3 NUCKS1 ORAOV1 PIK3R1 PLEKHA1 PTCH1 RBMS1P1 RFT1 RNPS1 RP11-425D10.10 RP11-73O6.3 RP11-864G5.3 TEAD3 TRA2A
Comparative body size at age 10	2.01	8	3	6.7	0.96	1.5e-04	HKDC1 KLHL24 LTBP3 ORAOV1 PLA2R1 RIT1 SRR WDR78
Seen a psychiatrist for nerves, anxiety, tension or depression	1.44	1	0	0.0	0.00	1.0e+00	ADRB1
Wheeze or whistling in the chest in last year	1.69	2	1	2.2	0.00	1.0e+00	HSPB2 XRN1
Age at first live birth	1.20	1	0	0.0	0.00	1.0e+00	DCAF16
Pulse wave peak to peak time	1.77	1	1	2.2	0.00	1.0e+00	ADAM1A
Qualifications: College or University degree	1.11	4	2	4.4	-0.01	9.9e-01	C6orf163 DCAF16 RP11-864G5.3 SND1
Medication: Blood pressure	3.04	9	2	4.4	-0.42	2.6e-01	ADAM1A ADRB1 C17orf81 DCAF16 FES HECTD4 HSPB2 TNNT3 WIT1
Angina (self-reported)	1.58	1	1	2.2	0.00	1.0e+00	FES
Medication: Allopurinol	1.24	1	0	0.0	0.00	1.0e+00	ADAM15
Medication: Seretide 50 evohaler	1.42	1	0	0.0	0.00	1.0e+00	PRMT7
Mean time to correctly identify matches	2.02	3	2	4.4	0.00	1.0e+00	C17orf81 HECTD4 RP11-73O6.3
Whole body fat mass	1.65	11	3	6.7	0.98	1.1e-07	ADAM15 ANAPC10 CNNM2 GNA12 GPR126 KLHL24 LTBP3 PLEKHA1 RNPS1 RP11-73O6.3 SRR
Leg fat mass (right)	1.35	7	2	4.4	0.99	1.5e-05	ADAM15 CNNM2 GNA12 HECTD4 KLHL24 LTBP3 RP11-73O6.3
Arm predicted mass (right)	4.82	27	18	40.0	0.90	2.8e-10	ADAM15 ANAPC10 BCL7B C11orf21 CCDC126 CNNM2 DCAF16 GNA12 GPR126 GPSM1 HECTD4 IAH1 IGFBP3 LTBP3 NUCKS1 ORAOV1 PIK3R1 PLEKHA1 PTCH1 RBMS1P1 RFT1 RNPS1 RP11-425D10.10 RP11-73O6.3 RP11-864G5.3 TEAD3 TRA2A
Pulse rate, automated reading	1.25	2	1	2.2	0.00	1.0e+00	RFT1 RP11-864G5.3
Comparative height size at age 10	5.22	26	19	42.2	0.90	2.2e-10	ADAM15 ANAPC10 C6orf126 CCDC126 COMMD7 DCAF16 GNA12 GPR126 GPSM1 HECTD4 HKDC1 IAH1 IGFBP3 KLHL24 NUCKS1 PIK3R1 PLEKHA1 PTCH1 RBMS1P1 RFT1 RNPS1 RP11-425D10.10 RP11-73O6.3 TEAD3 TRA2A WDR78
Overall health rating	1.07	1	0	0.0	0.00	1.0e+00	TRA2A
Age at last live birth	1.21	1	0	0.0	0.00	1.0e+00	EIF2S2P3
Family relationship satisfaction	1.32	1	0	0.0	0.00	1.0e+00	RP11-73O6.3
Medication: Aspirin	1.95	1	1	2.2	0.00	1.0e+00	FES
Hypertension (Self-reported)	3.48	14	7	15.6	-0.49	7.6e-02	ADAM1A ADRB1 C17orf81 CNNM2 DCAF16 FES HECTD4 HSPB2 KREMEN1 NUCKS1 SRR TNNT3 UCKL1AS WIT1
Illnesses of father: Heart disease	1.71	1	1	2.2	0.00	1.0e+00	FES
Illnesses of siblings: Diabetes	1.77	1	0	0.0	0.00	1.0e+00	EIF2S2P3
Smoking status: Previous	1.08	1	0	0.0	0.00	1.0e+00	HECTD4
Forced expiratory volume in 1-second (FEV1), predicted	4.47	11	6	13.3	0.96	1.7e-06	ANAPC10 COMMD7 DCAF16 GNA12 GPR126 GPSM1 PTCH1 RFT1 RP11-73O6.3 TEAD3 TRA2A
Whole body fat-free mass	5.22	30	22	48.9	0.91	4.0e-12	ADAM15 ANAPC10 BCL7B C6orf163 CCDC126 CNNM2 COMMD7 DCAF16 GNA12 GPR126 GPSM1 HECTD4 HIF1AN IAH1 IGFBP3 KLHL24 LTBP3 NUCKS1 ORAOV1 PIK3R1 PLEKHA1 PTCH1 RBMS1P1 RFT1 RNPS1 RP11-425D10.10 RP11-73O6.3 TEAD3 TRA2A WDR78
Leg fat-free mass (right)	4.71	29	19	42.2	0.93	1.7e-13	ADAM15 ANAPC10 BCL7B C6orf163 CCDC126 CNNM2 COMMD7 DCAF16 FES GNA12 GPR126 GPSM1 HECTD4 HIF1AN IAH1 IGFBP3 KLHL24 LTBP3 NUCKS1 ORAOV1 PIK3R1 PLEKHA1 PTCH1 RBMS1P1 RFT1 RNPS1 RP11-425D10.10 RP11-73O6.3 TRA2A
Arm fat percentage (left)	1.37	7	4	8.9	0.07	8.8e-01	CNNM2 DCAF16 KLHL24 LTBP3 PLEKHA1 SRR TEAD3
Diabetes diagnosed by doctor	2.66	3	2	4.4	0.00	1.0e+00	ANK1 EIF2S2P3 GPSM1
Mouth/teeth dental problems: Mouth ulcers	1.00	2	0	0.0	0.00	1.0e+00	DTWD1 STX16-NPEPL1
Medication for cholesterol	2.30	2	0	0.0	0.00	1.0e+00	FES HECTD4
Asthma (self-reported)	1.65	2	0	0.0	0.00	1.0e+00	EIF2S2P3 HSPB2
Osteoarthritis (self-reported)	1.18	1	0	0.0	0.00	1.0e+00	NUCKS1
Medication: Aspirin	2.04	1	1	2.2	0.00	1.0e+00	FES
Illnesses of father: None of the above (group 1)	2.07	1	1	2.2	0.00	1.0e+00	FES
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.43	1	0	0.0	0.00	1.0e+00	GPR126
Whole body water mass	5.20	29	22	48.9	0.93	1.8e-13	ADAM15 ANAPC10 BCL7B C6orf163 CCDC126 CNNM2 COMMD7 DCAF16 GNA12 GPR126 GPSM1 HECTD4 HIF1AN IAH1 IGFBP3 KLHL24 LTBP3 NUCKS1 ORAOV1 PIK3R1 PLEKHA1 PTCH1 RBMS1P1 RFT1 RNPS1 RP11-425D10.10 RP11-73O6.3 TEAD3 TRA2A
Leg predicted mass (right)	4.72	29	18	40.0	0.93	1.7e-13	ADAM15 ANAPC10 BCL7B C6orf163 CCDC126 CNNM2 COMMD7 DCAF16 FES GNA12 GPR126 GPSM1 HECTD4 HIF1AN IAH1 IGFBP3 KLHL24 LTBP3 NUCKS1 ORAOV1 PIK3R1 PLEKHA1 PTCH1 RBMS1P1 RFT1 RNPS1 RP11-425D10.10 RP11-73O6.3 TRA2A
Arm fat mass (left)	1.56	10	4	8.9	1.00	2.5e-10	ADAM15 CNNM2 GNA12 KLHL24 LTBP3 ORAOV1 PLEKHA1 RNPS1 RP11-73O6.3 SRR
Number of self-reported non-cancer illnesses	1.48	1	0	0.0	0.00	1.0e+00	HECTD4
Guilty feelings	1.10	1	0	0.0	0.00	1.0e+00	PTCH1
Medication: Blood pressure	2.98	7	5	11.1	-0.68	9.6e-02	ADRB1 CNNM2 FES HECTD4 HSPB2 TNNT3 UCKL1AS
High cholesterol (Self-reported)	1.25	1	0	0.0	0.00	1.0e+00	DCAF16
Medication: Bendroflumethiazide	1.94	3	1	2.2	0.00	1.0e+00	ADRB1 FES TNNT3
Illnesses of father: High blood pressure	1.88	1	1	2.2	0.00	1.0e+00	FES
Ever smoked	1.15	1	0	0.0	0.00	1.0e+00	SRR
Basal metabolic rate	4.81	29	19	42.2	0.93	2.2e-13	ADAM15 ANAPC10 BCL7B C6orf163 CCDC126 CNNM2 COMMD7 DCAF16 GNA12 GPR126 GPSM1 HECTD4 HIF1AN IAH1 IGFBP3 KLHL24 LTBP3 NUCKS1 ORAOV1 PIK3R1 PLEKHA1 PTCH1 RBMS1P1 RFT1 RNPS1 RP11-425D10.10 RP11-73O6.3 TEAD3 TRA2A
Leg fat percentage (left)	1.23	3	2	4.4	0.00	1.0e+00	DCAF16 LTBP3 TEAD3
Arm fat-free mass (left)	4.64	28	17	37.8	0.89	1.9e-10	ADAM15 ANAPC10 C11orf21 CCDC126 CNNM2 COMMD7 DCAF16 GNA12 GPR126 GPSM1 HECTD4 HIF1AN IAH1 IGFBP3 LTBP3 NUCKS1 ORAOV1 PIK3R1 PLEKHA1 PTCH1 RBMS1P1 RFT1 RNPS1 RP11-425D10.10 RP11-73O6.3 RP11-864G5.3 TEAD3 TRA2A
Number of operations (self-reported)	1.37	1	0	0.0	0.00	1.0e+00	CCDC126
Irritability	1.29	1	0	0.0	0.00	1.0e+00	RP11-73O6.3
Fractured/broken bones in last 5 years	1.23	1	0	0.0	0.00	1.0e+00	PLEKHA1
Diastolic blood pressure, automated reading	2.79	8	7	15.6	-0.27	5.2e-01	ADAM1A ADRB1 C17orf81 CNNM2 DCAF16 FES HECTD4 SRR
Vascular/heart problems diagnosed by doctor	3.66	13	8	17.8	0.68	1.0e-02	ADAM1A ADRB1 CNNM2 DCAF16 FES HECTD4 HSPB2 KREMEN1 NUCKS1 SRR TEAD3 TNNT3 UCKL1AS
Cholesterol lowering medication	1.37	1	0	0.0	0.00	1.0e+00	DCAF16
Pain experienced in last month	0.95	1	0	0.0	0.00	1.0e+00	HECTD4
Heart attack/myocardial infarction (self-reported)	1.85	1	1	2.2	0.00	1.0e+00	FES
Heart disease (siblings)	1.34	1	0	0.0	0.00	1.0e+00	FES
Impedance of whole body	2.11	12	7	15.6	-0.60	4.1e-02	ADAM15 ADAM1A C6orf163 CNNM2 GPR126 IGFBP3 KREMEN1 LTBP3 ORAOV1 PTCH1 RP11-73O6.3 WIT1
Leg fat mass (left)	1.38	7	2	4.4	0.99	1.7e-05	ADAM15 CNNM2 GNA12 HECTD4 KLHL24 LTBP3 RP11-73O6.3
Arm predicted mass (left)	4.60	27	16	35.6	0.89	4.6e-10	ADAM15 ANAPC10 CCDC126 CNNM2 COMMD7 DCAF16 GNA12 GPR126 GPSM1 HECTD4 HIF1AN IAH1 IGFBP3 LTBP3 NUCKS1 ORAOV1 PIK3R1 PLEKHA1 PTCH1 RBMS1P1 RFT1 RNPS1 RP11-425D10.10 RP11-73O6.3 RP11-864G5.3 TEAD3 TRA2A

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Adipose Subcutaneous	15	0.43	2.2
GTEx	Adipose Visceral Omentum	7	0.34	2.2
GTEx	Adrenal Gland	7	0.48	2.3
GTEx	Artery Aorta	14	0.47	2.2
GTEx	Artery Coronary	7	0.59	2.4
GTEx	Artery Tibial	11	0.29	2.3
GTEx	Brain Caudate basal ganglia	4	0.43	2.2
GTEx	Brain Cerebellar Hemisphere	4	0.27	2.2
GTEx	Brain Cerebellum	3	0.15	2.2
GTEx	Brain Cortex	3	0.29	2.1
GTEx	Brain Frontal Cortex BA9	4	0.43	2.2
GTEx	Brain Hippocampus	4	0.76	2.2
GTEx	Brain Hypothalamus	1	0.17	2.0
GTEx	Brain Nucleus accumbens basal ganglia	2	0.23	2.2
GTEx	Brain Putamen basal ganglia	3	0.48	2.2
GTEx	Breast Mammary Tissue	7	0.35	2.2
GTEx	Breast Mammary Tissue (Male)	5	0.42	2.2
GTEx	Breast Mammary Tissue (Female)	3	0.18	2.0
GTEx	Cells EBV-transformed lymphocytes	3	0.21	2.2
GTEx	Cells Transformed fibroblasts	15	0.36	2.1
GTEx	Colon Sigmoid	6	0.41	2.4
GTEx	Colon Transverse	8	0.39	2.2
GTEx	Esophagus Gastroesophageal Junction	5	0.35	2.3
GTEx	Esophagus Mucosa	9	0.27	2.2
GTEx	Esophagus Muscularis	12	0.37	2.2
GTEx	Heart Atrial Appendage	4	0.25	2.2
GTEx	Heart Left Ventricle	4	0.26	2.2
GTEx	Liver	4	0.56	2.3
GTEx	Lung	6	0.21	2.2
GTEx	Muscle Skeletal	10	0.35	2.3
GTEx	Nerve Tibial	14	0.32	2.2
GTEx	Ovary	3	0.33	2.1
GTEx	Pancreas	5	0.31	2.2
GTEx	Pituitary	3	0.27	2.3
GTEx	Prostate	6	0.72	2.3
GTEx	Skin Not Sun Exposed Suprapubic	7	0.28	2.3
GTEx	Skin Sun Exposed Lower leg	16	0.44	2.3
GTEx	Small Intestine Terminal Ileum	3	0.65	2.3
GTEx	Spleen	10	0.71	2.3
GTEx	Stomach	7	0.48	2.3
GTEx	Testis	13	0.41	2.3
GTEx	Thyroid	12	0.30	2.2
GTEx	Uterus	1	0.18	2.1
GTEx	Vagina	4	0.63	2.1
GTEx	Whole Blood	5	0.25	2.3
METSIM	Adipose	16	0.35	2.1
NTR	Blood	13	0.54	2.3
ROSMAP	Brain Pre-frontal Cortex	17	0.39	2.2
YFS	Blood	15	0.32	2.1
CommonMind	Brain Pre-frontal Cortex	15	0.28	2.1
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	4	0.24	2.2
The Cancer Genome Atlas	Breast Invasive Carcinoma	10	0.23	2.2
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	3	0.27	2.2
The Cancer Genome Atlas	Colon Adenocarcinoma	6	0.29	2.2
The Cancer Genome Atlas	Esophageal Carcinoma	2	0.29	2.2
The Cancer Genome Atlas	Glioblastoma Multiforme	5	0.49	2.1
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	7	0.26	2.2
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	12	0.29	2.0
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	4	0.20	2.1
The Cancer Genome Atlas	Brain Lower Grade Glioma	18	0.42	2.2
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	3	0.27	2.3
The Cancer Genome Atlas	Lung Adenocarcinoma	8	0.27	2.1
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	6	0.24	2.1
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	2	0.13	2.0
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	5	0.30	2.2
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	6	0.45	2.1
The Cancer Genome Atlas	Prostate Adenocarcinoma	12	0.26	2.1
The Cancer Genome Atlas	Rectum Adenocarcinoma	2	0.29	2.3
The Cancer Genome Atlas	Soft Tissue Sarcoma	2	0.19	2.0
The Cancer Genome Atlas	Skin Cutaneous Melanoma	2	0.37	2.1
The Cancer Genome Atlas	Stomach Adenocarcinoma	5	0.30	2.2
The Cancer Genome Atlas	Testicular Germ Cell Tumors	4	0.31	2.2
The Cancer Genome Atlas	Thyroid Carcinoma	15	0.29	2.1
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	1	0.20	2.2